Targeting the RAF–MEK–ERK pathway in cancer therapy von Montagut, Clara, Settleman, Jeff

Volltext

Drug Resistance via Feedback Activation of Stat3 in Oncogene-Addicted Cancer Cells von Lee, Ho-June, Zhuang, Guanglei, Cao, Yi, Du, Pan, Kim, Hyo-Jin, Settleman, Jeff

Volltext

Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents von Sharma, Sreenath V., Haber, Daniel A., Settleman, Jeff

Volltext

The Cancer Stem Cell Marker Aldehyde Dehydrogenase Is Required to Maintain a Drug-Tolerant Tumor Cell Subpopulation von RAHA, Debasish, WILSON, Timothy R, JING PENG, PETERSON, David, PENG YUE, EVANGELISTA, Marie, WILSON, Catherine, MERCHANT, Mark, SETTLEMAN, Jeff

Volltext

Personalized Cancer Therapy With Selective Kinase Inhibitors: An Emerging Paradigm in Medical Oncology von MCDERMOTT, Ultan, SETTLEMAN, Jeff

Volltext

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors von Wilson, Timothy R., Fridlyand, Jane, Yan, Yibing, Penuel, Elicia, Burton, Luciana, Chan, Emily, Peng, Jing, Lin, Eva, Wang, Yulei, Sosman, Jeff, Ribas, Antoni, Li, Jiang, Moffat, John, Sutherlin, Daniel P., Koeppen, Hartmut, Merchant, Mark, Neve, Richard, Settleman, Jeff

Volltext

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism von Perera, Rushika M., Stoykova, Svetlana, Nicolay, Brandon N., Ross, Kenneth N., Fitamant, Julien, Boukhali, Myriam, Lengrand, Justine, Deshpande, Vikram, Selig, Martin K., Ferrone, Cristina R., Settleman, Jeff, Stephanopoulos, Gregory, Dyson, Nicholas J., Zoncu, Roberto, Ramaswamy, Sridhar, Haas, Wilhelm, Bardeesy, Nabeel

Volltext

Unprovoked Stabilization and Nuclear Accumulation of the Naked Mole-Rat p53 Protein von Deuker, Marian M., Lewis, Kaitlyn N., Ingaramo, Maria, Kimmel, Jacob, Buffenstein, Rochelle, Settleman, Jeff

Volltext

A Therapeutic Opportunity in Melanoma: ErbB4 Makes a Mark on Skin von Settleman, Jeff

Volltext

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations von Sharma, Sreenath V., Lee, Diana Y., Li, Bihua, Quinlan, Margaret P., Takahashi, Fumiyuki, Maheswaran, Shyamala, McDermott, Ultan, Azizian, Nancy, Zou, Lee, Fischbach, Michael A., Wong, Kwok-Kin, Brandstetter, Kathleyn, Wittner, Ben, Ramaswamy, Sridhar, Classon, Marie, Settleman, Jeff

Volltext

Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer von Montagut, Clara, Dalmases, Alba, Bellosillo, Beatriz, Crespo, Marta, Pairet, Silvia, Iglesias, Mar, Salido, Marta, Gallen, Manuel, Marsters, Scot, Tsai, Siao Ping, Minoche, André, Seshagiri, Somasekar, Serrano, Sergi, Himmelbauer, Heinz, Bellmunt, Joaquim, Rovira, Ana, Settleman, Jeff, Bosch, Francesc, Albanell, Joan

Volltext

Repression of Stress-Induced LINE-1 Expression Protects Cancer Cell Subpopulations from Lethal Drug Exposure von Guler, Gulfem Dilek, Tindell, Charles Albert, Pitti, Robert, Wilson, Catherine, Nichols, Katrina, KaiWai Cheung, Tommy, Kim, Hyo-Jin, Wongchenko, Matthew, Yan, Yibing, Haley, Benjamin, Cuellar, Trinna, Webster, Joshua, Alag, Navneet, Hegde, Ganapati, Jackson, Erica, Nance, Tracy Leah, Giresi, Paul Garrett, Chen, Kuan-Bei, Liu, Jinfeng, Jhunjhunwala, Suchit, Settleman, Jeff, Stephan, Jean-Philippe, Arnott, David, Classon, Marie

Volltext

TAK1 Inhibition Promotes Apoptosis in KRAS-Dependent Colon Cancers von Singh, Anurag, Sweeney, Michael F., Yu, Min, Burger, Alexa, Greninger, Patricia, Benes, Cyril, Haber, Daniel A., Settleman, Jeff

Volltext

AXL inhibition sensitizes mesenchymal cancer cells to antimitotic drugs von Wilson, Catherine, Ye, Xiaofen, Pham, Thinh, Lin, Eva, Chan, Sara, McNamara, Erin, Neve, Richard M, Belmont, Lisa, Koeppen, Hartmut, Yauch, Robert L, Ashkenazi, Avi, Settleman, Jeff

Volltext

Cotargeting of MEK and PDGFR/STAT3 Pathways to Treat Pancreatic Ductal Adenocarcinoma von Sahu, Nisebita, Chan, Emily, Chu, Felix, Pham, Thinh, Koeppen, Hartmut, Forrest, William, Merchant, Mark, Settleman, Jeff

Volltext

Bet on drug resistance von Settleman, Jeff

Volltext

Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition von Wilson, Catherine, Nicholes, Katrina, Bustos, Daisy, Lin, Eva, Song, Qinghua, Stephan, Jean-Philippe, Kirkpatrick, Donald S, Settleman, Jeff

Volltext

Cancer: Bet on drug resistance von Settleman, Jeff

Volltext

Acquired Resistance of Non―Small Cell Lung Cancer Cells to MET Kinase Inhibition Is Mediated by a Switch to Epidermal Growth Factor Receptor Dependency von MCDERMOTT, Ultan, PUSAPATI, Raju V, CHRISTENSEN, James G, GRAY, Nathanael S, SETTLEMAN, Jeff

Volltext

Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events von Liu, Jinfeng, Lee, William, Jiang, Zhaoshi, Chen, Zhongqiang, Jhunjhunwala, Suchit, Haverty, Peter M, Gnad, Florian, Guan, Yinghui, Gilbert, Houston N, Stinson, Jeremy, Klijn, Christiaan, Guillory, Joseph, Bhatt, Deepali, Vartanian, Steffan, Walter, Kimberly, Chan, Jocelyn, Holcomb, Thomas, Dijkgraaf, Peter, Johnson, Stephanie, Koeman, Julie, Minna, John D, Gazdar, Adi F, Stern, Howard M, Hoeflich, Klaus P, Wu, Thomas D, Settleman, Jeff, de Sauvage, Frederic J, Gentleman, Robert C, Neve, Richard M, Stokoe, David, Modrusan, Zora, Seshagiri, Somasekar, Shames, David S, Zhang, Zemin

Volltext