Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma von Ensan, Deeba, Smil, David, Zepeda-Velázquez, Carlos A, Panagopoulos, Dimitrios, Wong, Jong Fu, Williams, Eleanor P, Adamson, Roslin, Bullock, Alex N, Kiyota, Taira, Aman, Ahmed, Roberts, Owen G, Edwards, Aled M, O’Meara, Jeff A, Isaac, Methvin B, Al-awar, Rima

Volltext

Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma von Smil, David, Wong, Jong Fu, Williams, Eleanor P, Adamson, Roslin J, Howarth, Alison, McLeod, David A, Mamai, Ahmed, Kim, Soyoung, Wilson, Brian J, Kiyota, Taira, Aman, Ahmed, Owen, Julie, Poda, Gennady, Horiuchi, Kurumi Y, Kuznetsova, Ekaterina, Ma, Haiching, Hamblin, J. Nicole, Cramp, Sue, Roberts, Owen G, Edwards, Aled M, Uehling, David, Al-awar, Rima, Bullock, Alex N, O’Meara, Jeff A, Isaac, Methvin B

Volltext

Compound Aggregation in Drug Discovery: Implementing a Practical NMR Assay for Medicinal Chemists von LaPlante, Steven R, Carson, Rebekah, Gillard, James, Aubry, Norman, Coulombe, René, Bordeleau, Sylvain, Bonneau, Pierre, Little, Michael, O’Meara, Jeff, Beaulieu, Pierre L

Volltext

Discovery of Hepatitis C Virus NS3-4A Protease Inhibitors with Improved Barrier to Resistance and Favorable Liver Distribution von Moreau, Benoît, O’Meara, Jeff A., Bordeleau, Josée, Garneau, Michel, Godbout, Cedrickx, Gorys, Vida, Leblanc, Mélissa, Villemure, Elisia, White, Peter W., Llinàs-Brunet, Montse

Volltext

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly von Fader, Lee D., Bethell, Richard, Bonneau, Pierre, Bös, Michael, Bousquet, Yves, Cordingley, Michael G., Coulombe, René, Deroy, Patrick, Faucher, Anne-Marie, Gagnon, Alexandre, Goudreau, Nathalie, Grand-Maître, Chantal, Guse, Ingrid, Hucke, Oliver, Kawai, Stephen H., Lacoste, Jean-Eric, Landry, Serge, Lemke, Christopher T., Malenfant, Eric, Mason, Stephen, Morin, Sébastien, O’Meara, Jeff, Simoneau, Bruno, Titolo, Steve, Yoakim, Christiane

Volltext

Phosphatidylinositol 4-Kinase III Beta Is Essential for Replication of Human Rhinovirus and Its Inhibition Causes a Lethal Phenotype In Vivo von SPICKLER, Catherine, LIPPENS, Julie, VAILLANCOURT, Fréderic H, DECOR, Anne, O'MEARA, Jeff, FRANTI, Michael, GAUTHIER, Annick, LABERGE, Marie-Kristine, DESMEULES, Sophie, BELLAVANCE, Edith, GARNEAU, Michel, GUO, Tim, HUCKE, Oliver, LEYSSEN, Pieter, NEYTS, Johan

Volltext

Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor von Mamai, Ahmed, Chau, Anh M., Wilson, Brian J., Watson, Iain D., Joseph, Babu B., Subramanian, Pandiaraju R., Morshed, Monzur M., Morin, Justin A., Prakesch, Michael A., Lu, Tianbao, Connolly, Pete, Kuntz, Douglas A., Pomroy, Neil C., Poda, Gennady, Nguyen, Kong, Marcellus, Richard, Strathdee, Graig, Theriault, Brigitte, Subramaniam, Ratheesh, Mohammed, Mohammed, Abibi, Ayome, Chan, Manuel, Winston, Jeffrey, Kiyota, Taira, Undzys, Elijus, Aman, Ahmed, Austin, Nigel, Du Jardin, Marc, Packman, Kathryn, Phillippar, Ulrike, Attar, Riccardo, Edwards, James, O’Meara, Jeff, Uehling, David E., Al-awar, Rima, Privé, Gilbert G., Isaac, Methvin B.

Volltext

Scaffold hopping in the rational design of novel HIV-1 non-nucleoside reverse transcriptase inhibitors von O’Meara, Jeff A., Jakalian, Araz, LaPlante, Steven, Bonneau, Pierre R., Coulombe, René, Faucher, Anne-Marie, Guse, Ingrid, Landry, Serge, Racine, Jennifer, Simoneau, Bruno, Thavonekham, Bounkham, Yoakim, Christiane

Volltext

N- versus O-alkylation: Utilizing NMR methods to establish reliable primary structure determinations for drug discovery von LaPlante, Steven R., Bilodeau, François, Aubry, Norman, Gillard, James R., O’Meara, Jeff, Coulombe, René

Volltext

Molecular Mechanism by Which a Potent Hepatitis C Virus NS3-NS4A Protease Inhibitor Overcomes Emergence of Resistance von O'Meara, Jeff A., Lemke, Christopher T., Godbout, Cédrickx, Kukolj, George, Lagacé, Lisette, Moreau, Benoît, Thibeault, Diane, White, Peter W., Llinàs-Brunet, Montse

Volltext

Practical Synthesis of A Benzophenone-Based NNRT Inhibitor of HIV-1 von Wang, Xiao-jun, Zhang, Li, Sun, Xiufeng, Lee, Heewon, Krishnamurthy, Dhileepkumar, O’Meara, Jeff A, Landry, Serge, Yoakim, Christiane, Simoneau, Bruno, Yee, Nathan K, Senanayake, Chris H

Volltext

Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus von Décor, Anne, Grand-Maître, Chantal, Hucke, Oliver, O’Meara, Jeff, Kuhn, Cyrille, -Forget, Léa Constantineau, Brochu, Christian, Malenfant, Eric, Bertrand-Laperle, Mégan, Bordeleau, Josée, Ghiro, Elise, Pesant, Marc, Fazal, Gulrez, Gorys, Vida, Little, Michael, Boucher, Colette, Bordeleau, Sylvain, Turcotte, Pascal, Guo, Tim, Garneau, Michel, Spickler, Catherine, Gauthier, Annick

Volltext

Synthesis and optimization of a novel series of HCV NS3 protease inhibitors: 4-Arylproline analogs von Bilodeau, François, Bailey, Murray D., Bhardwaj, Punit K., Bordeleau, Josée, Forgione, Pat, Garneau, Michel, Ghiro, Elise, Gorys, Vida, Halmos, Ted, Jolicoeur, Eric S., Leblanc, Mélissa, Lemke, Christopher T., Naud, Julie, O’Meara, Jeff, White, Peter W., Llinàs-Brunet, Montse

Volltext

Peptide backbone replacement of hepatitis C virus NS3 serine protease C-terminal cleavage product analogs: Discovery of potent succinamide inhibitors von Bailey, Murray D., Bordeleau, Josée, Garneau, Michel, Leblanc, Mélissa, Lemke, Christopher T., O’Meara, Jeff, White, Peter W., Llinàs-Brunet, Montse

Volltext

Optimization and determination of the absolute configuration of a series of potent inhibitors of human papillomavirus type-11 E1–E2 protein–protein interaction: A combined medicina... von Goudreau, Nathalie, Cameron, Dale R., Déziel, Robert, Haché, Bruno, Jakalian, Araz, Malenfant, Eric, Naud, Julie, Ogilvie, William W., O’Meara, Jeff, White, Peter W., Yoakim, Christiane

Volltext

Discovery of the first series of inhibitors of human papillomavirus type 11: inhibition of the assembly of the E1–E2–Origin DNA complex von Yoakim, Christiane, Ogilvie, William W., Goudreau, Nathalie, Naud, Julie, Haché, Bruno, O'Meara, Jeff A., Cordingley, Michael G., Archambault, Jacques, White, Peter W.

Volltext

Abstract 4457: Open science medicinal chemistry: Towards a treatment for DIPG von Cramp, Sue, Hamblin, Nicole, O'Meara, Jeff, Edwards, Aled, Roberts, Owen, Bullock, Alex, Brennan, Paul

Volltext

β-Lactam Derivatives as Inhibitors of Human Cytomegalovirus Protease von Yoakim, Christiane, Ogilvie, William W, Cameron, Dale R, Chabot, Catherine, Guse, Ingrid, Haché, Bruno, Naud, Julie, O'Meara, Jeff A, Plante, Raymond, Déziel, Robert

Volltext

Novel 8-Substituted Dipyridodiazepinone Inhibitors with a Broad-Spectrum of Activity against HIV-1 Strains Resistant to Non-nucleoside Reverse Transcriptase Inhibitors von O'Meara, Jeff A, Yoakim, Christiane, Bonneau, Pierre R, Bös, Michael, Cordingley, Michael G, Déziel, Robert, Doyon, Louise, Duan, Jianmin, Garneau, Michel, Guse, Ingrid, Landry, Serge, Malenfant, Eric, Naud, Julie, Ogilvie, William W, Thavonekham, Bounkham, Simoneau, Bruno

Volltext

Peptidomimetic Inhibitors of the Human Cytomegalovirus Protease von Ogilvie, William, Bailey, Murray, Poupart, Marc-André, Abraham, Bhavsar, Amit, Bonneau, Pierre, Bordeleau, Josée, Bousquet, Yves, Chabot, Catherine, Duceppe, Jean-Simon, Fazal, Gulrez, Goulet, Sylvie, Grand-Maître, Chantal, Guse, Ingrid, Halmos, Ted, Lavallée, Pierre, Leach, Michael, Malenfant, Eric, O'Meara, Jeff, Plante, Raymond, Plouffe, Céline, Poirier, Martin, Soucy, François, Yoakim, Christiane, Déziel, Robert

Volltext