Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters von Javierre, Biola M., Burren, Oliver S., Wilder, Steven P., Kreuzhuber, Roman, Hill, Steven M., Sewitz, Sven, Cairns, Jonathan, Wingett, Steven W., Várnai, Csilla, Thiecke, Michiel J., Burden, Frances, Farrow, Samantha, Cutler, Antony J., Rehnström, Karola, Downes, Kate, Grassi, Luigi, Kostadima, Myrto, Freire-Pritchett, Paula, Wang, Fan, Martens, Joost H., Kim, Bowon, Sharifi, Nilofar, Janssen-Megens, Eva M., Yaspo, Marie-Laure, Linser, Matthias, Kovacsovics, Alexander, Clarke, Laura, Richardson, David, Datta, Avik, Flicek, Paul, Stunnenberg, Hendrik G., Todd, John A., Zerbino, Daniel R., Stegle, Oliver, Ouwehand, Willem H., Frontini, Mattia, Wallace, Chris, Spivakov, Mikhail, Fraser, Peter

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Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes von Aymard, François, Aguirrebengoa, Marion, Guillou, Emmanuelle, Javierre, Biola M, Bugler, Beatrix, Arnould, Coline, Rocher, Vincent, Iacovoni, Jason S, Biernacka, Anna, Skrzypczak, Magdalena, Ginalski, Krzysztof, Rowicka, Maga, Fraser, Peter, Legube, Gaëlle

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The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia von Beekman, Renée, Chapaprieta, Vicente, Russiñol, Núria, Vilarrasa-Blasi, Roser, Verdaguer-Dot, Núria, Martens, Joost H. A., Duran-Ferrer, Martí, Kulis, Marta, Serra, François, Javierre, Biola M., Wingett, Steven W., Clot, Guillem, Queirós, Ana C., Castellano, Giancarlo, Blanc, Julie, Gut, Marta, Merkel, Angelika, Heath, Simon, Vlasova, Anna, Ullrich, Sebastian, Palumbo, Emilio, Enjuanes, Anna, Martín-García, David, Beà, Sílvia, Pinyol, Magda, Aymerich, Marta, Royo, Romina, Puiggros, Montserrat, Torrents, David, Datta, Avik, Lowy, Ernesto, Kostadima, Myrto, Roller, Maša, Clarke, Laura, Flicek, Paul, Agirre, Xabier, Prosper, Felipe, Baumann, Tycho, Delgado, Julio, López-Guillermo, Armando, Fraser, Peter, Yaspo, Marie-Laure, Guigó, Roderic, Siebert, Reiner, Martí-Renom, Marc A., Puente, Xose S., López-Otín, Carlos, Gut, Ivo, Stunnenberg, Hendrik G., Campo, Elias, Martin-Subero, Jose I.

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Highly interconnected enhancer communities control lineage-determining genes in human mesenchymal stem cells von Madsen, Jesper G. S., Madsen, Maria S., Rauch, Alexander, Traynor, Sofie, Van Hauwaert, Elvira L., Haakonsson, Anders K., Javierre, Biola M., Hyldahl, Mette, Fraser, Peter, Mandrup, Susanne

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The HDAC7–TET2 epigenetic axis is essential during early B lymphocyte development von Azagra, Alba, Meler, Ainara, de Barrios, Oriol, Tomás-Daza, Laureano, Collazo, Olga, Monterde, Beatriz, Obiols, Mireia, Rovirosa, Llorenç, Vila-Casadesús, Maria, Cabrera-Pasadas, Mónica, Gusi-Vives, Mar, Graf, Thomas, Varela, Ignacio, Sardina, José Luis, Javierre, Biola M, Parra, Maribel

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p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response von Serra, François, Nieto-Aliseda, Andrea, Fanlo-Escudero, Lucía, Rovirosa, Llorenç, Cabrera-Pasadas, Mónica, Lazarenkov, Aleksey, Urmeneta, Blanca, Alcalde-Merino, Alvaro, Nola, Emanuele M., Okorokov, Andrei L., Fraser, Peter, Graupera, Mariona, Castillo, Sandra D., Sardina, Jose L., Valencia, Alfonso, Javierre, Biola M.

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Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks von Choy, Mun-Kit, Javierre, Biola M., Williams, Simon G., Baross, Stephanie L., Liu, Yingjuan, Wingett, Steven W., Akbarov, Artur, Wallace, Chris, Freire-Pritchett, Paula, Rugg-Gunn, Peter J., Spivakov, Mikhail, Fraser, Peter, Keavney, Bernard D.

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Low input capture Hi-C (liCHi-C) identifies promoter-enhancer interactions at high-resolution von Tomás-Daza, Laureano, Rovirosa, Llorenç, López-Martí, Paula, Nieto-Aliseda, Andrea, Serra, François, Planas-Riverola, Ainoa, Molina, Oscar, McDonald, Rebecca, Ghevaert, Cedric, Cuatrecasas, Esther, Costa, Dolors, Camós, Mireia, Bueno, Clara, Menéndez, Pablo, Valencia, Alfonso, Javierre, Biola M.

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B-cell leukemia transdifferentiation to macrophage involves reconfiguration of DNA methylation for long-range regulation von Bueno-Costa, Alberto, Piñeyro, David, Soler, Marta, Javierre, Biola M., Raurell-Vila, Helena, Subirana-Granés, Marc, Pasquali, Lorenzo, Martinez-Climent, Jose A., Esteller, Manel

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The onset of PI3K‐related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib von Kobialka, Piotr, Sabata, Helena, Vilalta, Odena, Gouveia, Leonor, Angulo‐Urarte, Ana, Muixí, Laia, Zanoncello, Jasmina, Muñoz‐Aznar, Oscar, Olaciregui, Nagore G, Fanlo, Lucia, Esteve‐Codina, Anna, Lavarino, Cinzia, Javierre, Biola M, Celis, Veronica, Rovira, Carlota, López‐Fernández, Susana, Baselga, Eulàlia, Mora, Jaume, Castillo, Sandra D, Graupera, Mariona

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The Genome in a Three-Dimensional Context: Deciphering the Contribution of Noncoding Mutations at Enhancers to Blood Cancer von Rovirosa, Llorenc, Ramos-Morales, Alberto, Javierre, Biola M.

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Epigenomics and transcriptomics of systemic sclerosis CD4+T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci von Li, Tianlu, Ortiz-Fernandez, Lourdes, Andres-Leon, Eduardo, Ciudad, Laura, Javierre, Biola M., Lopez-Isac, Elena, Guillen-Del-Castillo, Alfredo, Simeon-Aznar, Carmen Pilar, Ballestar, Esteban, Martin, Javier

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Intra- and interchromosomal contact mapping reveals the Igh locus has extensive conformational heterogeneity and interacts with B-lineage genes von Mielczarek, Olga, Rogers, Carolyn H., Zhan, Yinxiu, Matheson, Louise S., Stubbington, Michael J.T., Schoenfelder, Stefan, Bolland, Daniel J., Javierre, Biola M., Wingett, Steven W., Várnai, Csilla, Segonds-Pichon, Anne, Conn, Simon J., Krueger, Felix, Andrews, Simon, Fraser, Peter, Giorgetti, Luca, Corcoran, Anne E.

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Leptin and TNF-alpha promoter methylation levels measured by MSP could predict the response to a low-calorie diet von Cordero, Paul, Campion, Javier, Milagro, Fermin I., Goyenechea, Estibaliz, Steemburgo, Thais, Javierre, Biola M., Martinez, J. Alfredo

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B cell transcription program mediates hypomethylation and overexpression of key genes in Epstein-Barr virus-associated proliferative conversion von Hernando, Henar, Shannon-Lowe, Claire, Islam, Abul B, Al-Shahrour, Fatima, Rodríguez-Ubreva, Javier, Rodríguez-Cortez, Virginia C, Javierre, Biola M, Mangas, Cristina, Fernández, Agustín F, Parra, Maribel, Delecluse, Henri-Jacques, Esteller, Manel, López-Granados, Eduardo, Fraga, Mario F, López-Bigas, Nuria, Ballestar, Esteban

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Author Correction: Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks von Choy, Mun-Kit, Javierre, Biola M., Williams, Simon G., Baross, Stephanie L., Liu, Yingjuan, Wingett, Steven W., Akbarov, Artur, Wallace, Chris, Freire-Pritchett, Paula, Rugg-Gunn, Peter J., Spivakov, Mikhail, Fraser, Peter, Keavney, Bernard D.

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From Loops to Looks: Transcription Factors and Chromatin Organization Shaping Terminal B Cell Differentiation von Azagra, Alba, Marina-Zárate, Ester, Ramiro, Almudena R., Javierre, Biola M., Parra, Maribel

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Environmental triggers and epigenetic deregulation in autoimmune disease von Javierre, Biola M, Hernando, Henar, Ballestar, Esteban

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High-resolution simulations of chromatin folding at genomic rearrangements in malignant B cells provide mechanistic insights into proto-oncogene deregulation von Rico, Daniel, Kent, Daniel, Karataraki, Nefeli, Mikulasova, Aneta, Berlinguer-Palmini, Rolando, Walker, Brian A, Javierre, Biola M, Russell, Lisa J, Brackley, Chris A

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IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation von Vento-Tormo, Roser, Company, Carlos, Rodríguez-Ubreva, Javier, de la Rica, Lorenzo, Urquiza, José M, Javierre, Biola M, Sabarinathan, Radhakrishnan, Luque, Ana, Esteller, Manel, Aran, Josep M, Álvarez-Errico, Damiana, Ballestar, Esteban

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