Development of CAR T cells designed to improve antitumor efficacy and safety von Jaspers, Janneke E, Brentjens, Renier J

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IL-18-secreting CAR T cells targeting DLL3 are highly effective in small cell lung cancer models von Jaspers, Janneke E, Khan, Jonathan F, Godfrey, William D, Lopez, Andrea V, Ciampricotti, Metamia, Rudin, Charles M, Brentjens, Renier J

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Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors von Jaspers, Janneke E, Kersbergen, Ariena, Boon, Ute, Sol, Wendy, van Deemter, Liesbeth, Zander, Serge A, Drost, Rinske, Wientjens, Ellen, Ji, Jiuping, Aly, Amal, Doroshow, James H, Cranston, Aaron, Martin, Niall M B, Lau, Alan, O'Connor, Mark J, Ganesan, Shridar, Borst, Piet, Jonkers, Jos, Rottenberg, Sven

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Impaired endothelial progenitor cell mobilization and dysfunctional bone marrow stroma in diabetes mellitus von Westerweel, Peter E, Teraa, Martin, Rafii, Shahin, Jaspers, Janneke E, White, Ian A, Hooper, Andrea T, Doevendans, Pieter A, Verhaar, Marianne C

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High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs von Rottenberg, Sven, Jaspers, Janneke E, Kersbergen, Ariena, van der Burg, Eline, Nygren, Anders O.H, Zander, Serge A.L, Derksen, Patrick W.B, de Bruin, Michiel, Zevenhoven, John, Lau, Alan, Boulter, Robert, Cranston, Aaron, O'Connor, Mark J, Martin, Niall M.B, Borst, Piet, Jonkers, Jos

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Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer von Henneman, Linda, van Miltenburg, Martine H., Michalak, Ewa M., Braumuller, Tanya M., Jaspers, Janneke E., Drenth, Anne Paulien, de Korte-Grimmerink, Renske, Gogola, Ewa, Szuhai, Karoly, Schlicker, Andreas, Ali, Rahmen Bin, Pritchard, Colin, Huijbers, Ivo J., Berns, Anton, Rottenberg, Sven, Jonkers, Jos

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BRCA2-deficient sarcomatoid mammary tumors exhibit multidrug resistance von Jaspers, Janneke E, Sol, Wendy, Kersbergen, Ariena, Schlicker, Andreas, Guyader, Charlotte, Xu, Guotai, Wessels, Lodewyk, Borst, Piet, Jonkers, Jos, Rottenberg, Sven

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The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models von Oplustil O'Connor, Lenka, Rulten, Stuart L, Cranston, Aaron N, Odedra, Rajesh, Brown, Henry, Jaspers, Janneke E, Jones, Louise, Knights, Charlotte, Evers, Bastiaan, Ting, Attilla, Bradbury, Robert H, Pajic, Marina, Rottenberg, Sven, Jonkers, Jos, Rudge, David, Martin, Niall M B, Caldecott, Keith W, Lau, Alan, O'Connor, Mark J

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Rlf-Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer von Ciampricotti, Metamia, Karakousi, Triantafyllia, Richards, Allison L, Quintanal-Villalonga, Àlvaro, Karatza, Angeliki, Caeser, Rebecca, Costa, Emily A, Allaj, Viola, Manoj, Parvathy, Spainhower, Kyle B, Kombak, Faruk E, Sanchez-Rivera, Francisco J, Jaspers, Janneke E, Zavitsanou, Anastasia-Maria, Maddalo, Danilo, Ventura, Andrea, Rideout, William M, Akama-Garren, Elliot H, Jacks, Tyler, Donoghue, Mark T A, Sen, Triparna, Oliver, Trudy G, Poirier, John T, Papagiannakopoulos, Thales, Rudin, Charles M

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REV7 counteracts DNA double-strand break resection and affects PARP inhibition von Xu, Guotai, Chapman, J. Ross, Brandsma, Inger, Yuan, Jingsong, Mistrik, Martin, Bouwman, Peter, Bartkova, Jirina, Gogola, Ewa, Warmerdam, Daniël, Barazas, Marco, Jaspers, Janneke E., Watanabe, Kenji, Pieterse, Mark, Kersbergen, Ariena, Sol, Wendy, Celie, Patrick H. N., Schouten, Philip C., van den Broek, Bram, Salman, Ahmed, Nieuwland, Marja, de Rink, Iris, de Ronde, Jorma, Jalink, Kees, Boulton, Simon J., Chen, Junjie, van Gent, Dik C., Bartek, Jiri, Jonkers, Jos, Borst, Piet, Rottenberg, Sven

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Therapeutic options for triple-negative breast cancers with defective homologous recombination von Jaspers, Janneke E., Rottenberg, Sven, Jonkers, Jos

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Sensitivity and Acquired Resistance of BRCA1 ;p53-Deficient Mouse Mammary Tumors to the Topoisomerase I Inhibitor Topotecan von ZANDER, Serge A. L, KERSBERGEN, Ariena, BORST, Piet, ROTTENBERG, Sven, VAN DER BURG, Eline, DE WATER, Niels, VAN TELLINGEN, Olaf, GUNNARSDOTTIR, Sjöfn, JASPERS, Janneke E, PAJIC, Marina, NYGREN, Anders O. H, JONKERS, Jos

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6-Thioguanine Selectively Kills BRCA2-Defective Tumors and Overcomes PARP Inhibitor Resistance von ISSAEVA, Natalia, THOMAS, Huw D, CHATZAKOS, Vicky, MULLIGAN, Evan A, LUNDIN, Cecilia, GUBANOVA, Evgenia, KERSBERGEN, Ariena, HARRIS, Adrian L, SHARMA, Ricky A, ROTTENBERG, Sven, CURTIN, Nicola J, HELLEDAY, Thomas, DJURENOVIC, Tatjana, JASPERS, Janneke E, STOIMENOV, Ivaylo, KYLE, Suzanne, PEDLEY, Nicholas, GOTTIPATI, Ponnari, ZUR, Rafal, SLEETH, Kate

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Impact of Intertumoral Heterogeneity on Predicting Chemotherapy Response of BRCA1-Deficient Mammary Tumors von ROTTENBERG, Sven, VOLLEBERGH, Marieke A, LODEN, Martin, SOL, Wendy, DER BURG, Eline Van, WESSELING, Jelle, GILLET, Jean-Pierre, GOTTESMAN, Michael M, GRIBNAU, Joost, WESSELS, Lodewyk, LINN, Sabine C, JONKERS, Jos, DE HOON, Bas, BORST, Piet, DE RONDE, Jorma, SCHOUTEN, Philip C, KERSBERGEN, Ariena, ZANDER, SergeA. L, PAJIC, Marina, JASPERS, Janneke E, JONKERS, Martijn

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Secretome proteomics reveals candidate non-invasive biomarkers of BRCA1 deficiency in breast cancer von Warmoes, Marc, Lam, Siu W, van der Groep, Petra, Jaspers, Janneke E, Smolders, Yvonne H C M, de Boer, Leon, Pham, Thang V, Piersma, Sander R, Rottenberg, Sven, Boven, Epie, Jonkers, Jos, van Diest, Paul J, Jimenez, Connie R

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Proteomics of Genetically Engineered Mouse Mammary Tumors Identifies Fatty Acid Metabolism Members as Potential Predictive Markers for Cisplatin Resistance von Warmoes, Marc, Jaspers, Janneke E., Xu, Guotai, Sampadi, Bharath K., Pham, Thang V., Knol, Jaco C., Piersma, Sander R., Boven, Epie, Jonkers, Jos, Rottenberg, Sven, Jimenez, Connie R.

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Proteomics of Mouse BRCA1-deficient Mammary Tumors Identifies DNA Repair Proteins with Potential Diagnostic and Prognostic Value in Human Breast Cancer von Warmoes, Marc, Jaspers, Janneke E., Pham, Thang V., Piersma, Sander R., Oudgenoeg, Gideon, Massink, Maarten P.G., Waisfisz, Quinten, Rottenberg, Sven, Boven, Epie, Jonkers, Jos, Jimenez, Connie R.

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Monitoring of Tumor Response to Cisplatin Using Optical Spectroscopy von Spliethoff, Jarich W, Evers, Daniel J, Jaspers, Janneke E, Hendriks, Benno H.W, Rottenberg, Sven, Ruers, Theo J.M

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Reversible epithelial to mesenchymal transition and acquired resistance to sunitinib in patients with renal cell carcinoma: evidence from a xenograft study von Hammers, Hans J, Verheul, Henk M, Salumbides, Brenda, Sharma, Rajni, Rudek, Michelle, Jaspers, Janneke, Shah, Preeti, Ellis, Leigh, Shen, Li, Paesante, Silvia, Dykema, Karl, Furge, Kyle, Teh, Bin T, Netto, George, Pili, Roberto

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Abstract LB-392: Loss of Rev7 causes PARP inhibitor resistance in BRCA1;p53-deficient mouse mammary tumor cells von Xu, Guotai, Bouwman, Peter, Jaspers, Janneke, Pieterse, Mark, Kersbergen, Ariena, Jonkers, Jos, Borst, Piet, Rottenberg, Sven

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