BAGEL: a computational framework for identifying essential genes from pooled library screens von Hart, Traver, Moffat, Jason

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Global Genetic Networks and the Genotype-to-Phenotype Relationship von Costanzo, Michael, Kuzmin, Elena, van Leeuwen, Jolanda, Mair, Barbara, Moffat, Jason, Boone, Charles, Andrews, Brenda

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Measuring error rates in genomic perturbation screens: gold standards for human functional genomics von Hart, Traver, Brown, Kevin R, Sircoulomb, Fabrice, Rottapel, Robert, Moffat, Jason

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High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities von Hart, Traver, Chandrashekhar, Megha, Aregger, Michael, Steinhart, Zachary, Brown, Kevin R., MacLeod, Graham, Mis, Monika, Zimmermann, Michal, Fradet-Turcotte, Amelie, Sun, Song, Mero, Patricia, Dirks, Peter, Sidhu, Sachdev, Roth, Frederick P., Rissland, Olivia S., Durocher, Daniel, Angers, Stephane, Moffat, Jason

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Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance von Marcotte, Richard, Sayad, Azin, Brown, Kevin R., Sanchez-Garcia, Felix, Reimand, Jüri, Haider, Maliha, Virtanen, Carl, Bradner, James E., Bader, Gary D., Mills, Gordon B., Pe’er, Dana, Moffat, Jason, Neel, Benjamin G.

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Digital microfluidic isolation of single cells for -Omics von Lamanna, Julian, Scott, Erica Y., Edwards, Harrison S., Chamberlain, M. Dean, Dryden, Michael D. M., Peng, Jiaxi, Mair, Barbara, Lee, Adam, Chan, Calvin, Sklavounos, Alexandros A., Heffernan, Austin, Abbas, Farhana, Lam, Charis, Olson, Maxwell E., Moffat, Jason, Wheeler, Aaron R.

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A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface von Gupta, Gagan D., Coyaud, Étienne, Gonçalves, João, Mojarad, Bahareh A., Liu, Yi, Wu, Qianzhu, Gheiratmand, Ladan, Comartin, David, Tkach, Johnny M., Cheung, Sally W.T., Bashkurov, Mikhail, Hasegan, Monica, Knight, James D., Lin, Zhen-Yuan, Schueler, Markus, Hildebrandt, Friedhelm, Moffat, Jason, Gingras, Anne-Claude, Raught, Brian, Pelletier, Laurence

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Yeast Proteome Dynamics from Single Cell Imaging and Automated Analysis von Chong, Yolanda T., Koh, Judice L.Y., Friesen, Helena, Kaluarachchi Duffy, Supipi, Cox, Michael J., Moses, Alan, Moffat, Jason, Boone, Charles, Andrews, Brenda J.

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The Rational Development of CD133-Targeting Immunotherapies for Glioblastoma von Vora, Parvez, Venugopal, Chitra, Salim, Sabra Khalid, Tatari, Nazanin, Bakhshinyan, David, Singh, Mohini, Seyfrid, Mathieu, Upreti, Deepak, Rentas, Stefan, Wong, Nicholas, Williams, Rashida, Qazi, Maleeha Ahmad, Chokshi, Chirayu, Ding, Avrilynn, Subapanditha, Minomi, Savage, Neil, Mahendram, Sujeivan, Ford, Emily, Adile, Ashley Ann, McKenna, Dillon, McFarlane, Nicole, Huynh, Vince, Wylie, Ryan Gavin, Pan, James, Bramson, Jonathan, Hope, Kristin, Moffat, Jason, Singh, Sheila

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Identifying chemogenetic interactions from CRISPR screens with drugZ von Colic, Medina, Wang, Gang, Zimmermann, Michal, Mascall, Keith, McLaughlin, Megan, Bertolet, Lori, Lenoir, W Frank, Moffat, Jason, Angers, Stephane, Durocher, Daniel, Hart, Traver

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SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination von Yanling Zhao, Dorothy, Gish, Gerald, Braunschweig, Ulrich, Li, Yue, Ni, Zuyao, Schmitges, Frank W., Zhong, Guoqing, Liu, Ke, Li, Weiguo, Moffat, Jason, Vedadi, Masoud, Min, Jinrong, Pawson, Tony J., Blencowe, Benjamin J., Greenblatt, Jack F.

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Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity von Gaudet, Ryan G., Sintsova, Anna, Buckwalter, Carolyn M., Leung, Nelly, Cochrane, Alan, Li, Jianjun, Cox, Andrew D., Moffat, Jason, Gray-Owen, Scott D.

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CRISPR screens are feasible in TP53 wild‐type cells von Brown, Kevin R, Mair, Barbara, Soste, Martin, Moffat, Jason

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Genome-wide CRISPR-Cas9 Interrogation of Splicing Networks Reveals a Mechanism for Recognition of Autism-Misregulated Neuronal Microexons von Gonatopoulos-Pournatzis, Thomas, Wu, Mingkun, Braunschweig, Ulrich, Roth, Jonathan, Han, Hong, Best, Andrew J, Raj, Bushra, Aregger, Michael, O'Hanlon, Dave, Ellis, Jonathan D, Calarco, John A, Moffat, Jason, Gingras, Anne-Claude, Blencowe, Benjamin J

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Protocol for CRISPR-based endogenous protein tagging in mammalian cells von Xiao, Yu-Xi, Wei, Jiarun, Moffat, Jason

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Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies von Mair, Barbara, Tomic, Jelena, Masud, Sanna N., Tonge, Peter, Weiss, Alexander, Usaj, Matej, Tong, Amy Hin Yan, Kwan, Jamie J., Brown, Kevin R., Titus, Emily, Atkins, Michael, Chan, Katherine S.K., Munsie, Lise, Habsid, Andrea, Han, Hong, Kennedy, Marion, Cohen, Brenda, Keller, Gordon, Moffat, Jason

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CellProfiler: image analysis software for identifying and quantifying cell phenotypes von Carpenter, Anne E, Jones, Thouis R, Lamprecht, Michael R, Clarke, Colin, Kang, In Han, Friman, Ola, Guertin, David A, Chang, Joo Han, Lindquist, Robert A, Moffat, Jason, Golland, Polina, Sabatini, David M

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Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer von Chang, Chewei Anderson, Jen, Jayu, Jiang, Shaowen, Sayad, Azin, Mer, Arvind Singh, Brown, Kevin R, Nixon, Allison M L, Dhabaria, Avantika, Tang, Kwan Ho, Venet, David, Sotiriou, Christos, Deng, Jiehui, Wong, Kwok-Kin, Adams, Sylvia, Meyn, Peter, Heguy, Adriana, Skok, Jane A, Tsirigos, Aristotelis, Ueberheide, Beatrix, Moffat, Jason, Singh, Abhyudai, Haibe-Kains, Benjamin, Khodadadi-Jamayran, Alireza, Neel, Benjamin G

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Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1–F-box interface von Gorelik, Maryna, Orlicky, Stephen, Sartori, Maria A., Tang, Xiaojing, Marcon, Edyta, Kurinov, Igor, Greenblatt, Jack F., Tyers, Mike, Moffat, Jason, Sicheri, Frank, Sidhu, Sachdev S.

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Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice von Tao, Yuyong, Mis, Monika, Blazer, Levi, Ustav, Jnr, Mart, Steinhart, Zachary, Chidiac, Rony, Kubarakos, Elli, O'Brien, Siobhan, Wang, Xiaomei, Jarvik, Nick, Patel, Nish, Adams, Jarrett, Moffat, Jason, Angers, Stephane, Sidhu, Sachdev S

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