Pan-KRAS inhibitor disables oncogenic signalling and tumour growth von Kim, Dongsung, Herdeis, Lorenz, Rudolph, Dorothea, Zhao, Yulei, Böttcher, Jark, Vides, Alberto, Ayala-Santos, Carlos I., Pourfarjam, Yasin, Cuevas-Navarro, Antonio, Xue, Jenny Y., Mantoulidis, Andreas, Bröker, Joachim, Wunberg, Tobias, Schaaf, Otmar, Popow, Johannes, Wolkerstorfer, Bernhard, Kropatsch, Katrin Gabriele, Qu, Rui, de Stanchina, Elisa, Sang, Ben, Li, Chuanchuan, McConnell, Darryl B., Kraut, Norbert, Lito, Piro

Volltext

BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition von Hofmann, Marco H, Gmachl, Michael, Ramharter, Juergen, Savarese, Fabio, Gerlach, Daniel, Marszalek, Joseph R, Sanderson, Michael P, Kessler, Dirk, Trapani, Francesca, Arnhof, Heribert, Rumpel, Klaus, Botesteanu, Dana-Adriana, Ettmayer, Peter, Gerstberger, Thomas, Kofink, Christiane, Wunberg, Tobias, Zoephel, Andreas, Fu, Szu-Chin, Teh, Jessica L, Böttcher, Jark, Pototschnig, Nikolai, Schachinger, Franziska, Schipany, Katharina, Lieb, Simone, Vellano, Christopher P, O'Connell, Jonathan C, Mendes, Rachel L, Moll, Jurgen, Petronczki, Mark, Heffernan, Timothy P, Pearson, Mark, McConnell, Darryl B, Kraut, Norbert

Volltext

Chemical coverage of human biological pathways von Kwak, Haejin Angela, Liu, Lihua, Tredup, Claudia, Röhm, Sandra, Prinos, Panagiotis, Böttcher, Jark, Schapira, Matthieu

Volltext

Structure–kinetic relationship study of CDK8/CycC specific compounds von Schneider, Elisabeth V., Böttcher, Jark, Huber, Robert, Maskos, Klaus, Neumann, Lars

Volltext

Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C Inhibitor von Bröker, Joachim, Waterson, Alex G., Smethurst, Chris, Kessler, Dirk, Böttcher, Jark, Mayer, Moriz, Gmaschitz, Gerhard, Phan, Jason, Little, Andrew, Abbott, Jason R., Sun, Qi, Gmachl, Michael, Rudolph, Dorothea, Arnhof, Heribert, Rumpel, Klaus, Savarese, Fabio, Gerstberger, Thomas, Mischerikow, Nikolai, Treu, Matthias, Herdeis, Lorenz, Wunberg, Tobias, Gollner, Andreas, Weinstabl, Harald, Mantoulidis, Andreas, Krämer, Oliver, McConnell, Darryl B., W. Fesik, Stephen

Volltext

One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS von Ramharter, Juergen, Kessler, Dirk, Ettmayer, Peter, Hofmann, Marco H, Gerstberger, Thomas, Gmachl, Michael, Wunberg, Tobias, Kofink, Christiane, Sanderson, Michael, Arnhof, Heribert, Bader, Gerd, Rumpel, Klaus, Zöphel, Andreas, Schnitzer, Renate, Böttcher, Jark, O’Connell, Jonathan C, Mendes, Rachel L, Richard, David, Pototschnig, Nikolai, Weiner, Irene, Hela, Wolfgang, Hauer, Katja, Haering, Daniela, Lamarre, Lyne, Wolkerstorfer, Bernhard, Salamon, Christian, Werni, Patrick, Munico-Martinez, Silvia, Meyer, Reiner, Kennedy, Matthew D, Kraut, Norbert, McConnell, Darryl B

Volltext

Drugging all RAS isoforms with one pocket von Kessler, Dirk, Bergner, Andreas, Böttcher, Jark, Fischer, Gerhard, Döbel, Sandra, Hinkel, Melanie, Müllauer, Barbara, Weiss-Puxbaum, Alexander, McConnell, Darryl B

Volltext

HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain von Grabarczyk, Daniel B., Petrova, Olga A., Deszcz, Luiza, Kurzbauer, Robert, Murphy, Paul, Ahel, Juraj, Vogel, Antonia, Gogova, Rebeca, Faas, Victoria, Kordic, Darja, Schleiffer, Alexander, Meinhart, Anton, Imre, Richard, Lehner, Anita, Neuhold, Jana, Bader, Gerd, Stolt-Bergner, Peggy, Böttcher, Jark, Wolkerstorfer, Bernhard, Fischer, Gerhard, Grishkovskaya, Irina, Haselbach, David, Kessler, Dirk, Clausen, Tim

Volltext

Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3 von Böttcher, Jark, Dilworth, David, Reiser, Ulrich, Neumüller, Ralph A., Schleicher, Michael, Petronczki, Mark, Zeeb, Markus, Mischerikow, Nikolai, Allali-Hassani, Abdellah, Szewczyk, Magdalena M., Li, Fengling, Kennedy, Steven, Vedadi, Masoud, Barsyte-Lovejoy, Dalia, Brown, Peter J., Huber, Kilian V. M., Rogers, Catherine M., Wells, Carrow I., Fedorov, Oleg, Rumpel, Klaus, Zoephel, Andreas, Mayer, Moriz, Wunberg, Tobias, Böse, Dietrich, Zahn, Stephan, Arnhof, Heribert, Berger, Helmut, Reiser, Christoph, Hörmann, Alexandra, Krammer, Teresa, Corcokovic, Maja, Sharps, Bernadette, Winkler, Sandra, Häring, Daniela, Cockcroft, Xiao-Ling, Fuchs, Julian E., Müllauer, Barbara, Weiss-Puxbaum, Alexander, Gerstberger, Thomas, Boehmelt, Guido, Vakoc, Christopher R., Arrowsmith, Cheryl H., Pearson, Mark, McConnell, Darryl B.

Volltext

Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance von Hofmann, Marco H, Mani, Rajeswaran, Engelhardt, Harald, Impagnatiello, Maria A, Carotta, Sebastian, Kerenyi, Marc, Lorenzo-Herrero, Seila, Böttcher, Jark, Scharn, Dirk, Arnhof, Heribert, Zoephel, Andreas, Schnitzer, Renate, Gerstberger, Thomas, Sanderson, Michael P, Rajgolikar, Girish, Goswami, Swagata, Vasu, Sumithira, Ettmayer, Peter, Gonzalez, Segundo, Pearson, Mark, McConnell, Darryl B, Kraut, Norbert, Muthusamy, Natarajan, Moll, Jürgen

Volltext

Ligandability assessment of the C‐terminal Rel‐homology domain of NFAT1 von Böttcher, Jark, Fuchs, Julian E., Mayer, Moriz, Kahmann, Jan, Zak, Krzysztof M., Wunberg, Tobias, Woehrle, Simon, Kessler, Dirk

Volltext

Ligand 1H NMR Chemical Shifts as Accurate Reporters for Protein‐Ligand Binding Interfaces in Solution von Platzer, Gerald, Ptaszek, Aleksandra L., Böttcher, Jark, Fuchs, Julian E., Geist, Leonhard, Braun, Daniel, McConnell, Darryl B., Konrat, Robert, Sánchez‐Murcia, Pedro A., Mayer, Moriz

Volltext

Cover Feature: Ligand 1H NMR Chemical Shifts as Accurate Reporters for Protein‐Ligand Binding Interfaces in Solution (ChemPhysChem 1/2024) von Platzer, Gerald, Ptaszek, Aleksandra L., Böttcher, Jark, Fuchs, Julian E., Geist, Leonhard, Braun, Daniel, McConnell, Darryl B., Konrat, Robert, Sánchez‐Murcia, Pedro A., Mayer, Moriz

Volltext

A Novel Antagonistic CD73 Antibody for Inhibition of the Immunosuppressive Adenosine Pathway von Wurm, Melanie, Schaaf, Otmar, Reutner, Katharina, Ganesan, Rajkumar, Mostböck, Sven, Pelster, Christina, Böttcher, Jark, de Andrade Pereira, Bruna, Taubert, Christina, Alt, Isabella, Serna, Garazi, Auguste, Aurelie, Stadermann, Kai B, Delic, Denis, Han, Fei, Capdevila, Jaume, Nuciforo, Paolo G, Kroe-Barrett, Rachel, Adam, Paul J, Vogt, Anne B, Hofmann, Irmgard

Volltext

Abstract A62: Three pronged strategy to enhance pharmacological effectiveness of pHLA targeting TcEs von Sabarth, Nicolas, Adam, Paul, Kumar, Sandeep, Liu, Yanyun, Konopitzky, Renate, Boettcher, Jark, Panavas, Tadas

Volltext

Getting a Grip on the Undrugged: Targeting β‐Catenin with Fragment‐Based Methods von Kessler, Dirk, Mayer, Moriz, Zahn, Stephan K., Zeeb, Markus, Wöhrle, Simon, Bergner, Andreas, Bruchhaus, Jens, Ciftci, Tuncay, Dahmann, Georg, Dettling, Maike, Döbel, Sandra, Fuchs, Julian E., Geist, Leonhard, Hela, Wolfgang, Kofink, Christiane, Kousek, Roland, Moser, Franziska, Puchner, Teresa, Rumpel, Klaus, Scharnweber, Maximilian, Werni, Patrick, Wolkerstorfer, Bernhard, Breitsprecher, Dennis, Baaske, Philipp, Pearson, Mark, McConnell, Darryl B., Böttcher, Jark

Volltext

Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments von Martinelli, Paola, Schaaf, Otmar, Mantoulidis, Andreas, Martin, Laetitia J., Fuchs, Julian E., Bader, Gerd, Gollner, Andreas, Wolkerstorfer, Bernhard, Rogers, Catherine, Balıkçı, Esra, Lipp, Jesse J., Mischerikow, Nikolai, Doebel, Sandra, Gerstberger, Thomas, Sommergruber, Wolfgang, Huber, Kilian V. M., Böttcher, Jark

Volltext

Abstract 4449: Synthetic lethality between CSTF2 and CSTF2T in lung adenocarcinoma and melanoma cell lines von Popow, Johannes, Wieshofer, Corinna, Schlattl, Andreas, Woehrle, Simon, Neumüller, Ralph, Petronczki, Mark P., Boettcher, Jark, Koegl, Manfred, Pearson, Mark

Volltext

Target 2035 - an update on private sector contributions von Ackloo, Suzanne, Antolin, Albert A, Bartolome, Jose Manuel, Beck, Hartmut, Bullock, Alex, Betz, Ulrich A. K, Böttcher, Jark, Brown, Peter J, Chaturvedi, Menorca, Crisp, Alisa, Daniels, Danette, Dreher, Jan, Edfeldt, Kristina, Edwards, Aled M, Egner, Ursula, Elkins, Jon, Fischer, Christian, Glendorf, Tine, Goldberg, Steven, Hartung, Ingo V, Hillisch, Alexander, Homan, Evert, Knapp, Stefan, Köster, Markus, Krämer, Oliver, Llaveria, Josep, Lessel, Uta, Lindemann, Sven, Linderoth, Lars, Matsui, Hisanori, Michel, Maurice, Montel, Florian, Mueller-Fahrnow, Anke, Müller, Susanne, Owen, Dafydd R, Saikatendu, Kumar Singh, Santhakumar, Vijayaratnam, Sanderson, Wendy, Scholten, Cora, Schapira, Matthieu, Sharma, Sujata, Shireman, Brock, Sundström, Michael, Todd, Matthew H, Tredup, Claudia, Venable, Jennifer, Willson, Timothy M, Arrowsmith, Cheryl H

Volltext

A ligand discovery toolbox for the WWE domain family of human E3 ligases von Münzker, Lena, Kimani, Serah W., Fowkes, Milan M., Dong, Aiping, Zheng, Hong, Li, Yanjun, Dasovich, Morgan, Zak, Krzysztof M., Leung, Anthony K. L., Elkins, Jonathan M., Kessler, Dirk, Arrowsmith, Cheryl H., Halabelian, Levon, Böttcher, Jark

Volltext