Clinical impact of the subclonal architecture and mutational complexity in chronic lymphocytic leukemia von Nadeu, F, Clot, G, Delgado, J, Martín-García, D, Baumann, T, Salaverria, I, Beà, S, Pinyol, M, Jares, P, Navarro, A, Suárez-Cisneros, H, Aymerich, M, Rozman, M, Villamor, N, Colomer, D, González, M, Alcoceba, M, Terol, M J, Navarro, B, Colado, E, Payer, ÁR, Puente, X S, López-Otín, C, López-Guillermo, A, Enjuanes, A, Campo, E

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KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program von van Krieken, J. H. J. M., Jung, A., Kirchner, T., Carneiro, F., Seruca, R., Bosman, F. T., Quirke, P., Fléjou, J. F., Plato Hansen, T., de Hertogh, G., Jares, P., Langner, C., Hoefler, G., Ligtenberg, M., Tiniakos, D., Tejpar, S., Bevilacqua, G., Ensari, A.

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NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome von Villamor, N, Conde, L, Martínez-Trillos, A, Cazorla, M, Navarro, A, Beà, S, López, C, Colomer, D, Pinyol, M, Aymerich, M, Rozman, M, Abrisqueta, P, Baumann, T, Delgado, J, Giné, E, González-Díaz, M, Hernández, J M, Colado, E, Payer, A R, Rayon, C, Navarro, B, José Terol, M, Bosch, F, Quesada, V, Puente, X S, López-Otín, C, Jares, P, Pereira, A, Campo, E, López-Guillermo, A

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Immune signatures identify three immune clusters in mCRC, with potential clinical implications von Pedrosa, L., Moreno, R., Esposito, F., Jares, P., Cuatrecasas, M., Pineda, E., Español, M., Paré, L., De la Iglesia, N., Benitez, D., Camps, J., Church, S., Cascante, M., Thomson, T., Prat, A., Maurel, J.

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Exploratory analysis of clinical benefit of ipilimumab and nivolumab treatment in patients with metastatic melanoma from a single institution von Vila, C. M., Moreno, F. A., Estébanez, M. M., Ares, G. R., Villacampa, G., Dashti, P., Oberoi, H. S., Martin-Huertas, R., Jares, P., Alos, L., Teixido, C., Rull, R., Sanchez, M., Malvehy, J., Carcelero, E., Valduvieco, I., Fernandez, A. A.

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Unraveling the clinicopathological and molecular changes induced by neoadjuvant chemotherapy and endocrine therapy in hormone receptor-positive/HER2-low and HER2-0 breast cancer von Schettini, F., Nucera, S., Brasó-Maristany, F., De Santo, I., Pascual, T., Bergamino, M., Galván, P., Conte, B., Seguí, E., García Fructuoso, I., Gómez Bravo, R., Rivera, P., Rodríguez, A.B., Martínez-Sáez, O., Ganau, S., Sanfeliu, E., González-Farre, B., Vidal Losada, M.J., Adamo, B., Cebrecos, I., Mension, E., Oses, G., Jares, P., Vidal-Sicart, S., Mollà, M., Muñoz, M., Prat, A.

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Identifying predictors of treatment response and molecular changes induced by neoadjuvant chemotherapy and endocrine therapy in hormone receptor-positive/HER2-negative breast cance... von Schettini, F., Brasó-Maristany, F., Pascual, T., Lorman-Carbó, N., Nucera, S., Bergamino, M., Galván, P., Conte, B., Seguí, E., García Fructuoso, I., Gómez Bravo, R., Rodríguez, A.B., Martínez-Sáez, O., Chic, N., Vidal, M., Adamo, B., González-Farre, B., Sanfeliu, E., Cebrecos, I., Mensión, E., Oses, G., Locci, M., Mollà, M., Ganau, S., Jares, P., Vidal-Sicart, S., Muñoz, M., Prat, A.

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P1295: DECIPHERING THE ROLE OF MSI2 AS A REGULATOR OF MANTLE CELL LYMPHOMA STEM‐LIKE PROPERTIES von Sureda‐Gómez, M., Balsas, P., Rodríguez, M.‐L., Nadeu, F., De Bolòs, A., Eguileor, Á., Kulis, M., Castellano, G., Giné, E., Demajo, S., Martín‐Subero, J. I., Jares, P., Campo, E., Amador, V.

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Identification of the active gene coding for the metastasis-associated 37LRP/p40 multifunctional protein von Clausse, N, Jackers, P, Jarès, P, Joris, B, Sobel, M E, Castronovo, V

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GENE MUTATIONS AND COPY NUMBER ALTERATIONS (CNA) PREDICT FOR EARLY FAILURE IN PATIENTS WITH DIFFUSE LARGE B‐CELL LYMPHOMA (DLBCL) TREATED WITH R‐CHOP von Dlouhy, I., Karube, K., Enjuanes, A., Salaverría, I., Pérez‐Galán, P., Jares, P., Martín‐García, D., Nadeu, F., Rivas‐Delgado, A., Rovira, J., Gonzalez, B., Mozos, A., Clot, G., Sancho, J.M., Salar, A., Mercadal, S., Escola, L., Briones, J., Colomo, L., Alcoceba, M., Valera, A., Campo, E., López‐Guillermo, A.

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The Cdc7/Dbf4 protein kinase: target of the S phase checkpoint? von Jares, Pedro, Donaldson, Anne, Blow, J Julian

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Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features von NAVARRO, Alba, CLOT, Guillem, PINYOL, Magda, PUIG, Xavier, PALOMERO, Jara, VEGLIANTE, Maria Carmela, AMADOR, Virgina, MARTINEZ-TRILLOS, Alejandra, STEFANCIKOVA, Lenka, WIESTNER, Adrian, WILSON, Wyndham, POTT, Christiane, ROYO, Cristina, CALASANZ, Maria José, TRIM, Nicola, ERBER, Wendy, SANDER, Birgitta, OTT, German, ROSENWALD, Andreas, COLOMER, Dolors, GINE, Eva, SIEBERT, Reiner, LOPEZ-GUILLERMO, Armando, JARES, Pedro, STAMATOPOULOS, Kostas, BEA, Sílvia, CAMPO, Elias, HADZIDIMITRIOU, Anastasia, AGATHANGELIDIS, Andreas, BIKOS, Vasilis, DARZENTAS, Nikos, PAPADAKI, Theodora, SALAVERRIA, Itziar

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Integrating genomic alterations in diffuse large B-cell lymphoma identifies new relevant pathways and potential therapeutic targets von Karube, K, Enjuanes, A, Dlouhy, I, Jares, P, Martin-Garcia, D, Nadeu, F, Ordóñez, G R, Rovira, J, Clot, G, Royo, C, Navarro, A, Gonzalez-Farre, B, Vaghefi, A, Castellano, G, Rubio-Perez, C, Tamborero, D, Briones, J, Salar, A, Sancho, J M, Mercadal, S, Gonzalez-Barca, E, Escoda, L, Miyoshi, H, Ohshima, K, Miyawaki, K, Kato, K, Akashi, K, Mozos, A, Colomo, L, Alcoceba, M, Valera, A, Carrió, A, Costa, D, Lopez-Bigas, N, Schmitz, R, Staudt, L M, Salaverria, I, López-Guillermo, A, Campo, E

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140MO HER2DX genomic test in HER2-positive/hormone receptor-positive (HER2+/HR+) breast cancer (BC) treated with neoadjuvant trastuzumab (T) and pertuzumab (P): A correlative analy... von Guarneri, V., Dieci, M.V., Griguolo, G., Pare Brunet, L., Marin, M., Miglietta, F., Bottosso, M., Giorgi, C.A., Blasco, P., Castillo, O., Galván, P., Jares, P., Puig-butille, J.A., Vivancos, A., Villagrasa Gonzalez, P., Parker, J., Perou, C.M., Conte, P.F., Prat, A.

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SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype von MOZOS, Ana, ROYO, Cristina, JAFFE, Elaine S, RUIZ-MARCELLAN, Carmen, DAVE, Sandeep, RIMSZA, Lisa, BRAZIEL, Rita, GASCOYNE, Randy D, SOLE, Francisco, LOPEZ-GUILLERMO, Armando, COLOMER, Dolors, STAUDT, Louis M, HARTMANN, Elena, ROSENWALD, Andreas, OTT, German, JARES, Pedro, CAMPO, Elias, DE JONG, Daphne, BARO, Cristina, VALERA, Alexandra, KAI FU, WEISENBURGER, Dennis D, DELABIE, Jan, CHUANG, Shih-Sung

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352P Mutations of SMAD4 and FBXW7 predict poor outcome in TP53-driven metastatic colorectal cancer von Lahoz, S., Rodriguez Hernandez, A., Fernandez-Mañas, L., Gorria, T., Zambrano, R.M., Esposito, F.M., Sauri Nadal, T., Pesantez Coronel, D.S., Riu, G., Cuatrecasas, M., Jares, P., Pedrosa, L., Pineda, E., Postigo, A., Castells, A., Prat, A., Maurel, J., Camps, J.

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25P Research-based HER2DX in patients with early-stage HER2-positive (HER2+) breast cancer treated in the N9831 phase III clinical trial von Brasó-Maristany, F., Martinez Saez, O., Pare Brunet, L., Marín-Aguilera, M., Conte, P.F., Jares, P., Guarneri, V., Pascual, T., Puig-Butille, J.A., Vivancos, A., Parker, J., Villagrasa Gonzalez, P., Tolaney, S.M., Carey, L.A., Perou, C.M., Prat, A.

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Stromal Gene Signatures in Large-B-Cell Lymphomas von Lenz, G, Wright, G, Dave, S.S, Xiao, W, Powell, J, Zhao, H, Xu, W, Tan, B, Goldschmidt, N, Iqbal, J, Vose, J, Bast, M, Fu, K, Weisenburger, D.D, Greiner, T.C, Armitage, J.O, Kyle, A, May, L, Gascoyne, R.D, Connors, J.M, Troen, G, Holte, H, Kvaloy, S, Dierickx, D, Verhoef, G, Delabie, J, Smeland, E.B, Jares, P, Martinez, A, Lopez-Guillermo, A, Montserrat, E, Campo, E, Braziel, R.M, Miller, T.P, Rimsza, L.M, Cook, J.R, Pohlman, B, Sweetenham, J, Tubbs, R.R, Fisher, R.I, Hartmann, E, Rosenwald, A, Ott, G, Muller-Hermelink, H.-K, Wrench, D, Lister, T.A, Jaffe, E.S, Wilson, W.H, Chan, W.C, Staudt, L.M

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High microvessel density determines a poor outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus chemotherapy von CARDESA-SALZMANN, Teresa M, COLOMO, Luis, TUBBS, Ray, DELABIE, Jan, GASCOYNE, Randy D, CONNORS, Joseph M, MATE, Jose L, RIMSZA, Lisa, BRAZIEL, Rita, ROSENWALD, Andreas, LENZ, Georg, WRIGHT, George, GUTIERREZ, Gonzalo, JAFFE, Elaine S, STAUDT, Louis, JARES, Pedro, LOPEZ-GUILLERMO, Armando, CAMPO, Elias, CHAN, Wing C, WEISENBURGER, Dennis, CLIMENT, Fina, GONZALEZ-BARCA, Eva, MERCADAL, Santiago, ARENILLAS, Leonor, SERRANO, Sergio

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182P Impact of SARS CoV 2 outbreak in the molecular diagnosis of advanced NSCLC: A retrospective comparative cohort study von Marin, E., Teixido, C., Arcocha, A., Castillo, S., Reyes, R., Viñolas, N., Mezquita, L., Muñoz, S., Martinez, D., Jares, P., Reguart, N.

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