Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Hi... von Das, Kalyan, Clark, Arthur D, Lewi, Paul J, Heeres, Jan, de Jonge, Marc R, Koymans, Lucien M. H, Vinkers, H. Maarten, Daeyaert, Frederik, Ludovici, Donald W, Kukla, Michael J, De Corte, Bart, Kavash, Robert W, Ho, Chih Y, Ye, Hong, Lichtenstein, Mark. A, Andries, Koen, Pauwels, Rudi, de Béthune, Marie-Pierre, Boyer, Paul L, Clark, Patrick, Hughes, Stephen H, Janssen, Paul A. J, Arnold, Eddy

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Concentration and pH Dependent Aggregation of Hydrophobic Drug Molecules and Relevance to Oral Bioavailability von Frenkel, Yulia Volovik, Clark, Arthur D, Das, Kalyan, Wang, Yuh-Hwa, Lewi, Paul J, Janssen, Paul A. J, Arnold, Eddy

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Loperamide : survey of studies on mechanism of its antidiarrheal activity von AWOUTERS, F, MEGENS, A, VERLINDEN, M, SCHUURKES, J, NIEMEGEERS, C, JANSSEN, P. A. J

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SYNOPSIS:  SYNthesize and OPtimize System in Silico von Vinkers, H. Maarten, de Jonge, Marc R, Daeyaert, Frederik F. D, Heeres, Jan, Koymans, Lucien M. H, van Lenthe, Joop H, Lewi, Paul J, Timmerman, Henk, Van Aken, Koen, Janssen, Paul A. J

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Synthesis of Novel Diarylpyrimidine Analogues and Their Antiviral Activity against Human Immunodeficiency Virus Type 1 von Guillemont, Jerome, Pasquier, Elisabeth, Palandjian, Patrice, Vernier, Daniel, Gaurrand, Sandrine, Lewi, Paul J, Heeres, Jan, de Jonge, Marc R, Koymans, Lucien M. H, Daeyaert, Frits F. D, Vinkers, Maarten H, Arnold, Eddy, Das, Kalyan, Pauwels, Rudi, Andries, Koen, de Béthune, Marie-Pierre, Bettens, Eva, Hertogs, Kurt, Wigerinck, Piet, Timmerman, Philip, Janssen, Paul A. J

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The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance von Hsiou, Yu, Ding, Jianping, Das, Kalyan, Clark, Arthur D, Boyer, Paul L, Lewi, Paul, Janssen, Paul A.J, Kleim, Jörg-Peter, Rösner, Manfred, Hughes, Stephen H, Arnold, Edward

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Evolution of anti-HIV drug candidates. Part 3: diarylpyrimidine (DAPY) analogues von Ludovici, Donald W., De Corte, Bart L., Kukla, Michael J., Ye, Hong, Ho, Chih Y., Lichtenstein, Mark A., Kavash, Robert W., Andries, Koen, de Béthune, Marie-Pierre, Azijn, Hilde, Pauwels, Rudi, Lewi, Paul J., Heeres, Jan, Koymans, Lucien M.H., de Jonge, Marc R., Van Aken, Koen J.A., Daeyaert, Frederik F.D., Das, Kalyan, Arnold, Edward, Janssen, Paul A.J.

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Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors von Ding, Jianping, Das, Kalyan, Moereels, Henri, Koymans, Luc, Andries, Koen, Janssen, Paul A.J, Hughes, Stepen H, Arnold, Edward

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Locations of Anti-AIDS Drug Binding Sites and Resistance Mutations in the Three-dimensional Structure of HIV-1 Reverse Transcriptase: Implications for Mechanisms of Drug Inhibition... von Tantillo, Chris, Ding, Jianping, Jacobo-Molina, Alfredo, Nanni, Raymond G., Boyer, Paul L., Hughes, Stephen H., Pauwels, Rudi, Andries, Koen, Janssen, Paul A.J., Arnold, Edward

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Design, Synthesis, and SAR of a Novel Pyrazinone Series with Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitory Activity von Heeres, Jan, de Jonge, Marc R, Koymans, Lucien M. H, Daeyaert, Frits F. D, Vinkers, Maarten, Van Aken, Koen J. A, Arnold, Eddy, Das, Kalyan, Kilonda, Amuri, Hoornaert, Georges J, Compernolle, Frans, Cegla, Marek, Azzam, Rasha A, Andries, Koen, de Béthune, Marie-Pierre, Azijn, Hilde, Pauwels, Rudi, Lewi, Paul J, Janssen, Paul A. J

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A pharmacophore docking algorithm and its application to the cross-docking of 18 HIV-NNRTI's in their binding pockets von Daeyaert, Frits, de Jonge, Marc, Heeres, Jan, Koymans, Luc, Lewi, Paul, Vinkers, Maarten H., Janssen, Paul A.J.

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Evolution of anti-HIV drug candidates. Part 2 : Diaryltriazine (DATA) analogues von LUDOVICI, Donald W, KAVASH, Robert W, MOEREELS, Henry E. L, HEERES, Jan, KOYMANS, Lucien M. H, DE JONGE, Marc R, VAN AKEN, Koen J. A, DAEYAERT, Frederik F. D, LEWI, Paul J, DAS, Kalyan, ARNOLD, Edward, JANSSEN, Paul A. J, KUKLA, Michael J, HO, Chih Y, HONG YE, DE CORTE, Bart L, ANDRIES, Koen, DE BETHUNE, Marie-Pierre, AZIJN, Hilde, PAUWELS, Rudi

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Evolution of anti-HIV drug candidates. Part 1: From α-Anilinophenylacetamide (α-APA) to imidoyl thiourea (ITU) von Ludovici, Donald W., Kukla, Michael J., Grous, Philip G., Krishnan, Suma, Andries, Koen, de Béthune, Marie-Pierre, Azijn, Hilde, Pauwels, Rudi, De Clercq, Erik, Arnold, Edward, Janssen, Paul A.J.

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Crystal Structures of 8-Cl and 9-Cl TIBO Complexed with Wild-type HIV-1 RT and 8-Cl TIBO Complexed with the Tyr181Cys HIV-1 RT Drug-resistant Mutant von Das, Kalyan, Ding, Jianping, Hsiou, Yu, Clark, Arthur D., Moereels, Henri, Koymans, Luc, Andries, Koen, Pauwels, Rudi, Janssen, Paul A.J., Boyer, Paul L., Clark, Patrick, Smith, Richard H., Kroeger Smith, Marilyn B., Michejda, Christopher J., Hughes, Stephen H., Arnold, Edward

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Potent and Highly Selective Human Immunodeficiency Virus Type 1 (HIV-1) Inhibition by a Series of α-Anilinophenylacetamide Derivatives Targeted at HIV-1 Reverse Transcriptase von Pauwels, Rudi, Andries, Koen, Debyser, Zeger, Van Daele, Paul, Schols, Dominique, Stoffels, Paul, De Vreese, Karen, Woestenborghs, Robert, Vandamme, Anne-Mieke, Cornelus G. M. Janssen, Anne, Jef, Cauwenbergh, Geert, Desmyter, Jan, Heykants, Jozef, Marcel A. C. Janssen, De Clercq, Erik, Paul A. J. Janssen

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Prediction of Binding Affinities for TIBO Inhibitors of HIV-1 Reverse Transcriptase Using Monte Carlo Simulations in a Linear Response Method von Smith, Richard H, Jorgensen, William L, Tirado-Rives, Julian, Lamb, Michelle L, Janssen, Paul A. J, Michejda, Christopher J, Kroeger Smith, Marilyn B

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Structure Based Activity Prediction of HIV-1 Reverse Transcriptase Inhibitors von de Jonge, Marc R, Koymans, Lucien M. H, Vinkers, H. Maarten, Daeyaert, Frits F. D, Heeres, Jan, Lewi, Paul J, Janssen, Paul A. J

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Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor α-APA R 95845 at 2.8 å resolution von Ding, J, Das, K, Tantillo, C, Zhang, W, Clark, Jr, AD, Jessen, S, Lu, X, Hsiou, Y, Jacobo-Molina, A, Andries, K, Pauwels, R, Moereels, H, Koymans, L, Janssen, PAJ, Smith, Jr, RH, Koepke, M.Kroeger, Michejda, CJ, Hughes, SH, Arnold, E

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Does phenylethylamine act as an endogenous amphetamine in some patients? von Janssen, Paul A. J., Leysen, Josée E., Megens, Anton A. H. P., Awouters, Frans H. L.

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Photochemical stroke model: flunarizine prevents sensorimotor deficits after neocortical infarcts in rats von DE RYCK, M, VAN REEMPTS, J, BORGERS, M, WAUQUIER, A, JANSSEN, P. A. J

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