Rethinking drug design in the artificial intelligence era von Schneider, Petra, Walters, W. Patrick, Plowright, Alleyn T., Sieroka, Norman, Listgarten, Jennifer, Goodnow, Robert A., Fisher, Jasmin, Jansen, Johanna M., Duca, José S., Rush, Thomas S., Zentgraf, Matthias, Hill, John Edward, Krutoholow, Elizabeth, Kohler, Matthias, Blaney, Jeff, Funatsu, Kimito, Luebkemann, Chris, Schneider, Gisbert

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Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site von Fang, Zhenhao, Marshall, Christopher B., Nishikawa, Tadateru, Gossert, Alvar D., Jansen, Johanna M., Jahnke, Wolfgang, Ikura, Mitsuhiko

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Biased Diversity for Effective Virtual Screening von Martin, Eric J, Jansen, Johanna M

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D3R grand challenge 4: blind prediction of protein–ligand poses, affinity rankings, and relative binding free energies von Parks, Conor D., Gaieb, Zied, Chiu, Michael, Yang, Huanwang, Shao, Chenghua, Walters, W. Patrick, Jansen, Johanna M., McGaughey, Georgia, Lewis, Richard A., Bembenek, Scott D., Ameriks, Michael K., Mirzadegan, Tara, Burley, Stephen K., Amaro, Rommie E., Gilson, Michael K.

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Inhibition of prenylated KRAS in a lipid environment von Jansen, Johanna M, Wartchow, Charles, Jahnke, Wolfgang, Fong, Susan, Tsang, Tiffany, Pfister, Keith, Zavorotinskaya, Tatiana, Bussiere, Dirksen, Cheng, Jan Marie, Crawford, Kenneth, Dai, Yumin, Dove, Jeffrey, Fang, Eric, Feng, Yun, Florent, Jean-Michel, Fuller, John, Gossert, Alvar D, Hekmat-Nejad, Mohammad, Henry, Chrystèle, Klopp, Julia, Lenahan, William P, Lingel, Andreas, Ma, Sylvia, Meyer, Arndt, Mishina, Yuji, Narberes, Jamie, Pardee, Gwynn, Ramurthy, Savithri, Rieffel, Sebastien, Stuart, Darrin, Subramanian, Sharadha, Tandeske, Laura, Widger, Stephania, Widmer, Armin, Winterhalter, Aurelie, Zaror, Isabel, Hardy, Stephen

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Biased Complement Diversity Selection for Effective Exploration of Chemical Space in Hit-Finding Campaigns von Jansen, Johanna M, De Pascale, Gianfranco, Fong, Susan, Lindvall, Mika, Moser, Heinz E, Pfister, Keith, Warne, Bob, Wartchow, Charles

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Inferring and perturbing cell fate regulomes in human brain organoids von Fleck, Jonas Simon, Jansen, Sophie Martina Johanna, Wollny, Damian, Zenk, Fides, Seimiya, Makiko, Jain, Akanksha, Okamoto, Ryoko, Santel, Malgorzata, He, Zhisong, Camp, J. Gray, Treutlein, Barbara

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Design and Discovery of N‑(2-Methyl-5′-morpholino-6′-((tetrahydro‑2H‑pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficaci... von Nishiguchi, Gisele A, Rico, Alice, Tanner, Huw, Aversa, Robert J, Taft, Benjamin R, Subramanian, Sharadha, Setti, Lina, Burger, Matthew T, Wan, Lifeng, Tamez, Victoriano, Smith, Aaron, Lou, Yan, Barsanti, Paul A, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Dix, Ina, Tellew, John E, Huang, Shenlin, Mathews Griner, Lesley A, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Ma, Sylvia, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Jansen, Johanna M, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Lees, Emma, Shao, Wenlin, Stuart, Darrin D, Dillon, Michael P, Ramurthy, Savithri

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Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Syntha... von Wagman, Allan S, Boyce, Rustum S, Brown, Sean P, Fang, Eric, Goff, Dane, Jansen, Johanna M, Le, Vincent P, Levine, Barry H, Ng, Simon C, Ni, Zhi-Jie, Nuss, John M, Pfister, Keith B, Ramurthy, Savithri, Renhowe, Paul A, Ring, David B, Shu, Wei, Subramanian, Sharadha, Zhou, Xiaohui A, Shafer, Cynthia M, Harrison, Stephen D, Johnson, Kirk W, Bussiere, Dirksen E

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The volcanic history of Olympus Mons from paleo-topography and flexural modeling von Isherwood, Ryan J., Jozwiak, Lauren M., Jansen, Johanna C., Andrews-Hanna, Jeffrey C.

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Similar Effect of Autologous and Allogeneic Cell Therapy for Ischemic Heart Disease: Systematic Review and Meta-Analysis of Large Animal Studies von Jansen of Lorkeers, Sanne Johanna, Eding, Joep Egbert Coenraad, Vesterinen, Hanna Mikaela, van der Spoel, Tycho Ids Gijsbert, Sena, Emily Shamiso, Duckers, Henricus Johannes, Doevendans, Pieter Adrianus, Macleod, Malcolm Robert, Chamuleau, Steven Anton Jozef

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CACHE (Critical Assessment of Computational Hit-finding Experiments): A public–private partnership benchmarking initiative to enable the development of computational methods for hi... von Ackloo, Suzanne, Al-awar, Rima, Amaro, Rommie E., Arrowsmith, Cheryl H., Azevedo, Hatylas, Batey, Robert A., Bengio, Yoshua, Betz, Ulrich A. K., Bologa, Cristian G., Chodera, John D., Cornell, Wendy D., Dunham, Ian, Ecker, Gerhard F., Edfeldt, Kristina, Edwards, Aled M., Gilson, Michael K., Gordijo, Claudia R., Hessler, Gerhard, Hillisch, Alexander, Hogner, Anders, Irwin, John J., Jansen, Johanna M., Kuhn, Daniel, Leach, Andrew R., Lee, Alpha A., Lessel, Uta, Morgan, Maxwell R., Moult, John, Muegge, Ingo, Oprea, Tudor I., Perry, Benjamin G., Riley, Patrick, Rousseaux, Sophie A. L., Saikatendu, Kumar Singh, Santhakumar, Vijayaratnam, Schapira, Matthieu, Scholten, Cora, Todd, Matthew H., Vedadi, Masoud, Volkamer, Andrea, Willson, Timothy M.

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Design, Structure−Activity Relationships and in Vivo Characterization of 4-Amino-3-benzimidazol-2-ylhydroquinolin-2-ones: A Novel Class of Receptor Tyrosine Kinase Inhibitors von Renhowe, Paul A, Pecchi, Sabina, Shafer, Cynthia M, Machajewski, Timothy D, Jazan, Elisa M, Taylor, Clarke, Antonios-McCrea, William, McBride, Christopher M, Frazier, Kelly, Wiesmann, Marion, Lapointe, Gena R, Feucht, Paul H, Warne, Robert L, Heise, Carla C, Menezes, Daniel, Aardalen, Kimberly, Ye, Helen, He, Molly, Le, Vincent, Vora, Jayesh, Jansen, Johanna M, Wernette-Hammond, Mary Ellen, Harris, Alex L

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Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors von Smith, Aaron, Ni, Zhi-Jie, Poon, Daniel, Huang, Zilin, Chen, Zheng, Zhang, Qiong, Tandeske, Laura, Merritt, Hanne, Shoemaker, Kevin, Chan, John, Kaufman, Susan, Huh, Kay, Murray, Jeremy, Appleton, Brent A., Cowan-Jacob, Sandra W., Scheufler, Clemens, Kanazawa, Takanori, Jansen, Johanna M., Stuart, Darrin, Shafer, Cynthia M.

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Challenges of antibacterial drug discovery von Reck, Folkert, Jansen, Johanna M., Moser, Heinz E.

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High-Throughput Screen for Inhibitors of Klebsiella pneumoniae Virulence Using a Tetrahymena pyriformis Co-Culture Surrogate Host Model von Woods, Angela L, Parker, David, Glick, Meir M, Peng, Yunshan, Lenoir, Francois, Mulligan, Evan, Yu, Vincent, Piizzi, Grazia, Lister, Troy, Lilly, Maria-Dawn, Dzink-Fox, JoAnn, Jansen, Johanna M, Ryder, Neil S, Dean, Charles R, Smith, Thomas M

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Design and Synthesis of Orally Bioavailable Benzimidazoles as Raf Kinase Inhibitors von Ramurthy, Savithri, Subramanian, Sharadha, Aikawa, Mina, Amiri, Payman, Costales, Abran, Dove, Jeff, Fong, Susan, Jansen, Johanna M, Levine, Barry, Ma, Sylvia, McBride, Christopher M, Michaelian, Jonah, Pick, Teresa, Poon, Daniel J, Girish, Sandhya, Shafer, Cynthia M, Stuart, Darrin, Sung, Leonard, Renhowe, Paul A

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Size Matters and How You Measure It: A Gram-Negative Antibacterial Example Exceeding Typical Molecular Weight Limits von Ruggiu, Fiorella, Yang, Shengtian, Simmons, Robert L, Casarez, Anthony, Jones, Adriana K, Li, Cindy, Jansen, Johanna M, Moser, Heinz E, Dean, Charles R, Reck, Folkert, Lindvall, Mika

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Cardiac Stem Cell Treatment in Myocardial Infarction: A Systematic Review and Meta-Analysis of Preclinical Studies von Zwetsloot, Peter Paul, Végh, Anna Maria Dorothea, Jansen of Lorkeers, Sanne Johanna, van Hout, Gerardus P.J, Currie, Gillian L, Sena, Emily S, Gremmels, Hendrik, Buikema, Jan Willem, Goumans, Marie-Jose, Macleod, Malcolm R, Doevendans, Pieter A, Chamuleau, Steven A.J, Sluijter, Joost P.G

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Design and synthesis of 6,6-fused heterocyclic amides as raf kinase inhibitors von Ramurthy, Savithri, Costales, Abran, Jansen, Johanna M., Levine, Barry, Renhowe, Paul A., Shafer, Cynthia M., Subramanian, Sharadha

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