Enhancement of epidermal growth factor receptor antibody tumor immunotherapy by glutaminyl cyclase inhibition to interfere with CD47/signal regulatory protein alpha interactions von Baumann, Niklas, Rösner, Thies, Jansen, J. H. Marco, Chan, Chilam, Marie Eichholz, Klara, Klausz, Katja, Winterberg, Dorothee, Müller, Kristina, Humpe, Andreas, Burger, Renate, Peipp, Matthias, Schewe, Denis M., Kellner, Christian, Leusen, Jeanette H. W., Valerius, Thomas

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In vivo cytotoxicity of type I CD20 antibodies critically depends on Fc receptor ITAM signaling von de Haij, Simone, Jansen, J H Marco, Boross, Peter, Beurskens, Frank J, Bakema, Jantine E, Bos, Desiree L, Martens, Anton, Verbeek, J Sjef, Parren, Paul W H I, van de Winkel, Jan G J, Leusen, Jeanette H W

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Novel chimerized IgA CD20 antibodies: Improving neutrophil activation against CD20-positive malignancies von Evers, Mitchell, Ten Broeke, Toine, Jansen, J. H. Marco, Nederend, Maaike, Hamdan, Firas, Reiding, Karli R., Meyer, Saskia, Moerer, Petra, Brinkman, Iris, Roesner, Thies, Lebbink, Robert Jan, Valerius, Thomas, Leusen, Jeanette H. W.

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The in vivo mechanism of action of CD20 monoclonal antibodies depends on local tumor burden von BOROSS, Peter, MARCO JANSEN, J. H, LEUSEN, Jeanette H. W, DE HAIJ, Simone, BEURSKENS, Frank J, VAN DER POEL, Cees E, BEVAART, Lisette, NEDEREND, Maaike, GOLAY, Josée, VAN DE WINKEL, Jan G. J, PARREN, Paul W. H. I

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Both activating and inhibitory Fc gamma receptors mediate rituximab-induced trogocytosis of CD20 in mice von Boross, Peter, Jansen, J.H. Marco, Pastula, Agnieszka, van der Poel, Cees E, Leusen, Jeanette H.W

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Immune Effector Functions of Human IgG2 Antibodies against EGFR von Rösner, Thies, Kahle, Steffen, Montenegro, Francesca, Matlung, Hanke L, Jansen, J H Marco, Evers, Mitchell, Beurskens, Frank, Leusen, Jeanette H W, van den Berg, Timo K, Valerius, Thomas

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An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo von Lohse, Stefan, Meyer, Saskia, Meulenbroek, Laura A P M, Jansen, J H Marco, Nederend, Maaike, Kretschmer, Anna, Klausz, Katja, Möginger, Uwe, Derer, Stefanie, Rösner, Thies, Kellner, Christian, Schewe, Denis, Sondermann, Peter, Tiwari, Sanjay, Kolarich, Daniel, Peipp, Matthias, Leusen, Jeanette H W, Valerius, Thomas

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IgA-Mediated Killing of Tumor Cells by Neutrophils Is Enhanced by CD47-SIRP alpha Checkpoint Inhibition von Treffers, Louise W., ten Broeke, Toine, Roesner, Thies, Jansen, J. H. Marco, van Houdt, Michel, Kahle, Steffen, Schornagel, Karin, Verkuijlen, Paul J. J. H., Prins, Jan M., Franke, Katka, Kuijpers, Taco W., van den Berg, Timo K., Valerius, Thomas, Leusen, Jeanette H. W., Matlung, Hanke L.

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Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting von Meyer, Saskia, Nederend, Maaike, Jansen, J H Marco, Reiding, Karli R, Jacobino, Shamir R, Meeldijk, Jan, Bovenschen, Niels, Wuhrer, Manfred, Valerius, Thomas, Ubink, Ruud, Boross, Peter, Rouwendal, Gerard, Leusen, Jeanette H W

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CD20 Antibodies of Human IgA Isotype Mediate CDC, and ADCC By Myeloid Effector Cells von Kretschmer, Anna, Lohse, Stefan, Rösner, Thies, Jansen, Marco J.H., Kellner, Christian, Peipp, Matthias, Cragg, Mark S, Alsadeq, Ameera, Schewe, Denis M, Leusen, Jeanette H.W., Valerius, Thomas

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Simultaneous Targeting of FcγRs and FcαRI Enhances Tumor Cell Killing von Brandsma, Arianne M, Ten Broeke, Toine, Nederend, Maaike, Meulenbroek, Laura A P M, van Tetering, Geert, Meyer, Saskia, Jansen, J H Marco, Beltrán Buitrago, M Alejandra, Nagelkerke, Sietse Q, Németh, István, Ubink, Ruud, Rouwendal, Gerard, Lohse, Stefan, Valerius, Thomas, Leusen, Jeanette H W, Boross, Peter

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Anti-tumor activity of human IgG1 anti-gp75 TA99 mAb against B16F10 melanoma in human FcgammaRI transgenic mice von Boross, Peter, Jansen, J.H. Marco, van Tetering, Geert, Nederend, Maaike, Brandsma, Arianne, Meyer, Saskia, Torfs, Ellen, van den Ham, Henk-Jan, Meulenbroek, Laura, de Haij, Simone, Leusen, Jeanette H.W

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The high-affinity IgG receptor, FcγRI, plays a central role in antibody therapy of experimental melanoma von BEVAART, Lisette, JANSEN, Marco J. H, VAN VUGT, Martine J, VERBEEK, J. Sjef, VAN DE WINKEL, Jan G. J, LEUSEN, Jeanette H. W

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Pharmacokinetics and myeloid effector cell engagement of an engineered IgA antibody against the epidermal growth factor receptor von Valerius, Thomas, Lohse, Stefan, Meyer, Saskia, Jansen, Marco J.H., Meulenbroek, Laura A.P., Nederend, Maaike, Möginger, Uwe, Kretschmer, Anna, Klausz, Katja, Derer, Stefanie, Sondermann, Peter, Kolarich, Daniel, Peipp, Matthias, Leusen, Jeanette H. W., Gramatzki, Martin

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Daratumumab, a Human CD38 Antibody Induces Apoptosis of Myeloma Tumor Cells Via Fc Receptor-Mediated Crosslinking von Jansen, J.H. Marco, Boross, Peter, Overdijk, Marije B., van Bueren, Jeroen J. Lammerts, Parren, Paul W.H.I., Leusen, Jeanette H.W.

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Inhibition of the Classical and Lectin Pathway of the Complement System by Recombinant LAIR-2 von Olde Nordkamp, Marloes J.M., Boross, Peter, Yildiz, Cafer, Jansen, J.H. Marco, Leusen, Jeanette H.W., Wouters, Diana, Urbanus, Rolf T., Hack, C. Erik, Meyaard, Linde

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CpG-A and B oligodeoxynucleotides enhance the efficacy of antibody therapy by activating different effector cell populations von VAN OJIK, Heidi H, BEVAART, Lisette, DAHLE, Christopher E, BAKKER, Annie, JANSEN, Marco J. H, VAN VUGT, Martine J, VAN DE WINKEL, Jan G. J, WEINER, George J

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Mac-1 (CD11b/CD18) is crucial for effective Fc receptor–mediated immunity to melanoma von van Spriel, Annemiek B., van Ojik, Heidi H., Bakker, Annie, Jansen, MarcoJ.H., van de Winkel, JanG.J.

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Novel chimerized IgA CD20 antibodies: Improving neutrophil activation against CD20-positive malignancies von Evers, Mitchell, Ten Broeke, Toine, Jansen, J.H. Marco, Nederend, Maaike, Hamdan, Firas, Reiding, Karli R., Meyer, Saskia, Moerer, Petra, Brinkman, Iris, Rösner, Thies, Lebbink, Robert Jan, Valerius, Thomas, Leusen, Jeanette H.W.

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Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting von Meyer, Saskia, Nederend, Maaike, Jansen, J.H. Marco, Reiding, Karli R., Jacobino, Shamir R., Meeldijk, Jan, Bovenschen, Niels, Wuhrer, Manfred, Valerius, Thomas, Ubink, Ruud, Boross, Peter, Rouwendal, Gerard, Leusen, Jeanette H.W.

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