Osimertinib in Pretreated T790M-Positive Advanced Non-Small-Cell Lung Cancer: AURA Study Phase II Extension Component von Yang, James Chih-Hsin, Ahn, Myung-Ju, Kim, Dong-Wan, Ramalingam, Suresh S, Sequist, Lecia V, Su, Wu-Chou, Kim, Sang-We, Kim, Joo-Hang, Planchard, David, Felip, Enriqueta, Blackhall, Fiona, Haggstrom, Daniel, Yoh, Kiyotaka, Novello, Silvia, Gold, Kathryn, Hirashima, Tomonori, Lin, Chia-Chi, Mann, Helen, Cantarini, Mireille, Ghiorghiu, Serban, Jänne, Pasi A

Volltext

Efficacy and Safety of Patritumab Deruxtecan (HER3-DXd) in EGFR Inhibitor-Resistant, EGFR -Mutated Non-Small Cell Lung Cancer von Jänne, Pasi A, Baik, Christina, Su, Wu-Chou, Johnson, Melissa L, Hayashi, Hidetoshi, Nishio, Makoto, Kim, Dong-Wan, Koczywas, Marianna, Gold, Kathryn A, Steuer, Conor E, Murakami, Haruyasu, Yang, James Chih-Hsin, Kim, Sang-We, Vigliotti, Michele, Shi, Rong, Qi, Zhenhao, Qiu, Yang, Zhao, Lihui, Sternberg, David, Yu, Channing, Yu, Helena A

Volltext

Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity von Ballard, Peter, Yates, James W T, Yang, Zhenfan, Kim, Dong-Wan, Yang, James Chih-Hsin, Cantarini, Mireille, Pickup, Kathryn, Jordan, Angela, Hickey, Mike, Grist, Matthew, Box, Matthew, Johnström, Peter, Varnäs, Katarina, Malmquist, Jonas, Thress, Kenneth S, Jänne, Pasi A, Cross, Darren

Volltext

Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints von Koyama, Shohei, Akbay, Esra A., Li, Yvonne Y., Herter-Sprie, Grit S., Buczkowski, Kevin A., Richards, William G., Gandhi, Leena, Redig, Amanda J., Rodig, Scott J., Asahina, Hajime, Jones, Robert E., Kulkarni, Meghana M., Kuraguchi, Mari, Palakurthi, Sangeetha, Fecci, Peter E., Johnson, Bruce E., Janne, Pasi A., Engelman, Jeffrey A., Gangadharan, Sidharta P., Costa, Daniel B., Freeman, Gordon J., Bueno, Raphael, Hodi, F. Stephen, Dranoff, Glenn, Wong, Kwok-Kin, Hammerman, Peter S.

Volltext

A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies von Boettcher, Steffen, Miller, Peter G, Sharma, Rohan, McConkey, Marie, Leventhal, Matthew, Krivtsov, Andrei V, Giacomelli, Andrew O, Wong, Waihay, Kim, Jesi, Chao, Sherry, Kurppa, Kari J, Yang, Xiaoping, Milenkowic, Kirsten, Piccioni, Federica, Root, David E, Rücker, Frank G, Flamand, Yael, Neuberg, Donna, Lindsley, R Coleman, Jänne, Pasi A, Hahn, William C, Jacks, Tyler, Döhner, Hartmut, Armstrong, Scott A, Ebert, Benjamin L

Volltext

Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C von Zeng, Mei, Lu, Jia, Li, Lianbo, Feru, Frederic, Quan, Chunshan, Gero, Thomas W., Ficarro, Scott B., Xiong, Yuan, Ambrogio, Chiara, Paranal, Raymond M., Catalano, Marco, Shao, Jay, Wong, Kwok-Kin, Marto, Jarrod A., Fischer, Eric S., Jänne, Pasi A., Scott, David A., Westover, Kenneth D., Gray, Nathanael S.

Volltext

Unique Clinicopathologic Features Characterize ALK-Rearranged Lung Adenocarcinoma in the Western Population von RODIG, Scott J, MINO-KENUDSON, Mari, JANNE, Pasi A, LYNCH, Thomas, JOHNSON, Bruce E, LAFRATE, A. John, CHIRIEAC, Lucian R, DACIC, Sanja, YEAP, Beow Y, SHAW, Alice, BARLETTA, Justine A, STUBBS, Hannah, LAW, Kenny, LINDEMAN, Neal, MARK, Eugene

Volltext

Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors von Akbay, Esra A, Koyama, Shohei, Carretero, Julian, Altabef, Abigail, Tchaicha, Jeremy H, Christensen, Camilla L, Mikse, Oliver R, Cherniack, Andrew D, Beauchamp, Ellen M, Pugh, Trevor J, Wilkerson, Matthew D, Fecci, Peter E, Butaney, Mohit, Reibel, Jacob B, Soucheray, Margaret, Cohoon, Travis J, Janne, Pasi A, Meyerson, Matthew, Hayes, D Neil, Shapiro, Geoffrey I, Shimamura, Takeshi, Sholl, Lynette M, Rodig, Scott J, Freeman, Gordon J, Hammerman, Peter S, Dranoff, Glenn, Wong, Kwok-Kin

Volltext

Overcoming MET-Dependent Resistance to Selective RET Inhibition in Patients with RET Fusion-Positive Lung Cancer by Combining Selpercatinib with Crizotinib von Rosen, Ezra Y., Johnson, Melissa L., Clifford, Sarah E., Somwar, Romel, Kherani, Jennifer F., Son, Jieun, Bertram, Arrien A., Davare, Monika A., Gladstone, Eric, Ivanova, Elena, Henry, Dahlia N., Kelley, Elaine M., Lin, Mika, Milan, Marina S. D., Nair, Binoj C., Olek, Elizabeth A., Scanlon, Jenna E., Vojnic, Morana, Ebata, Kevin, Hechtman, Jaclyn F., Li, Bob T., Sholl, Lynette M., Taylor, Barry S., Ladanyi, Marc, Janne, Pasi A., Rothenberg, S. Michael, Drilon, Alexander, Oxnard, Geoffrey R.

Volltext

EGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody-Drug Conjugate HER3-DXd von Haikala, Heidi M, Lopez, Timothy, Köhler, Jens, Eser, Pinar O, Xu, Man, Zeng, Qing, Teceno, Tyler J, Ngo, Kenneth, Zhao, Yutong, Ivanova, Elena V, Bertram, Arrien A, Leeper, Brittaney A, Chambers, Emily S, Adeni, Anika E, Taus, Luke J, Kuraguchi, Mari, Kirschmeier, Paul T, Yu, Channing, Shiose, Yoshinobu, Kamai, Yasuki, Qiu, Yang, Paweletz, Cloud P, Gokhale, Prafulla C, Jänne, Pasi A

Volltext

Amplification of Wild-type KRAS Imparts Resistance to Crizotinib in MET Exon 14 Mutant Non-Small Cell Lung Cancer von Bahcall, Magda, Awad, Mark M, Sholl, Lynette M, Wilson, Frederick H, Xu, Man, Wang, Stephen, Palakurthi, Sangeetha, Choi, Jihyun, Ivanova, Elena V, Leonardi, Giulia C, Ulrich, Bryan C, Paweletz, Cloud P, Kirschmeier, Paul T, Watanabe, Masayuki, Baba, Hideo, Nishino, Mizuki, Nagy, Rebecca J, Lanman, Richard B, Capelletti, Marzia, Chambers, Emily S, Redig, Amanda J, VanderLaan, Paul A, Costa, Daniel B, Imamura, Yu, Jänne, Pasi A

Volltext

Primary Pulmonary NUT Midline Carcinoma: Clinical, Radiographic, and Pathologic Characterizations von Sholl, Lynette M., Nishino, Mizuki, Pokharel, Saraswati, Mino-Kenudson, Mari, French, Christopher A., Janne, Pasi A., Lathan, Christopher

Volltext

MET-Induced CD73 Restrains STING-Mediated Immunogenicity of EGFR-Mutant Lung Cancer von Yoshida, Ryohei, Saigi, Maria, Tani, Tetsuo, Springer, Benjamin F, Shibata, Hirofumi, Kitajima, Shunsuke, Mahadevan, Navin R, Campisi, Marco, Kim, William, Kobayashi, Yoshihisa, Thai, Tran C, Haratani, Koji, Yamamoto, Yurie, Sundararaman, Shriram K, Knelson, Erik H, Vajdi, Amir, Canadas, Israel, Uppaluri, Ravindra, Paweletz, Cloud P, Miret, Juan J, Lizotte, Patrick H, Gokhale, Prafulla C, Jänne, Pasi A, Barbie, David A

Volltext

Use of Ex Vivo Patient-Derived Tumor Organotypic Spheroids to Identify Combination Therapies for HER2 Mutant Non-Small Cell Lung Cancer von Ivanova, Elena, Kuraguchi, Mari, Xu, Man, Portell, Andrew J., Taus, Luke, Diala, Irmina, Lalani, Alshad S., Choi, Jihyun, Chambers, Emily S., Li, Shuai, Liu, Shengwu, Chen, Ting, Barbie, Thanh U., Oxnard, Geoffrey R., Haworth, Jacob J., Wong, Kwok-Kin, Dahlberg, Suzanne E., Aref, Amir A., Barbie, David A., Bahcall, Magda, Paweletz, Cloud P., Janne, Pasi A.

Volltext

Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer von Engelman, Jeffrey A, Mukohara, Toru, Zejnullahu, Kreshnik, Lifshits, Eugene, Borrás, Ana M, Gale, Christopher-Michael, Naumov, George N, Yeap, Beow Y, Jarrell, Emily, Sun, Jason, Tracy, Sean, Zhao, Xiaojun, Heymach, John V, Johnson, Bruce E, Cantley, Lewis C, Jänne, Pasi A

Volltext

Kinase drug discovery 20 years after imatinib: progress and future directions von Cohen, Philip, Cross, Darren, Jänne, Pasi A.

Volltext

The Combined Effect of FGFR Inhibition and PD-1 Blockade Promotes Tumor-Intrinsic Induction of Antitumor Immunity von Palakurthi, Sangeetha, Kuraguchi, Mari, Zacharek, Sima J, Zudaire, Enrique, Huang, Wei, Bonal, Dennis M, Liu, Jeffrey, Dhaneshwar, Abha, DePeaux, Kristin, Gowaski, Martha R, Bailey, Dyane, Regan, Samuel N, Ivanova, Elena, Ferrante, Catherine, English, Jessie M, Khosla, Aditya, Beck, Andrew H, Rytlewski, Julie A, Sanders, Catherine, Laquerre, Sylvie, Bittinger, Mark A, Kirschmeier, Paul T, Packman, Kathryn, Janne, Pasi A, Moy, Christopher, Wong, Kwok-Kin, Verona, Raluca I, Lorenzi, Matthew V

Volltext

Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR von QINGSONG LIU, CHUNXIAO XU, ERCAN, Dalia, NIEPEL, Mario, THOREEN, Carson C, KANG, Seong A, PATRICELLI, Matthew P, YUCHUAN WANG, TUPPER, Tanya, ALTABEF, Abigail, KAWAMURA, Hidemasa, HELD, Kathryn D, KIRUBAKARAN, Sivapriya, CHOU, Danny M, ELLEDGE, Stephen J, JANNE, Pasi A, WONG, Kwok-Kin, SABATINI, David M, GRAY, Nathanael S, XIN ZHANG, HUR, Wooyoung, YAN LIU, KWIATKOWSKI, Nicholas P, JINHUA WANG, WESTOVER, Kenneth D, PENG GAO

Volltext

ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1 von Su, Wenjing, Mukherjee, Radha, Yaeger, Rona, Son, Jieun, Xu, Jianing, Na, Na, Merna Timaul, Neilawattie, Hechtman, Jaclyn, Paroder, Viktoriya, Lin, Mika, Mattar, Marissa, Qiu, Juan, Chang, Qing, Zhao, Huiyong, Zhang, Jonathan, Little, Megan, Adachi, Yuta, Han, Sae-Won, Taylor, Barry S, Ebi, Hiromichi, Abdel-Wahab, Omar, de Stanchina, Elisa, Rudin, Charles M, Jänne, Pasi A, McCormick, Frank, Yao, Zhan, Rosen, Neal

Volltext

An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer von To, Ciric, Beyett, Tyler S, Jang, Jaebong, Feng, William W, Bahcall, Magda, Haikala, Heidi M, Shin, Bo H, Heppner, David E, Rana, Jaimin K, Leeper, Brittaney A, Soroko, Kara M, Poitras, Michael J, Gokhale, Prafulla C, Kobayashi, Yoshihisa, Wahid, Kamal, Kurppa, Kari J, Gero, Thomas W, Cameron, Michael D, Ogino, Atsuko, Mushajiang, Mierzhati, Xu, Chunxiao, Zhang, Yanxi, Scott, David A, Eck, Michael J, Gray, Nathanael S, Jänne, Pasi A

Volltext