Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells von Patel, Anand G., Sarkaria, Jann N., Kaufmann, Scott H., Hanawalt, Philip C.

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Is the blood-brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data von Sarkaria, Jann N, Hu, Leland S, Parney, Ian F, Pafundi, Deanna H, Brinkmann, Debra H, Laack, Nadia N, Giannini, Caterina, Burns, Terence C, Kizilbash, Sani H, Laramy, Janice K, Swanson, Kristin R, Kaufmann, Timothy J, Brown, Paul D, Agar, Nathalie Y R, Galanis, Evanthia, Buckner, Jan C, Elmquist, William F

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A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma von Chen, Xiaoyue, Zhang, Minjie, Gan, Haiyun, Wang, Heping, Lee, Jeong-Heon, Fang, Dong, Kitange, Gaspar J., He, Lihong, Hu, Zeng, Parney, Ian F., Meyer, Fredric B., Giannini, Caterina, Sarkaria, Jann N., Zhang, Zhiguo

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Strategies to improve delivery of anticancer drugs across the blood-brain barrier to treat glioblastoma von Oberoi, Rajneet K, Parrish, Karen E, Sio, Terence T, Mittapalli, Rajendar K, Elmquist, William F, Sarkaria, Jann N

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Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake von Flavahan, William A, Wu, Qiulian, Hitomi, Masahiro, Rahim, Nasiha, Kim, Youngmi, Sloan, Andrew E, Weil, Robert J, Nakano, Ichiro, Sarkaria, Jann N, Stringer, Brett W, Day, Bryan W, Li, Meizhang, Lathia, Justin D, Rich, Jeremy N, Hjelmeland, Anita B

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Purine metabolism regulates DNA repair and therapy resistance in glioblastoma von Zhou, Weihua, Yao, Yangyang, Scott, Andrew J., Wilder-Romans, Kari, Dresser, Joseph J., Werner, Christian K., Sun, Hanshi, Pratt, Drew, Sajjakulnukit, Peter, Zhao, Shuang G., Davis, Mary, Nelson, Barbara S., Halbrook, Christopher J., Zhang, Li, Gatto, Francesco, Umemura, Yoshie, Walker, Angela K., Kachman, Maureen, Sarkaria, Jann N., Xiong, Jianping, Morgan, Meredith A., Rehemtualla, Alnawaz, Castro, Maria G., Lowenstein, Pedro, Chandrasekaran, Sriram, Lawrence, Theodore S., Lyssiotis, Costas A., Wahl, Daniel R.

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Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation von Pastori, Chiara, Philipp Kapranov, Clara Penas, Veronica Peschansky, Claude-Henry Volmar, Jann N. Sarkaria, Amade Bregy, Ricardo Komotar, Georges St. Laurent, Nagi G. Ayad, Claes Wahlestedt

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Peak learning of mass spectrometry imaging data using artificial neural networks von Abdelmoula, Walid M., Lopez, Begona Gimenez-Cassina, Randall, Elizabeth C., Kapur, Tina, Sarkaria, Jann N., White, Forest M., Agar, Jeffrey N., Wells, William M., Agar, Nathalie Y. R.

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Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma von Cosset, Érika, Ilmjärv, Sten, Dutoit, Valérie, Elliott, Kathryn, von Schalscha, Tami, Camargo, Maria F., Reiss, Alexander, Moroishi, Toshiro, Seguin, Laetitia, Gomez, German, Moo, Jung-Soon, Preynat-Seauve, Olivier, Krause, Karl-Heinz, Chneiweiss, Hervé, Sarkaria, Jann N., Guan, Kun-Liang, Dietrich, Pierre-Yves, Weis, Sara M., Mischel, Paul S., Cheresh, David A.

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Genomic and Phenotypic Characterization of a Broad Panel of Patient-Derived Xenografts Reflects the Diversity of Glioblastoma von Vaubel, Rachael A., Tian, Shulan, Remonde, Dioval, Schroeder, Mark A., Mladek, Ann C., Kitange, Gaspar J., Caron, Alissa, Kollmeyer, Thomas M., Grove, Rebecca, Peng, Sen, Carlson, Brett L., Ma, Daniel J., Sarkar, Gobinda, Evers, Lisa, Decker, Paul A., Yan, Huihuang, Dhruv, Harshil D., Berens, Michael E., Wang, Qianghu, Marin, Bianca M., Klee, Eric W., Califano, Andrea, LaChance, Daniel H., Eckel-Passow, Jeanette E., Verhaak, Roel G., Sulman, Erik P., Burns, Terry C., Meyer, Fredrick B., O'Neill, Brian P., Tran, Nhan L., Giannini, Caterina, Jenkins, Robert B., Parney, Ian F., Sarkaria, Jann N.

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DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme von Nagel, Zachary D, Kitange, Gaspar J, Gupta, Shiv K, Joughin, Brian A, Chaim, Isaac A, Mazzucato, Patrizia, Lauffenburger, Douglas A, Sarkaria, Jann N, Samson, Leona D

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A TNF–JNK–Axl–ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma von Guo, Gao, Gong, Ke, Ali, Sonia, Ali, Neha, Shallwani, Shahzad, Hatanpaa, Kimmo J, Pan, Edward, Mickey, Bruce, Burma, Sandeep, Wang, David H, Kesari, Santosh, Sarkaria, Jann N, Zhao, Dawen, Habib, Amyn A

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The efficacy of an unrestricted cycling ketogenic diet in preclinical models of IDH wild-type and IDH mutant glioma von Javier, Rodrigo, Wang, Wenxia, Drumm, Michael, McCortney, Kathleen, Sarkaria, Jann N, Horbinski, Craig

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Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1 von Verhaak, Roel G.W., Hoadley, Katherine A., Purdom, Elizabeth, Wang, Victoria, Qi, Yuan, Wilkerson, Matthew D., Miller, C. Ryan, Ding, Li, Golub, Todd, Mesirov, Jill P., Alexe, Gabriele, Lawrence, Michael, O'Kelly, Michael, Tamayo, Pablo, Weir, Barbara A., Gabriel, Stacey, Winckler, Wendy, Gupta, Supriya, Jakkula, Lakshmi, Feiler, Heidi S., Hodgson, J. Graeme, James, C. David, Sarkaria, Jann N., Brennan, Cameron, Kahn, Ari, Spellman, Paul T., Wilson, Richard K., Speed, Terence P., Gray, Joe W., Meyerson, Matthew, Getz, Gad, Perou, Charles M., Hayes, D. Neil

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Barriers to Effective Drug Treatment for Brain Metastases: A Multifactorial Problem in the Delivery of Precision Medicine von Kim, Minjee, Kizilbash, Sani H., Laramy, Janice K., Gampa, Gautham, Parrish, Karen E., Sarkaria, Jann N., Elmquist, William F.

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ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL von Pietrobono, Silvia, Anichini, Giulia, Sala, Cesare, Manetti, Fabrizio, Almada, Luciana L., Pepe, Sara, Carr, Ryan M., Paradise, Brooke D., Sarkaria, Jann N., Davila, Jaime I., Tofani, Lorenzo, Battisti, Ilaria, Arrigoni, Giorgio, Ying, Li, Zhang, Cheng, Li, Hu, Meves, Alexander, Fernandez-Zapico, Martin E., Stecca, Barbara

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Localized Metabolomic Gradients in Patient-Derived Xenograft Models of Glioblastoma von Randall, Elizabeth C., Lopez, Begona G. C., Peng, Sen, Regan, Michael S., Abdelmoula, Walid M., Basu, Sankha S., Santagata, Sandro, Yoon, Haejin, Haigis, Marcia C., Agar, Jeffrey N., Tran, Nhan L., Elmquist, William F., White, Forest M., Sarkaria, Jann N., Agar, Nathalie Y. R.

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Drug and disease signature integration identifies synergistic combinations in glioblastoma von Stathias, Vasileios, Jermakowicz, Anna M., Maloof, Marie E., Forlin, Michele, Walters, Winston, Suter, Robert K., Durante, Michael A., Williams, Sion L., Harbour, J. William, Volmar, Claude-Henry, Lyons, Nicholas J., Wahlestedt, Claes, Graham, Regina M., Ivan, Michael E., Komotar, Ricardo J., Sarkaria, Jann N., Subramanian, Aravind, Golub, Todd R., Schürer, Stephan C., Ayad, Nagi G.

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Brain Distribution of a Panel of Epidermal Growth Factor Receptor Inhibitors Using Cassette Dosing in Wild-Type and Abcb1/Abcg2 -Deficient Mice von Kim, Minjee, Laramy, Janice K, Mohammad, Afroz S, Talele, Surabhi, Fisher, James, Sarkaria, Jann N, Elmquist, William F

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H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers von Fang, Dong, Gan, Haiyun, Cheng, Liang, Lee, Jeong-Heon, Zhou, Hui, Sarkaria, Jann N, Daniels, David J, Zhang, Zhiguo

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