UBE2G1 governs the destruction of cereblon neomorphic substrates von Lu, Gang, Weng, Stephanie, Matyskiela, Mary, Zheng, Xinde, Fang, Wei, Wood, Scott, Surka, Christine, Mizukoshi, Reina, Lu, Chin-Chun, Mendy, Derek, Jang, In Sock, Wang, Kai, Marella, Mathieu, Couto, Suzana, Cathers, Brian, Carmichael, James, Chamberlain, Philip, Rolfe, Mark

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Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform von Xia, Yifeng, Ji, Xiaodong, Jang, In Sock, Surka, Christine, Hsu, Christy, Wang, Kai, Rolfe, Mark, Bence, Neil, Lu, Gang

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CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells von Surka, Christine, Jin, Liqing, Mbong, Nathan, Lu, Chin-Chun, Jang, In Sock, Rychak, Emily, Mendy, Derek, Clayton, Thomas, Tindall, Elizabeth, Hsu, Christy, Fontanillo, Celia, Tran, Eileen, Contreras, Adrian, Ng, Stanley W.K., Matyskiela, Mary, Wang, Kai, Chamberlain, Philip, Cathers, Brian, Carmichael, James, Hansen, Joshua, Wang, Jean C.Y., Minden, Mark D., Fan, Jinhong, Pierce, Daniel W., Pourdehnad, Michael, Rolfe, Mark, Lopez-Girona, Antonia, Dick, John E., Lu, Gang

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Database of genomic biomarkers for cancer drugs and clinical targetability in solid tumors von Dienstmann, Rodrigo, Jang, In Sock, Bot, Brian, Friend, Stephen, Guinney, Justin

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Elucidating the Mechanism of Action of CC-90009, a Novel Cereblon E3 Ligase Modulator, in AML Via Genome-Wide CRISPR Screen von Lu, Gang, Surka, Christine, Lu, Chin-Chun, Jang, In Sock, Wang, Kai, Rolfe, Mark

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Integrative multi-omics identifies high risk multiple myeloma subgroup associated with significant DNA loss and dysregulated DNA repair and cell cycle pathways von Ortiz-Estévez, María, Towfic, Fadi, Flynt, Erin, Stong, Nicholas, Jang, In Sock, Wang, Kai, Trotter, Matthew W B, Thakurta, Anjan

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Improving breast cancer survival analysis through competition-based multidimensional modeling von Bilal, Erhan, Dutkowski, Janusz, Guinney, Justin, Jang, In Sock, Logsdon, Benjamin A, Pandey, Gaurav, Sauerwine, Benjamin A, Shimoni, Yishai, Moen Vollan, Hans Kristian, Mecham, Brigham H, Rueda, Oscar M, Tost, Jorg, Curtis, Christina, Alvarez, Mariano J, Kristensen, Vessela N, Aparicio, Samuel, Børresen-Dale, Anne-Lise, Caldas, Carlos, Califano, Andrea, Friend, Stephen H, Ideker, Trey, Schadt, Eric E, Stolovitzky, Gustavo A, Margolin, Adam A

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Functional Kinomics Identifies Candidate Therapeutic Targets in Head and Neck Cancer von MOSER, Russell, CHANG XU, MARGOLIN, Adam A, GRANDORI, Carla, KEMP, Christopher J, MENDEZ, Eduardo, KAO, Michael, ANNIS, James, LERMA, Luisa Angelica, SCHAUPP, Christopher M, GURLEY, Kay E, IN SOCK JANG, BIKTASOVA, Asel, YARBROUGH, Wendell G

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Systematic Assessment of Analytical Methods for Drug Sensitivity Prediction from Cancer Cell Line Data von Neto, Elias, Margolin, Adam, Friend, Stephen, Jang, In, Guinney, Justin

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Elucidating the Molecular Mechanisms of Action of CC-99282, a Novel Cereblon (CRBN) E3 Ligase Modulator (CELMoD) Agent, Via Genome-Wide CRISPR Screen in a Preclinical Model of Non-... von Mo, Zhongying, Groocock, Lynda, Wood, Scott, Jankeel, Diana, Janardhanan, Preethi, Mendy, Derek, Angelo, Michael, Jang, In Sock, Fontanillo, Celia, Wang, Kai, Rolfe, Mark, Lopez-Girona, Antonia

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Synthetic lethal screens as a means to understand and treat MYC-driven cancers von Cermelli, Silvia, Jang, In Sock, Bernard, Brady, Grandori, Carla

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A High-Risk Multiple Myeloma Group Identified By Integrative Multi-Omics Segmentation of Newly Diagnosed Patients von Ortiz, Maria, Towfic, Fadi, Samur, Mehmet Kemal, Flynt, Erin, Jang, In Sock, Wang, Kai, Ashby, Cody, Walker, Brian A, Trotter, Matthew, Morgan, Gareth, Munshi, Nikhil, Thakurta, Anjan

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hARACNe: improving the accuracy of regulatory model reverse engineering via higher-order data processing inequality tests von Jang, In Sock, Margolin, Adam, Califano, Andrea

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The Stream Algorithm: Computationally Efficient Ridge-Regression via Bayesian Model Averaging, and Applications to Pharmacogenomic Prediction of Cancer Cell Line Sensitivity von Neto, Elias, Margolin, Adam, Friend, Stephen, Jang, In

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Deciphering the mechanisms of CC-122 resistance in DLBCL via a genome-wide CRISPR screen von Mo, Zhongying, Wood, Scott, Namiranian, Shawn, Mizukoshi, Reina, Weng, Stephanie, Jang, In Sock, Fontanillo, Celia, Baughman, Joshua M., Silva-Torres, Arianna, Slade, Michelle, Khater, Marwa, Wang, Kai, Rolfe, Mark, Lu, Gang

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Abstract IA15: Predicting drug sensitivity from cancer cell lines von Margolin, Adam Arne, Jang, In Sock, Friend, Stephen

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Prospective: Database of genomic biomarkers for cancer drugs and clinical targetability in solid tumors von Dienstmann, Rodrigo, Jang, In Sock, Bot, Brian, Friend, Stephen, Guinney, Justin

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Abstract IA11: Identification of therapeutic targets for MYC-driven cancers by functional genomics von Toyoshima, Masafumi, Jang, In Sock, Cermelli, Silvia, Bernard, Brady, Grandori, Carla

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Abstract PR05: Construction of synthetic lethal networks for p53 tumor suppressor pathways identifies candidate therapeutic targets for metastatic, chemotherapy resistant HNSCC von Moser, Russell, Xu, Chang, Kao, Michael, Jang, In Sock, Gurley, Kay, Margolin, Adam, Grandori, Carla, Mendez, Eddie, Kemp, Chris

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Abstract 5323: Integrated computational cell-line modeling of drug sensitivity and high-throughput siRNA screening reveals novel molecular biomarkers for conventional chemotherapy von Nikolova, Olga H., Gönen, Mehmet, Dienstmann, Rodrigo, Jang, In Sock, Moser, Russell, Cermelli, Silvia, Xu, Chang, Mitchell, Ryan M., Mendez, Eduardo, Grandori, Carla, Kemp, Christopher, Friend, Stephen, Guinney, Justin, Margolin, Adam

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