Dual Inhibitors of Human DNA Topoisomerase II and Other Cancer-Related Targets von Skok, Žiga, Zidar, Nace, Kikelj, Danijel, Ilaš, Janez

Volltext

Discovery of Benzothiazole Scaffold-Based DNA Gyrase B Inhibitors von Gjorgjieva, Marina, Tomašič, Tihomir, Barančokova, Michaela, Katsamakas, Sotirios, Ilaš, Janez, Tammela, Päivi, Peterlin Mašič, Lucija, Kikelj, Danijel

Volltext

Exploring protein hotspots by optimized fragment pharmacophores von Bajusz, Dávid, Wade, Warren S., Satała, Grzegorz, Bojarski, Andrzej J., Ilaš, Janez, Ebner, Jessica, Grebien, Florian, Papp, Henrietta, Jakab, Ferenc, Douangamath, Alice, Fearon, Daren, von Delft, Frank, Schuller, Marion, Ahel, Ivan, Wakefield, Amanda, Vajda, Sándor, Gerencsér, János, Pallai, Péter, Keserű, György M.

Volltext

Identification of a Novel Structural Class of HV1 Inhibitors by Structure-Based Virtual Screening von Piga, Martina, Varga, Zoltan, Feher, Adam, Papp, Ferenc, Korpos, Eva, Bangera, Kavya C., Frlan, Rok, Ilaš, Janez, Dernovšek, Jaka, Tomašič, Tihomir, Zidar, Nace

Volltext

Discovery of 4,5,6,7-Tetrahydrobenzo[1,2‑d]thiazoles as Novel DNA Gyrase Inhibitors Targeting the ATP-Binding Site von Tomašič, Tihomir, Katsamakas, Sotirios, Hodnik, Žiga, Ilaš, Janez, Brvar, Matjaž, Solmajer, Tom, Montalvão, Sofia, Tammela, Päivi, Banjanac, Mihailo, Ergović, Gabrijela, Anderluh, Marko, Mašič, Lucija Peterlin, Kikelj, Danijel

Volltext

A road map for prioritizing warheads for cysteine targeting covalent inhibitors von Ábrányi-Balogh, Péter, Petri, László, Imre, Tímea, Szijj, Péter, Scarpino, Andrea, Hrast, Martina, Mitrović, Ana, Fonovič, Urša Pečar, Németh, Krisztina, Barreteau, Hélène, Roper, David I., Horváti, Kata, Ferenczy, György G., Kos, Janko, Ilaš, Janez, Gobec, Stanislav, Keserű, György M.

Volltext

Rational design of balanced dual-targeting antibiotics with limited resistance von Nyerges, Akos, Tomasic, Tihomir, Durcik, Martina, Revesz, Tamas, Szili, Petra, Draskovits, Gabor, Bogar, Ferenc, Skok, Ziga, Zidar, Nace, Ilas, Janez, Zega, Anamarija, Kikelj, Danijel, Daruka, Lejla, Kintses, Balint, Vasarhelyi, Balint, Foldesi, Imre, Kata, Diana, Welin, Martin, Kimbung, Raymond, Focht, Dorota, Masic, Lucija Peterlin, Pal, Csaba

Volltext

N‑Phenyl-4,5-dibromopyrrolamides and N‑Phenylindolamides as ATP Competitive DNA Gyrase B Inhibitors: Design, Synthesis, and Evaluation von Zidar, Nace, Macut, Helena, Tomašič, Tihomir, Brvar, Matjaž, Montalvão, Sofia, Tammela, Päivi, Solmajer, Tom, Peterlin Mašič, Lucija, Ilaš, Janez, Kikelj, Danijel

Volltext

Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors von Skok, Žiga, Barančoková, Michaela, Benek, Ondřej, Cruz, Cristina Durante, Tammela, Päivi, Tomašič, Tihomir, Zidar, Nace, Mašič, Lucija Peterlin, Zega, Anamarija, Stevenson, Clare E. M, Mundy, Julia E. A, Lawson, David M, Maxwell, Anthony, Kikelj, Danijel, Ilaš, Janez

Volltext

Synthesis and Evaluation of Spumigin Analogues Library with Thrombin Inhibitory Activity von Žula, Aleš, Będziak, Izabela, Kikelj, Danijel, Ilaš, Janez

Volltext

On the Stability and Degradation Pathways of Venetoclax under Stress Conditions von Zigart, Nina, Crnugelj, Martin, Ilas, Janez, Casar, Zdenko

Volltext

Development of narrow-spectrum topoisomerase-targeting antibacterials against mycobacteria von Sterle, Maša, Habjan, Eva, Piga, Martina, Peršolja, Peter, Durcik, Martina, Dernovšek, Jaka, Szili, Petra, Czikkely, Marton Simon, Zidar, Nace, Janez, Ilaš, Pal, Csaba, Accetto, Tomaž, Pardo, Luis A., Kikelj, Danijel, Peterlin Mašič, Lucija, Tomašič, Tihomir, Bitter, Wilbert, Cotman, Andrej Emanuel, Speer, Alexander, Zega, Anamarija

Volltext

Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa von Cotman, Andrej Emanuel, Durcik, Martina, Benedetto Tiz, Davide, Fulgheri, Federica, Secci, Daniela, Sterle, Maša, Možina, Štefan, Skok, Žiga, Zidar, Nace, Zega, Anamarija, Ilaš, Janez, Peterlin Mašič, Lucija, Tomašič, Tihomir, Hughes, Diarmaid, Huseby, Douglas L., Cao, Sha, Garoff, Linnéa, Berruga Fernández, Talía, Giachou, Paraskevi, Crone, Lisa, Simoff, Ivailo, Svensson, Richard, Birnir, Bryndis, Korol, Sergiy V., Jin, Zhe, Vicente, Francisca, Ramos, Maria C., de la Cruz, Mercedes, Glinghammar, Björn, Lenhammar, Lena, Henderson, Sara R., Mundy, Julia E. A., Maxwell, Anthony, Stevenson, Clare E. M., Lawson, David M., Janssen, Guido V., Sterk, Geert Jan, Kikelj, Danijel

Volltext

Next-Generation Heterocyclic Electrophiles as Small-Molecule Covalent MurA Inhibitors von Ábrányi-Balogh, Péter, Keeley, Aaron, Ferenczy, György G, Petri, László, Imre, Tímea, Grabrijan, Katarina, Hrast, Martina, Knez, Damijan, Ilaš, Janez, Gobec, Stanislav, Keserű, György M

Volltext

Selective DNA Gyrase Inhibitors: Multi-Target in Silico Profiling with 3D-Pharmacophores von Tomasic, Tihomir, Zubriene, Asta, Skok, Ziga, Martini, Riccardo, Pajk, Stane, Sosic, Izidor, Ilas, Janez, Matulis, Daumantas, Bryant, Sharon D.

Volltext

3,4-Dihydro-2H-1,4-benzoxazine Derivatives Combining Thrombin Inhibitory and Glycoprotein IIb/IIIa Receptor Antagonistic Activity as a Novel Class of Antithrombotic Compounds with... von Ilaš, Janez, Jakopin, Žiga, Borštnar, Tina, Stegnar, Mojca, Kikelj, Danijel

Volltext

New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus von Durcik, Martina, Cotman, Andrej Emanuel, Toplak, Žan, Možina, Štefan, Skok, Žiga, Szili, Petra Eva, Czikkely, Márton, Maharramov, Elvin, Vu, Thu Hien, Piras, Maria Vittoria, Zidar, Nace, Ilaš, Janez, Zega, Anamarija, Trontelj, Jurij, Pardo, Luis A., Hughes, Diarmaid, Huseby, Douglas, Berruga-Fernández, Tália, Cao, Sha, Simoff, Ivailo, Svensson, Richard, Korol, Sergiy V., Jin, Zhe, Vicente, Francisca, Ramos, Maria C., Mundy, Julia E. A., Maxwell, Anthony, Stevenson, Clare E. M., Lawson, David M., Glinghammar, Björn, Sjöström, Eva, Bohlin, Martin, Oreskär, Joanna, Alvér, Sofie, Janssen, Guido V., Sterk, Geert Jan, Kikelj, Danijel, Pal, Csaba, Tomašič, Tihomir, Peterlin Mašič, Lucija

Volltext

Targeted Cancer Therapy Using Compounds Activated by Light von Dunkel, Petra, Ilas, Janez

Volltext

Efficient Synthesis of Hydroxy-Substituted 2‑Aminobenzo[d]thiazole-6-carboxylic Acid Derivatives as New Building Blocks in Drug Discovery von Durcik, Martina, Toplak, Žan, Zidar, Nace, Ilaš, Janez, Zega, Anamarija, Kikelj, Danijel, Mašič, Lucija Peterlin, Tomašič, Tihomir

Volltext

Exploring the 5‑Substituted 2‑Aminobenzothiazole-Based DNA Gyrase B Inhibitors Active against ESKAPE Pathogens von Sterle, Maša, Durcik, Martina, Stevenson, Clare E. M., Henderson, Sara R., Szili, Petra Eva, Czikkely, Marton, Lawson, David M., Maxwell, Anthony, Cahard, Dominique, Kikelj, Danijel, Zidar, Nace, Pal, Csaba, Mašič, Lucija Peterlin, Ilaš, Janez, Tomašič, Tihomir, Cotman, Andrej Emanuel, Zega, Anamarija

Volltext