Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase von Padyana, Anil K., Gross, Stefan, Jin, Lei, Cianchetta, Giovanni, Narayanaswamy, Rohini, Wang, Feng, Wang, Rui, Fang, Cheng, Lv, Xiaobing, Biller, Scott A., Dang, Lenny, Mahoney, Christopher E., Nagaraja, Nelamangala, Pirman, David, Sui, Zhihua, Popovici-Muller, Janeta, Smolen, Gromoslaw A.

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A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition von Mahoney, Christopher E., Pirman, David, Chubukov, Victor, Sleger, Taryn, Hayes, Sebastian, Fan, Zi Peng, Allen, Eric L., Chen, Ying, Huang, Lingling, Liu, Meina, Zhang, Yingjia, McDonald, Gabrielle, Narayanaswamy, Rohini, Choe, Sung, Chen, Yue, Gross, Stefan, Cianchetta, Giovanni, Padyana, Anil K., Murray, Stuart, Liu, Wei, Marks, Kevin M., Murtie, Joshua, Dorsch, Marion, Jin, Shengfang, Nagaraja, Nelamangala, Biller, Scott A., Roddy, Thomas, Popovici-Muller, Janeta, Smolen, Gromoslaw A.

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An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells von Rohle, Dan, Popovici-Muller, Janeta, Palaskas, Nicolaos, Turcan, Sevin, Grommes, Christian, Campos, Carl, Tsoi, Jennifer, Clark, Owen, Oldrini, Barbara, Komisopoulou, Evangelia, Kunii, Kaiko, Pedraza, Alicia, Schalm, Stefanie, Silverman, Lee, Miller, Alexandra, Wang, Fang, Yang, Hua, Chen, Yue, Kernytsky, Andrew, Rosenblum, Marc K., Liu, Wei, Biller, Scott A., Su, Shinsan M., Brennan, Cameron W., Chan, Timothy A., Graeber, Thomas G., Yen, Katharine E., Mellinghoff, Ingo K.

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Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers von Popovici-Muller, Janeta, Lemieux, René M, Artin, Erin, Saunders, Jeffrey O, Salituro, Francesco G, Travins, Jeremy, Cianchetta, Giovanni, Cai, Zhenwei, Zhou, Ding, Cui, Dawei, Chen, Ping, Straley, Kimberly, Tobin, Erica, Wang, Fang, David, Muriel D, Penard-Lacronique, Virginie, Quivoron, Cyril, Saada, Véronique, de Botton, Stéphane, Gross, Stefan, Dang, Lenny, Yang, Hua, Utley, Luke, Chen, Yue, Kim, Hyeryun, Jin, Shengfang, Gu, Zhiwei, Yao, Gui, Luo, Zhiyong, Lv, Xiaobing, Fang, Cheng, Yan, Liping, Olaharski, Andrew, Silverman, Lee, Biller, Scott, Su, Shin-San M, Yen, Katharine

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Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma von Konteatis, Zenon, Artin, Erin, Nicolay, Brandon, Straley, Kimberly, Padyana, Anil K, Jin, Lei, Chen, Yue, Narayaraswamy, Rohini, Tong, Shuilong, Wang, Feng, Zhou, Ding, Cui, Dawei, Cai, Zhenwei, Luo, Zhiyong, Fang, Cheng, Tang, Huachun, Lv, Xiaobing, Nagaraja, Raj, Yang, Hua, Su, Shin-San M, Sui, Zhihua, Dang, Lenny, Yen, Katharine, Popovici-Muller, Janeta, Codega, Paolo, Campos, Carl, Mellinghoff, Ingo K, Biller, Scott A

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Biochemical, Cellular, and Biophysical Characterization of a Potent Inhibitor of Mutant Isocitrate Dehydrogenase IDH1 von Davis, Mindy I., Gross, Stefan, Shen, Min, Straley, Kimberly S., Pragani, Rajan, Lea, Wendy A., Popovici-Muller, Janeta, DeLaBarre, Byron, Artin, Erin, Thorne, Natasha, Auld, Douglas S., Li, Zhuyin, Dang, Lenny, Boxer, Matthew B., Simeonov, Anton

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Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer von Saha, Supriya K., Parachoniak, Christine A., Ghanta, Krishna S., Fitamant, Julien, Ross, Kenneth N., Najem, Mortada S., Gurumurthy, Sushma, Akbay, Esra A., Sia, Daniela, Cornella, Helena, Miltiadous, Oriana, Walesky, Chad, Deshpande, Vikram, Zhu, Andrew X., Hezel, Aram F., Yen, Katharine E., Straley, Kimberly S., Travins, Jeremy, Popovici-Muller, Janeta, Gliser, Camelia, Ferrone, Cristina R., Apte, Udayan, Llovet, Josep M., Wong, Kwok-Kin, Ramaswamy, Sridhar, Bardeesy, Nabeel

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AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency von Kung, Charles, Hixon, Jeff, Kosinski, Penelope A., Cianchetta, Giovanni, Histen, Gavin, Chen, Yue, Hill, Collin, Gross, Stefan, Si, Yaguang, Johnson, Kendall, DeLaBarre, Byron, Luo, Zhiyong, Gu, Zhiwei, Yao, Gui, Tang, Huachun, Fang, Cheng, Xu, Yingxia, Lv, Xiaobing, Biller, Scott, Su, Shin-San Michael, Yang, Hua, Popovici-Muller, Janeta, Salituro, Francesco, Silverman, Lee, Dang, Lenny

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Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation von Wang, Fang, Travins, Jeremy, DeLaBarre, Byron, Penard-Lacronique, Virginie, Schalm, Stefanie, Hansen, Erica, Straley, Kimberly, Kernytsky, Andrew, Liu, Wei, Gliser, Camelia, Yang, Hua, Gross, Stefan, Artin, Erin, Saada, Veronique, Mylonas, Elena, Quivoron, Cyril, Popovici-Muller, Janeta, Saunders, Jeffrey O., Salituro, Francesco G., Yan, Shunqi, Murray, Stuart, Wei, Wentao, Gao, Yi, Dang, Lenny, Dorsch, Marion, Agresta, Sam, Schenkein, David P., Biller, Scott A., Su, Shinsan M., de Botton, Stephane, Yen, Katharine E.

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Preclinical toxicology profile of squalene epoxidase inhibitors von Nagaraja, Raj, Olaharski, Andrew, Narayanaswamy, Rohini, Mahoney, Christopher, Pirman, David, Gross, Stefan, Roddy, Thomas P., Popovici-Muller, Janeta, Smolen, Gromoslaw A., Silverman, Lee

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Preclinical Drug Metabolism, Pharmacokinetic, and Pharmacodynamic Profiles of Ivosidenib, an Inhibitor of Mutant Isocitrate Dehydrogenase 1 for Treatment of Isocitrate Dehydrogenas... von Chen, Yue, Nagaraja, Nelamangala, Fan, Bin, Utley, Luke, Lemieux, Rene M., Popovici-Muller, Janeta, Dang, Lenny, Kim, Hyeryun, Yan, Liping, Su, Shin-San M., Biller, Scott A., Yang, Hua

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Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2‑HG in Vivo von Popovici-Muller, Janeta, Saunders, Jeffrey O, Salituro, Francesco G, Travins, Jeremy M, Yan, Shunqi, Zhao, Fang, Gross, Stefan, Dang, Lenny, Yen, Katharine E, Yang, Hua, Straley, Kimberly S, Jin, Shengfang, Kunii, Kaiko, Fantin, Valeria R, Zhang, Shunan, Pan, Qiongqun, Shi, Derek, Biller, Scott A, Su, Shinsan M

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Preparation and biochemical evaluation of fluorenone-containing lipid analogs von Spencer, Thomas A., Wang, Pingzhen, Popovici-Müller, Janeta V., Peltan, Ithan D., Fielding, Phoebe E., Fielding, Christopher J.

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Fused bi-heteroaryl substituted hydantoin compounds as TACE inhibitors von Tong, Ling, Kim, Seong Heon, Rosner, Kristin, Yu, Wensheng, Shankar, Bandarpalle B., Chen, Lei, Li, Dansu, Dai, Chaoyang, Girijavallabhan, Vinay, Popovici-Muller, Janeta, Yang, Liping, Zhou, Guowei, Kosinski, Aneta, Siddiqui, M. Arshad, Shih, Neng-Yang, Guo, Zhuyan, Orth, Peter, Chen, Shiying, Lundell, Daniel, Niu, Xiaoda, Umland, Shelby, Kozlowski, Joseph A.

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Abstract B126: AG-881, a brain penetrant, potent, pan-mutant IDH (mIDH) inhibitor for use in mIDH solid and hematologic malignancies von Yen, Katharine, Konteatis, Zenon, Sui, Zhihua, Artin, Erin, Dang, Lenny, Straley, Kimberly, Tobin, Erica, Campos, Carl, Yang, Hua, Nagaraja, Raj, Chen, Yue, Kim, Hyeryun, Gliser, Camelia, Nicolay, Brandon, Olaharski, Andrew, Silverman, Lee, Biller, Scott, Su, Shinsan M., Mellinghoff, Ingo, Popovici-Muller, Janeta

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Abstract 1194: IDH1 mutant inhibitor induces cellular differentiation and offers a combination benefit with Ara-C in a primary human Idh1 mutant AML xenograft model von Ellwood-Yen, Kate, Chen, Yue, Wang, Fang, Lemieux, Rene, Popovici-Muller, Janeta, Yang, Hua, Straley, Kimberly, Choe, Sung, Dorsch, Marion, Agresta, Sam, Schenkein, David, Biller, Scott, Su, Michael

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Syntheses of 5′-amino-2′,5′-dideoxy-2′,2′-difluorocytidine derivatives as novel anticancer nucleoside analogs von Labroli, Marc A., Dwyer, Michael P., Shen, Ruichao, Popovici-Muller, Janeta, Pu, Qinglin, Richard, Judson, Rosner, Kristen, Paruch, Kamil, Guzi, Timothy J.

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IDH1 Mutant Inhibitor Induces Cellular Differentiation and Offers a Combination Benefit With Ara-C In a Primary Human Idh1 Mutant AML Xenograft Model von Yen, Katharine, Lemieux, Rene, Popovici-Muller, Janeta, Chen, Yue, Yang, Hua, Straley, Kim, Choe, Sung, Dorsch, Marion, Agresta, Samuel, Schenkein, David P., Biller, Scott, Su, Michael, Wang, Fang

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Correction: Corrigendum: Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer von Saha, Supriya K., Parachoniak, Christine A., Ghanta, Krishna S., Fitamant, Julien, Ross, Kenneth N., Najem, Mortada S., Gurumurthy, Sushma, Akbay, Esra A., Sia, Daniela, Cornella, Helena, Miltiadous, Oriana, Walesky, Chad, Deshpande, Vikram, Zhu, Andrew X., Hezel, Aram F., Yen, Katharine E., Straley, Kimberly S., Travins, Jeremy, Popovici-Muller, Janeta, Gliser, Camelia, Ferrone, Cristina R., Apte, Udayan, Llovet, Josep M., Wong, Kwok-Kin, Ramaswamy, Sridhar, Bardeesy, Nabeel

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Erratum: Corrigendum: Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer von Saha, Supriya K., Parachoniak, Christine A., Ghanta, Krishna S., Fitamant, Julien, Ross, Kenneth N., Najem, Mortada S., Gurumurthy, Sushma, Akbay, Esra A., Sia, Daniela, Cornella, Helena, Miltiadous, Oriana, Walesky, Chad, Deshpande, Vikram, Zhu, Andrew X., Hezel, Aram F., Yen, Katharine E., Straley, Kimberly S., Travins, Jeremy, Popovici-Muller, Janeta, Gliser, Camelia, Ferrone, Cristina R., Apte, Udayan, Llovet, Josep M., Wong, Kwok-Kin, Ramaswamy, Sridhar, Bardeesy, Nabeel

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