Clinical Evaluation and Biomarker Profiling of Hsp90 Inhibitors von Yuno, Akira, Lee, Min-Jung, Lee, Sunmin, Tomita, Yusuke, Rekhtman, David, Moore, Brittni, Trepel, Jane B.

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Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer von Roper, Nitin, Velez, Moises J., Chiappori, Alberto, Kim, Yoo Sun, Wei, Jun S., Sindiri, Sivasish, Takahashi, Nobuyuki, Mulford, Deborah, Kumar, Suresh, Ylaya, Kris, Trindade, Christopher, Manukyan, Irena, Brown, Anna-Leigh, Trepel, Jane B., Lee, Jung-Min, Hewitt, Stephen, Khan, Javed, Thomas, Anish

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Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development von Neckers, Len, Blagg, Brian, Haystead, Timothy, Trepel, Jane B., Whitesell, Luke, Picard, Didier

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Randomized Phase II, Double-Blind, Placebo-Controlled Study of Exemestane With or Without Entinostat in Postmenopausal Women With Locally Recurrent or Metastatic Estrogen Receptor-... von YARDLEY, Denise A, ISMAIL-KHAN, Roohi R, MELICHAR, Bohuslav, LICHINITSER, Mikhail, MUNSTER, Pamela N, KLEIN, Pamela M, CRUICKSHANK, Scott, MILLER, Kathy D, LEE, Min J, TREPEL, Jane B

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Prexasertib, a cell cycle checkpoint kinase 1 and 2 inhibitor, in BRCA wild-type recurrent high-grade serous ovarian cancer: a first-in-class proof-of-concept phase 2 study von Lee, Jung-Min, Nair, Jayakumar, Zimmer, Alexandra, Lipkowitz, Stanley, Annunziata, Christina M, Merino, Maria J, Swisher, Elizabeth M, Harrell, Maria I, Trepel, Jane B, Lee, Min-Jung, Bagheri, Mohammad H, Botesteanu, Dana-Adriana, Steinberg, Seth M, Minasian, Lori, Ekwede, Irene, Kohn, Elise C

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Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity von Ogawa, Mikako, Tomita, Yusuke, Nakamura, Yuko, Lee, Min-Jung, Lee, Sunmin, Tomita, Saori, Nagaya, Tadanobu, Sato, Kazuhide, Yamauchi, Toyohiko, Iwai, Hidenao, Kumar, Abhishek, Haystead, Timothy, Shroff, Hari, Choyke, Peter L, Trepel, Jane B, Kobayashi, Hisataka

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Stressing the Development of Small Molecules Targeting HSP90 von NECKERS, Len, TREPEL, Jane B

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A brief review of the management of platinum-resistant–platinum-refractory ovarian cancer von Oronsky, Bryan, Ray, Carolyn M., Spira, Alexander I., Trepel, Jane B., Carter, Corey A., Cottrill, Hope M.

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HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation von Kijima, Toshiki, Prince, Thomas L., Tigue, Megan L., Yim, Kendrick H., Schwartz, Harvey, Beebe, Kristin, Lee, Sunmin, Budzynski, Marek A., Williams, Heinric, Trepel, Jane B., Sistonen, Lea, Calderwood, Stuart, Neckers, Len

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Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer von Moses, Michael A, Kim, Yeong Sang, Rivera-Marquez, Genesis M, Oshima, Nobu, Watson, Matthew J, Beebe, Kristin E, Wells, Catherine, Lee, Sunmin, Zuehlke, Abbey D, Shao, Hao, Bingman, 3rd, William E, Kumar, Vineet, Malhotra, Sanjay V, Weigel, Nancy L, Gestwicki, Jason E, Trepel, Jane B, Neckers, Leonard M

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Threonine 22 Phosphorylation Attenuates Hsp90 Interaction with Cochaperones and Affects Its Chaperone Activity von Mollapour, Mehdi, Tsutsumi, Shinji, Truman, Andrew W., Xu, Wanping, Vaughan, Cara K., Beebe, Kristin, Konstantinova, Anna, Vourganti, Srinivas, Panaretou, Barry, Piper, Peter W., Trepel, Jane B., Prodromou, Chrisostomos, Pearl, Laurence H., Neckers, Len

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A Phase II Single Arm Pilot Study of the CHK1 Inhibitor Prexasertib (LY2606368) in BRCA Wild‐Type, Advanced Triple‐Negative Breast Cancer von Gatti‐Mays, Margaret E., Karzai, Fatima H., Soltani, Sanaz N., Zimmer, Alexandra, Green, Jeffrey E., Lee, Min‐Jung, Trepel, Jane B., Yuno, Akira, Lipkowitz, Stanley, Nair, Jayakumar, McCoy, Ann, Lee, Jung‐Min

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The CHK1 inhibitor prexasertib in BRCA wild-type platinum-resistant recurrent high-grade serous ovarian carcinoma: a phase 2 trial von Giudice, Elena, Huang, Tzu-Ting, Nair, Jayakumar R., Zurcher, Grant, McCoy, Ann, Nousome, Darryl, Radke, Marc R., Swisher, Elizabeth M., Lipkowitz, Stanley, Ibanez, Kristen, Donohue, Duncan, Malys, Tyler, Lee, Min-Jung, Redd, Bernadette, Levy, Elliot, Rastogi, Shraddha, Sato, Nahoko, Trepel, Jane B., Lee, Jung-Min

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Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1 von Xu, Wanping, Beebe, Kristin, Chavez, Juan D., Boysen, Marta, Lu, YinYing, Zuehlke, Abbey D., Keramisanou, Dimitra, Trepel, Jane B., Prodromou, Christosomos, Mayer, Matthias P., Bruce, James E., Gelis, Ioannis, Neckers, Len

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Asymmetric Hsp90 N Domain SUMOylation Recruits Aha1 and ATP-Competitive Inhibitors von Mollapour, Mehdi, Bourboulia, Dimitra, Beebe, Kristin, Woodford, Mark R., Polier, Sigrun, Hoang, Anthony, Chelluri, Raju, Li, Yu, Guo, Ailan, Lee, Min-Jung, Fotooh-Abadi, Elham, Khan, Sahar, Prince, Thomas, Miyajima, Naoto, Yoshida, Soichiro, Tsutsumi, Shinji, Xu, Wanping, Panaretou, Barry, Stetler-Stevenson, William G., Bratslavsky, Gennady, Trepel, Jane B., Prodromou, Chrisostomos, Neckers, Len

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Effects of Anticancer Drugs on Chromosome Instability and New Clinical Implications for Tumor-Suppressing Therapies von Lee, Hee-Sheung, Lee, Nicholas C O, Kouprina, Natalay, Kim, Jung-Hyun, Kagansky, Alex, Bates, Susan, Trepel, Jane B, Pommier, Yves, Sackett, Dan, Larionov, Vladimir

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Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants von Prince, Thomas L, Kijima, Toshiki, Tatokoro, Manabu, Lee, Sunmin, Tsutsumi, Shinji, Yim, Kendrick, Rivas, Candy, Alarcon, Sylvia, Schwartz, Harvey, Khamit-Kush, Kofi, Scroggins, Bradley T, Beebe, Kristin, Trepel, Jane B, Neckers, Len

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Immunotherapy: a new treatment paradigm in bladder cancer von Davarpanah, Nicole N, Yuno, Akira, Trepel, Jane B, Apolo, Andrea B

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A phase I study of the PD-L1 inhibitor, durvalumab, in combination with a PARP inhibitor, olaparib, and a VEGFR1-3 inhibitor, cediranib, in recurrent women's cancers with biomarker... von Zimmer, Alexandra S, Nichols, Erin, Cimino-Mathews, Ashley, Peer, Cody, Cao, Liang, Lee, Min-Jung, Kohn, Elise C, Annunziata, Christina M, Lipkowitz, Stanley, Trepel, Jane B, Sharma, Rajni, Mikkilineni, Lekha, Gatti-Mays, Margaret, Figg, William D, Houston, Nicole D, Lee, Jung-Min

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Structural and functional complexity of HSP90 in cellular homeostasis and disease von Chiosis, Gabriela, Digwal, Chander S., Trepel, Jane B., Neckers, Len

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