The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8+ T Cell Effector Function von Johnston, Robert J., Comps-Agrar, Laetitia, Hackney, Jason, Yu, Xin, Huseni, Mahrukh, Yang, Yagai, Park, Summer, Javinal, Vincent, Chiu, Henry, Irving, Bryan, Eaton, Dan L., Grogan, Jane L.

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Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer von Patil, Namrata S., Nabet, Barzin Y., Müller, Sören, Koeppen, Hartmut, Zou, Wei, Giltnane, Jennifer, Au-Yeung, Amelia, Srivats, Shyam, Cheng, Jason H., Takahashi, Chikara, de Almeida, Patricia E., Chitre, Avantika S., Grogan, Jane L., Rangell, Linda, Jayakar, Sangeeta, Peterson, Maureen, Hsia, Allison W., O’Gorman, William E., Ballinger, Marcus, Banchereau, Romain, Shames, David S.

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A role for Th17 cells in the regulation of tertiary lymphoid follicles von Grogan, Jane L., Ouyang, Wenjun

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Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC + CD127 + natural killer-like cells von Cupedo, Tom, Crellin, Natasha K, Papazian, Natalie, Rombouts, Elwin J, Weijer, Kees, Grogan, Jane L, Fibbe, Willem E, Cornelissen, Jan J, Spits, Hergen

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High-throughput electrophysiological assays for voltage gated ion channels using SyncroPatch 768PE von Li, Tianbo, Lu, Gang, Chiang, Eugene Y, Chernov-Rogan, Tania, Grogan, Jane L, Chen, Jun

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A Platform for Extracellular Interactome Discovery Identifies Novel Functional Binding Partners for the Immune Receptors B7-H3/CD276 and PVR/CD155 von Husain, Bushra, Ramani, Sree R., Chiang, Eugene, Lehoux, Isabelle, Paduchuri, Sairupa, Arena, Tia A., Patel, Ashka, Wilson, Blair, Chan, Pamela, Franke, Yvonne, Wong, Athena W., Lill, Jennie R., Turley, Shannon J., Gonzalez, Lino C., Grogan, Jane L., Martinez-Martin, Nadia

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Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions von Chiang, Eugene Y., Li, Tianbo, Jeet, Surinder, Peng, Ivan, Zhang, Juan, Lee, Wyne P., DeVoss, Jason, Caplazi, Patrick, Chen, Jun, Warming, Søren, Hackos, David H., Mukund, Susmith, Koth, Christopher M., Grogan, Jane L.

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Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell–cell adhesion and signaling mechanism that requires cis-trans receptor clustering von Stengel, Katharina F, Harden-Bowles, Kristin, Yu, Xin, Rouge, Lionel, Yin, Jianping, Comps-Agrar, Laëtitia, Wiesmann, Christian, Bazan, J. Fernando, Eaton, Dan L, Grogan, Jane L

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HPK1 citron homology domain regulates phosphorylation of SLP76 and modulates kinase domain interaction dynamics von Chitre, Avantika S., Wu, Ping, Walters, Benjamin T., Wang, Xiangdan, Bouyssou, Alexandre, Du, Xiangnan, Lehoux, Isabelle, Fong, Rina, Arata, Alisa, Chan, Joyce, Wang, Die, Franke, Yvonne, Grogan, Jane L., Mellman, Ira, Comps-Agrar, Laetitia, Wang, Weiru

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The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function von Hernandez, Sairy, Qing, Jing, Thibodeau, Rebecca Hong, Du, Xiangnan, Park, Summer, Lee, Hyang-Mi, Xu, Min, Oh, Soyoung, Navarro, Armando, Roose-Girma, Meron, Newman, Robert J., Warming, Soren, Nannini, Michelle, Sampath, Deepak, Kim, Jeong M., Grogan, Jane L., Mellman, Ira

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TIGIT Enhances Antigen-Specific Th2 Recall Responses and Allergic Disease von Kourepini, Evangelia, Paschalidis, Nikolaos, Simoes, Davina C M, Aggelakopoulou, Maria, Grogan, Jane L, Panoutsakopoulou, Vily

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CD226 regulates natural killer cell antitumor responses via phosphorylation-mediated inactivation of transcription factor FOXO1 von Du, Xiangnan, de Almeida, Patricia, Manieri, Nick, de Almeida Nagata, Denise, Wu, Thomas D., Bowles, Kristin Harden, Arumugam, Vidhyalakshmi, Schartner, Jill, Cubas, Rafael, Mittman, Stephanie, Javinal, Vincent, Anderson, Keith R., Warming, Søren, Grogan, Jane L., Chiang, Eugene Y.

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Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics von Bumbaca Yadav, Daniela, Sharma, Vikas K., Boswell, Charles Andrew, Hotzel, Isidro, Tesar, Devin, Shang, Yonglei, Ying, Yong, Fischer, Saloumeh K., Grogan, Jane L., Chiang, Eugene Y., Urban, Konnie, Ulufatu, Sheila, Khawli, Leslie A., Prabhu, Saileta, Joseph, Sean, Kelley, Robert F.

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Regulation of Tumor-Associated Myeloid Cell Activity by CBP/EP300 Bromodomain Modulation of H3K27 Acetylation von de Almeida Nagata, Denise E., Chiang, Eugene Y., Jhunjhunwala, Suchit, Caplazi, Patrick, Arumugam, Vidhyalakshmi, Modrusan, Zora, Chan, Emily, Merchant, Mark, Jin, Lingyan, Arnott, David, Romero, F. Anthony, Magnuson, Steven, Gascoigne, Karen E., Grogan, Jane L.

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TIGIT: A Key Inhibitor of the Cancer Immunity Cycle von Manieri, Nicholas A, Chiang, Eugene Y, Grogan, Jane L

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Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair von Perez-Bermejo, Juan A., Efagene, Oghene, Matern, William M., Holden, Jeffrey K., Kabir, Shaheen, Chew, Glen M., Andreoletti, Gaia, Catton, Eniola, Ennis, Craig L., Garcia, Angelica, Gerstenberg, Trevor L., Hill, Kaisle A., Jain, Aayami, Krassovsky, Kristina, Lalisan, Cassandra D., Lord, Daniel, Quejarro, B. Joy, Sales-Lee, Jade, Shah, Meet, Silva, Brian J., Skowronski, Jason, Strukov, Yuri G., Thomas, Joshua, Veraz, Michael, Vijay, Twaritha, Wallace, Kirby A., Yuan, Yue, Grogan, Jane L., Wienert, Beeke, Lahiri, Premanjali, Treusch, Sebastian, Dever, Daniel P., Soros, Vanessa B., Partridge, James R., Seim, Kristen L.

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EBI2 is a negative regulator of type I interferons in plasmacytoid and myeloid dendritic cells von Chiang, Eugene Y, Johnston, Robert J, Grogan, Jane L

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Efficacy and safety of pateclizumab (anti-lymphotoxin-α) compared to adalimumab in rheumatoid arthritis: a head-to-head phase 2 randomized controlled study (The ALTARA Study) von Kennedy, William P, Simon, J Abraham, Offutt, Carolyn, Horn, Priscilla, Herman, Ann, Townsend, Michael J, Tang, Meina T, Grogan, Jane L, Hsieh, Frank, Davis, John C

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Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses von Banta, Karl L., Xu, Xiaozheng, Chitre, Avantika S., Au-Yeung, Amelia, Takahashi, Chikara, O’Gorman, William E., Wu, Thomas D., Mittman, Stephanie, Cubas, Rafael, Comps-Agrar, Laetitia, Fulzele, Amit, Bennett, Eric J., Grogan, Jane L., Hui, Enfu, Chiang, Eugene Y., Mellman, Ira

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Dimerization of LTβR by LTα₁β₂ is necessary and sufficient for signal transduction von Sudhamsu, Jawahar, Yin, JianPing, Chiang, Eugene Y., Starovasnik, Melissa A., Grogan, Jane L., Hymowitz, Sarah G.

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