Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity von Janas, Maja M., Schlegel, Mark K., Harbison, Carole E., Yilmaz, Vedat O., Jiang, Yongfeng, Parmar, Rubina, Zlatev, Ivan, Castoreno, Adam, Xu, Huilei, Shulga-Morskaya, Svetlana, Rajeev, Kallanthottathil G., Manoharan, Muthiah, Keirstead, Natalie D., Maier, Martin A., Jadhav, Vasant

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Akt-Mediated Phosphorylation of Argonaute 2 Downregulates Cleavage and Upregulates Translational Repression of MicroRNA Targets von Horman, Shane R., Janas, Maja M., Litterst, Claudia, Wang, Bingbing, MacRae, Ian J., Sever, Mary J., Morrissey, David V., Graves, Paul, Luo, Biao, Umesalma, Shaikamjad, Qi, Hank H., Miraglia, Loren J., Novina, Carl D., Orth, Anthony P.

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siRNAs containing 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2′... von Akabane-Nakata, Masaaki, Erande, Namrata D, Kumar, Pawan, Degaonkar, Rohan, Gilbert, Jason A, Qin, June, Mendez, Martha, Woods, Lauren Blair, Jiang, Yongfeng, Janas, Maja M, O’Flaherty, Derek K, Zlatev, Ivan, Schlegel, Mark K, Matsuda, Shigeo, Egli, Martin, Manoharan, Muthiah

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Mechanisms of RNA loading into exosomes von Janas, Teresa, Janas, Maja M., Sapoń, Karolina, Janas, Tadeusz

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Transcription Factor/microRNA Axis Blocks Melanoma Invasion Program by miR-211 Targeting NUAK1 von Bell, Rachel E., Khaled, Mehdi, Netanely, Dvir, Schubert, Steffen, Golan, Tamar, Buxbaum, Amir, Janas, Maja M., Postolsky, Benny, Goldberg, Michael S., Shamir, Ron, Levy, Carmit

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Intronic miR-211 Assumes the Tumor Suppressive Function of Its Host Gene in Melanoma von Levy, Carmit, Khaled, Mehdi, Iliopoulos, Dimitrios, Janas, Maja M., Schubert, Steffen, Pinner, Sophie, Chen, Po-Hao, Li, Shuqiang, Fletcher, Anne L., Yokoyama, Satoru, Scott, Kenneth L., Garraway, Levi A., Song, Jun S., Granter, Scott R., Turley, Shannon J., Fisher, David E., Novina, Carl D.

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Alternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins von Janas, Maja M, Wang, Bingbing, Harris, Abigail S, Aguiar, Mike, Shaffer, Jonathan M, Subrahmanyam, Yerramilli V B K, Behlke, Mark A, Wucherpfennig, Kai W, Gygi, Steven P, Gagnon, Etienne, Novina, Carl D

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Feed-forward microprocessing and splicing activities at a microRNA-containing intron von Janas, Maja M, Khaled, Mehdi, Schubert, Steffen, Bernstein, Jacob G, Golan, David, Veguilla, Rosa A, Fisher, David E, Shomron, Noam, Levy, Carmit, Novina, Carl D

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Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates von Brown, Kirk M., Nair, Jayaprakash K., Janas, Maja M., Anglero-Rodriguez, Yesseinia I., Dang, Lan T. H., Peng, Haiyan, Theile, Christopher S., Castellanos-Rizaldos, Elena, Brown, Christopher, Foster, Donald, Kurz, Jeffrey, Allen, Jeffrey, Maganti, Rajanikanth, Li, Jing, Matsuda, Shigeo, Stricos, Matthew, Chickering, Tyler, Jung, Michelle, Wassarman, Kelly, Rollins, Jeff, Woods, Lauren, Kelin, Alex, Guenther, Dale C., Mobley, Melissa W., Petrulis, John, McDougall, Robin, Racie, Timothy, Bombardier, Jessica, Cha, Diana, Agarwal, Saket, Johnson, Lei, Jiang, Yongfeng, Lentini, Scott, Gilbert, Jason, Nguyen, Tuyen, Chigas, Samantha, LeBlanc, Sarah, Poreci, Urjana, Kasper, Anne, Rogers, Arlin B., Chong, Saeho, Davis, Wendell, Sutherland, Jessica E., Castoreno, Adam, Milstein, Stuart, Schlegel, Mark K., Zlatev, Ivan, Charisse, Klaus, Keating, Mark, Manoharan, Muthiah, Fitzgerald, Kevin, Wu, Jing-Tao, Maier, Martin A., Jadhav, Vasant

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Evaluation of RNAi therapeutics VIR-2218 and ALN-HBV for chronic hepatitis B: Results from randomized clinical trials von Gane, Ed, Lim, Young-Suk, Kim, Jae B., Jadhav, Vasant, Shen, Ling, Bakardjiev, Anna I., Huang, Stephen A., Cathcart, Andrea L., Lempp, Florian A., Janas, Maja M., Cloutier, Daniel J., Kaittanis, Charalambos, Sepp-Lorenzino, Laura, Hinkle, Gregory, Taubel, Jorg, Haslett, Patrick, Milstein, Stuart, Anglero-Rodriguez, Yesseinia I., Hebner, Christy M., Pang, Phillip S., Yuen, Man-Fung

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The Chicken or the Egg: MicroRNA-Mediated Regulation of mRNA Translation or mRNA Stability von Omer, Arina D., Janas, Maja M., Novina, Carl D.

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From bench to bedside: Improving the clinical safety of GalNAc–siRNA conjugates using seed-pairing destabilization von Schlegel, Mark K, Janas, Maja M, Jiang, Yongfeng, Barry, Joseph D, Davis, Wendell, Agarwal, Saket, Berman, Daniel, Brown, Christopher R, Castoreno, Adam, LeBlanc, Sarah, Liebow, Abigail, Mayo, Tara, Milstein, Stuart, Nguyen, Tuyen, Shulga-Morskaya, Svetlana, Hyde, Sarah, Schofield, Sally, Szeto, John, Woods, Lauren Blair, Yilmaz, Vedat O, Manoharan, Muthiah, Egli, Martin, Charissé, Klaus, Sepp-Lorenzino, Laura, Haslett, Patrick, Fitzgerald, Kevin, Jadhav, Vasant, Maier, Martin A

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Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex von Datta, Dhrubajyoti, Theile, Christopher S, Wassarman, Kelly, Qin, June, Racie, Tim, Schmidt, Karyn, Jiang, Yongfeng, Sigel, Rachel, Janas, Maja M, Egli, Martin, Manoharan, Muthiah

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The Nonclinical Safety Profile of GalNAc-conjugated RNAi Therapeutics in Subacute Studies von Janas, Maja M., Harbison, Carole E., Perry, Victoria K., Carito, Brenda, Sutherland, Jessica E., Vaishnaw, Akshay K., Keirstead, Natalie D., Warner, Garvin

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Safety evaluation of 2′-deoxy-2′-fluoro nucleotides in GalNAc-siRNA conjugates von Janas, Maja M, Zlatev, Ivan, Liu, Ju, Jiang, Yongfeng, Barros, Scott A, Sutherland, Jessica E, Davis, Wendell P, Liu, Jingxuan, Brown, Christopher R, Liu, Xiumin, Schlegel, Mark K, Blair, Lauren, Zhang, Xuemei, Das, Biplab, Tran, Chris, Aluri, Krishna, Li, Jing, Agarwal, Saket, Indrakanti, Ramesh, Charisse, Klaus, Nair, Jayaprakash, Matsuda, Shigeo, Rajeev, Kallanthottathil G, Zimmermann, Tracy, Sepp-Lorenzino, Laura, Xu, Yuanxin, Akinc, Akin, Fitzgerald, Kevin, Vaishnaw, Akshay K, Smith, Peter F, Manoharan, Muthiah, Jadhav, Vasant, Wu, Jing-Tao, Maier, Martin A

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Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc-siRNA conjugates: in vitro and in vivo RNAi activit... von Kumar, Pawan, Degaonkar, Rohan, Guenther, Dale C, Abramov, Mikhail, Schepers, Guy, Capobianco, Marie, Jiang, Yongfeng, Harp, Joel, Kaittanis, Charalambos, Janas, Maja M, Castoreno, Adam, Zlatev, Ivan, Schlegel, Mark K, Herdewijn, Piet, Egli, Martin, Manoharan, Muthiah

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Reduced Expression of Ribosomal Proteins Relieves MicroRNA-Mediated Repression von Janas, Maja M., Wang, Eric, Love, Tara, Harris, Abigail S., Stevenson, Kristen, Semmelmann, Karlheinz, Shaffer, Jonathan M., Chen, Po-Hao, Doench, John G., Yerramilli, Subrahmanyam V.B.K., Neuberg, Donna S., Iliopoulos, Dimitrios, Housman, David E., Burge, Christopher B., Novina, Carl D.

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Shorter Is Better: The α‑(l)‑Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RN... von Matsuda, Shigeo, Bala, Saikat, Liao, Jen-Yu, Datta, Dhrubajyoti, Mikami, Atsushi, Woods, Lauren, Harp, Joel M., Gilbert, Jason A., Bisbe, Anna, Manoharan, Rajar M., Kim, MaryBeth, Theile, Christopher S., Guenther, Dale C., Jiang, Yongfeng, Agarwal, Saket, Maganti, Rajanikanth, Schlegel, Mark K., Zlatev, Ivan, Charisse, Klaus, Rajeev, Kallanthottathil G., Castoreno, Adam, Maier, Martin, Janas, Maja M., Egli, Martin, Chaput, John C., Manoharan, Muthiah

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Impact of Serum Proteins on the Uptake and RNAi Activity of GalNAc-Conjugated siRNAs von Agarwal, Saket, Allard, Ruth, Darcy, Justin, Chigas, Samantha, Gu, Yongli, Nguyen, Tuyen, Bond, Sarah, Chong, Saeho, Wu, Jing-Tao, Janas, Maja M

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Role of a “Magic” Methyl: 2′-Deoxy-2′-α-F-2′-β‑C‑methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5′-Phosphate Mimics and Mitigation of Off-Tar... von Guenther, Dale C., Mori, Shohei, Matsuda, Shigeo, Gilbert, Jason A., Willoughby, Jennifer L. S., Hyde, Sarah, Bisbe, Anna, Jiang, Yongfeng, Agarwal, Saket, Madaoui, Mimouna, Janas, Maja M., Charisse, Klaus, Maier, Martin A., Egli, Martin, Manoharan, Muthiah

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