IL-8 as Antibody Therapeutic Target in Inflammatory Diseases: Reduction of Clinical Activity in Palmoplantar Pustulosis von Skov, Lone, Beurskens, Frank J, Zachariae, Claus O. C, Reitamo, Sakari, Teeling, Jessica, Satijn, David, Knudsen, Kim M, Boot, Elmieke P. J, Hudson, Debra, Baadsgaard, Ole, Parren, Paul W. H. I, van de Winkel, Jan G. J

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The Biological Activity of Human CD20 Monoclonal Antibodies Is Linked to Unique Epitopes on CD20 von Teeling, Jessica L, Mackus, Wendy J. M, Wiegman, Luus J. J. M, van den Brakel, Jeroen H. N, Beers, Stephen A, French, Ruth R, van Meerten, Tom, Ebeling, Saskia, Vink, Tom, Slootstra, Jerry W, Parren, Paul W. H. I, Glennie, Martin J, van de Winkel, Jan G. J

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IGA FC RECEPTORS von Monteiro, Renato C, van de Winkel, Jan G. J

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Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors von de Weers, Michel, Tai, Yu-Tzu, van der Veer, Michael S, Bakker, Joost M, Vink, Tom, Jacobs, Daniëlle C H, Oomen, Lukas A, Peipp, Matthias, Valerius, Thomas, Slootstra, Jerry W, Mutis, Tuna, Bleeker, Wim K, Anderson, Kenneth C, Lokhorst, Henk M, van de Winkel, Jan G J, Parren, Paul W H I

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Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange von van der Neut Kolfschoten, Marijn, Schuurman, Janine, Losen, Mario, Bleeker, Wim K., Martínez-Martínez, Pilar, Vermeulen, Ellen, Bleker, Tamara H. den, Wiegman, Luus, Vink, Tom, Aarden, Lucien A., De Baets, Marc H., van de Winkel, Jan G. J., Aalberse, Rob C., Parren, Paul W. H. I.

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Human IgG2 Antibodies against Epidermal Growth Factor Receptor Effectively Trigger Antibody-Dependent Cellular Cytotoxicity but, in Contrast to IgG1, Only by Cells of Myeloid Linea... von Schneider-Merck, Tanja, Lammerts van Bueren, Jeroen J, Berger, Sven, Rossen, Kai, van Berkel, Patrick H.C, Derer, Stefanie, Beyer, Thomas, Lohse, Stefan, Bleeker, Wim K, Peipp, Matthias, Parren, Paul W. H. I, van de Winkel, Jan G. J, Valerius, Thomas, Dechant, Michael

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Effector Mechanisms of Recombinant IgA Antibodies against Epidermal Growth Factor Receptor von Dechant, Michael, Beyer, Thomas, Schneider-Merck, Tanja, Weisner, Wencke, Peipp, Matthias, van de Winkel, Jan G. J, Valerius, Thomas

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Cytokine-induced immune complex binding to the high-affinity IgG receptor, FcγRI, in the presence of monomeric IgG von van der Poel, Cees E., Karssemeijer, Roos A., Boross, Peter, van der Linden, Joke A., Blokland, Miranda, van de Winkel, Jan G.J., Leusen, Jeanette H.W.

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Dual Mode of Action of a Human Anti-Epidermal Growth Factor Receptor Monoclonal Antibody for Cancer Therapy von Bleeker, Wim K, Lammerts van Bueren, Jeroen J, van Ojik, Heidi H, Gerritsen, Arnout F, Pluyter, Marielle, Houtkamp, Mischa, Halk, Ed, Goldstein, Joel, Schuurman, Janine, van Dijk, Marc A, van de Winkel, Jan G. J, Parren, Paul W. H. I

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Loss of CD20 and bound CD20 antibody from opsonized B cells occurs more rapidly because of trogocytosis mediated by Fc receptor-expressing effector cells than direct internalizatio... von Beum, Paul V, Peek, Elizabeth M, Lindorfer, Margaret A, Beurskens, Frank J, Engelberts, Patrick J, Parren, Paul W H I, van de Winkel, Jan G J, Taylor, Ronald P

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Antibody fucosylation differentially impacts cytotoxicity mediated by NK and PMN effector cells von Peipp, Matthias, Lammerts van Bueren, Jeroen J., Schneider-Merck, Tanja, Bleeker, Wim W.K., Dechant, Michael, Beyer, Thomas, Repp, Roland, van Berkel, Patrick H.C., Vink, Tom, van de Winkel, Jan G.J., Parren, Paul W.H.I., Valerius, Thomas

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Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange von Labrijn, Aran F, Meesters, Joyce I, de Goeij, Bart E C G, van den Bremer, Ewald T J, Neijssen, Joost, van Kampen, Muriel D, Strumane, Kristin, Verploegen, Sandra, Kundu, Amitava, Gramer, Michael J, van Berkel, Patrick H C, van de Winkel, Jan G J, Schuurman, Janine, Parren, Paul W H I

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Complement Is Activated by IgG Hexamers Assembled at the Cell Surface von Diebolder, Christoph A., Beurskens, Frank J., de Jong, Rob N., Koning, Roman I., Strumane, Kristin, Lindorfer, Margaret A., Voorhorst, Marleen, Ugurlar, Deniz, Rosati, Sara, Heck, Albert J. R., van de Winkel, Jan G. J., Wilson, Ian A., Koster, Abraham J., Taylor, Ronald P., Saphire, Erica Ollmann, Burton, Dennis R., Schuurman, Janine, Gros, Piet, Parren, Paul W. H. I.

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Complement Activation on B Lymphocytes Opsonized with Rituximab or Ofatumumab Produces Substantial Changes in Membrane Structure Preceding Cell Lysis von Beum, Paul V, Lindorfer, Margaret A, Beurskens, Frank, Stukenberg, P. Todd, Lokhorst, Henk M, Pawluczkowycz, Andrew W, Parren, Paul W. H. I, van de Winkel, Jan G. J, Taylor, Ronald P

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Recombinant dimeric IgA antibodies against the epidermal growth factor receptor mediate effective tumor cell killing von Lohse, Stefan, Derer, Stefanie, Beyer, Thomas, Klausz, Katja, Peipp, Matthias, Leusen, Jeanette H W, van de Winkel, Jan G J, Dechant, Michael, Valerius, Thomas

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Immature Neutrophils Mediate Tumor Cell Killing via IgA but Not IgG Fc Receptors von Otten, Marielle A, Rudolph, Esther, Dechant, Michael, Tuk, Cornelis W, Reijmers, Rogier M, Beelen, Robert H. J, van de Winkel, Jan G. J, van Egmond, Marjolein

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Binding of Submaximal C1q Promotes Complement-Dependent Cytotoxicity (CDC) of B Cells Opsonized with Anti-CD20 mAbs Ofatumumab (OFA) or Rituximab (RTX): Considerably Higher Levels... von Pawluczkowycz, Andrew W, Beurskens, Frank J, Beum, Paul V, Lindorfer, Margaret A, van de Winkel, Jan G. J, Parren, Paul W. H. I, Taylor, Ronald P

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Effect of target dynamics on pharmacokinetics of a novel therapeutic antibody against the epidermal growth factor receptor : Implications for the mechanisms of action von LAMMERTS VAN BUEREN, Jeroen J, BLEEKER, Wim K, BOGH, Henrik O, HOUTKAMP, Mischa, SCHUURMAN, Janine, VAN DE WINKEL, Jan G. J, PARREN, Paul W. H. I

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Functional characteristics of the high affinity IgG receptor, FcγRI von van der Poel, Cees E, Spaapen, Robbert M, van de Winkel, Jan G J, Leusen, Jeanette H W

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Estimation of dose requirements for sustained in vivo activity of a therapeutic human anti‐CD20 antibody von Bleeker, Wim K., Munk, Martin E., Mackus, Wendy J. M., Van Den Brakel, Jeroen H. N., Pluyter, Marielle, Glennie, Martin J., Van De Winkel, Jan G. J., Parren, Paul W. H. I.

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