Telavancin Disrupts the Functional Integrity of the Bacterial Membrane through Targeted Interaction with the Cell Wall Precursor Lipid II von LUNDE, Christopher S, HARTOUNI, Stephanie R, JANC, James W, MAMMEN, Mathai, HUMPHREY, Patrick P, BENTON, Bret M

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Specificity of Induction of the vanA and vanB Operons in Vancomycin-Resistant Enterococci by Telavancin von HILL, Craig M, KRAUSE, Kevin M, LEWIS, Stacey R, BLAIS, Johanne, BENTON, Bret M, MAMMEN, Mathai, HUMPHREY, Patrick P, KINANA, Alfred, JANC, James W

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3,4-Disubstituted azetidinones as selective inhibitors of the cysteine protease cathepsin K. Exploring P3 elements for potency and selectivity von Setti, Eduardo L., Davis, Dana, Janc, James W., Jeffery, Douglas A., Cheung, Harry, Yu, Walter

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Factor VIIa inhibitors: Chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model von Young, Wendy B., Mordenti, Joyce, Torkelson, Steven, Shrader, William D., Kolesnikov, Aleksandr, Rai, Roopa, Liu, Liang, Hu, Huiyong, Leahy, Ellen M., Green, Michael J., Sprengeler, Paul A., Katz, Bradley A., Yu, Christine, Janc, James W., Elrod, Kyle C., Marzec, Ulla M., Hanson, Stephen R.

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Quinolones as HCV NS5B polymerase inhibitors von Kumar, Dange V., Rai, Roopa, Brameld, Ken A., Somoza, John R., Rajagopalan, Ravi, Janc, James W., Xia, Yu M., Ton, Tony L., Shaghafi, Michael B., Hu, Huiyong, Lehoux, Isabelle, To, Nhat, Young, Wendy B., Green, Michael J.

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Keto-1,3,4-oxadiazoles as cathepsin K inhibitors von Palmer, James T., Hirschbein, Bernard L., Cheung, Harry, McCarter, John, Janc, James W., Yu, Z. Walter, Wesolowski, Gregg

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Optimization of Subsite Binding to the β5 Subunit of the Human 20S Proteasome Using Vinyl Sulfones and 2-Keto-1,3,4-oxadiazoles:  Syntheses and Cellular Properties of Potent, Selec... von Rydzewski, Robert M, Burrill, Leland, Mendonca, Rohan, Palmer, James T, Rice, Mark, Tahilramani, Ram, Bass, Kathryn E, Leung, Ling, Gjerstad, Erik, Janc, James W, Pan, Lin

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3-Heterocyclyl quinolone inhibitors of the HCV NS5B polymerase von Kumar, Dange V., Rai, Roopa, Brameld, Ken A., Riggs, Jennifer, Somoza, John R., Rajagopalan, Ravi, Janc, James W., Xia, Yu M., Ton, Tony L., Hu, Huiyong, Lehoux, Isabelle, Ho, Joseph D., Young, Wendy B., Hart, Barry, Green, Michael J.

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Synthesis of a statistically exhaustive fluorescent peptide substrate library for profiling protease specificity von Sheppeck II, James E, Kar, Heidi, Gosink, Luke, Wheatley, Jeffrey B, Gjerstad, Erik, Loftus, Siobhan M, Zubiria, Alexi R, Janc, James W

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Impact of telavancin on prothrombin time and activated partial thromboplastin time as determined using point-of-care coagulometers von Ero, Michael P., Harvey, Nathaniel R., Harbert, Jack L., Janc, James W., Chin, Kay H., Barriere, Steven L.

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Peptide Ketobenzoxazole Inhibitors Bound to Cathepsin K von McGrath, Mary E, Sprengeler, Paul A, Hill, Craig M, Martichonok, Valeri, Cheung, Harry, Somoza, John R, Palmer, James T, Janc, James W

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Structure-Guided Design of Peptide-Based Tryptase Inhibitors von McGrath, Mary E, Sprengeler, Paul A, Hirschbein, Bernard, Somoza, John R, Lehoux, Isabelle, Janc, James W, Gjerstad, Erik, Graupe, Michael, Estiarte, Angeles, Venkataramani, Chandru, Liu, Yang, Yee, Robb, Ho, Joseph D, Green, Michael J, Lee, Chang-Sun, Liu, Liang, Tai, Vincent, Spencer, Jeffrey, Sperandio, David, Katz, Bradley A

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Dissecting and Designing Inhibitor Selectivity Determinants at the S1 Site Using an Artificial Ala190 Protease (Ala190 uPA) von Katz, Bradley A., Luong, Christine, Ho, Joseph D., Somoza, John R., Gjerstad, Erik, Tang, Jie, Williams, Steven R., Verner, Erik, Mackman, Richard L., Young, Wendy B., Sprengeler, Paul A., Chan, Hedy, Mortara, Kyle, Janc, James W., McGrath, Mary E.

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The ITK Inhibitor Cpi-818 Blocks Activation of T Cells from Autoimmune Lymphoproliferative Syndrome (ALPS) Patients and Is Active in a Murine Model of ALPS von Rao, V. Koneti Koneti, Ng, Patrick P., Hill, Craig M., Miller, Richard A., Buggy, Joseph J., Janc, James W.

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Expression and characterization of recombinant γ-tryptase von Yuan, Jing, Beltman, Jeri, Gjerstad, Erik, Nguyen, Margaret T., Sampang, Jun, Chan, Hedy, Janc, James W., Clark, James M.

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Structure-activity relationship studies of a bisbenzimidazole-based, Zn2+-dependent inhibitor of HCV NS3 serine protease von YEUNG, Kap-Sun, MEANWELL, Nicholas A, ZHILEI QIU, HERNANDEZ, Dennis, ZHANG, Sharon, MCPHEE, Fiona, WEINHEIMER, Steve, CLARK, James M, JANC, James W

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Practical Robust Fit of Enzyme Inhibition Data von Kuzmič, Petr, Hill, Craig, Janc, James W.

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High-Throughput Screening of Enzyme Inhibitors: Simultaneous Determination of Tight-Binding Inhibition Constants and Enzyme Concentration von Kuzmič, Petr, Elrod, Kyle C, Cregar, Lynne M, Sideris, Steve, Rai, Roopa, Janc, James W

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Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-directed Serine Protease Inhibitors von Katz, Bradley A., Elrod, Kyle, Verner, Erik, Mackman, Richard L., Luong, Christine, Shrader, William D., Sendzik, Martin, Spencer, Jeffrey R., Sprengeler, Paul A., Kolesnikov, Aleks, Tai, Vincent W.-F., Hui, Hon C., Guy Breitenbucher, J., Allen, Darin, Janc, James W.

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Highly Selective Irreversible ITK Inhibitor Cpi-818 Reduces Acute Graft-Versus Host Disease von Lindner, Sarah, Lee, Nicole, Armijo, Gabriel K, Burgos da Silva, Marina D, Herrera, Pamela S, Nguyen, Chi L, Dwomoh, Emmanuel A, Ghale, Romina, Smith, Melody, Perales, Miguel-Angel, Markey, Kate A, Buggy, Joseph J, Janc, James W, van den Brink, Marcel

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