Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165 von Wrobleski, Stephen T, Moslin, Ryan, Lin, Shuqun, Zhang, Yanlei, Spergel, Steven, Kempson, James, Tokarski, John S, Strnad, Joann, Zupa-Fernandez, Adriana, Cheng, Lihong, Shuster, David, Gillooly, Kathleen, Yang, Xiaoxia, Heimrich, Elizabeth, McIntyre, Kim W, Chaudhry, Charu, Khan, Javed, Ruzanov, Max, Tredup, Jeffrey, Mulligan, Dawn, Xie, Dianlin, Sun, Huadong, Huang, Christine, D’Arienzo, Celia, Aranibar, Nelly, Chiney, Manoj, Chimalakonda, Anjaneya, Pitts, William J, Lombardo, Louis, Carter, Percy H, Burke, James R, Weinstein, David S

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Synthesis of Cyclobutane-Fused Tetracyclic Scaffolds via Visible-Light Photocatalysis for Building Molecular Complexity von Oderinde, Martins S, Mao, Edna, Ramirez, Antonio, Pawluczyk, Joseph, Jorge, Christine, Cornelius, Lyndon A. M, Kempson, James, Vetrichelvan, Muthalagu, Pitchai, Manivel, Gupta, Anuradha, Gupta, Arun Kumar, Meanwell, Nicholas A, Mathur, Arvind, Dhar, T. G. Murali

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Photocatalytic Dearomative Intermolecular [2 + 2] Cycloaddition of Heterocycles for Building Molecular Complexity von Oderinde, Martins S, Ramirez, Antonio, Dhar, T G Murali, Cornelius, Lyndon A M, Jorge, Christine, Aulakh, Darpandeep, Sandhu, Bhupinder, Pawluczyk, Joseph, Sarjeant, Amy A, Meanwell, Nicholas A, Mathur, Arvind, Kempson, James

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Total synthesis of (-)-ulapualide A, a novel tris-oxazole macrolide from marine nudibranchs, based on some biosynthesis speculation von Pattenden, Gerald, Ashweek, Neil J, Baker-Glenn, Charles A G, Kempson, James, Walker, Gary M, Yee, James G K

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Route evaluation and development of a practical synthesis of methyl (S)-2-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-7-carboxylate von Pawluczyk, Joseph M., Kempson, James, Mathur, Arvind, Oderinde, Martins S.

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Large-scale purification of a deprotected macrocyclic peptide by supercritical fluid chromatography (SFC) integrated with liquid chromatography in discovery chemistry von Li, Peng, Wu, Dauh-Rurng, Yip, Shiuhang Henry, Sun, Dawn, Pawluczyk, Joseph, Smith, Aaron, Kempson, James, Mathur, Arvind

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Metallaphotoredox Decarboxylative Arylation of Natural Amino Acids via an Elusive Mechanistic Pathway von Pitchai, Manivel, Ramirez, Antonio, Mayder, Don M., Ulaganathan, Sankar, Kumar, Hemantha, Aulakh, Darpandeep, Gupta, Anuradha, Mathur, Arvind, Kempson, James, Meanwell, Nicholas, Hudson, Zachary M., Oderinde, Martins S.

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Advances in the synthesis of three-dimensional molecular architectures by dearomatizing photocycloadditions von Oderinde, Martins S., Jin, Soomin, Dhar, T.G. Murali, Meanwell, Nicholas A., Mathur, Arvind, Kempson, James

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Unveiling the Stereoselectivity Aspects of Metallaphotoredox Decarboxylative Arylation von Nallagonda, Rajender, Quan, Rachel, Grant, Lauren, Jorge, Christine, Yip, Shiuhang, Wu, Dauh-Rurng, Dhar, T. G. Murali, Kempson, James, Mathur, Arvind, Oderinde, Martins S.

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Regioselective synthesis of N1-substituted-4-nitropyrazole-5-carboxylates the cyclocondensation of ethyl 4-(dimethylamino)-3-nitro-2-oxobut-3-enoate with substituted hydrazines von Zhao, Rulin, Hong, Zhenqiu, Wang, Bei, Kempson, James, Cornelius, Lyndon, Li, Jianqing, Li, Yi-Xin, Mathur, Arvind

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The effect of water on the large-scale supercritical fluid chromatography purification of two factor XIa active pharmaceutical ingredients von Li, Peng, Wu, Dauh-Rurng, Yip, Henry, Sun, Dawn, Zhang, Huiping, Hou, Xiaoping, Kempson, James, Mathur, Arvind

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Sub/supercritical Fluid Chromatography Purification and Desalting of a Cyclic Dinucleotide STING Agonist von Li, Peng, Yip, Henry, Sun, Dawn, Kempson, James, Caceres-Cortes, Janet, Mathur, Arvind, Wu, Dauh-Rurng

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Process Development of a Macrocyclic Peptide Inhibitor of PD-L1 von Mukherjee, Subha, Rogers, Amanda, Creech, Gardner, Hang, Chao, Ramirez, Antonio, Dummeldinger, Michael, Brueggemeier, Shawn, Mapelli, Claudio, Zaretsky, Serge, Huang, Masano, Black, Regina, Peddicord, Michael B., Cuniere, Nicolas, Kempson, James, Pawluczyk, Joseph, Allen, Martin, Parsons, Rodney, Sfouggatakis, Chris

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Regioselective synthesis of N1-substituted-4-nitropyrazole-5-carboxylates via the cyclocondensation of ethyl 4-(dimethylamino)-3-nitro-2-oxobut-3-enoate with substituted hydrazines von Zhao, Rulin, Hong, Zhenqiu, Wang, Bei, Kempson, James, Cornelius, Lyndon, Li, Jianqing, Li, Yi-Xin, Mathur, Arvind

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Large-scale supercritical fluid chromatography purification of unstable STING agonist intermediates von Sun, Dawn, Wu, Dauh-Rurng, Li, Peng, Yip, Henry, Wang, Bei, Hou, Xiaoping, Zhao, Rulin, Zhang, Huiping, Kempson, James, Mathur, Arvind

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Challenges with the Synthesis of a Macrocyclic Thioether Peptide: From Milligram to Multigram Using Solid Phase Peptide Synthesis (SPPS) von Kempson, James, Zhao, Rulin, Pawluczyk, Joseph, Wang, Bei, Zhang, Huiping, Hou, Xiaoping, Allen, Martin P., Wu, Dauh-Rurng, Li, Peng, Yip, Shiuhang, Smith, Aaron, Traeger, Sarah C., Huang, Stella, Cutrone, Jingfang, Mukherjee, Subha, Sfouggatakis, Chris, Poss, Michael, Scola, Paul M., Meanwell, Nicholas A., Carter, Percy H., Mathur, Arvind

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Development of a Safe and Practical Synthesis of Enantiomerically Pure (S)- and (R)‑N‑Boc-3-(Trifluoromethyl)piperazines Enabled by Aza-Michael Addition of Optically Pure 4‑Phenyl-... von Darne, Chetan Padmakar, Li, Ning, Smith, Daniel, Zhang, Shasha, Neithnadka, Premsai Rai, Silamkoti, Arundutt, Arumugam, Arunachalam, Gupta, Anuradha, Hong, Zhenqiu, Krishnananthan, Subramaniam, Wang, Bei, Zhao, Rulin, Yip, Shiuhang, Wu, Dauh-Rurng, Kempson, James, Mortensen, Deborah S., Mathur, Arvind, Li, Jianqing

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Photo-Initiated Nickel Catalysis (PiNiC): Unmasking Dimethylnickel with Light von Oderinde, Martins S., Jin, Soomin, Das, Jayanta, Jorge, Christine, Yip, Shiuhang, Ramirez, Antonio, Wu, Dauh-Rurng, Li, Ying, Kempson, James, Meanwell, Nicholas A., Mathur, Arvind, Dhar, T. G. Murali

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Discovery of highly potent, selective, covalent inhibitors of JAK3 von Kempson, James, Ovalle, Damaso, Guo, Junqing, Wrobleski, Stephen T., Lin, Shuqun, Spergel, Steven H., Duan, James J.-W., Jiang, Bin, Lu, Zhonghui, Das, Jagabandhu, Yang, Bingwei V., Hynes, John, Wu, Hong, Tokarski, John, Sack, John S., Khan, Javed, Schieven, Gary, Blatt, Yuval, Chaudhry, Charu, Salter-Cid, Luisa M., Fura, Aberra, Barrish, Joel C., Carter, Percy H., Pitts, William J.

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Long-Acting Tumor-Activated Prodrug of a TGFβR Inhibitor von Zhang, Yong, Parrish, Karen E, Tortolani, David R, Poss, Michael A, Huang, Audris, Wan, Honghe, Purandare, Ashok V, Donnell, Andrew F, Kempson, James, Hou, Xiaoping, Pawluczyk, Joseph, Yip, Shiuhang, Luk, Emily, Raghavan, Nimmi, Swanson, Jesse, Smalley, James, Murtaza, Anwar, Yang, Zheng, Augustine-Rauch, Karen, Lombardo, Louis J, Borzilleri, Robert

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