The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging von Chini, Eduardo N., Chini, Claudia C.S., Espindola Netto, Jair Machado, de Oliveira, Guilherme C., van Schooten, Wim

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Apoptotic stress causes mtDNA release during senescence and drives the SASP von Victorelli, Stella, Salmonowicz, Hanna, Chapman, James, Martini, Helene, Vizioli, Maria Grazia, Riley, Joel S., Cloix, Catherine, Hall-Younger, Ella, Machado Espindola-Netto, Jair, Jurk, Diana, Lagnado, Anthony B., Sales Gomez, Lilian, Farr, Joshua N., Saul, Dominik, Reed, Rebecca, Kelly, George, Eppard, Madeline, Greaves, Laura C., Dou, Zhixun, Pirius, Nicholas, Szczepanowska, Karolina, Porritt, Rebecca A., Huang, Huijie, Huang, Timothy Y., Mann, Derek A., Masuda, Claudio Akio, Khosla, Sundeep, Dai, Haiming, Kaufmann, Scott H., Zacharioudakis, Emmanouil, Gavathiotis, Evripidis, LeBrasseur, Nathan K., Lei, Xue, Sainz, Alva G., Korolchuk, Viktor I., Adams, Peter D., Shadel, Gerald S., Tait, Stephen W. G., Passos, João F.

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Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer von Espindola-Netto, Jair Machado, Chini, Claudia C S, Tarragó, Mariana, Wang, Enfeng, Dutta, Shamit, Pal, Krishnendu, Mukhopadhyay, Debabrata, Sola-Penna, Mauro, Chini, Eduardo N

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Targeting CD38-dependent NAD+ metabolism to mitigate multiple organ fibrosis von Shi, Bo, Wang, Wenxia, Korman, Benjamin, Kai, Li, Wang, Qianqian, Wei, Jun, Bale, Swarna, Marangoni, Roberta Goncalves, Bhattacharyya, Swati, Miller, Stephen, Xu, Dan, Akbarpour, Mahzad, Cheresh, Paul, Proccissi, Daniele, Gursel, Demirkan, Espindola-Netto, Jair Machado, Chini, Claudia C.S., de Oliveira, Guilherme C., Gudjonsson, Johann E., Chini, Eduardo N., Varga, John

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Antidiabetic activity of Sedum dendroideum: Metabolic enzymes as putative targets for the bioactive flavonoid kaempferitrin von Silva, Daniel, Casanova, Livia Marques, Marcondes, Mariah Celestino, Espindola‐Netto, Jair Machado, Paixão, Larissa Pereira, Melo, Giany Oliveira, Zancan, Patricia, Sola‐Penna, Mauro, Costa, Sônia Soares

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Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging von Hayashi, Yujiro, Asuzu, David T., Bardsley, Michael R., Gajdos, Gabriella B., Kvasha, Sergiy M., Linden, David R., Nagy, Rea A., Saravanaperumal, Siva Arumugam, Syed, Sabriya A., Toyomasu, Yoshitaka, Yan, Huihuang, Chini, Eduardo N., Gibbons, Simon J., Kellogg, Todd A., Khazaie, Khashayarsha, Kuro-o, Makoto, Machado Espindola Netto, Jair, Singh, Mahendra Pal, Tidball, James G., Wehling-Henricks, Michelle, Farrugia, Gianrico, Ordog, Tamas

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The Use of NMR Metabolite Profiling and in vivo Hypoglycemic Assay for Comparison of Unfractionated Aqueous Leaf Extracts of Two Ocimum Species von Casanova, Livia Marques, Espíndola-Netto, Jair Machado, Tinoco, Luzineide Wanderley, Sola-Penna, Mauro, Costa, Sônia Soares

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Strategies for late phase preclinical and early clinical trials of senolytics von Wissler Gerdes, Erin O., Misra, Avanish, Netto, Jair Machado Espindola, Tchkonia, Tamar, Kirkland, James L.

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Senolytics reduce coronavirus-related mortality in old mice von Camell, Christina D, Yousefzadeh, Matthew J, Zhu, Yi, Prata, Larissa G P Langhi, Huggins, Matthew A, Pierson, Mark, Zhang, Lei, O'Kelly, Ryan D, Pirtskhalava, Tamar, Xun, Pengcheng, Ejima, Keisuke, Xue, Ailing, Tripathi, Utkarsh, Espindola-Netto, Jair Machado, Giorgadze, Nino, Atkinson, Elizabeth J, Inman, Christina L, Johnson, Kurt O, Cholensky, Stephanie H, Carlson, Timothy W, LeBrasseur, Nathan K, Khosla, Sundeep, O'Sullivan, M Gerard, Allison, David B, Jameson, Stephen C, Meves, Alexander, Li, Ming, Prakash, Y S, Chiarella, Sergio E, Hamilton, Sara E, Tchkonia, Tamara, Niedernhofer, Laura J, Kirkland, James L, Robbins, Paul D

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Clotrimazole is effective for the regression of endometriotic implants in a Wistar rat experimental model of endometriosis von Machado, Daniel Escorsim, Perini, Jamila Alessandra, de Mendonça, Erika Menezes, Branco, Jessica Ristow, Rodrigues-Baptista, Karina Cristina, Alessandra-Perini, Jessica, Espíndola-Netto, Jair Machado, dos Santos, Thiago Alves, Coelho, Wagner Santos, Nasciutti, Luiz Eurico, Sola-Penna, Mauro, Zancan, Patricia

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SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3 von Tripathi, Utkarsh, Nchioua, Rayhane, Prata, Larissa G P Langhi, Zhu, Yi, Gerdes, Erin O Wissler, Giorgadze, Nino, Pirtskhalava, Tamar, Parker, Erik, Xue, Ailing, Espindola-Netto, Jair Machado, Stenger, Steffen, Robbins, Paul D, Niedernhofer, Laura J, Dickinson, Stephanie L, Allison, David B, Kirchhoff, Frank, Sparrer, Konstantin Maria Johannes, Tchkonia, Tamar, Kirkland, James L

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CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels von Chini, Claudia C. S., Peclat, Thais R., Warner, Gina M., Kashyap, Sonu, Espindola-Netto, Jair Machado, de Oliveira, Guilherme C., Gomez, Lilian S., Hogan, Kelly A., Tarragó, Mariana G., Puranik, Amrutesh S., Agorrody, Guillermo, Thompson, Katie L., Dang, Kevin, Clarke, Starlynn, Childs, Bennett G., Kanamori, Karina S., Witte, Micaela A., Vidal, Paola, Kirkland, Anna L., De Cecco, Marco, Chellappa, Karthikeyani, McReynolds, Melanie R., Jankowski, Connor, Tchkonia, Tamara, Kirkland, James L., Sedivy, John M., van Deursen, Jan M., Baker, Darren J., van Schooten, Wim, Rabinowitz, Joshua D., Baur, Joseph A., Chini, Eduardo N.

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The Pharmacology of CD38/NADase: An emerging target for cancer and aging diseases von Chini, Eduardo N., Chini, Claudia C.S., Netto, Jair Machado Espindola, de Oliveira, Guilherme C., van Schooten, Wim

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Author Correction: Apoptotic stress causes mtDNA release during senescence and drives the SASP von Victorelli, Stella, Salmonowicz, Hanna, Chapman, James, Martini, Helene, Vizioli, Maria Grazia, Riley, Joel S., Cloix, Catherine, Hall-Younger, Ella, Machado Espindola-Netto, Jair, Jurk, Diana, Lagnado, Anthony B., Sales Gomez, Lilian, Farr, Joshua N., Saul, Dominik, Reed, Rebecca, Kelly, George, Eppard, Madeline, Greaves, Laura C., Dou, Zhixun, Pirius, Nicholas, Szczepanowska, Karolina, Porritt, Rebecca A., Huang, Huijie, Huang, Timothy Y., Mann, Derek A., Masuda, Claudio Akio, Khosla, Sundeep, Dai, Haiming, Kaufmann, Scott H., Zacharioudakis, Emmanouil, Gavathiotis, Evripidis, LeBrasseur, Nathan K., Lei, Xue, Sainz, Alva G., Korolchuk, Viktor I., Adams, Peter D., Shadel, Gerald S., Tait, Stephen W. G., Passos, João F.

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Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans von Zhu, Yi, Prata, Larissa G.P. Langhi, Gerdes, Erin O. Wissler, Netto, Jair Machado Espindola, Pirtskhalava, Tamar, Giorgadze, Nino, Tripathi, Utkarsh, Inman, Christina L., Johnson, Kurt O., Xue, Ailing, Palmer, Allyson K., Chen, Tingjun, Schaefer, Kalli, Justice, Jamie N., Nambiar, Anoop M., Musi, Nicolas, Kritchevsky, Stephen B., Chen, Jun, Khosla, Sundeep, Jurk, Diana, Schafer, Marissa J., Tchkonia, Tamar, Kirkland, James L.

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Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During AgingSummary von Yujiro Hayashi, David T. Asuzu, Michael R. Bardsley, Gabriella B. Gajdos, Sergiy M. Kvasha, David R. Linden, Rea A. Nagy, Siva Arumugam Saravanaperumal, Sabriya A. Syed, Yoshitaka Toyomasu, Huihuang Yan, Eduardo N. Chini, Simon J. Gibbons, Todd A. Kellogg, Khashayarsha Khazaie, Makoto Kuro-o, Jair Machado Espindola Netto, Mahendra Pal Singh, James G. Tidball, Michelle Wehling-Henricks, Gianrico Farrugia, Tamas Ordog

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CD38 ecto-enzyme in immune cells is induced during aging regulating NAD+ and NMN levels von Chini, Claudia C.S., Peclat, Thais R., Warner, Gina M., Kashyap, Sonu, Espindola-Netto, Jair Machado, de Oliveira, Guilherme C., Gomez, Lilian S., Hogan, Kelly A., Tarragó, Mariana G., Puranik, Amrutesh S., Agorrody, Guillermo, Thompson, Katie L., Dang, Kevin, Clarke, Starlynn, Childs, Bennett G., Kanamori, Karina S., Witte, Micaela A., Vidal, Paola, Kirkland, Anna L., De Cecco, Marco, Chellappa, Karthikeyani, McReynolds, Melanie R., Jankowski, Connor, Tchkonia, Tamara, Kirkland, James L., Sedivy, John M., van Deursen, Jan M., Baker, Darren J., van Schooten, Wim, Rabinowitz, Joshua D., Baur, Joseph A., Chini, Eduardo N.

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METHODS AND MATERIALS FOR USING AND ASSESSING ANTI-SENESCENCE TREATMENTS WITHIN MAMMALS von ESPINDOLA NETTO, Jair Machado, ZHU, Yi, KIRKLAND, James L, TCHKONIA, Tamar

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