Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation von Carson, Cheryl, Raman, Pichai, Tullai, Jennifer, Xu, Lei, Henault, Martin, Thomas, Emily, Yeola, Sarita, Lao, Jianmin, McPate, Mark, Verkuyl, J Martin, Marsh, George, Sarber, Jason, Amaral, Adam, Bailey, Scott, Lubicka, Danuta, Pham, Helen, Miranda, Nicolette, Ding, Jian, Tang, Hai-Ming, Ju, Haisong, Tranter, Pamela, Ji, Nan, Krastel, Philipp, Jain, Rishi K, Schumacher, Andrew M, Loureiro, Joseph J, George, Elizabeth, Berellini, Giuliano, Ross, Nathan T, Bushell, Simon M, Erdemli, Gül, Solomon, Jonathan M

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Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex von Carelli, Jordan D, Sethofer, Steven G, Smith, Geoffrey A, Miller, Howard R, Simard, Jillian L, Merrick, William C, Jain, Rishi K, Ross, Nathan T, Taunton, Jack

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Examining the influence of specificity ligands and ATP-competitive ligands on the overall effectiveness of bivalent kinase inhibitors von Wong, Margaret L, Murphy, Jason, Harrington, Edmund, Gower, Carrie M, Jain, Rishi K, Schirle, Markus, Thomas, Jason R

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Mechanism of Resistance to the WDR5 Inhibitor in MLL-Rearranged Leukemia von Liu, Lulu, Shen, Lingling, Ding, Zhilou, He, Miao, Li, En, Tallarico, John A., Jain, Rishi K., Wang, He

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Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)–MYC Interaction von Ding, Jian, Liu, Lulu, Chiang, Ying-Ling, Zhao, Mengxi, Liu, Hejun, Yang, Fei, Shen, Lingling, Lin, Ying, Deng, Huiwen, Gao, Jingyan, Sage, David R., West, Laura, Llamas, Luis A., Hao, Xin, Kawatkar, Sameer, Li, En, Jain, Rishi K., Tallarico, John A., Canham, Stephen M., Wang, He

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Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy von Bonazzi, Simone, d’Hennezel, Eva, Beckwith, Rohan E.J., Xu, Lei, Fazal, Aleem, Magracheva, Anna, Ramesh, Radha, Cernijenko, Artiom, Antonakos, Brandon, Bhang, Hyo-eun C., Caro, Roxana García, Cobb, Jennifer S., Ornelas, Elizabeth, Ma, Xiaolei, Wartchow, Charles A., Clifton, Matthew C., Forseth, Ry R., Fortnam, Bethany Hughes, Lu, Hongbo, Csibi, Alfredo, Tullai, Jennifer, Carbonneau, Seth, Thomsen, Noel M., Larrow, Jay, Chie-Leon, Barbara, Hainzl, Dominik, Gu, Yi, Lu, Darlene, Meyer, Matthew J., Alexander, Dylan, Kinyamu-Akunda, Jacqueline, Sabatos-Peyton, Catherine A., Dales, Natalie A., Zécri, Frédéric J., Jain, Rishi K., Shulok, Janine, Wang, Y. Karen, Briner, Karin, Porter, Jeffery A., Tallarico, John A., Engelman, Jeffrey A., Dranoff, Glenn, Bradner, James E., Visser, Michael, Solomon, Jonathan M.

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Systematic Chemogenetic Library Assembly von Canham, Stephen M., Wang, Yuan, Cornett, Allen, Auld, Douglas S., Baeschlin, Daniel K., Patoor, Maude, Skaanderup, Philip R., Honda, Ayako, Llamas, Luis, Wendel, Greg, Mapa, Felipa A., Aspesi, Peter, Labbé-Giguère, Nancy, Gamber, Gabriel G., Palacios, Daniel S., Schuffenhauer, Ansgar, Deng, Zhan, Nigsch, Florian, Frederiksen, Mathias, Bushell, Simon M., Rothman, Deborah, Jain, Rishi K., Hemmerle, Horst, Briner, Karin, Porter, Jeffery A., Tallarico, John A., Jenkins, Jeremy L.

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Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction von Ding, Jian, Li, Guo, Liu, Hejun, Liu, Lulu, Lin, Ying, Gao, Jingyan, Zhou, Guoqiang, Shen, Lingling, Zhao, Mengxi, Yu, Yanyan, Guo, Weihui, Hommel, Ulrich, Ottl, Johannes, Blank, Jutta, Aubin, Nicola, Wei, Yi, He, Hu, Sage, David R., Atadja, Peter W., Li, En, Jain, Rishi K., Tallarico, John A., Canham, Stephen M., Chiang, Ying-Ling, Wang, He

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Activation of human STING by a molecular glue-like compound von Li, Jie, Canham, Stephen M., Wu, Hua, Henault, Martin, Chen, Lihao, Liu, Guoxun, Chen, Yu, Yu, Gary, Miller, Howard R., Hornak, Viktor, Brittain, Scott M., Michaud, Gregory A., Tutter, Antonin, Broom, Wendy, Digan, Mary Ellen, McWhirter, Sarah M., Sivick, Kelsey E., Pham, Helen T., Chen, Christine H., Tria, George S., McKenna, Jeffery M., Schirle, Markus, Mao, Xiaohong, Nicholson, Thomas B., Wang, Yuan, Jenkins, Jeremy L., Jain, Rishi K., Tallarico, John A., Patel, Sejal J., Zheng, Lianxing, Ross, Nathan T., Cho, Charles Y., Zhang, Xuewu, Bai, Xiao-Chen, Feng, Yan

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Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39 von Bassilana, Frederic, Carlson, Adam, DaSilva, Jennifer A, Grosshans, Bianka, Vidal, Solange, Beck, Valerie, Wilmeringwetter, Barbara, Llamas, Luis A, Showalter, Todd B, Rigollier, Pascal, Bourret, Aaron, Ramamurthy, Arun, Wu, Xu, Harbinski, Fred, Plonsky, Samantha, Lee, Lac, Ruffner, Heinz, Grandi, Paola, Schirle, Markus, Jenkins, Jeremy, Sailer, Andreas W, Bouwmeester, Tewis, Porter, Jeffrey A, Myer, Vic, Finan, Peter M, Tallarico, John A, Kelleher, Joseph F, Seuwen, Klaus, Jain, Rishi K, Luchansky, Sarah J

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Protein Surface Recognition by Synthetic Receptors Based on a Tetraphenylporphyrin Scaffold von Jain, Rishi K, Hamilton, Andrew D

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Discovery of a ZIP7 inhibitor from a Notch pathway screen von Nolin, Erin, Gans, Sara, Llamas, Luis, Bandyopadhyay, Somnath, Brittain, Scott M., Bernasconi-Elias, Paula, Carter, Kyle P., Loureiro, Joseph J., Thomas, Jason R., Schirle, Markus, Yang, Yi, Guo, Ning, Roma, Guglielmo, Schuierer, Sven, Beibel, Martin, Lindeman, Alicia, Sigoillot, Frederic, Chen, Amy, Xie, Kevin X., Ho, Samuel, Reece-Hoyes, John, Weihofen, Wilhelm A., Tyskiewicz, Kayla, Hoepfner, Dominic, McDonald, Richard I., Guthrie, Nicolette, Dogra, Abhishek, Guo, Haibing, Shao, Jian, Ding, Jian, Canham, Stephen M., Boynton, Geoff, George, Elizabeth L., Kang, Zhao B., Antczak, Christophe, Porter, Jeffery A., Wallace, Owen, Tallarico, John A., Palmer, Amy E., Jenkins, Jeremy L., Jain, Rishi K., Bushell, Simon M., Fryer, Christy J.

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Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury von Larraufie, Marie-Hélène, Gao, Xiaolin, Xia, Xiaobo, Devine, Patrick J., Kallen, Joerg, Liu, Dong, Michaud, Gregory, Harsch, Andreas, Savage, Nik, Ding, Jian, Tan, Kian, Mihalic, Manuel, Roggo, Silvio, Canham, Stephen M., Bushell, Simon M., Krastel, Philipp, Gao, Jinhai, Izaac, Aude, Altinoglu, Erhan, Lustenberger, Philipp, Salcius, Michael, Harbinski, Fred, Williams, Eric T., Zeng, Liling, Loureiro, Joseph, Cong, Feng, Fryer, Christy J., Klickstein, Lloyd, Tallarico, John A., Jain, Rishi K., Rothman, Deborah M., Wang, Shaowen

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A Photoaffinity Labeling-Based Chemoproteomics Strategy for Unbiased Target Deconvolution of Small Molecule Drug Candidates von Thomas, Jason R., Brittain, Scott M., Lipps, Jennifer, Llamas, Luis, Jain, Rishi K., Schirle, Markus

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Enhancing the Small-Scale Screenable Biological Space beyond Known Chemogenomics Libraries with Gray Chemical MatterCompounds with Novel Mechanisms from High-Throughput Screening... von Thomas, Jason R., Shelton, Claude, Murphy, Jason, Brittain, Scott, Bray, Mark-Anthony, Aspesi, Peter, Concannon, John, King, Frederick J., Ihry, Robert J., Ho, Daniel J., Henault, Martin, Hadjikyriacou, Andrea, Neri, Marilisa, Sigoillot, Frederic D., Pham, Helen T., Shum, Matthew, Barys, Louise, Jones, Michael D., Martin, Eric J., Blechschmidt, Anke, Rieffel, Sébastien, Troxler, Thomas J., Mapa, Felipa A., Jenkins, Jeremy L., Jain, Rishi K., Kutchukian, Peter S., Schirle, Markus, Renner, Steffen

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Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39 von Bassilana, Frederic, Carlson, Adam, DaSilva, Jennifer A, Grosshans, Bianka, Vidal, Solange, Beck, Valerie, Wilmeringwetter, Barbara, Llamas, Luis A, Showalter, Todd B, Rigollier, Pascal, Bourret, Aaron, Ramamurthy, Arun, Wu, Xu, Harbinski, Fred, Plonsky, Samantha, Lee, Lac, Ruffner, Heinz, Grandi, Paola, Schirle, Markus, Jenkins, Jeremy, Sailer, Andreas W, Bouwmeester, Tewis, Porter, Jeffrey A, Myer, Vic, Finan, Peter M, Tallarico, John A, Kelleher, Joseph F, Seuwen, Klaus, Jain, Rishi K, Luchansky, Sarah J

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Previously Uncharacterized Vacuolar-type ATPase Binding Site Discovered from Structurally Similar Compounds with Distinct Mechanisms of Action von Wang, Andrew C, Pham, Helen T, Lipps, Jennifer M, Brittain, Scott M, Harrington, Edmund, Wang, Yuan, King, Fred J, Russ, Carsten, Pan, Xuewen, Hoepfner, Dominic, Tallarico, John, Feng, Yan, Jain, Rishi K, Schirle, Markus, Thomas, Jason R

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1-Amino-4-benzylphthalazines as Orally Bioavailable Smoothened Antagonists with Antitumor Activity von Miller-Moslin, Karen, Peukert, Stefan, Jain, Rishi K, McEwan, Michael A, Karki, Rajesh, Llamas, Luis, Yusuff, Naeem, He, Feng, Li, Yanhong, Sun, Yingchuan, Dai, Miao, Perez, Lawrence, Michael, Walter, Sheng, Tao, Lei, Huangshu, Zhang, Rui, Williams, Juliet, Bourret, Aaron, Ramamurthy, Arun, Yuan, Jing, Guo, Ribo, Matsumoto, Melissa, Vattay, Anthony, Maniara, Wieslawa, Amaral, Adam, Dorsch, Marion, Kelleher, Joseph F

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Conversion of a Single Polypharmacological Agent into Selective Bivalent Inhibitors of Intracellular Kinase Activity von Gower, Carrie M., Thomas, Jason R., Harrington, Edmund, Murphy, Jason, Chang, Matthew E. K., Cornella-Taracido, Ivan, Jain, Rishi K., Schirle, Markus, Maly, Dustin J.

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Substrate Activity Screening:  A Fragment-Based Method for the Rapid Identification of Nonpeptidic Protease Inhibitors von Wood, Warren J. L, Patterson, Andrew W, Tsuruoka, Hiroyuki, Jain, Rishi K, Ellman, Jonathan A

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