A genetic variant in telomerase reverse transcriptase (TERT) modifies cancer risk in Lynch syndrome patients harbouring pathogenic MSH2 variants von Wiik, Mariann Unhjem, Evans, Tiffany-Jane, Belhadj, Sami, Bolton, Katherine A., Dymerska, Dagmara, Jagmohan-Changur, Shantie, Capellá, Gabriel, Kurzawski, Grzegorz, Wijnen, Juul T., Valle, Laura, Vasen, Hans F. A., Lubinski, Jan, Scott, Rodney J., Talseth-Palmer, Bente A.

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Heterozygous Mutations in PMS2 Cause Hereditary Nonpolyposis Colorectal Carcinoma (Lynch Syndrome) von Hendriks, Yvonne M.C., Jagmohan–Changur, Shantie, van der Klift, Heleen M., Morreau, Hans, van Puijenbroek, Marjo, Tops, Carli, van Os, Theo, Wagner, Anja, Ausems, Margreet G.F.M., Gomez, Encarna, Breuning, Martijn H., Bröcker–Vriends, Annette H.J.T., Vasen, Hans F.A., Wijnen, Juul Th

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Whole Gene Capture Analysis of 15 CRC Susceptibility Genes in Suspected Lynch Syndrome Patients von Jansen, Anne M L, Geilenkirchen, Marije A, van Wezel, Tom, Jagmohan-Changur, Shantie C, Ruano, Dina, van der Klift, Heleen M, van den Akker, Brendy E W M, Laros, Jeroen F J, van Galen, Michiel, Wagner, Anja, Letteboer, Tom G W, Gómez-García, Encarna B, Tops, Carli M J, Vasen, Hans F, Devilee, Peter, Hes, Frederik J, Morreau, Hans, Wijnen, Juul T

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Comprehensive genetic analysis of seven large families with mismatch repair proficient colorectal cancer von Middeldorp, Anneke, Jagmohan-Changur, Shantie C., van der Klift, Heleen M., van Puijenbroek, Marjo, Houwing-Duistermaat, Jeanine J., Webb, Emily, Houlston, Richard, Tops, Carli, Vasen, Hans F. A., Devilee, Peter, Morreau, Hans, van Wezel, Tom, Wijnen, Juul

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Enrichment of Low Penetrance Susceptibility Loci in a Dutch Familial Colorectal Cancer Cohort von MIDDELDORP, Anneke, JAGMOHAN-CHANGUR, Shantie, WIJNEN, Juul T, MORREAU, Hans, VAN WEDEL, Tom, VAN EIJK, Ronald, TOPS, Carli, DEVILEE, Peter, VASEN, Hans F. A, HES, Frederik J, HOULSTON, Richard, TOMLINSON, Ian, HOUWING-DUISTERMAAT, Jeanine J

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A new conditional Apc-mutant mouse model for colorectal cancer von Robanus-Maandag, Els C., Koelink, Pim J., Breukel, Cor, Salvatori, Daniela C.F., Jagmohan-Changur, Shantie C., Bosch, Cathy A.J., Verspaget, Hein W., Devilee, Peter, Fodde, Riccardo, Smits, Ron

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Combined analysis of three lynch syndrome cohorts confirms the modifying effects of 8q23.3 and 11q23.1 in MLH1 mutation carriers von Talseth‐Palmer, Bente A., Wijnen, Juul T., Brenne, Ingvild S., Jagmohan‐Changur, Shantie, Barker, Daniel, Ashton, Katie A., Tops, Carli M., Evans, Tiffany‐Jane, McPhillips, Mary, Groombridge, Claire, Suchy, Janina, Kurzawski, Grzegorz, Spigelman, Allan, Møller, Pål, Morreau, Hans M., Van Wezel, Tom, Lubinski, Jan, Vasen, Hans F.A., Scott, Rodney J.

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Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene von Hohenstein, Peter, Molenaar, Lia, Elsinga, Joyce, Morreau, Hans, van der Klift, Heleen, Struijk, Ada, Jagmohan-Changur, Shantie, Smits, Ron, van Kranen, Henk, van Ommen, Gert-Jan B., Cornelisse, Cees, Devilee, Peter, Fodde, Riccardo

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Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor) von POON, Raymond, SMITS, Ron, LI, Catherine, JAGMOHAN-CHANGUR, Shantie, KONG, Michael, CHEON, Sophia, CHUNYING YU, FODDE, Riccardo, ALMAN, Benjamin A

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Somatic Apc mutations are selected upon their capacity to inactivate the β-catenin downregulating activity von Smits, Ron, Hofland, Nandy, Edelmann, Winfried, Geugien, Marjan, Jagmohan-Changur, Shantie, Albuquerque, Cristina, Breukel, Cor, Kucherlapati, Raju, Kielman, Menno F., Fodde, Riccardo

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The CHEK2 1100delC Mutation Identifies Families with a Hereditary Breast and Colorectal Cancer Phenotype von Meijers-Heijboer, Hanne, Wasielewski, Marijke, Wagner, Anja, Hollestelle, Antoinette, Elstrodt, Fons, van den Bos, Renate, de Snoo, Anja, Tjon A Fat, Grace, Brekelmans, Cecile, Jagmohan, Shantie, Franken, Patrick, Verkuijlen, Paul, van den Ouweland, Ans, Chapman, Pamela, Tops, Carli, Möslein, Gabriela, Burn, John, Lynch, Henry, Klijn, Jan, Fodde, Riccardo, Wijnen, Juul, Vasen, Hans, Schutte, Mieke

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E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice von Smits, Ron, Ruiz, Patricia, Diaz-Cano, Salvador, Luz, Arne, Jagmohan-Changur, Shantie, Breukel, Cor, Birchmeier, Carmen, Birchmeier, Walter, Fodde, Riccardo

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Chromosome 8q23.3, 10p14 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome – a combined analysis of the Australian, Dutch and Polish Lynch syndrome cohorts von Talseth-Palmer, Bente A, Wijnen, Juul T, Brenne, Ingvild S, Jagmohan-Changur, Shantie, Ashton, Katie A, Tops, Carli M, Evans, Tiffany-Jane, McPhillips, Mary, Groombridge, Claire, Suchy, Janina, Kurzawski, Grzegorz, Spigelman, Allan, Møller, Pål, Morreau, Hans M, Van Wezel, Tom, Lubinski, Jan, Vasen, Hans FA, Scott, Rodney J

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A procedure for the detection of linkage with high density SNP arrays in a large pedigree with colorectal cancer von Middeldorp, Anneke, Jagmohan-Changur, Shantie, Helmer, Quinta, van der Klift, Heleen M, Tops, Carli M J, Vasen, Hans F A, Devilee, Peter, Morreau, Hans, Houwing-Duistermaat, Jeanine J, Wijnen, Juul T, van Wezel, Tom

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Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis von Tricarico, Rossella, Cortellino, Salvatore, Riccio, Antonio, Jagmohan-Changur, Shantie, Van der Klift, Heleen, Wijnen, Juul, Turner, David, Ventura, Andrea, Rovella, Valentina, Percesepe, Antonio, Lucci-Cordisco, Emanuela, Radice, Paolo, Bertario, Lucio, Pedroni, Monica, Ponz de Leon, Maurizio, Mancuso, Pietro, Devarajan, Karthik, Cai, Kathy Q, Klein-Szanto, Andres J P, Neri, Giovanni, Møller, Pål, Viel, Alessandra, Genuardi, Maurizio, Fodde, Riccardo, Bellacosa, Alfonso

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Whole Gene Capture Analysis of 15 CRC Susceptibility Genes in Suspected Lynch Syndrome Patients von Jansen, Anne M L, Geilenkirchen, Marije A, van Wezel, Tom, Jagmohan-Changur, Shantie C, Ruano, Dina, van der Klift, Heleen M, van den Akker, Brendy E W M, Laros, Jeroen F J, van Galen, Michiel, Wagner, Anja, Letteboer, Tom G W, Gómez-García, Encarna B, Tops, Carli M J, Vasen, Hans F, Devilee, Peter, Hes, Frederik J, Morreau, Hans, Wijnen, Juul T

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Genetic variant in the telomerase gene modifies cancer risk in Lynch syndrome von Bellido, Fernando, Guinó, Elisabet, Jagmohan-Changur, Shantie, Seguí, Nuria, Pineda, Marta, Navarro, Matilde, Lázaro, Conxi, Blanco, Ignacio, Vasen, Hans F A, Moreno, Victor, Capellá, Gabriel, Wijnen, Juul T, Valle, Laura

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Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development von Smits, R, Kielman, M F, Breukel, C, Zurcher, C, Neufeld, K, Jagmohan-Changur, S, Hofland, N, van Dijk, J, White, R, Edelmann, W, Kucherlapati, R, Khan, P M, Fodde, R

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Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis von Tricarico, Rossella, Cortellino, Salvatore, Riccio, Antonio, Jagmohan-Changur, Shantie, van der Klift, Heleen, Wijnen, Juul, Turner, David, Ventura, Andrea, Rovella, Valentina, Percesepe, Antonio, Lucci-Cordisco, Emanuela, Radice, Paolo, Bertario, Lucio, Pedroni, Monica, de Leon, Maurizio Ponz, Mancuso, Pietro, Devarajan, Karthik, Cai, Kathy Q, Klein-Szanto, Andres J.P, Neri, Giovanni, Møller, Pål, Viel, Alessandra, Genuardi, Maurizio, Fodde, Riccardo, Bellacosa, Alfonso

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The importance of a large sample cohort for studies on modifier genes influencing disease severity in FAP patients von Talseth-Palmer, Bente A, Wijnen, Juul T, Andreassen, Eva K, Barker, Daniel, Jagmohan-Changur, Shantie, Tops, Carli M, Meldrum, Cliff, Spigelman, Allan, Hes, Frederik J, Van Wezel, Tom, Vasen, Hans Fa, Scott, Rodney J

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