Immunotherapy for pancreatic cancer - science driving clinical progress von Jaffee, Elizabeth M, Laheru, Dan

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Leveraging the activity of tumor vaccines with cytotoxic chemotherapy von EMENS, Leisha A, JAFFEE, Elizabeth M

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Abstract P2-09-10: Epigenetic modulation—unlocking the potential of checkpoint inhibition in breast cancer von Roussos Torres, ET, Rafie, C, Armstrong, T, Jaffee, EM

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Major histocompatibility complex class II‐restricted presentation of a cytosolic antigen by autophagy von Nimmerjahn, Falk, Milosevic, Slavoljub, Behrends, Uta, Jaffee, Elizabeth M., Pardoll, Drew M., Bornkamm, Georg W., Mautner, Josef

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Abstract P1-08-01: Combination checkpoint inhibition and epigenetic modulation promotes tumor suppression and improves survival in Her2+ models of breast cancer von Roussos Torres, ET, Ma, H, Christmas, B, Armstrong, T, Jaffee, EM

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Recruitment of latent pools of high-avidity CD8(+) T cells to the antitumor immune response von Ercolini, Anne M, Ladle, Brian H, Manning, Elizabeth A, Pfannenstiel, Lukas W, Armstrong, Todd D, Machiels, Jean-Pascal H, Bieler, Joan G, Emens, Leisha A, Reilly, R Todd, Jaffee, Elizabeth M

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Defining the critical hurdles in cancer immunotherapy von Fox, Bernard A, Schendel, Dolores J, Butterfield, Lisa H, Aamdal, Steinar, Allison, James P, Ascierto, Paolo Antonio, Atkins, Michael B, Bartunkova, Jirina, Bergmann, Lothar, Berinstein, Neil, Bonorino, Cristina C, Borden, Ernest, Bramson, Jonathan L, Britten, Cedrik M, Cao, Xuetao, Carson, William E, Chang, Alfred E, Characiejus, Dainius, Choudhury, A Raja, Coukos, George, de Gruijl, Tanja, Dillman, Robert O, Dolstra, Harry, Dranoff, Glenn, Durrant, Lindy G, Finke, James H, Galon, Jerome, Gollob, Jared A, Gouttefangeas, Cécile, Grizzi, Fabio, Guida, Michele, Håkansson, Leif, Hege, Kristen, Herberman, Ronald B, Hodi, F Stephen, Hoos, Axel, Huber, Christoph, Hwu, Patrick, Imai, Kohzoh, Jaffee, Elizabeth M, Janetzki, Sylvia, June, Carl H, Kalinski, Pawel, Kaufman, Howard L, Kawakami, Koji, Kawakami, Yutaka, Keilholtz, Ulrich, Khleif, Samir N, Kiessling, Rolf, Kotlan, Beatrix, Kroemer, Guido, Lapointe, Rejean, Levitsky, Hyam I, Lotze, Michael T, Maccalli, Cristina, Maio, Michele, Marschner, Jens-Peter, Mastrangelo, Michael J, Masucci, Giuseppe, Melero, Ignacio, Melief, Cornelius, Murphy, William J, Nelson, Brad, Nicolini, Andrea, Nishimura, Michael I, Odunsi, Kunle, Ohashi, Pamela S, O'Donnell-Tormey, Jill, Old, Lloyd J, Ottensmeier, Christian, Papamichail, Michael, Parmiani, Giorgio, Pawelec, Graham, Proietti, Enrico, Qin, Shukui, Rees, Robert, Ribas, Antoni, Ridolfi, Ruggero, Ritter, Gerd, Rivoltini, Licia, Romero, Pedro J, Salem, Mohamed L, Scheper, Rik J, Seliger, Barbara, Sharma, Padmanee, Shiku, Hiroshi, Singh-Jasuja, Harpreet, Song, Wenru, Straten, Per Thor, Tahara, Hideaki, Tian, Zhigang, van Der Burg, Sjoerd H, von Hoegen, Paul, Wang, Ena, Welters, Marij Jp, Winter, Hauke, Withington, Tara, Wolchok, Jedd D, Xiao, Weihua, Zitvogel, Laurence

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Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients von Thomas, Amy Morck, Santarsiero, Lynn M, Lutz, Eric R, Armstrong, Todd D, Chen, Yi-Cheng, Huang, Lan-Qing, Laheru, Daniel A, Goggins, Michael, Hruban, Ralph H, Jaffee, Elizabeth M

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Abstract OT3-02-03: IMMUNe mOdulation in early stage estrogen receptor positive breast cancer treated with neoADjuvant Avelumab, Palbociclib, and Tamoxifen: The ImmunoADAPT study (... von Santa-Maria, CA, Wang, C, Cimino-Mathews, A, Roussos-Torres, E, Connolly, RM, Wolff, AC, Jaffee, EM, Stearns, V

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Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice von Alli, Patricia M, Pinn, Michael L, Jaffee, Elizabeth M, McFadden, Jill M, Kuhajda, Francis P

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Fusion to Listeriolysin O and Delivery by Listeria monocytogenes Enhances the Immunogenicity of HER-2/neu and Reveals Subdominant Epitopes in the FVB/N Mouse von Singh, Reshma, Dominiecki, Mary E, Jaffee, Elizabeth M, Paterson, Yvonne

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Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2/neu t... von MACHIELS, Jean-Pascal H, REILLY, R. Todd, EMENS, Leisha A, ERCOLINI, Anne M, LEI, Rachel Y, WEINTRAUB, Diane, OKOYE, Francesca I, JAFFEE, Elizabeth M

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Novel Allogeneic Granulocyte-Macrophage Colony-Stimulating Factor–Secreting Tumor Vaccine for Pancreatic Cancer: A Phase I Trial of Safety and Immune Activation von JAFFEE, Elizabeth M, HRUBAN, Ralph H, LILLEMOE, Keith D, O'REILLY, Seamus, ABRAMS, Ross A, PARDOLL, Drew M, CAMERON, John L, YEO, Charles J, BIEDRZYCKI, Barbara, LAHERU, Daniel, SCHEPERS, Karen, SAUTER, Patricia R, GOEMANN, Marti, COLEMAN, Joanne, GROCHOW, Louise, DONEHOWER, Ross C

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Abstract P2-04-11: Promotion of immunogenicity using epigenetic modulation and immune checkpoint inhibition in mouse models of breast cancer von Roussos Torres, ET, Ma, H, Armstrong, T, Connolly, R, Stearns, V, Jaffee, EM

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Focus on pancreas cancer von Jaffee, Elizabeth M, Hruban, Ralph H, Canto, Marcia, Kern, Scott E

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Allergies and the Risk of Pancreatic Cancer: A Meta-analysis with Review of Epidemiology and Biological Mechanisms von GANDINI, Sara, LOWENFELS, Albert B, JAFFEE, Elizabeth M, ARMSTRONG, Todd D, MAISONNEUVE, Patrick

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Apoptotic, but not necrotic, tumor cell vaccines induce a potent immune response in vivo von Scheffer, Stephan R., Nave, Heike, Korangy, Firouzeh, Schlote, Karola, Pabst, Reinhard, Jaffee, Elizabeth M., Manns, Michael P., Greten, Tim F.

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Discovery of new markers of cancer through serial analysis of gene expression : Prostate stem cell antigen is overexpressed in pancreatic adenocarcinoma von ARGANI, Pedram, ROSTY, Christophe, YEO, Charles J, CAMERON, John L, KERN, Scott E, HRUBAN, Ralph H, REITER, Robert E, WILENTZ, Robb E, MURUGESAN, Selva R, LEACH, Steven D, RYU, Byungwoo, SKINNER, Halcyon G, GOGGINS, Michael, JAFFEE, Elizabeth M

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Enhanced Antigen-Specific Antitumor Immunity with Altered Peptide Ligands that Stabilize the MHC-Peptide-TCR Complex von Slansky, Jill E, Rattis, Frédérique M, Boyd, Lisa F, Fahmy, Tarek, Jaffee, Elizabeth M, Schneck, Jonathan P, Margulies, David H, Pardoll, Drew M

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OX40 Costimulation Synergizes with GM-CSF Whole-Cell Vaccination to Overcome Established CD8+ T Cell Tolerance to an Endogenous Tumor Antigen von Murata, Satoshi, Ladle, Brian H, Kim, Peter S, Lutz, Eric R, Wolpoe, Matthew E, Ivie, Susan E, Smith, Holly M, Armstrong, Todd D, Emens, Leisha A, Jaffee, Elizabeth M, Reilly, R. Todd

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