Triclosan Derivatives: Towards Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis von Freundlich, Joel S., Wang, Feng, Vilchèze, Catherine, Gulten, Gulcin, Langley, Robert, Schiehser, Guy A., Jacobus, David P., Jacobs Jr, William R., Sacchettini, James C.

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3,4‐diaminopyridine base effectively treats the weakness of Lambert‐Eaton myasthenia von Sanders, Donald B., Juel, Vern C., Harati, Yadollah, Smith, A. Gordon, Peltier, Amanda C., Marburger, Tessa, Lou, Jau‐Shin, Pascuzzi, Robert M., Richman, David P., Xie, Tai, Demmel, Valentin, Jacobus, Laura R., Aleš, Kathy L., Jacobus, David P.

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X-ray Structural Analysis of Plasmodium falciparum Enoyl Acyl Carrier Protein Reductase as a Pathway toward the Optimization of Triclosan Antimalarial Efficacy von Freundlich, Joel S., Wang, Feng, Tsai, Han-Chun, Kuo, Mack, Shieh, Hong-Ming, Anderson, John W., Nkrumah, Louis J., Valderramos, Juan-Carlos, Yu, Min, Kumar, T.R. Santha, Valderramos, Stephanie G., Jacobs, William R., Schiehser, Guy A., Jacobus, David P., Fidock, David A., Sacchettini, James C.

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Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum von Birrell, Geoffrey W., Challis, Matthew P., De Paoli, Amanda, Anderson, Dovile, Devine, Shane M., Heffernan, Gavin D., Jacobus, David P., Edstein, Michael D., Siddiqui, Ghizal, Creek, Darren J.

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Relevance of Higher-Order Epistasis in Drug Resistance von Lozovsky, Elena R, Daniels, Rachel F, Heffernan, Gavin D, Jacobus, David P, Hartl, Daniel L

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Novel Triazine JPC-2067-B Inhibits Toxoplasma gondii In Vitro and In Vivo von Mui, Ernest J, Schiehser, Guy A, Milhous, Wilbur K, Hsu, Honghue, Roberts, Craig W, Kirisits, Michael, Muench, Stephen, Rice, David, Dubey, J.P, Fowble, Joseph W, Rathod, Pradipsinh K, Queener, Sherry F, Liu, Susan R, Jacobus, David P, McLeod, Rima

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Characterization of the Preclinical Pharmacology of the New 2-Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention von Birrell, Geoffrey W, Heffernan, Gavin D, Schiehser, Guy A, Anderson, John, Ager, Arba L, Morales, Pablo, MacKenzie, Donna, van Breda, Karin, Chavchich, Marina, Jacobus, Laura R, Shanks, G Dennis, Jacobus, David P, Edstein, Michael D

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Lead Selection of a New Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention von Chavchich, Marina, Birrell, Geoffrey W, Ager, Arba L, MacKenzie, Donna O, Heffernan, Gavin D, Schiehser, Guy A, Jacobus, Laura R, Shanks, G Dennis, Jacobus, David P, Edstein, Michael D

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In Vivo Efficacy and Pharmacokinetics of the 2-Aminomethylphenol Antimalarial JPC-3210 in the Aotus Monkey-Human Malaria Model von McCallum, Fiona J., Birrell, Geoffrey W., Chavchich, Marina, Harris, Ivor, Obaldia, Nicanor, Van Breda, Karin, Heffernan, Gavin D., Jacobus, David P., Shanks, Dennis, Edstein, Michael D.

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Novel Saccharomyces cerevisiae Screen Identifies WR99210 Analogues That Inhibit Mycobacterium tuberculosis Dihydrofolate Reductase von GERUM, A'Lissa B, ULMER, Jonathan E, JACOBUS, David P, JENSEN, Norman P, SHERMAN, David R, SIBLEY, Carol Hopkins

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In Vitro Metabolism of Phenoxypropoxybiguanide Analogues in Human Liver Microsomes to Potent Antimalarial Dihydrotriazines von Shearer, Todd. W, Kozar, Michael. P, O'Neil, Michael T, Smith, Philip L, Schiehser, Guy A, Jacobus, David. P, Diaz, Damaris S, Yang, Young-Sun, Milhous, Wilbur. K, Skillman, Donald. R

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The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites von Yu, Min, Kumar, T R Santha, Nkrumah, Louis J, Coppi, Alida, Retzlaff, Silke, Li, Celeste D, Kelly, Brendan J, Moura, Pedro A, Lakshmanan, Viswanathan, Freundlich, Joel S, Valderramos, Juan-Carlos, Vilcheze, Catherine, Siedner, Mark, Tsai, Jennifer H-C, Falkard, Brie, Sidhu, Amar Bir Singh, Purcell, Lisa A, Gratraud, Paul, Kremer, Laurent, Waters, Andrew P, Schiehser, Guy, Jacobus, David P, Janse, Chris J, Ager, Arba, Jacobs, Jr, William R, Sacchettini, James C, Heussler, Volker, Sinnis, Photini, Fidock, David A

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Validation of the triple timed up‐and‐go test in Lambert‐Eaton myasthenia von Raja, Shruti M., Sanders, Donald B., Juel, Vern C., Harati, Yadollah, Smith, A. Gordon, Pascuzzi, Robert, Richman, David P., Wu, Angie, Aleš, Kathy L., Jacobus, Laura R., Jacobus, David P., Guptill, Jeffrey T.

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JPC-2997, a new aminomethylphenol with high in vitro and in vivo antimalarial activities against blood stages of Plasmodium von Birrell, Geoffrey W, Chavchich, Marina, Ager, Arba L, Shieh, Hong-Ming, Heffernan, Gavin D, Zhao, Wenyi, Krasucki, Peter E, Saionz, Kurt W, Terpinski, Jacek, Schiehser, Guy A, Jacobus, Laura R, Shanks, G Dennis, Jacobus, David P, Edstein, Michael D

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Reliability of the triple‐timed up‐and‐go test von Sanders, Donald B., Guptill, Jeffrey T., Aleš, Kathy L., Hobson‐Webb, Lisa D., Jacobus, David P., Mahmood, Riaz, Massey, Janice M., Pittman, Melissa M., Prather, Kristi, Raja, Shruti M., Yow, Eric, Juel, Vern C.

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Evaluation of the 2-Aminomethylphenol JPC-2997 in Aotus Monkeys Infected with Plasmodium falciparum von McCallum, Fiona, Harris, Ivor, van Breda, Karin, De, Sai Lata, Stanisic, Danielle I, Good, Michael F, Jacobus, David P, Edstein, Michael D

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Discrimination of Potent Inhibitors of Toxoplasma gondii Enoyl-Acyl Carrier Protein Reductase by a Thermal Shift Assay von Afanador, Gustavo A, Muench, Stephen P, McPhillie, Martin, Fomovska, Alina, Schön, Arne, Zhou, Ying, Cheng, Gang, Stec, Jozef, Freundlich, Joel S, Shieh, Hong-Ming, Anderson, John W, Jacobus, David P, Fidock, David A, Kozikowski, Alan P, Fishwick, Colin W, Rice, David W, Freire, Ernesto, McLeod, Rima, Prigge, Sean T

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Novel diaryl ureas with efficacy in a mouse model of malaria von Anderson, John W., Sarantakis, Dimitri, Terpinski, Jacek, Santha Kumar, T.R., Tsai, Han-Chun, Kuo, Mack, Ager, Arba L., Jacobs, William R., Schiehser, Guy A., Ekins, Sean, Sacchettini, James C., Jacobus, David P., Fidock, David A., Freundlich, Joel S.

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Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4′-Substituted triclosan... von Freundlich, Joel S., Anderson, John W., Sarantakis, Dimitri, Shieh, Hong-Ming, Yu, Min, Valderramos, Juan-Carlos, Lucumi, Edinson, Kuo, Mack, Jacobs, William R., Fidock, David A., Schiehser, Guy A., Jacobus, David P., Sacchettini, James C.

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Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2′-Substituted triclosan derivatives von Freundlich, Joel S., Yu, Min, Lucumi, Edinson, Kuo, Mack, Tsai, Han-Chun, Valderramos, Juan-Carlos, Karagyozov, Luchezar, Jacobs, William R., Schiehser, Guy A., Fidock, David A., Jacobus, David P., Sacchettini, James C.

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