Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers von Mars, Nina, Koskela, Jukka T., Ripatti, Pietari, Kiiskinen, Tuomo T. J., Havulinna, Aki S., Lindbohm, Joni V., Ahola-Olli, Ari, Kurki, Mitja, Karjalainen, Juha, Palta, Priit, Neale, Benjamin M., Daly, Mark, Salomaa, Veikko, Palotie, Aarno, Widén, Elisabeth, Ripatti, Samuli

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Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells von Bao, Erik L., Nandakumar, Satish K., Liao, Xiaotian, Bick, Alexander G., Karjalainen, Juha, Tabaka, Marcin, Gan, Olga I., Havulinna, Aki S., Kiiskinen, Tuomo T. J., Lareau, Caleb A., de Lapuente Portilla, Aitzkoa L., Li, Bo, Emdin, Connor, Codd, Veryan, Nelson, Christopher P., Walker, Christopher J., Churchhouse, Claire, de la Chapelle, Albert, Klein, Daryl E., Nilsson, Björn, Wilson, Peter W. F., Cho, Kelly, Pyarajan, Saiju, Gaziano, J. Michael, Samani, Nilesh J., Regev, Aviv, Palotie, Aarno, Neale, Benjamin M., Dick, John E., Natarajan, Pradeep, O’Donnell, Christopher J., Daly, Mark J., Milyavsky, Michael, Kathiresan, Sekar, Sankaran, Vijay G.

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The role of polygenic risk and susceptibility genes in breast cancer over the course of life von Mars, Nina, Widén, Elisabeth, Kerminen, Sini, Meretoja, Tuomo, Pirinen, Matti, della Briotta Parolo, Pietro, Palta, Priit, Palotie, Aarno, Kaprio, Jaakko, Joensuu, Heikki, Daly, Mark, Ripatti, Samuli

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Genetic architecture of human plasma lipidome and its link to cardiovascular disease von Tabassum, Rubina, Rämö, Joel T., Ripatti, Pietari, Koskela, Jukka T., Kurki, Mitja, Karjalainen, Juha, Palta, Priit, Hassan, Shabbeer, Nunez-Fontarnau, Javier, Kiiskinen, Tuomo T. J., Söderlund, Sanni, Matikainen, Niina, Gerl, Mathias J., Surma, Michal A., Klose, Christian, Stitziel, Nathan O., Laivuori, Hannele, Havulinna, Aki S., Service, Susan K., Salomaa, Veikko, Pirinen, Matti, Jauhiainen, Matti, Daly, Mark J., Freimer, Nelson B., Palotie, Aarno, Taskinen, Marja-Riitta, Simons, Kai, Ripatti, Samuli

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Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing von Fang, Li Tai, Zhu, Bin, Zhao, Yongmei, Chen, Wanqiu, Yang, Zhaowei, Kerrigan, Liz, Langenbach, Kurt, de Mars, Maryellen, Lu, Charles, Idler, Kenneth, Jacob, Howard, Zheng, Yuanting, Ren, Luyao, Yu, Ying, Jaeger, Erich, Schroth, Gary P., Abaan, Ogan D., Talsania, Keyur, Lack, Justin, Shen, Tsai-Wei, Chen, Zhong, Stanbouly, Seta, Tran, Bao, Shetty, Jyoti, Kriga, Yuliya, Meerzaman, Daoud, Nguyen, Cu, Petitjean, Virginie, Sultan, Marc, Cam, Margaret, Mehta, Monika, Hung, Tiffany, Peters, Eric, Kalamegham, Rasika, Sahraeian, Sayed Mohammad Ebrahim, Mohiyuddin, Marghoob, Guo, Yunfei, Yao, Lijing, Song, Lei, Lam, Hugo Y. K., Drabek, Jiri, Vojta, Petr, Maestro, Roberta, Gasparotto, Daniela, Kõks, Sulev, Reimann, Ene, Scherer, Andreas, Nordlund, Jessica, Liljedahl, Ulrika, Jensen, Roderick V., Pirooznia, Mehdi, Li, Zhipan, Xiao, Chunlin, Sherry, Stephen T., Kusko, Rebecca, Moos, Malcolm, Donaldson, Eric, Tezak, Zivana, Ning, Baitang, Tong, Weida, Li, Jing, Duerken-Hughes, Penelope, Catalanotti, Claudia, Maheshwari, Shamoni, Shuga, Joe, Liang, Winnie S., Keats, Jonathan, Adkins, Jonathan, Tassone, Erica, Zismann, Victoria, McDaniel, Timothy, Trent, Jeffrey, Foox, Jonathan, Butler, Daniel, Mason, Christopher E., Hong, Huixiao, Shi, Leming, Wang, Charles, Xiao, Wenming

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Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy von Ollila, Hanna M., Sharon, Eilon, Lin, Ling, Sinnott-Armstrong, Nasa, Ambati, Aditya, Yogeshwar, Selina M., Hillary, Ryan P., Jolanki, Otto, Faraco, Juliette, Einen, Mali, Luo, Guo, Zhang, Jing, Han, Fang, Yan, Han, Dong, Xiao Song, Li, Jing, Zhang, Jun, Hong, Seung-Chul, Kim, Tae Won, Dauvilliers, Yves, Barateau, Lucie, Lammers, Gert Jan, Fronczek, Rolf, Mayer, Geert, Santamaria, Joan, Arnulf, Isabelle, Knudsen-Heier, Stine, Bredahl, May Kristin Lyamouri, Thorsby, Per Medbøe, Plazzi, Giuseppe, Pizza, Fabio, Moresco, Monica, Crowe, Catherine, Van den Eeden, Stephen K., Lecendreux, Michel, Bourgin, Patrice, Kanbayashi, Takashi, Martínez-Orozco, Francisco J., Peraita-Adrados, Rosa, Benetó, Antonio, Montplaisir, Jacques, Desautels, Alex, Huang, Yu-Shu, Jennum, Poul, Nevsimalova, Sona, Kemlink, David, Iranzo, Alex, Overeem, Sebastiaan, Wierzbicka, Aleksandra, Geisler, Peter, Sonka, Karel, Honda, Makoto, Högl, Birgit, Stefani, Ambra, Coelho, Fernando Morgadinho, Mantovani, Vilma, Feketeova, Eva, Wadelius, Mia, Eriksson, Niclas, Smedje, Hans, Hallberg, Pär, Hesla, Per Egil, Rye, David, Pelin, Zerrin, Ferini-Strambi, Luigi, Bassetti, Claudio L., Mathis, Johannes, Khatami, Ramin, Aran, Adi, Nampoothiri, Sheela, Olsson, Tomas, Kockum, Ingrid, Partinen, Markku, Perola, Markus, Kornum, Birgitte R., Rueger, Sina, Winkelmann, Juliane, Miyagawa, Taku, Toyoda, Hiromi, Khor, Seik-Soon, Shimada, Mihoko, Tokunaga, Katsushi, Rivas, Manuel, Pritchard, Jonathan K., Risch, Neil, Kutalik, Zoltan, O’Hara, Ruth, Hallmayer, Joachim, Ye, Chun Jimmie, Mignot, Emmanuel J.

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IRF2BPL Is Associated with Neurological Phenotypes von Marcogliese, Paul C., Rosenfeld, Jill A., Koenig, Mary Kay, Chen, Agnes H., Dickson, Patricia I., Vera, Moin U., Salamon, Noriko, Infante, Elena, Poppe, Bruce, Chung, Hyung-Lok, Zuo, Zhongyuan, Kanca, Oguz, Xia, Fan, Smith, Edward C., Jasien, Joan, Kansagra, Sujay, Lark, Robert, Riley, Kacie, Golden-Grant, Katie, Poppe, Bruce, Terryn, Wim, Adams, David R., Allard, Patrick, Bacino, Carlos A., Bick, David P., Bostwick, Bret L., Brush, Matthew, Burrage, Lindsay C., Clark, Gary D., Cooper, Cynthia M., D’Souza, Precilla, Davids, Mariska, Dell’Angelica, Esteban C., Dhar, Shweta U., Dillon, Ani, Dorrani, Naghmeh, Dorset, Daniel C., Esteves, Cecilia, Fogel, Brent L., Gahl, William A., Gourdine, Jean-Philippe F., Haendel, Melissa, Hamid, Rizwan, Hanchard, Neil A., Howerton, Ellen M., Jiang, Yong-hui, Johnston, Jean M., Krier, Joel B., Lalani, Seema R., Lau, C. Christopher, Lee, Brendan H., Levy, Shawn E., Lewis, Richard A., Lipson, Allen, Loo, Sandra K., Macnamara, Ellen F., MacRae, Calum A., Manolio, Teri A., Martínez-Agosto, Julian A., McConkie-Rosell, Allyn, McCormack, Colleen E., Morimoto, Marie, Mulvihill, John J., Muzny, Donna M., Nelson, Stan F., Newberry, J. Scott, Nicholas, Sarah K., Pallais, J. Carl, Palmer, Christina G.S., Papp, Jeanette C., Parker, Neil H., Phillips, John A., Posey, Jennifer E., Postlethwait, John H., Potocki, Lorraine, Robertson, Amy K., Sampson, Jacinda B., Schoch, Kelly, Shashi, Vandana, Smith, Kevin S., Splinter, Kimberly, Stoler, Joan M., Sweetser, David A., Toro, Camilo, Urv, Tiina K., Vilain, Eric, Vogel, Tiphanie P., Wahl, Colleen E., Walley, Nicole M., Walsh, Chris A., Waters, Katrina M., Westerfield, Monte, Yu, Guoyun, Zheng, Allison, Yamamoto, Shinya, Wangler, Michael F., Lee, Brendan, Nelson, Stanley F., Goldstein, David B., Bellen, Hugo J.

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A comprehensive iterative approach is highly effective in diagnosing individuals who are exome negative von Schoch, Kelly, Spillmann, Rebecca, Tan, Queenie K.-G., McConkie-Rosell, Allyn, Jiang, Yong-Hui, Goldstein, David B., Adams, David R., Allard, Patrick, Ashley, Euan A., Bacino, Carlos A., Beggs, Alan H., Birch, Camille L., Bonner, Devon, Boone, Braden E., Brown, Donna M., Chen, Shan, Coakley, Terra R., Cogan, Joy D., Cooper, Cynthia M., Cope, Heidi, Craigen, William J., Davidson, Jean M., Dayal, Jyoti G., Dell’Angelica, Esteban C., Dipple, Katrina M., Donnell-Fink, Laurel A., Dorrani, Naghmeh, Draper, David D., Dries, Annika M., Eckstein, David J., Emrick, Lisa T., Enns, Gregory M., Esteves, Cecilia, Estwick, Tyra, Fernandez, Liliana, Ferreira, Carlos, Fisher, Paul G., Fogel, Brent L., Friedman, Noah D., Gahl, William A., Goldstein, David B., Gourdine, Jean-Philippe F., Haendel, Melissa, Handley, Lori H., Krasnewich, Donna M., Krier, Joel B., Lazar, Jozef, Levy, Shawn E., Lincoln, Sharyn A., Loo, Sandra K., Loscalzo, Joseph, Maas, Richard L., MacRae, Calum A., Majcherska, Marta M., Mamounas, Laura A., Manolio, Teri A., Markello, Thomas C., Marom, Ronit, Martin, Martin G., McConkie-Rosell, Allyn, McCormack, Colleen E., Might, Matthew, Morimoto, Marie, Mulvihill, John J., Murphy, Jennifer L., Muzny, Donna M., Nehrebecky, Michele E., Nelson, Stan F., Newberry, J. Scott, Newman, John H., Nicholas, Sarah K., Pallais, J. Carl, Palmer, Christina GS, Parker, Neil H., Phillips, John A., Postlethwait, John H., Reuter, Chloe M., Sampson, Jacinda B., Scott, Daryl A., Sharma, Prashant, Shashi, Vandana, Silverman, Edwin K., Tifft, Cynthia J., Toro, Camilo, Tran, Alyssa A., Urv, Tiina K., Vogel, Tiphanie P., Wahl, Colleen E., Walsh, Chris A., Wan, Jijun, Wangler, Michael F., Ward, Patricia A., Wheeler, Matthew T., Wolfe, Lynne A., Worthey, Elizabeth A., Yamamoto, Shinya, Yang, Yaping, Yu, Guoyun, Zhao, Chunli, Zheng, Allison

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Risk of Midlife Stroke After Adverse Pregnancy Outcomes: The FinnGen Study von Miller, Eliza C., Kauko, Anni, Tom, Sarah E., Laivuori, Hannele, Niiranen, Teemu, Bello, Natalie A.

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Sleep apnoea is a risk factor for severe COVID-19 von Kiiskinen, Tuomo, Ruotsalainen, Sanni, McCarthy, Mark, Hunkapiller, Julie, Perola, Markus, Pitkäranta, Anne, Vainio, Seppo, Savinainen, Kimmo, Kujala, Urho, Pakkanen, Raimo, Liu, Jimmy, Diogo, Dorothee, Hu, Xinli, Gossel, Matthias, Schleutker, Johanna, Hinttala, Reetta, Kettunen, Johannes, Paloneva, Juha, Soininen, Hilkka, Remes, Anne, Ziemann, Adam, Waring, Jeffrey, Lehtonen, Anne, Eaton, Susan, Kerchner, Geoff, Bowers, Natalie, Teng, Edmond, Merck, John, Xu, Fanli, Pulford, David, Färkkilä, Martti, Pikkarainen, Sampsa, Blomster, Timo, Georgantas, Bob, Usiskin, Keith, Oh, Danny, Kalpala, Kirsi, Miller, Melissa, McCarthy, Linda, Eklund, Kari, Isomäki, Pia, Huhtakangas, Johanna, Bing, Nan, Laitinen, Tarja, Pelkonen, Margit, Chen, Hubert, Betts, Jo, Juonala, Markus, Metsärinne, Kaj, Junttila, Juhani, Laakso, Markku, Sinisalo, Juha, Taskinen, Marja-Riitta, Laukkanen, Jari, Ben Challis, Andrew Peterson, Chu, Audrey, Popovic, Relja, Schutzman, Jennifer, Lehtonen, Heli, Kulkarni, Diptee, Seitsonen, Sanna, Aaltonen, Vesa, Uusitalo-Järvinen, Hannele, Luodonpää, Marja, Strauss, Erich, Hoffman, Joshua, Huilaja, Laura, Hannula-Jouppi, Katariina, Koulu, Leena, Choy, David, Lyhs, Ulrike, Kaunisto, Mari, Quarless, Danjuma, Chang, Diana, Bhangale, Tushar, Hedman, Åsa, Auro, Kirsi, Xu, Ethan, Chatelain, Clement, Kurki, Mitja, Palta, Priit, Lemmelä, Susanna, Rivas, Manuel, Ganna, Andrea, Llorens, Vincent, Kristiansson, Kati, Wahlfors, Tiina, Pylkäs, Katri, Mantere, Tuomo, Laakkonen, Eija, Kononen, Juha, Sistonen, Tuuli, Laukkanen, Markku, Järvensivu, Elina, Awaisa, Ghazal, Sipilä, Tuomas, Siirtola, Harri, Tabuenca, Javier, Soini, Sirpa, Pitkänen, Kimmo

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Genetic susceptibility to acute viral bronchiolitis von Pasanen, Anu, Karjalainen, Minna K, Korppi, Matti, Hallman, Mikko, Rämet, Mika

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Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations von Salo, Ville, Määttä, Juhani, Sliz, Eeva, Reimann, Ene, Mägi, Reedik, Reis, Kadri, Elhanas, Abdelrahman G., Reigo, Anu, Palta, Priit, Esko, Tõnu, Karppinen, Jaro, Kettunen, Johannes

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De Novo Truncating Variants in ASXL2 Are Associated with a Unique and Recognizable Clinical Phenotype von Pena, Loren D.M., Hempel, Maja, McLaughlin, Heather M., Cho, Megan, Stong, Nicholas, Shuss, Christine M., Burrage, Lindsay C., Dhar, Shweta U., Emrick, Lisa T., Graham, Brett H., Lalani, Seema R., Lewis, Richard A., Posey, Jennifer E., Hanchard, Neil A., Mercedes, Alejandro E., Wangler, Michael F., Muzny, Donna M., Ward, Patricia A., Ramoni, Rachel B., McCray, Alexa T., Mazur, Paul, Splinter, Kimberly, Esteves, Cecilia, Jiang, Yong-hui, Pena, Loren D.M., McConkie-Rosell, Allyn, Schoch, Kelly, Spillmann, Rebecca C., Goldstein, David B., Loscalzo, Joseph, Rodan, Lance H., Walsh, Chris A., Cooper, Cynthia M., Donnell-Fink, Laurel A., Krieg, Elizabeth L., Lincoln, Sharyn A., Worthey, Elizabeth A., Lazar, Joe, Handley, Lori H., Newberry, J. Scott, Schroeder, Molly C., Brown, Donna M., Levy, Shawn E., Dorset, Dan C., Jones, Angela L., Manolio, Teri A., Wise, Anastasia L., Eckstein, David J., Krasnewich, Donna M., Loomis, Carson R., Iglesias, Brenda, Martin, Casey, Koeller, David M., Ashley, Euan A., Zornio, Patricia A., Nelson, Stan F., Palmer, Christina G.S., Allard, Patrick, Dell Angelica, Esteban C., Lee, Hane, Papp, Jeanette C., Dorrani, Naghmeh, Draper, David D., Estwick, Tyra, Gahl, William A., Gartner, Valerie, Godfrey, Rena A., Goheen, Mitchell, Johnston, Jean M., Latham, Lea, Macnamara, Ellen F., Maduro, Valerie V., Malicdan, May V., McCarty, Alexandra J., Murphy, Jennifer L., Novacic, Donna, Pusey, Barbara N., Sadozai, Sarah, Schaffer, Katherine E., Sharma, Prashant, Soldatos, Ariane G., Tifft, Cynthia J., Tolman, Nathanial J., Toro, Camilo, Wahl, Colleen E., Weech, Alec A., Yu, Guoyun, Hamid, Rizwan, Bellet, Jane S., Keels, Martha Ann, El-Dairi, Maysantoine, Stumpel, Constance T.R.M., Klinkenberg, Sylvia, Oberndorff, Karin, Petrovski, Slavé, Kuismin, Outi, Korpi-Heikkilä, Satu, Kurki, Mitja I., Hoischen, Alexander, Goldstein, David B.

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Data Resource Profile: Nationwide registry data for high-throughput epidemiology and machine learning (FinRegistry) von Viippola, Essi, Kuitunen, Sara, Rodosthenous, Rodosthenis S, Vabalas, Andrius, Hartonen, Tuomo, Vartiainen, Pekka, Demmler, Joanne, Vuorinen, Anna-Leena, Liu, Aoxing, Havulinna, Aki S, Llorens, Vincent, Detrois, Kira E, Wang, Feiyi, Ferro, Matteo, Karvanen, Antti, German, Jakob, Jukarainen, Sakari, Gracia-Tabuenca, Javier, Hiekkalinna, Tero, Koskelainen, Sami, Kiiskinen, Tuomo, Lahtela, Elisa, Lemmelä, Susanna, Paajanen, Teemu, Siirtola, Harri, Reeve, Mary Pat, Kristiansson, Kati, Brunfeldt, Minna, Aavikko, Mervi, Gen, Finn, Perola, Markus, Ganna, Andrea

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Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata von Sliz, Eeva, Tyrmi, Jaakko S., Rahmioglu, Nilufer, Zondervan, Krina T., Becker, Christian M., Uimari, Outi, Kettunen, Johannes

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Major Genetic Risk Factors for Dupuytren's Disease Are Inherited From Neandertals von Ågren, Richard, Patil, Snehal, Zhou, Xiang, Sahlholm, Kristoffer, Pääbo, Svante, Zeberg, Hugo

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High-Resolution Genotyping of Formalin-Fixed Tissue Accurately Estimates Polygenic Risk Scores in Human Diseases von Youssef, Omar, Plenge, Robert, Ehm, Margaret G., Auro, Kirsi, Longerich, Simonne, Chatelain, Clement, Kaprio, Jaakko, Virolainen, Petri, Raivio, Taneli, Tikkanen, Jani, Kosma, Veli-Matti, Laukkanen, Jari, Ding, Zhihao, Hu, Xinli, Hedman, Åsa, Renaud, Nicole, Obeidat, Maen, Ripatti, Samuli, Arvas, Mikko, Hinttala, Reetta, Kettunen, Johannes, Mäkelä, Johanna, Hiltunen, Mikko, Peltola, Jukka, Raivio, Minna, Partanen, Juulia, Abbasi, Ali, Eaton, Susan, Xu, Fanli, Addis, Laura, Eicher, John, Pikkarainen, Sampsa, Jussila, Airi, Voutilainen, Markku, Miller, Jason, Miller, Melissa, Eklund, Kari, Lertratanakul, Apinya, Pelkonen, Margit, Mouded, Majd, Ngo, Debby, Niiranen, Teemu, Aittokallio, Jenni, Hernesniemi, Jussi, Hiltunen, Timo, Reeve, Mary Pat, Mattson, Johanna, Auranen, Annika, Auvinen, Päivi, Fabre, Margarete, Kulkarni, Diptee, Loboda, Andrey, Ollila, Terhi, Loomis, Stephanie, Hannula-Jouppi, Katariina, Salmi, Teea, Pussinen, Pirkko, Salo, Tuula, Siponen, Maria, Mäntylä, Päivi, Anttonen, Vuokko, Kotaniemi-Talonen, Laura, Välimäki, Niko, Laakkonen, Eija, Laisk, Triin, Hovatta, Iiris, Isometsä, Erkki, Ollila, Hanna, Mäkitie, Antti, Aarnisalo, Antti, Aittomäki, Kristiina, Havulinna, Aki, Della Briotta Parolo, Pietro, Liu, Aoxing, Ganna, Andrea, Heyne, Henrike, Rodosthenous, Rodos, Palotie, Tuula, Palin, Kimmo, Garcia-Tabuenca, Javier, Siirtola, Harri, Kristiansson, Kati, Ritari, Jarmo, Pylkäs, Katri, Karjalainen, Minna, Mantere, Tuomo, Siltanen, Sanna, Kuopio, Teijo, Kajanne, Risto, Aavikko, Mervi, Cooper, Helen, Palin, Henna, Dada, Oluwaseun Alexander, Donner, Kati, Kaiharju, Essi, Lähteenmäki, Sini, Toivola, Auli, Paajanen, Teemu, Niemi, Marianna, Donner, Kati

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NTHL1 is a recessive cancer susceptibility gene von Nurmi, Anna K., Pelttari, Liisa M., Kiiski, Johanna I., Khan, Sofia, Nurmikolu, Mika, Suvanto, Maija, Aho, Niina, Tasmuth, Tiina, Kalso, Eija, Schleutker, Johanna, Kallioniemi, Anne, Heikkilä, Päivi, Aittomäki, Kristiina, Blomqvist, Carl, Nevanlinna, Heli

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An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease von Ruotsalainen, Sanni E., Partanen, Juulia J., Cichonska, Anna, Lin, Jake, Benner, Christian, Surakka, Ida, Reeve, FinnGen Mary Pat, Palta, Priit, Salmi, Marko, Jalkanen, Sirpa, Ahola-Olli, Ari, Palotie, Aarno, Salomaa, Veikko, Daly, Mark J., Pirinen, Matti, Ripatti, Samuli, Koskela, Jukka

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A window into living with an undiagnosed disease: illness narratives from the Undiagnosed Diseases Network von Spillmann, Rebecca C, McConkie-Rosell, Allyn, Pena, Loren, Jiang, Yong-Hui, Schoch, Kelly, Walley, Nicole, Sanders, Camilla, Sullivan, Jennifer, Hooper, Stephen R, Shashi, Vandana

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