Abstract CT143: Pembrolizumab bioavailability after subcutaneous administration: analysis from the KEYNOTE-555 Cohort A in metastatic melanoma von Jacobs, Conrad R., Rapoport, Bernardo Leon, Cohen, Graham Lawrence, Lala, Mallika, Silva, Carolina De Miranda, Vaddady, Pavan, Gheyas, Ferdous, de Alwis, Dinesh, Sinha, Vikram, Akala, Omobolaji Oyekunle, Chartash, Elliot, Jain, Lokesh

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KEYNOTE-555 Cohort B: Efficacy, safety, and PK of pembrolizumab (pembro) 400 mg every 6 weeks (Q6W) as 1L therapy for advanced melanoma von Jacobs, Conrad R., Rapoport, Bernardo Leon, Chan, Sze Wai, Ruff, Paul, Arance, Ana Maria, Mujika, Karmele, Anderson, James Robert, Lala, Mallika, Jain, Lokesh, Akala, Omobolaji Oyekunle, Chartash, Elliot, Cohen, Graham Lawrence

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obligately aerobic soil bacterium activates fermentative hydrogen production to survive reductive stress during hypoxia von Berney, Michael, Greening, Chris, Conrad, Ralf, Jacob, William R., Cook, Gregory M.

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Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis von Rowan, Kathryn M, Angus, Derek C, Bailey, Michael, Barnato, Amber E, Bellomo, Rinaldo, Canter, Ruth R, Coats, Timothy J, Delaney, Anthony, Gimbel, Elizabeth, Grieve, Richard D, Harrison, David A, Higgins, Alisa M, Howe, Belinda, Huang, David T, Kellum, John A, Mouncey, Paul R, Music, Edvin, Peake, Sandra L, Pike, Francis, Reade, Michael C, Sadique, M Zia, Singer, Mervyn, Yealy, Donald M

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Pembrolizumab 400 mg every 6 weeks as first-line therapy for advanced melanoma (KEYNOTE-555): Results from cohort B of an open-label, phase 1 study von Cohen, Graham, Rapoport, Bernardo, Chan, Sze W, Ruff, Paul, Arance, Ana, Mujika Eizmendi, Karmele, Houghton, Baerin, Brown, Michael P, Zielinski, Robert M, Muñoz Couselo, Eva, Lyle, Megan, Anderson, James R, Jain, Lokesh, de Alwis, Dinesh, Lala, Mallika, Akala, Omobolaji, Chartash, Elliot, Jacobs, Conrad

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A Randomized Trial of Protocol-Based Care for Early Septic Shock von YEALY, Donald M, KELLUM, John A, FILBIN, Michael R, SHAPIRO, Nathan I, ANGUS, Derek C, HUANG, David T, BARNATO, Amber E, WEISSFELD, Lisa A, PIKE, Francis, TERNDRUP, Thomas, WANG, Henry E, HOU, Peter C, LOVECCHIO, Frank

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Reintroduction of at-risk forest tree species using biotechnology depends on regulatory policy, informed by science and with public support von Jacobs, Douglass F., Dumroese, R. Kasten, Brennan, Andrea N., Campbell, Faith T., Conrad, Anna O., Delborne, Jason A., Fitzsimmons, Sara, Flores, David, Giardina, Christian P., Greenwood, Leigh, Martín, Juan A., Merkle, Scott A., Nelson, C. Dana, Newhouse, Andrew E., Powell, William A., Romero-Severson, Jeanne, Showalter, David N., Sniezko, Richard A., Strauss, Steven H., Westbrook, Jared, Woodcock, Paul

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Effect of Hemodynamics on Stroke Risk in Symptomatic Atherosclerotic Vertebrobasilar Occlusive Disease von Amin-Hanjani, Sepideh, Pandey, Dilip K, Rose-Finnell, Linda, Du, Xinjian, Richardson, DeJuran, Thulborn, Keith R, Elkind, Mitchell S. V, Zipfel, Gregory J, Liebeskind, David S, Silver, Frank L, Kasner, Scott E, Aletich, Victor A, Caplan, Louis R, Derdeyn, Colin P, Gorelick, Philip B, Charbel, Fady T

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The Effects of Alternative Resuscitation Strategies on Acute Kidney Injury in Patients with Septic Shock von Kellum, John A, Chawla, Lakhmir S, Keener, Christopher, Singbartl, Kai, Palevsky, Paul M, Pike, Francis L, Yealy, Donald M, Huang, David T, Angus, Derek C

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Efficacy of the Irreversible ErbB Family Blocker Afatinib in Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI)–Pretreated Non–Small-Cell Lung Cancer Patients... von Hoffknecht, Petra, Tufman, Amanda, Wehler, Thomas, Pelzer, Theo, Wiewrodt, Rainer, Schütz, Martin, Serke, Monika, Stöhlmacher-Williams, Jan, Märten, Angela, Maria Huber, Rudolf, Dickgreber, Nicolas J.

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The Society of Thoracic Surgeons General Thoracic Surgery Database: 2016 Update on Research von Gaissert, Henning A., MD, Fernandez, Felix G., MD, Allen, Mark S., MD, Burfeind, William R., MD, Block, Mark I., MD, Donahue, James M., MD, Mitchell, John D., MD, Schipper, Paul H., MD, Onaitis, Mark W., MD, Kosinski, Andrzej S., PhD, Jacobs, Jeffrey P., MD, Shahian, David M., MD, Kozower, Benjamin D., MD, Edwards, Fred H., MD, Conrad, Emily A., MS, Patterson, G. Alexander, MD

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Pembrolizumab 400 mg every 6 weeks as first-line therapy for advanced melanoma von Cohen, Graham, Rapoport, Bernardo, Chan, Sze W, Ruff, Paul, Arance, Ana, Mujika Eizmendi, Karmele, Houghton, Baerin, Brown, Michael P, Zielinski, Robert M, Muñoz Couselo, Eva, Lyle, Megan, Anderson, James R, Jain, Lokesh, de Alwis, Dinesh, Lala, Mallika, Akala, Omobolaji, Chartash, Elliot, Jacobs, Conrad

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Prevalence of CADASIL and Fabry Disease in a Cohort of MRI Defined Younger Onset Lacunar Stroke von Kilarski, Laura L, Rutten-Jacobs, Loes C A, Bevan, Steve, Baker, Rob, Hassan, Ahamad, Hughes, Derralynn A, Markus, Hugh S

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Microcirculatory perfusion disturbances in septic shock: results from the ProCESS trial von Massey, Michael J, Hou, Peter C, Filbin, Michael, Wang, Henry, Ngo, Long, Huang, David T, Aird, William C, Novack, Victor, Trzeciak, Stephen, Yealy, Donald M, Kellum, John A, Angus, Derek C, Shapiro, Nathan I

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Hemodynamic Features of Symptomatic Vertebrobasilar Disease von Amin-Hanjani, Sepideh, Du, Xinjian, Rose-Finnell, Linda, Pandey, Dilip K, Richardson, DeJuran, Thulborn, Keith R, Elkind, Mitchell S.V, Zipfel, Gregory J, Liebeskind, David S, Silver, Frank L, Kasner, Scott E, Aletich, Victor A, Caplan, Louis R, Derdeyn, Colin P, Gorelick, Philip B, Charbel, Fady T, Xie, Hui, Flannery, Michael P, Ganin, Hagai, Ruland, Sean, Grysiewicz, Rebecca, Khaja, Aslam, Pedelty, Laura, Testai, Fernando, Ong, Archie, Epstein, Noam, Muqtadar, Hurmina, Watson, Karriem, Mlinarevich, Nada, Hillmann, Maureen, Hirsch, Joy, Dashnaw, Stephen, Meyers, Philip M, Willey, Josh Z, McNeill-Simaan, Edwina, Perez, Veronica, Canaan, Alberto, Paulino-Hernandez, Wayna, Vo, Katie, Foster, Glenn, Ford, Andria, Nassief, Abdullah, Bradley, Abbie, Serna-Northway, Jannie, Kraus, Kristi, Shiwani, Lina, Hantler, Nancy, Alger, Jeffrey, Godinez, Sergio, Saver, Jeffrey L, Ali, Latisha, Kim, Doojin, Tenser, Matthew, Froehler, Michael, Raychev, Radoslav, Song, Sarah, Ovbiagele, Bruce, Abcede, Hermelinda, Adamczyk, Peter, Rao, Neal, Yallapragada, Anil, Modir, Royya, Hinman, Jason, Tansy, Aaron, Calderon-Arnulphi, Mateo, Sheth, Sunil, Noorian, Alireza, Ng, Kwan, Liang, Conrad, Gadhia, Jignesh, Smith, Hannah, Avila, Gilda, Avelar, Johanna, Mikulis, David, Fierstra, Jorn, Hlasny, Eugen, Casaubon, Leanne K, Vergouwen, Mervyn, del Campo, J.C Martin, Jaigobin, Cheryl S, Astorga, Cherissa, Kalman, Libby, Kramer, Jeffrey, Vaughan, Susan, Owens, Laura, Kissela, Brett, Turan, Tanya N, Jacobs, Tom P, Janis, Scott

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The Choice of Normative Pediatric Reference Database Changes Spine Bone Mineral Density Z-Scores But Not the Relationship Between Bone Mineral Density and Prevalent Vertebral Fract... von Ma, Jinhui, Siminoski, Kerry, Alos, Nathalie, Halton, Jacqueline, Ho, Josephine, Lentle, Brian, Matzinger, MaryAnn, Shenouda, Nazih, Atkinson, Stephanie, Barr, Ronald, Cabral, David A, Couch, Robert, Cummings, Elizabeth A, Fernandez, Conrad V, Grant, Ronald M, Rodd, Celia, Sbrocchi, Anne Marie, Scharke, Maya, Rauch, Frank, Ward, Leanne M

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Afatinib in Non‐Small Cell Lung Cancer Harboring Uncommon EGFR Mutations Pretreated With Reversible EGFR Inhibitors von Schumann, Christian, Sebastian, Martin, Sadjadian, Parvis, Märten, Angela, Abdollahi, A., Aries, S.P., Arntzen, C., Atmaca, A., Basara, N., Borchard, B., Bos, M., Brugger, W., Budweiser, S., Corduan, K., Cortes‐Incio, D., Dallmeier, B., Denzlinger, C., Dittrich, I., Engel‐Riedel, W., Faehling, M., Fertl, A., Fischer, J.R., Fleckenstein, D., Folprecht, G., Forstbauer, A., France, Y., Frickhofen, N., Gardizi, M., Gauler, T., Gessner, C., Gökkurt, E., Görner, M., Grah, C., Greeve, J., Greiner, J., Grohé, C., Grüning, W., Guggenberger, D., Heinrich, B., Hense, G., Hoiczyk, M., Huber, R.M., Illerhaus, G., Jacobs, G., Jung, P., Kern, J., Kersten, J., Kiehl, M., Kisro, J., Knipp, H., Ko, Y.D., Koch, J.U., Koehne, C.H., Kollmeier, J., Kommer, A., Körber, W., Krause, G., Krügel, R., Leistner, R., Liebers, U., Lommatzsch, M., Maintz, C., Mohr, M., Neumeister, W., Overbeck, T., Panse, J., Pelzer, T., Peters, K., Planker, M., Reissig, A., Ritter, M., Sadjadian, P., Sandritter, B., Schatz, M., Scheffler, M., Schmid‐Bindert, G., Schneider, C.P., Schneider‐Kappus, W., Schreiber, J., Schütte, W., Schütz, S., Sebastian, M., Serke, M., Staiger, H., Stehle, I., Stengele, K., Stöhlmacher‐Williams, J., Strapatsas, T., Sulzbach, B., Tessmer, A., Thomas, M., Ukena, D., Wagner, B., Wagner‐Hug, D., Witt, C., Wohlleber, M., Wolf, J., Wricke, K., Zaba, O., Zander, I.

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The OPTN Deceased Donor Potential Study: Implications for Policy and Practice von Klassen, D. K., Edwards, L. B., Stewart, D. E., Glazier, A. K., Orlowski, J. P., Berg, C. L., McCleary, Karl J, Hirsch, Gary B, Boulware, L. Ebony, King, Gary, Myer, Kevin A, Reibel, Michael, Rosendale, John D, Saeed, Khalid, Siminoff, Laura A, Soret, Samuel, Wagstaff, David A, Wile, Kristina, Essien, Joyce D K, Crandall, Betty C, Cornell, Danielle L, Jacobs, David G, Bosch, David W, Howard, David H, Faulkner, Dorothy L, Bergstrom, George F, Rushton, Gerald, Franklin, Glen, Wilkins, Harry E, Rahmandad, Hazhir, Nathan, Howard M, Tuttle‐Newhall, J Elizabeth, Wynn, James J, Whaley, Janice, Perryman, Jennie P, Schold, Jesse, Belcher, John, Mayglothing, Julie A, Garcia, Karen, O'Conner, Kevin J, Kyckholm, Laurie J, Ohler, Linda, Markham, Lori E, Sastry, M Anjali, Farinelli Fierro, Marcella, DeLauro, Maria, Kelleher‐Crabtree, Mary, Johnson, Maryl R, Rogers, Meg M, Pyrsopoulos, Nikolaos T, Geraghty, P J, Halverson, Paul K, Bennett, Renee, Hasz, Richard D, Higgins, Robert S D, Youngner, Stuart J, Conrad, Suzanne Lane, Mone, Thomas, Nakagawa, Thomas A, Bleck, Thomas P, Pruett, Timothy L, Durbin, Richard, McLaughlin, Christopher J, Belgay, Teresa M, Shepard, Brian

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The sac evolution imaging follow-up after endovascular aortic repair: An international expert opinion-based Delphi consensus study von Tinelli, Giovanni, Sica, Simona, Rancic, Zoran, Beccia, Flavia, Azizzadeh, Ali, Gargiulo, Mauro, Lepidi, Sandro, Oderich, Gustavo S., Haulon, Stéphan, Hertault, Adrien, Froio, Alberto, Zimmermann, Alexander, Queiroz, Andre Brito, Schanzer, Andres, Lorido, Antonio, Millon, Antoine, Abai, Babak, Mees, Barend, Maurel, Blandine, Cavazzini, Carlo, Setacci, Carlo, Lee, Cheong Jun, Ferrer, Ciro, Bicknell, Colin, Clair, Daniel, Kotelis, Drosos, Mujagic, Edin, Chisci, Emiliano, Cieri, Enrico, Gallitto, Enrico, Marone, Enrico Maria, Verzini, Fabio, Pecoraro, Felice, Serracino-Inglott, Ferdinand, Stilo, Francesco, Pagliariccio, Gabriele, Piffaretti, Gabriele, Philipp, Geisbüsch, Geenberg, George, Melissano, Germano, Veraldi, Gian Franco, Parlani, Gianbattista, Pratesi, Giovanni, Torsello, Giovanni, Verhagen, Hence, Koleilat, Issam, de Vries, J.P.P.M., Black, James, Eldrup-Jorgensen, Jens, Hockley, Joe, Bath, Jonathan, Sobocinski, Jonathan, van Herwaarden, Joost A., Reinhard, Kopp, Amankwah, Kwame, Bertoglio, Luca, di Marzo, Luca, Garriboli, Luca, Rizzo, Luigi, Sheahan, Malachi, Schermerhorn, Marc, Lescan, Mario, Conrad, Mark, Czerny, Martin, Orrico, Matteo, Smeds, Matthew R., Wohlauer, Max, Tsilimparis, Nikolaos, Dias, Nuno, Sirignano, Pasqualino, Chong, Patrick, DiMuzio, Paul, Henke, Peter, Düppers, Philip, Holt, Peter, Helmiö, Päivi, Cuff, Robert, Pini, Rodolfo, Milner, Ross, Scali, Salvatore T., Bahia, Sandeep, Laukontaus, Sani, Trimarchi, Santi, Fernandez-Alonso, Sebastian, Deglise, Sebastien, Bellmunt-Montoya, Sergi, Yusuf, Syed W., Camparini, Stefano, Pirrelli, Stefano, Hörer, Tal, Lattmann, Thomas, Wyss, Thomas Rudolf, Donati, Tommaso, Tracci, Margaret, Bracale, Umberto Marcello, Tolva, Valerio Stefano, Palazzo, Vincenzo, Makaloski, Vladimir, Von Allmen, Regula S., Dorigo, Walter

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Utility of Biomarkers for Sepsis-Associated Acute Kidney Injury Staging von Molinari, Luca, Del Rio-Pertuz, Gaspar, Smith, Ali, Landsittel, Douglas P, Singbartl, Kai, Palevsky, Paul M, Chawla, Lakhmir S, Huang, David T, Yealy, Donald M, Angus, Derek C, Kellum, John A

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