Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge von Maun, Henry R., Vij, Rajesh, Walters, Benjamin T., Morando, Ashley, Jackman, Janet K., Wu, Ping, Estevez, Alberto, Chen, Xiaocheng, Franke, Yvonne, Lipari, Michael T., Dennis, Mark S., Kirchhofer, Daniel, Ciferri, Claudio, Loyet, Kelly M., Yi, Tangsheng, Eigenbrot, Charles, Lazarus, Robert A., Koerber, James T.

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An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma von Maun, Henry R., Jackman, Janet K., Choy, David F., Loyet, Kelly M., Staton, Tracy L., Jia, Guiquan, Dressen, Amy, Hackney, Jason A., Bremer, Meire, Walters, Benjamin T., Vij, Rajesh, Chen, Xiaocheng, Trivedi, Neil N., Morando, Ashley, Lipari, Michael T., Franke, Yvonne, Wu, Xiumin, Zhang, Juan, Liu, John, Wu, Ping, Chang, Diana, Orozco, Luz D., Christensen, Erin, Wong, Manda, Corpuz, Racquel, Hang, Julie Q., Lutman, Jeff, Sukumaran, Siddharth, Wu, Yan, Ubhayakar, Savita, Liang, Xiaorong, Schwartz, Lawrence B., Babina, Magda, Woodruff, Prescott G., Fahy, John V., Ahuja, Rahul, Caughey, George H., Kusi, Aija, Dennis, Mark S., Eigenbrot, Charles, Kirchhofer, Daniel, Austin, Cary D., Wu, Lawren C., Koerber, James T., Lee, Wyne P., Yaspan, Brian L., Alatsis, Kathila R., Arron, Joseph R., Lazarus, Robert A., Yi, Tangsheng

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Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma von Shikotra, Aarti, BSc, Choy, David F., BSc, Ohri, Chandra M., MD, Doran, Emma, BSc, Butler, Claire, MBBCh, Hargadon, Beverley, BSc, Shelley, Maria, BA, Abbas, Alexander R., PhD, Austin, Cary D., MD, PhD, Jackman, Janet, MSc, Wu, Lawren C., PhD, Heaney, Liam G., MD, Arron, Joseph R., MD, PhD, Bradding, Peter, DM

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Conditional Deletion of NF-κB-Inducing Kinase (NIK) in Adult Mice Disrupts Mature B Cell Survival and Activation von Brightbill, Hans D, Jackman, Janet K, Suto, Eric, Kennedy, Heather, Jones, 3rd, Charles, Chalasani, Sreedevi, Lin, Zhonghua, Tam, Lucinda, Roose-Girma, Meron, Balazs, Mercedesz, Austin, Cary D, Lee, Wyne P, Wu, Lawren C

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Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma von Jackman, Janet K., Stockwell, Amy, Choy, David F., Xie, Markus M., Lu, Peipei, Jia, Guiquan, Li, Hong, Abbas, Alexander R., Bronson, Paola G., Lin, Wei-Yu, Chiu, Cecilia P.C., Maun, Henry R., Roose-Girma, Merone, Tam, Lucinda, Zhang, Juan, Modrusan, Zora, Graham, Robert R., Behrens, Timothy W., White, Steven R., Naureckas, Ted, Ober, Carole, Ferreira, Manuel, Sedlacek, Radislav, Wu, Jiansheng, Lee, Wyne P., Lazarus, Robert A., Koerber, James T., Arron, Joseph R., Yaspan, Brian L., Yi, Tangsheng

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LUZ-Y, a Novel Platform for the Mammalian Cell Production of Full-length IgG-bispecific Antibodies von Wranik, Bernd J., Christensen, Erin L., Schaefer, Gabriele, Jackman, Janet K., Vendel, Andrew C., Eaton, Dan

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A CEACAM6-High Airway Neutrophil Phenotype and CEACAM6-High Epithelial Cells Are Features of Severe Asthma von Shikotra, Aarti, Choy, David F, Siddiqui, Salman, Arthur, Greer, Nagarkar, Deepti R, Jia, Guiquan, Wright, Adam K A, Ohri, Chandra M, Doran, Emma, Butler, Claire A, Hargadon, Beverley, Abbas, Alexander R, Jackman, Janet, Wu, Lawren C, Heaney, Liam G, Arron, Joseph R, Bradding, Peter

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An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma von Maun, Henry R., Jackman, Janet K., Choy, David F., Loyet, Kelly M., Staton, Tracy L., Jia, Guiquan, Dressen, Amy, Hackney, Jason A., Bremer, Meire, Walters, Benjamin T., Vij, Rajesh, Chen, Xiaocheng, Trivedi, Neil N., Morando, Ashley, Lipari, Michael T., Franke, Yvonne, Wu, Xiumin, Zhang, Juan, Liu, John, Wu, Ping, Chang, Diana, Orozco, Luz D., Christensen, Erin, Wong, Manda, Corpuz, Racquel, Hang, Julie Q., Lutman, Jeff, Sukumaran, Siddharth, Wu, Yan, Ubhayakar, Savita, Liang, Xiaorong, Schwartz, Lawrence B., Babina, Magda, Woodruff, Prescott G., Fahy, John V., Ahuja, Rahul, Caughey, George H., Kusi, Aija, Dennis, Mark S., Eigenbrot, Charles, Kirchhofer, Daniel, Austin, Cary D., Wu, Lawren C., Koerber, James T., Lee, Wyne P., Yaspan, Brian L., Alatsis, Kathila R., Arron, Joseph R., Lazarus, Robert A., Yi, Tangsheng

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Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice von Brightbill, Hans D, Jeet, Surinder, Lin, Zhonghua, Yan, Donghong, Zhou, Meijuan, Tan, Martha, Nguyen, Allen, Yeh, Sherry, Delarosa, Donnie, Leong, Steven R, Wong, Terence, Chen, Yvonne, Ultsch, Mark, Luis, Elizabeth, Ramani, Sree Ranjani, Jackman, Janet, Gonzalez, Lino, Dennis, Mark S, Chuntharapai, Anan, DeForge, Laura, Meng, Y Gloria, Xu, Min, Eigenbrot, Charles, Lee, Wyne P, Refino, Canio J, Balazs, Mercedesz, Wu, Lawren C

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An agonistic anti-signal regulatory protein α antibody for chronic inflammatory diseases von Xie, Markus M, Dai, Bingbing, Hackney, Jason A, Sun, Tianhe, Zhang, Juan, Jackman, Janet K, Jeet, Surinder, Irizarry-Caro, Ricardo A, Fu, Yongyao, Liang, Yuxin, Bender, Hannah, Shamir, Eliah R, Keir, Mary E, Bevers, Jack, Nakamura, Gerald, Townsend, Michael J, Fox, David A, Scherl, Alexis, Lee, Wyne P, Martin, Flavius, Godowski, Paul J, Pappu, Rajita, Yi, Tangsheng

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Lung Gene Expression in a Rhesus Allergic Asthma Model Correlates with Physiologic Parameters of Disease and Exhibits Common and Distinct Pathways with Human Asthma and a Mouse Ast... von Abbas, Alexander R, Jackman, Janet K, Bullens, Sherron L, Davis, Sarah M, Choy, David F, Fedorowicz, Grazyna, Tan, Martha, Truong, Bao-Tran, Gloria Meng, Y, Diehl, Lauri, Miller, Lisa A, Schelegle, Edward S, Hyde, Dallas M, Clark, Hilary F, Modrusan, Zora, Arron, Joseph R, Wu, Lawren C

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Phosphorylation of SLP-76 by the ZAP-70 Protein-tyrosine Kinase Is Required for T-cell Receptor Function von Wardenburg, Juliane Bubeck, Fu, Chong, Jackman, Janet K., Flotow, Horst, Wilkinson, Sandra E., Williams, David H., Johnson, Robin, Kong, Guanghui, Chan, Andrew C., Findell, Paul R.

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Molecular Cloning of SLP-76, a 76-kDa Tyrosine Phosphoprotein Associated with Grb2 in T Cells (∗) von Jackman, Janet K., Motto, David G., Sun, Qiming, Tanemoto, Masayuki, Turck, Chris W., Peltz, Gary A., Koretzky, Gary A., Findell, Paul R.

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Development of a conditional NIK knockout mouse (P3293) von Brightbill, Hans, Jackman, Janet, Wu, Lawren

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Development of a Human IgG4 Bispecific Antibody for Dual Targeting of Interleukin-4 (IL-4) and Interleukin-13 (IL-13) Cytokines von Spiess, Christoph, Bevers, Jack, Jackman, Janet, Chiang, Nancy, Nakamura, Gerald, Dillon, Michael, Liu, Hongbin, Molina, Patricia, Elliott, J. Michael, Shatz, Whitney, Scheer, Justin M., Giese, Glen, Persson, Josefine, Zhang, Yin, Dennis, Mark S., Giulianotti, James, Gupta, Prateek, Reilly, Dorothea, Palma, Enzo, Wang, Jianyong, Stefanich, Eric, Scheerens, Heleen, Fuh, Germaine, Wu, Lawren C.

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Endogenously Expressed IL-13R alpha 2 Attenuates IL-13-Mediated Responses but Does Not Activate Signaling in Human Lung Fibroblasts von Chandriani, Sanjay, DePianto, Daryle J, N'Diaye, Elsa N, Abbas, Alexander R, Jackman, Janet, Bevers, Jack, Ramirez-Carrozzi, Vladimir, Pappu, Rajita, Kauder, Steven E, Toy, Karen, Ha, Connie, Modrusan, Zora, Wu, Lawren C, Collard, Harold R, Wolters, Paul J, Egen, Jackson G, Arron, Joseph R

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Endogenously expressed IL-13Rα2 attenuates IL-13-mediated responses but does not activate signaling in human lung fibroblasts von Chandriani, Sanjay, DePianto, Daryle J, N'Diaye, Elsa N, Abbas, Alexander R, Jackman, Janet, Bevers, 3rd, Jack, Ramirez-Carrozzi, Vladimir, Pappu, Rajita, Kauder, Steven E, Toy, Karen, Ha, Connie, Modrusan, Zora, Wu, Lawren C, Collard, Harold R, Wolters, Paul J, Egen, Jackson G, Arron, Joseph R

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Development of a Two-part Strategy to Identify a Therapeutic Human Bispecific Antibody That Inhibits IgE Receptor Signaling von Jackman, Janet, Chen, Yongmei, Huang, Arthur, Moffat, Barbara, Scheer, Justin M., Leong, Steven R., Lee, Wyne P., Zhang, Juan, Sharma, Navneet, Lu, Yanmei, Iyer, Suhasini, Shields, Robert L., Chiang, Nancy, Bauer, Michele C., Wadley, Diana, Roose-Girma, Merone, Vandlen, Richard, Yansura, Daniel G., Wu, Yan, Wu, Lawren C.

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Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response von Sun, Yonglian, Peng, Ivan, Webster, Joshua D, Suto, Eric, Lesch, Justin, Wu, Xiumin, Senger, Kate, Francis, George, Barrett, Kathy, Collier, Jenna L, Burch, Jason D, Zhou, Meijuan, Chen, Yuan, Chan, Connie, Eastham-Anderson, Jeff, Ngu, Hai, Li, Olga, Staton, Tracy, Havnar, Charles, Jaochico, Allan, Jackman, Janet, Jeet, Surinder, Riol-Blanco, Lorena, Wu, Lawren C, Choy, David F, Arron, Joseph R, McKenzie, Brent S, Ghilardi, Nico, Ismaili, Moulay Hicham Alaoui, Pei, Zhonghua, DeVoss, Jason, Austin, Cary D, Lee, Wyne P, Zarrin, Ali A

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Development of a Two-part Strategy to Identify a Therapeutic Human Bispecific Antibody That Inhibits IgE Receptor Signaling<inline-graphic xlink:href="sbox.jpg"/> von Jackman, Janet, Chen, Yongmei, Huang, Arthur, Moffat, Barbara, Scheer, Justin M, Leong, Steven R, Lee, Wyne P, Zhang, Juan, Sharma, Navneet, Lu, Yanmei, Iyer, Suhasini, Shields, Robert L, Chiang, Nancy, Bauer, Michele C, Wadley, Diana, Roose-Girma, Merone, Vandlen, Richard, Yansura, Daniel G, Wu, Yan, Wu, Lawren C

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