Actions of a Novel Bacterial Topoisomerase Inhibitor against Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks von Dauda, Soziema E, Collins, Jessica A, Byl, Jo Ann W, Lu, Yanran, Yalowich, Jack C, Mitton-Fry, Mark J, Osheroff, Neil

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Use of CRISPR/Cas9 with homology-directed repair to silence the human topoisomerase IIα intron-19 5' splice site: Generation of etoposide resistance in human leukemia K562 cells von Hernandez, Victor A, Carvajal-Moreno, Jessika, Wang, Xinyi, Pietrzak, Maciej, Yalowich, Jack C, Elton, Terry S

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Discovery of Anticancer Agents of Diverse Natural Origin von Aldrich, Leslie N, Burdette, Joanna E, Carcache de Blanco, Esperanza, Coss, Christopher C, Eustaquio, Alessandra S, Fuchs, James R, Kinghorn, A. Douglas, MacFarlane, Amanda, Mize, Brittney K, Oberlies, Nicholas H, Orjala, Jimmy, Pearce, Cedric J, Phelps, Mitch A, Rakotondraibe, Liva Harinantenaina, Ren, Yulin, Soejarto, Djaja Doel, Stockwell, Brent R, Yalowich, Jack C, Zhang, Xiaoli

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Cytotoxic and natural killer cell stimulatory constituents of Phyllanthus songboiensis von Ren, Yulin, Yuan, Chunhua, Deng, Youcai, Kanagasabai, Ragu, Ninh, Tran Ngoc, Tu, Vuong Tan, Chai, Hee-Byung, Soejarto, Djaja D, Fuchs, James R, Yalowich, Jack C, Yu, Jianhua, Kinghorn, A Douglas

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Mechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase IIα Isoform von Hasinoff, Brian B, Wu, Xing, Patel, Daywin, Kanagasabai, Ragu, Karmahapatra, Soumendrakrishna, Yalowich, Jack C

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Effects of hsa‐miR‐9‐3p and hsa‐miR‐9‐5p on Topoisomerase IIβ Expression in Human Leukemia K562 Cells with Acquired Resistance to Etoposide von Carvajal‐Moreno, Jessika J., Hernandez, Victor A., Yalowich, Jack C., Elton, Terry S.

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Capsicodendrin from Cinnamosma fragrans Exhibits Antiproliferative and Cytotoxic Activity in Human Leukemia Cells: Modulation by Glutathione von Karmahapatra, Soumendrakrishna, Kientz, Corey, Shetty, Shruthi, Yalowich, Jack C, Rakotondraibe, L. Harinantenaina

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hsa-miR-9-3p and hsa-miR-9-5p as Post-Transcriptional Modulators of DNA Topoisomerase IIα in Human Leukemia K562 Cells with Acquired Resistance to Etoposide von Kania, Evan E., Carvajal-Moreno, Jessika, Hernandez, Victor A., English, Anthony, Papa, Jonathan L., Shkolnikov, Nicholas, Ozer, Hatice Gulcin, Yilmaz, Ayse Selen, Yalowich, Jack C., Elton, Terry S.

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Synthesis and anti-staphylococcal activity of novel bacterial topoisomerase inhibitors with a 5-amino-1,3-dioxane linker moiety von Li, Linsen, Okumu, Antony, Dellos-Nolan, Sheri, Li, Zoe, Karmahapatra, Soumendrakrishna, English, Anthony, Yalowich, Jack C., Wozniak, Daniel J., Mitton-Fry, Mark J.

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The Novel C-terminal Truncated 90-kDa Isoform of Topoisomerase IIα (TOP2α/90) Is a Determinant of Etoposide Resistance in K562 Leukemia Cells via Heterodimerization with the TOP2α/... von Kanagasabai, Ragu, Karmahapatra, Soumendrakrishna, Kientz, Corey A., Yu, Yang, Hernandez, Victor A., Kania, Evan E., Yalowich, Jack C., Elton, Terry S.

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Novel bacterial topoisomerase inhibitors derived from isomannide von Okumu, Antony, Lu, Yanran, Dellos-Nolan, Sheri, Papa, Jonathan L., Koci, Bryan, Cockroft, Nicholas T., Gallucci, Judith, Wozniak, Daniel J., Yalowich, Jack C., Mitton-Fry, Mark J.

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The anticancer multi-kinase inhibitor dovitinib also targets topoisomerase I and topoisomerase II von Hasinoff, Brian B., Wu, Xing, Nitiss, John L., Kanagasabai, Ragu, Yalowich, Jack C.

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Potent Cytotoxic Arylnaphthalene Lignan Lactones from Phyllanthus poilanei von Ren, Yulin, Lantvit, Daniel D, Deng, Youcai, Kanagasabai, Ragu, Gallucci, Judith C, Ninh, Tran Ngoc, Chai, Hee-Byung, Soejarto, Djaja D, Fuchs, James R, Yalowich, Jack C, Yu, Jianhua, Swanson, Steven M, Kinghorn, A. Douglas

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Development of Novel Bacterial Topoisomerase Inhibitors Assisted by Computational Screening von Powell, Joshua W., Mann, Chelsea A., Toth, Paul D., Nolan, Sheri, Steinert, Anja, Ove, Clarissa, Seffernick, Justin T., Wozniak, Daniel J., Kebriaei, Razieh, Lindert, Steffen, Osheroff, Neil, Yalowich, Jack C., Mitton-Fry, Mark J.

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Alternative RNA Processing of Topoisomerase IIα in Etoposide-Resistant Human Leukemia K562 Cells: Intron Retention Results in a Novel C-Terminal Truncated 90-kDa Isoform von Kanagasabai, Ragu, Serdar, Lucas, Karmahapatra, Soumendrakrishna, Kientz, Corey A, Ellis, Justin, Ritke, Mary K, Elton, Terry S, Yalowich, Jack C

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c-Abl Kinase Regulates Curcumin-Induced Cell Death through Activation of c-Jun N-Terminal Kinase von Kamath, Ravindra, Jiang, Zhihua, Sun, Guoming, Yalowich, Jack C, Baskaran, R

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Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin–N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA von Yadav, Arun A., Wu, Xing, Patel, Daywin, Yalowich, Jack C., Hasinoff, Brian B.

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1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum von Lu, Yanran, Mann, Chelsea A., Nolan, Sheri, Collins, Jessica A., Parker, Elizabeth, Papa, Jonathan, Vibhute, Sandip, Jahanbakhsh, Seyedehameneh, Thwaites, Mary, Hufnagel, David, Hazbón, Manzour H., Moreno, Jane, Stedman, Timothy T., Wittum, Thomas, Wozniak, Daniel J., Osheroff, Neil, Yalowich, Jack C., Mitton-Fry, Mark J.

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1,3-Dioxane-Linked Bacterial Topoisomerase Inhibitors with Enhanced Antibacterial Activity and Reduced hERG Inhibition von Li, Linsen, Okumu, Antony A, Nolan, Sheri, English, Anthony, Vibhute, Sandip, Lu, Yanran, Hervert-Thomas, Katherine, Seffernick, Justin T, Azap, Lovette, Cole, Serena L, Shinabarger, D, Koeth, Laura M, Lindert, Steffen, Yalowich, Jack C, Wozniak, Daniel J, Mitton-Fry, Mark J

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Design, synthesis, and biological evaluation of a novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazole compounds as anticancer agents von Zhang, Rui, Wu, Xing, Yalowich, Jack C., Hasinoff, Brian B.

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