The novel chemokine receptor CXCR7 regulates trans-endothelial migration of cancer cells von Zabel, Brian A, Lewén, Susanna, Berahovich, Robert D, Jaén, Juan C, Schall, Thomas J

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C5a Receptor (CD88) Blockade Protects against MPO-ANCA GN von HONG XIAO, DAIRAGHI, Daniel J, BAO LU, GERARD, Norma P, GERARD, Craig, SCHALL, Thomas J, JAEN, Juan C, FALK, Ronald J, JENNETTE, J. Charles, POWERS, Jay P, ERTL, Linda S, BAUMGART, Trageen, YU WANG, SEITZ, Lisa C, PENFOLD, Mark E. T, LIN GAN, PEIQI HU

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Elucidation of CXCR7-Mediated Signaling Events and Inhibition of CXCR4-Mediated Tumor Cell Transendothelial Migration by CXCR7 Ligands von Zabel, Brian A, Wang, Yu, Lewen, Susanna, Berahovich, Robert D, Penfold, Mark E. T, Zhang, Penglie, Powers, Jay, Summers, Bretton C, Miao, Zhenhua, Zhao, Bin, Jalili, Ali, Janowska-Wieczorek, Anna, Jaen, Juan C, Schall, Thomas J

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CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice von Sullivan, Timothy, Miao, Zhenhua, Dairaghi, Daniel J, Krasinski, Antoni, Wang, Yu, Zhao, Bin N, Baumgart, Trageen, Ertl, Linda S, Pennell, Andrew, Seitz, Lisa, Powers, Jay, Zhao, Ruiping, Ungashe, Solomon, Wei, Zheng, Boring, Landin, Tsou, Chia-Lin, Charo, Israel, Berahovich, Robert D, Schall, Thomas J, Jaen, Juan C

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CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease von Dairaghi, Daniel J., Oyajobi, Babatunde O., Gupta, Anjana, McCluskey, Brandon, Miao, Shichang, Powers, Jay P., Seitz, Lisa C., Wang, Yu, Zeng, Yibin, Zhang, Penglie, Schall, Thomas J., Jaen, Juan C.

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Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease von Walters, Matthew J, Wang, Yu, Lai, Nu, Baumgart, Trageen, Zhao, Bin N, Dairaghi, Daniel J, Bekker, Pirow, Ertl, Linda S, Penfold, Mark E T, Jaen, Juan C, Keshav, Satish, Wendt, Emily, Pennell, Andrew, Ungashe, Solomon, Wei, Zheng, Wright, J J Kim, Schall, Thomas J

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Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors von Jiao, XianYun, Kopecky, David J., Liu, JinSong, Liu, JinQian, Jaen, Juan C., Cardozo, Mario G., Sharma, Rajiv, Walker, Nigel, Wesche, Holger, Li, Shyun, Farrelly, Ellyn, Xiao, Shou-Hua, Wang, Zhulun, Kayser, Frank

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Experimental evidence for the use of CCR2 antagonists in the treatment of type 2 diabetes von Sullivan, Timothy J, Miao, Zhenhua, Zhao, Bin N, Ertl, Linda S, Wang, Yu, Krasinski, Antoni, Walters, Matthew J, Powers, Jay P, Dairaghi, Daniel J, Baumgart, Trageen, Seitz, Lisa C, Berahovich, Robert D, Schall, Thomas J, Jaen, Juan C

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Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4 von Powers, Jay P., Li, Shyun, Jaen, Juan C., Liu, Jinqian, Walker, Nigel P.C., Wang, Zhulun, Wesche, Holger

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Tissue proteases convert CCL23 into potent monocyte chemoattractants in patients with chronic rhinosinusitis von Poposki, Julie A., MS, Keswani, Anjeni, MD, Kim, Julie K., MD, Klingler, Aiko I., PhD, Suh, Lydia A., BS, Norton, James, MS, Carter, Roderick G., BS, Peters, Anju T., MD, Hulse, Kathryn E., PhD, Grammer, Leslie C., MD, Tan, Bruce K., MD, Conley, David B., MD, Jaen, Juan C., PhD, Schall, Thomas J., PhD, Kern, Robert C., MD, Kato, Atsushi, PhD

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CCR9 Antagonists in the Treatment of Ulcerative Colitis von Sullivan, Timothy J., Jaen, Juan C., Schall, Thomas J., Powers, Jay P., Punna, Sreenivas, Charvat, Trevor T., Ertl, Linda S., Berahovich, Robert D., Walters, Matthew J., Ebsworth, Karen, Bekker, Pirow, Campbell, James J.

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Endothelial expression of CXCR7 and the regulation of systemic CXCL12 levels von Berahovich, Robert D., Zabel, Brian A., Lewén, Susanna, Walters, Matthew J., Ebsworth, Karen, Wang, Yu, Jaen, Juan C., Schall, Thomas J.

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CXCR7 protein is not expressed on human or mouse leukocytes von Berahovich, Robert D, Zabel, Brian A, Penfold, Mark E T, Lewén, Susanna, Wang, Yu, Miao, Zhenhua, Gan, Lin, Pereda, Jaime, Dias, Jessica, Slukvin, Igor I, McGrath, Kathleen E, Jaen, Juan C, Schall, Thomas J

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CXCR7 protein expression correlates with elevated mmp-3 secretion in breast cancer cells von ZABEL, BRIAN A, MIAO, ZHENHUA, LAI, NU L, WANG, YU, LEWÉN, SUSANNA, BERAHOVICH, ROBERT D, JAÉN, JUAN C, SCHALL, THOMAS J

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SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase von Powers, Jay P, Piper, Derek E, Li, Yang, Mayorga, Veronica, Anzola, John, Chen, James M, Jaen, Juan C, Lee, Gary, Liu, Jinqian, Peterson, M. Greg, Tonn, George R, Ye, Qiuping, Walker, Nigel P. C, Wang, Zhulun

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Discovery of potent, selective, and orally bioavailable inhibitors of interleukin-1 receptor-associate kinase-4 von Wang, Zhulun, Sun, Daqing, Johnstone, Sheree, Cao, Zhaodan, Gao, Xiong, Jaen, Juan C., Liu, Jingqian, Lively, Sarah, Miao, Shichang, Sudom, Athena, Tomooka, Craig, Walker, Nigel P.C., Wright, Matthew, Yan, Xuelei, Ye, Qiuping, Powers, Jay P.

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ITOC2 – 011. Identification of second-generation potent and selective inhibitors of indoleamine-2,3-dioxygenase-1 (IDO1) for the treatment of cancer von Juan, Jaen C, Pia, Bjorck, Jordan, Fridman S, Lisa, Marshall, Jan, Melom, Rajkumar, Noubade, Max, Osipov, Matthew, Walters J, Mikhail, Zibinsky, Jay, Powers P

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Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11β-HSD1 inhibitors von Rew, Yosup, DeGraffenreid, Michael, He, Xiao, Jaen, Juan C., McMinn, Dustin L., Sun, Daqing, Tu, Hua, Ursu, Stefania, Powers, Jay P.

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CCR9 inhibition does not interfere with the development of immune tolerance to oral antigens von Walters, Matthew J, Ebsworth, Karen, Sullivan, Timothy J, Zhang, Penglie, Powers, Jay P, Jaen, Juan C, Schall, Thomas J

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Distinctive molecular inhibition mechanisms for selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 von Tu, Hua, Powers, Jay P., Liu, Jinsong, Ursu, Stefania, Sudom, Athena, Yan, Xuelei, Xu, Haoda, Meininger, David, DeGraffenreid, Michael, He, Xiao, Jaen, Juan C., Sun, Daqing, Labelle, Marc, Yamamoto, Hiroshi, Shan, Bei, Walker, Nigel P.C., Wang, Zhulun

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