Synthesis and structure–activity relationship of 3,4′-bispyridinylethylenes: Discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment... von Li, Qun, Woods, Keith W., Thomas, Sheela, Zhu, Gui-Dong, Packard, Garrick, Fisher, John, Li, Tongmei, Gong, Jianchun, Dinges, Jurgen, Song, Xiaohong, Abrams, Jason, Luo, Yan, Johnson, Eric F., Shi, Yan, Liu, Xuesong, Klinghofer, Vered, Des Jong, Ron, Oltersdorf, Tilman, Stoll, Vincent S., Jakob, Clarissa G., Rosenberg, Saul H., Giranda, Vincent L.

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Hit-to-lead optimization of 1,4-dihydroindeno[1,2- c]pyrazoles as a novel class of KDR kinase inhibitors von Dinges, Jürgen, Akritopoulou-Zanze, Irini, Arnold, Lee D., Barlozzari, Teresa, Bousquet, Peter F., Cunha, George A., Ericsson, Anna M., Iwasaki, Nobuhiko, Michaelides, Michael R., Ogawa, Nobuo, Phelan, Kathleen M., Rafferty, Paul, Sowin, Thomas J., Stewart, Kent D., Tokuyama, Ryukou, Xia, Zhiren, Zhang, Henry Q.

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1,4-Dihydroindeno[1,2- c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors von Dinges, Jürgen, Ashworth, Kimba L., Akritopolou-Zanze, Irini, Arnold, Lee D., Baumeister, Steven A., Bousquet, Peter F., Cunha, George A., Davidsen, Steven K., Djuric, Stevan W., Gracias, Vijaya J., Michaelides, Michael R., Rafferty, Paul, Sowin, Thomas J., Stewart, Kent D., Xia, Zhiren, Zhang, Henry Q.

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours von Oltersdorf, Tilman, Elmore, Steven W., Shoemaker, Alexander R., Armstrong, Robert C., Augeri, David J., Belli, Barbara A., Bruncko, Milan, Deckwerth, Thomas L., Dinges, Jurgen, Hajduk, Philip J., Joseph, Mary K., Kitada, Shinichi, Korsmeyer, Stanley J., Kunzer, Aaron R., Letai, Anthony, Li, Chi, Mitten, Michael J., Nettesheim, David G., Ng, ShiChung, Nimmer, Paul M., O'Connor, Jacqueline M., Oleksijew, Anatol, Petros, Andrew M., Reed, John C., Shen, Wang, Tahir, Stephen K., Thompson, Craig B., Tomaselli, Kevin J., Wang, Baole, Wendt, Michael D., Zhang, Haichao, Fesik, Stephen W., Rosenberg, Saul H.

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Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-x L from NMR and Parallel Synthesis von Petros, Andrew M., Dinges, Jurgen, Augeri, David J., Baumeister, Steven A., Betebenner, David A., Bures, Mark G., Elmore, Steven W., Hajduk, Philip J., Joseph, Mary K., Landis, Shelley K., Nettesheim, David G., Rosenberg, Saul H., Shen, Wang, Thomas, Sheela, Wang, Xilu, Zanze, Irini, Zhang, Haichao, Fesik, Stephen W.

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A convergent approach toward the tigliane ring system von Dauben, William G, Dinges, Jurgen, Smith, Timothy C

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Creation of a S1P Lyase bacterial surrogate for structure-based drug design von Argiriadi, Maria A., Banach, David, Radziejewska, Elzbieta, Marchie, Susan, DiMauro, Jennifer, Dinges, Jurgen, Dominguez, Eric, Hutchins, Charles, Judge, Russell A., Queeney, Kara, Wallace, Grier, Harris, Christopher M.

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Hit-to-lead evaluation of a novel class of sphingosine 1-phosphate lyase inhibitors von Dinges, Jurgen, Harris, Christopher M., Wallace, Grier A., Argiriadi, Maria A., Queeney, Kara L., Perron, Denise C., Dominguez, Eric, Kebede, Tegest, Desino, Kelly E., Patel, Hetal, Vasudevan, Anil

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Creation of a S1P Lyase bacterial surrogate for structure-based drug design von Argiriadi, Maria A., Banach, David, Radziejewska, Elzbieta, Marchie, Susan, DiMauro, Jennifer, Dinges, Jurgen, Dominguez, Eric, Hutchins, Charles, Judge, Russell A., Queeney, Kara, Wallace, Grier, Harris, Christopher M.

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Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-xL from NMR and Parallel Synthesis von Petros, Andrew M, Dinges, Jurgen, Augeri, David J, Baumeister, Steven A, Betebenner, David A, Bures, Mark G, Elmore, Steven W, Hajduk, Philip J, Joseph, Mary K, Landis, Shelley K, Nettesheim, David G, Rosenberg, Saul H, Shen, Wang, Thomas, Sheela, Wang, Xilu, Zanze, Irini, Zhang, Haichao, Fesik, Stephen W

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1,4-Dihydroindeno[1,2-c]pyrazoles with Acetylenic Side Chains as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors with Low Affinity for the hERG Ion Channel von Dinges, Jürgen, Albert, Daniel H, Arnold, Lee D, Ashworth, Kimba L, Akritopoulou-Zanze, Irini, Bousquet, Peter F, Bouska, Jennifer J, Cunha, George A, Davidsen, Steven K, Diaz, Gilbert J, Djuric, Stevan W, Gasiecki, Alan F, Gintant, Gary A, Gracias, Vijaya J, Harris, Christopher M, Houseman, Kathryn A, Hutchins, Charles W, Johnson, Eric F, Li, Hu, Marcotte, Patrick A, Martin, Ruth L, Michaelides, Michael R, Nyein, Michelle, Sowin, Thomas J, Su, Zhi, Tapang, Paul H, Xia, Zhiren, Zhang, Henry Q

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Discovery of adamantane ethers as inhibitors of 11β-HSD-1: Synthesis and biological evaluation von Patel, Jyoti R., Shuai, Qi, Dinges, Jurgen, Winn, Marty, Pliushchev, Marina, Fung, Steven, Monzon, Katina, Chiou, William, Wang, Jiahong, Pan, Liping, Wagaw, Seble, Engstrom, Kenneth, Kerdesky, Francis A., Longenecker, Kenton, Judge, Russell, Qin, Wenying, Imade, Hovis M., Stolarik, DeAnne, Beno, David W.A., Brune, Michael, Chovan, Linda E., Sham, Hing L., Jacobson, Peer, Link, J.T.

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Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2- c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors von Akritopoulou-Zanze, Irini, Albert, Daniel H., Bousquet, Peter F., Cunha, George A., Harris, Christopher M., Moskey, Maria, Dinges, Jurgen, Stewart, Kent D., Sowin, Thomas J.

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Aminoalkoxybiphenylnitriles as histamine-3 receptor ligands von Faghih, Ramin, Dwight, Wesley, Vasudevan, Anil, Dinges, Jurgen, Conner, Scott E., Esbenshade, Timothy A., Bennani, Youssef L., Hancock, Arthur A.

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A concise synthesis of ortho-substituted aryl-acrylamides—potent activators of soluble guanylyl cyclase von Zhang, Henry Q., Xia, Zhiren, Kolasa, Teodozyj, Dinges, Jurgen

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Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation von Patel, Jyoti R, Shuai, Qi, Dinges, Jurgen, Winn, Marty, Pliushchev, Marina, Fung, Steven, Monzon, Katina, Chiou, William, Wang, Jiahong, Pan, Liping, Wagaw, Seble, Engstrom, Kenneth, Kerdesky, Francis A, Longenecker, Kenton, Judge, Russell, Qin, Wenying, Imade, Hovis M, Stolarik, Deanne, Beno, David W A, Brune, Michael, Chovan, Linda E, Sham, Hing L, Jacobson, Peer, Link, J T

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Structure-activity relationships of non-imidazole H3 receptor ligands. Part 3: 5-Substituted 3-phenyl-1,2,4-oxadiazoles as potent antagonists von GFESSER, Gregory A, ZHANG, Henry, KRUEGER, Kathy M, BENNANI, Youssef L, HANCOCK, Arthur A, FAGHIH, Ramin, DINGES, Jurgen, FOX, Gerard B, PAN, Jia Bao, ESBENSHADE, Timothy A, YAO, Betty B, WITTE, David, MILLER, Thomas R, KANG, Chae-Hee

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Structure–activity relationships of non-imidazole H 3 receptor ligands. Part 3: 5-Substituted 3-phenyl-1,2,4-oxadiazoles as potent antagonists von Gfesser, Gregory A., Zhang, Henry, Dinges, Jurgen, Fox, Gerard B., Pan, Jia Bao, Esbenshade, Timothy A., Yao, Betty B., Witte, David, Miller, Thomas R., Kang, Chae-Hee, Krueger, Kathy M., Bennani, Youssef L., Hancock, Arthur A., Faghih, Ramin

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Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 3: 5-Substituted 3-phenyl-1,2,4-oxadiazoles as potent antagonists von Gfesser, Gregory A, Zhang, Henry, Dinges, Jurgen, Fox, Gerard B, Pan, Jia Bao, Esbenshade, Timothy A, Yao, Betty B, Witte, David, Miller, Thomas R, Kang, Chae-Hee, Krueger, Kathy M, Bennani, Youssef L, Hancock, Arthur A, Faghih, Ramin

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Novel Inhibitors of Erm Methyltransferases from NMR and Parallel Synthesis von Hajduk, Philip J, Dinges, Jürgen, Schkeryantz, Jeffrey M, Janowick, David, Kaminski, Michele, Tufano, Michael, Augeri, David J, Petros, Andrew, Nienaber, Vicki, Zhong, Ping, Hammond, Rachel, Coen, Michael, Beutel, Bruce, Katz, Leonard, Fesik, Stephen W

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