The Current State of NAD+‐Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets von Schiedel, Matthias, Robaa, Dina, Rumpf, Tobias, Sippl, Wolfgang, Jung, Manfred

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New lysine methyltransferase drug targets in cancer von Wagner, Tobias, Jung, Manfred

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HDAC8: a multifaceted target for therapeutic interventions von Chakrabarti, Alokta, Oehme, Ina, Witt, Olaf, Oliveira, Guilherme, Sippl, Wolfgang, Romier, Christophe, Pierce, Raymond J, Jung, Manfred

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Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals) von Schiedel, Matthias, Herp, Daniel, Hammelmann, Sören, Swyter, Sören, Lehotzky, Attila, Robaa, Dina, Oláh, Judit, Ovádi, Judit, Sippl, Wolfgang, Jung, Manfred

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Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors von Senger, Johanna, Melesina, Jelena, Marek, Martin, Romier, Christophe, Oehme, Ina, Witt, Olaf, Sippl, Wolfgang, Jung, Manfred

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KATching-Up on Small Molecule Modulators of Lysine Acetyltransferases von Simon, Roman P, Robaa, Dina, Alhalabi, Zayan, Sippl, Wolfgang, Jung, Manfred

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Selective Sirt2 inhibition by ligand-induced rearrangement of the active site von Rumpf, Tobias, Schiedel, Matthias, Karaman, Berin, Roessler, Claudia, North, Brian J., Lehotzky, Attila, Oláh, Judit, Ladwein, Kathrin I., Schmidtkunz, Karin, Gajer, Markus, Pannek, Martin, Steegborn, Clemens, Sinclair, David A., Gerhardt, Stefan, Ovádi, Judit, Schutkowski, Mike, Sippl, Wolfgang, Einsle, Oliver, Jung, Manfred

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Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants von Marek, Martin, Shaik, Tajith B, Heimburg, Tino, Chakrabarti, Alokta, Lancelot, Julien, Ramos-Morales, Elizabeth, Da Veiga, Cyrielle, Kalinin, Dmitrii, Melesina, Jelena, Robaa, Dina, Schmidtkunz, Karin, Suzuki, Takayoshi, Holl, Ralph, Ennifar, Eric, Pierce, Raymond J, Jung, Manfred, Sippl, Wolfgang, Romier, Christophe

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Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors von Vögerl, Katharina, Ong, Nghia, Senger, Johanna, Herp, Daniel, Schmidtkunz, Karin, Marek, Martin, Müller, Martin, Bartel, Karin, Shaik, Tajith B, Porter, Nicholas J, Robaa, Dina, Christianson, David W, Romier, Christophe, Sippl, Wolfgang, Jung, Manfred, Bracher, Franz

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Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis von Heimburg, Tino, Chakrabarti, Alokta, Lancelot, Julien, Marek, Martin, Melesina, Jelena, Hauser, Alexander-Thomas, Shaik, Tajith B, Duclaud, Sylvie, Robaa, Dina, Erdmann, Frank, Schmidt, Matthias, Romier, Christophe, Pierce, Raymond J, Jung, Manfred, Sippl, Wolfgang

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Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy von Wagner, Julia M, Hackanson, Björn, Lübbert, Michael, Jung, Manfred

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Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity von Darwish, Salma, Ghazy, Ehab, Heimburg, Tino, Herp, Daniel, Zeyen, Patrik, Salem-Altintas, Rabia, Ridinger, Johannes, Robaa, Dina, Schmidtkunz, Karin, Erdmann, Frank, Schmidt, Matthias, Romier, Christophe, Jung, Manfred, Oehme, Ina, Sippl, Wolfgang

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Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor von Willmann, Dominica, Lim, Soyoung, Wetzel, Stefan, Metzger, Eric, Jandausch, Anett, Wilk, Wolfram, Jung, Manfred, Forne, Ignasi, Imhof, Axel, Janzer, Andreas, Kirfel, Jutta, Waldmann, Herbert, Schüle, Roland, Buettner, Reinhard

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Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly von Suzuki, Takayoshi, Kasuya, Yuki, Itoh, Yukihiro, Ota, Yosuke, Zhan, Peng, Asamitsu, Kaori, Nakagawa, Hidehiko, Okamoto, Takashi, Miyata, Naoki

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Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure–Activity Relationship Study von Schiedel, Matthias, Rumpf, Tobias, Karaman, Berin, Lehotzky, Attila, Oláh, Judit, Gerhardt, Stefan, Ovádi, Judit, Sippl, Wolfgang, Einsle, Oliver, Jung, Manfred

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Targeting histone deacetylase 8 as a therapeutic approach to cancer and neurodegenerative diseases von Chakrabarti, Alokta, Melesina, Jelena, Kolbinger, Fiona R, Oehme, Ina, Senger, Johanna, Witt, Olaf, Sippl, Wolfgang, Jung, Manfred

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Continuous Fluorescent Sirtuin Activity Assay Based on Fatty Acylated Lysines von Zessin, Matthes, Meleshin, Marat, Hilscher, Sebastian, Schiene-Fischer, Cordelia, Barinka, Cyril, Jung, Manfred, Schutkowski, Mike

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Structure-Based Development of an Affinity Probe for Sirtuin 2 von Schiedel, Matthias, Rumpf, Tobias, Karaman, Berin, Lehotzky, Attila, Gerhardt, Stefan, Ovádi, Judit, Sippl, Wolfgang, Einsle, Oliver, Jung, Manfred

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Structure-metabolism relationships of valine and tert-leucine-derived synthetic cannabinoid receptor agonists: a systematic comparison of the in vitro phase I metabolism using pool... von Franz, Florian, Jechle, Hanna, Wilde, Maurice, Angerer, Verena, Huppertz, Laura M., Longworth, Mitchell, Kassiou, Michael, Jung, Manfred, Auwärter, Volker

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Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni von Marek, Martin, Kannan, Srinivasaraghavan, Hauser, Alexander-Thomas, Moraes Mourão, Marina, Caby, Stéphanie, Cura, Vincent, Stolfa, Diana A, Schmidtkunz, Karin, Lancelot, Julien, Andrade, Luiza, Renaud, Jean-Paul, Oliveira, Guilherme, Sippl, Wolfgang, Jung, Manfred, Cavarelli, Jean, Pierce, Raymond J, Romier, Christophe

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