Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology von Blagg, Julian, Workman, Paul

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Chemical biology approaches to target validation in cancer von Blagg, Julian, Workman, Paul

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Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19 von Mallinger, Aurélie, Schiemann, Kai, Rink, Christian, Stieber, Frank, Calderini, Michel, Crumpler, Simon, Stubbs, Mark, Adeniji-Popoola, Olajumoke, Poeschke, Oliver, Busch, Michael, Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Ortiz-Ruiz, Maria-Jesus, Schneider, Richard, Thai, Ching, Valenti, Melanie, de Haven Brandon, Alexis, Burke, Rosemary, Workman, Paul, Dale, Trevor, Wienke, Dirk, Clarke, Paul A, Esdar, Christina, Raynaud, Florence I, Eccles, Suzanne A, Rohdich, Felix, Blagg, Julian

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Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells von Rodgers, Ursula R, Lanyon-Hogg, Thomas, Masumoto, Naoko, Ritzefeld, Markus, Burke, Rosemary, Blagg, Julian, Magee, Anthony I, Tate, Edward W

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Diverse functionalization of Aurora-A kinase at specified surface and buried sites by native chemical modification von Rowan, Fiona, Richards, Meirion, Widya, Marcella, Bayliss, Richard, Blagg, Julian

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Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore von Schiemann, Kai, Mallinger, Aurélie, Wienke, Dirk, Esdar, Christina, Poeschke, Oliver, Busch, Michael, Rohdich, Felix, Eccles, Suzanne A., Schneider, Richard, Raynaud, Florence I., Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Urbahns, Klaus, Blagg, Julian

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Structure-Based Design of Orally Bioavailable 1H‑Pyrrolo[3,2‑c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1) von Naud, Sébastien, Westwood, Isaac M, Faisal, Amir, Sheldrake, Peter, Bavetsias, Vassilios, Atrash, Butrus, Cheung, Kwai-Ming J, Liu, Manjuan, Hayes, Angela, Schmitt, Jessica, Wood, Amy, Choi, Vanessa, Boxall, Kathy, Mak, Grace, Gurden, Mark, Valenti, Melanie, de Haven Brandon, Alexis, Henley, Alan, Baker, Ross, McAndrew, Craig, Matijssen, Berry, Burke, Rosemary, Hoelder, Swen, Eccles, Suzanne A, Raynaud, Florence I, Linardopoulos, Spiros, van Montfort, Rob L. M, Blagg, Julian

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Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor von Whittaker, Steven R., Barlow, Clare, Martin, Mathew P., Mancusi, Caterina, Wagner, Steve, Self, Annette, Barrie, Elaine, Te Poele, Robert, Sharp, Swee, Brown, Nathan, Wilson, Stuart, Jackson, Wayne, Fischer, Peter M., Clarke, Paul A., Walton, Michael I., McDonald, Edward, Blagg, Julian, Noble, Martin, Garrett, Michelle D., Workman, Paul

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A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription von EWAN, Kenneth, PAJAK, Bożena, BATTERSBY, Alysia, RAYNAUD, Florence, ALLEN, Nicholas, WILSON, Stephen, LATINKIC, Branko, WORKMAN, Paul, MCDONALD, Edward, BLAGG, Julian, AHERNE, Wynne, DALE, Trevor, STUBBS, Mark, TODD, Helen, BARBEAU, Olivier, QUEVEDO, Camilo, BOTFIELD, Hannah, YOUNG, Rodrigo, RUDDLE, Ruth, SAMUEL, Lee

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Combining Mutational Signatures, Clonal Fitness, and Drug Affinity to Define Drug-Specific Resistance Mutations in Cancer von Kaserer, Teresa, Blagg, Julian

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Scaffold-Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitors von Langdon, Sarah R, Westwood, Isaac M, van Montfort, Rob L. M, Brown, Nathan, Blagg, Julian

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Potent and Selective Nonpeptidic Inhibitors of Procollagen C-Proteinase von Fish, Paul V, Allan, Gillian A, Bailey, Simon, Blagg, Julian, Butt, Richard, Collis, Michael G, Greiling, Doris, James, Kim, Kendall, Jackie, McElroy, Andrew, McCleverty, Dawn, Reed, Charlotte, Webster, Robert, Whitlock, Gavin A

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Analysis of water patterns in protein kinase binding sites von Barillari, Caterina, Duncan, Anna L., Westwood, Isaac M., Blagg, Julian, van Montfort, Rob L. M.

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Assessing histone demethylase inhibitors in cells: lessons learned von Hatch, Stephanie B., Yapp, Clarence, Montenegro, Raquel C., Savitsky, Pavel, Gamble, Vicki, Tumber, Anthony, Ruda, Gian Filippo, Bavetsias, Vassilios, Fedorov, Oleg, Atrash, Butrus, Raynaud, Florence, Lanigan, Rachel, Carmichael, LeAnne, Tomlin, Kathy, Burke, Rosemary, Westaway, Susan M., Brown, Jack A., Prinjha, Rab K., Martinez, Elisabeth D., Oppermann, Udo, Schofield, Christopher J., Bountra, Chas, Kawamura, Akane, Blagg, Julian, Brennan, Paul E., Rossanese, Olivia, Müller, Susanne

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JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells von Walters, Z S, Villarejo-Balcells, B, Olmos, D, Buist, T W S, Missiaglia, E, Allen, R, Al-Lazikani, B, Garrett, M D, Blagg, J, Shipley, J

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Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14 von Blagg, Julian A., Noe, Mark C., Wolf-Gouveia, Lilli A., Reiter, Lawrence A., Laird, Ellen R., Chang, Shang-Poa P., Danley, Dennis E., Downs, James T., Elliott, Nancy C., Eskra, James D., Griffiths, Richard J., Hardink, Joel R., Haugeto, Amber I., Jones, Christopher S., Liras, Jennifer L., Lopresti-Morrow, Lori L., Mitchell, Peter G., Pandit, Jayvardhan, Robinson, Ralph P., Subramanyam, Chakrapani, Vaughn-Bowser, Marcie L., Yocum, Sue A.

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Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single‐Molecule Spectroscopy von Gilburt, James A. H., Sarkar, Hajrah, Sheldrake, Peter, Blagg, Julian, Ying, Liming, Dodson, Charlotte A.

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Small-molecule targeting of brachyury transcription factor addiction in chordoma von Sharifnia, Tanaz, Wawer, Mathias J., Chen, Ting, Huang, Qing-Yuan, Weir, Barbara A., Sizemore, Ann, Lawlor, Matthew A., Goodale, Amy, Cowley, Glenn S., Vazquez, Francisca, Ott, Christopher J., Francis, Joshua M., Sassi, Slim, Cogswell, Patricia, Sheppard, Hadley E., Zhang, Tinghu, Gray, Nathanael S., Clarke, Paul A., Blagg, Julian, Workman, Paul, Sommer, Josh, Hornicek, Francis, Root, David E., Hahn, William C., Bradner, James E., Wong, Kwok K., Clemons, Paul A., Lin, Charles Y., Kotz, Joanne D., Schreiber, Stuart L.

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Mapping the 3D structures of small molecule binding sites von Meyers, Joshua, Brown, Nathan, Blagg, Julian

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Physicochemical drug properties associated with in vivo toxicological outcomes: a review von Price, David A, Blagg, Julian, Jones, Lyn, Greene, Nigel, Wager, Travis

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