HIV-1 Escape from the CCR5 Antagonist Maraviroc Associated with an Altered and Less-Efficient Mechanism of gp120-CCR5 Engagement That Attenuates Macrophage Tropism von ROCHE, Michael, JAKOBSEN, Martin R, CHURCHILL, Melissa J, GORRY, Paul R, STERJOVSKI, Jasminka, ELLETT, Anne, POSTA, Filippo, LEE, Benhur, JUBB, Becky, WESTBY, Mike, LEWIN, Sharon R, RAMSLAND, Paul A

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Incidence of CXCR4 tropism and CCR5-tropic resistance in treatment-experienced participants receiving maraviroc in the 48-week MOTIVATE 1 and 2 trials von Jubb, Becky, Lewis, Marilyn, McFadyen, Lynn, Simpson, Paul, Mori, Julie, Chan, Phylinda, Weatherley, Barry, van der Ryst, Elna, Westby, Mike, Craig, Charles

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A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations von Roche, Michael, Salimi, Hamid, Duncan, Renee, Wilkinson, Brendan L, Chikere, Kelechi, Moore, Miranda S, Webb, Nicholas E, Zappi, Helena, Sterjovski, Jasminka, Flynn, Jacqueline K, Ellett, Anne, Gray, Lachlan R, Lee, Benhur, Jubb, Becky, Westby, Mike, Ramsland, Paul A, Lewin, Sharon R, Payne, Richard J, Churchill, Melissa J, Gorry, Paul R

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HIV-1 predisposed to acquiring resistance to maraviroc (MVC) and other CCR5 antagonists in vitro has an inherent, low-level ability to utilize MVC-bound CCR5 for entry von Roche, Michael, Jakobsen, Martin R, Ellett, Anne, Salimiseyedabad, Hamid, Jubb, Becky, Westby, Mike, Lee, Benhur, Lewin, Sharon R, Churchill, Melissa J, Gorry, Paul R

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Analysis of Clinical HIV-1 Strains with Resistance to Maraviroc Reveals Strain-Specific Resistance Mutations, Variable Degrees of Resistance, and Minimal Cross-Resistance to Other... von Flynn, Jacqueline K, Ellenberg, Paula, Duncan, Renee, Ellett, Anne, Zhou, Jingling, Sterjovski, Jasminka, Cashin, Kieran, Borm, Katharina, Gray, Lachlan R, Lewis, Marilyn, Jubb, Becky, Westby, Mike, Lee, Benhur, Lewin, Sharon R, Churchill, Melissa, Roche, Michael, Gorry, Paul R

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The magnitude of HIV-1 resistance to the CCR5 antagonist maraviroc may impart a differential alteration in HIV-1 tropism for macrophages and T-cell subsets von Flynn, Jacqueline K, Paukovics, Geza, Moore, Miranda S, Ellett, Anne, Gray, Lachlan R, Duncan, Renee, Salimi, Hamid, Jubb, Becky, Westby, Mike, Purcell, Damian F.J, Lewin, Sharon R, Lee, Benhur, Churchill, Melissa J, Gorry, Paul R, Roche, Michael

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Investigating HIV-1 Resistance to CCR5 Antagonist Maraviroc for the Design of New Prevention Strategies von Flynn, Jacqueline K., Roche, Michael, Paukovics, Geza, Salimi, Hamid, Duncan, Renee C., Moore, Miranda S., Ellet, Anne, Gray, Lachlan R., Jubb, Becky, Westby, Mike, Purcell, Damian F. J., Lewin, Sharon R., Lee, Benhur, Payne, Richard J, Churchill, Melissa J., Gorry, Paul R.

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A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations von Roche, Michael, Salimi, Hamid, Duncan, Renee, Wilkinson, Brendan L, Chikere, Kelechi, Moore, Miranda S, Webb, Nicholas E, Zappi, Helena, Sterjovski, Jasminka, Flynn, Jacqueline K, Ellett, Anne, Gray, Lachlan R, Lee, Benhur, Jubb, Becky, Westby, Mike, Ramsland, Paul A, Lewin, Sharon R, Payne, Richard J, Churchull, Melissa J, Gorry, Paul R

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