MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants von SUMMA, Vincenzo, LUDMERER, Steven W, GATES, Adam T, GRAHAM, Donald J, HARPER, Steven, HAZUDA, Daria J, MCHALE, Carolyn, MONTEAGUDO, Edith, PUCCI, Vincenzo, ROWLEY, Michael, RUDD, Michael T, SORIANO, Aileen, MCCAULEY, John A, STAHLHUT, Mark W, VACCA, Joseph P, OLSEN, David B, LIVERTON, Nigel J, CARROLL, Steven S, FANDOZZI, Christine, BURLEIN, Christine, CLAUDIO, Giuliano, COLEMAN, Paul J, DIMUZIO, Jillian M, FERRARA, Marco, DI FILIPPO, Marcello

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Discovery of MK-8742: An HCV NS5A Inhibitor with Broad Genotype Activity von Coburn, Craig A., Meinke, Peter T., Chang, Wei, Fandozzi, Christine M., Graham, Donald J., Hu, Bin, Huang, Qian, Kargman, Stacia, Kozlowski, Joseph, Liu, Rong, McCauley, John A., Nomeir, Amin A., Soll, Richard M., Vacca, Joseph P., Wang, Dahai, Wu, Hao, Zhong, Bin, Olsen, David B., Ludmerer, Steven W.

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Discovery of KB-0742, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of CDK9 for MYC-Dependent Cancers von Freeman, David B., Hopkins, Tamara D., Mikochik, Peter J., Vacca, Joseph P., Gao, Hua, Naylor-Olsen, Adel, Rudra, Sonali, Li, Huixu, Pop, Marius S., Villagomez, Rosa A., Lee, Christina, Li, Heng, Zhou, Minyun, Saffran, Douglas C., Rioux, Nathalie, Hood, Tressa R., Day, Melinda A. L., McKeown, Michael R., Lin, Charles Y., Bischofberger, Norbert, Trotter, B. Wesley

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Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor von McCauley, John A, McIntyre, Charles J, Rudd, Michael T, Nguyen, Kevin T, Romano, Joseph J, Butcher, John W, Gilbert, Kevin F, Bush, Kimberly J, Holloway, M. Katharine, Swestock, John, Wan, Bang-Lin, Carroll, Steven S, DiMuzio, Jillian M, Graham, Donald J, Ludmerer, Steven W, Mao, Shi-Shan, Stahlhut, Mark W, Fandozzi, Christine M, Trainor, Nicole, Olsen, David B, Vacca, Joseph P, Liverton, Nigel J

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MK-7009, a Potent and Selective Inhibitor of Hepatitis C Virus NS3/4A Protease von LIVERTON, Nigel J, CARROLL, Steven S, OLSEN, David B, RUDD, Michael T, STAHLHUT, Mark, VACCA, Joseph P, DIMUZIO, Jillian, FANDOZZI, Christine, GRAHAM, Donald J, HAZUDA, Daria, KATHERINE HOLLOWAY, M, LUDMERER, Steven W, MCCAULEY, John A, MCINTYRE, Charles J

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Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor von Harper, Steven, McCauley, John A, Rudd, Michael T, Ferrara, Marco, DiFilippo, Marcello, Crescenzi, Benedetta, Koch, Uwe, Petrocchi, Alessia, Holloway, M. Katharine, Butcher, John W, Romano, Joseph J, Bush, Kimberly J, Gilbert, Kevin F, McIntyre, Charles J, Nguyen, Kevin T, Nizi, Emanuela, Carroll, Steven S, Ludmerer, Steven W, Burlein, Christine, DiMuzio, Jillian M, Graham, Donald J, McHale, Carolyn M, Stahlhut, Mark W, Olsen, David B, Monteagudo, Edith, Cianetti, Simona, Giuliano, Claudio, Pucci, Vincenzo, Trainor, Nicole, Fandozzi, Christine M, Rowley, Michael, Coleman, Paul J, Vacca, Joseph P, Summa, Vincenzo, Liverton, Nigel J

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Design and Synthesis of 8-Hydroxy-[1,6]Naphthyridines as Novel Inhibitors of HIV-1 Integrase in Vitro and in Infected Cells von Zhuang, Linghang, Wai, John S, Embrey, Mark W, Fisher, Thorsten E, Egbertson, Melissa S, Payne, Linda S, Guare, James P, Vacca, Joseph P, Hazuda, Daria J, Felock, Peter J, Wolfe, Abigail L, Stillmock, Kara A, Witmer, Marc V, Moyer, Gregory, Schleif, William A, Gabryelski, Lori J, Leonard, Yvonne M, Lynch, Joseph J, Michelson, Stuart R, Young, Steven D

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Molecular Modeling Based Approach to Potent P2−P4 Macrocyclic Inhibitors of Hepatitis C NS3/4A Protease von Liverton, Nigel J, Holloway, M. Katharine, McCauley, John A, Rudd, Michael T, Butcher, John W, Carroll, Steven S, DiMuzio, Jillian, Fandozzi, Christine, Gilbert, Kevin F, Mao, Shi-Shan, McIntyre, Charles J, Nguyen, Kevin T, Romano, Joseph J, Stahlhut, Mark, Wan, Bang-Lin, Olsen, David B, Vacca, Joseph P

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Integrase Inhibitors and Cellular Immunity Suppress Retroviral Replication in Rhesus Macaques von Hazuda, Daria J., Young, Steven D., Guare, James P., Anthony, Neville J., Gomez, Robert P., Wai, John S., Vacca, Joseph P., Handt, Larry, Motzel, Sherri L., Klein, Hilton J., Dornadula, Geethanjali, Danovich, Robert M., Witmer, Marc V., Keith A. A. Wilson, Tussey, Lynda, Schleif, William A., Gabryelski, Lori S., Jin, Lixia, Miller, Michael D., Casimiro, Danilo R., Emini, Emilio A., Shiver, John W.

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Potent, Orally Bioavailable Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine:  Discovery of N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1- (2,2,2-trif... von Paone, Daniel V, Shaw, Anthony W, Nguyen, Diem N, Burgey, Christopher S, Deng, James Z, Kane, Stefanie A, Koblan, Kenneth S, Salvatore, Christopher A, Mosser, Scott D, Johnston, Victor K, Wong, Bradley K, Miller-Stein, Cynthia M, Hershey, James C, Graham, Samuel L, Vacca, Joseph P, Williams, Theresa M

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Discovery of 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Tra... von Tucker, Thomas J, Sisko, John T, Tynebor, Robert M, Williams, Theresa M, Felock, Peter J, Flynn, Jessica A, Lai, Ming-Tain, Liang, Yuexia, McGaughey, Georgia, Liu, Meiquing, Miller, Mike, Moyer, Gregory, Munshi, Vandna, Perlow-Poehnelt, Rebecca, Prasad, Sridhar, Reid, John C, Sanchez, Rosa, Torrent, Maricel, Vacca, Joseph P, Wan, Bang-Lin, Yan, Youwei

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Approaches Toward New Alzheimer's Treatments von Vacca, Joseph P

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Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human β-Secretase (BACE-1) von Stachel, Shawn J, Coburn, Craig A, Steele, Thomas G, Jones, Kristen G, Loutzenhiser, Elizabeth F, Gregro, Alison R, Rajapakse, Hemaka A, Lai, Ming-Tain, Crouthamel, Ming-Chih, Xu, Min, Tugusheva, Katherine, Lineberger, Janet E, Pietrak, Beth L, Espeseth, Amy S, Shi, Xiao-Ping, Chen-Dodson, Elizabeth, Holloway, M. Katharine, Munshi, Sanjeev, Simon, Adam J, Kuo, Lawrence, Vacca, Joseph P

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Raltegravir: the first HIV-1 integrase strand transfer inhibitor in the HIV armamentarium von Nguyen, Bach-Yen T., Isaacs, Robin D., Teppler, Hedy, Leavitt, Randi Y., Sklar, Peter, Iwamoto, Marian, Wenning, Larissa A., Miller, Michael D., Chen, Joshua, Kemp, Ramon, Xu, Wei, Fromtling, Robert A., Vacca, Joseph P., Young, Steven D., Rowley, Michael, Lower, Michael W., Gottesdiener, Keith M., Hazuda, Daria J.

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Diketo Acid Inhibitor Mechanism and HIV-1 Integrase: Implications for Metal Binding in the Active Site of Phosphotransferase Enzymes von Grobler, Jay A., Stillmock, Kara, Hu, Binghua, Witmer, Marc, Felock, Peter, Espeseth, Amy S., Wolfe, Abigail, Egbertson, Melissa, Bourgeois, Michele, Melamed, Jeffrey, Wai, John S., Young, Steve, Vacca, Joseph, Hazuda, Daria J.

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Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist von Salvatore, Christopher A, Moore, Eric L, Calamari, Amy, Cook, Jacquelynn J, Michener, Maria S, O'Malley, Stacey, Miller, Patricia J, Sur, Cyrille, Williams, Jr, David L, Zeng, Zhizhen, Danziger, Andrew, Lynch, Joseph J, Regan, Christopher P, Fay, John F, Tang, Yui S, Li, Chi-Chung, Pudvah, Nicole T, White, Rebecca B, Bell, Ian M, Gallicchio, Steven N, Graham, Samuel L, Selnick, Harold G, Vacca, Joseph P, Kane, Stefanie A

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First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman prim... von Sankaranarayanan, Sethu, Holahan, Marie A, Colussi, Dennis, Crouthamel, Ming-Chih, Devanarayan, Viswanath, Ellis, Joan, Espeseth, Amy, Gates, Adam T, Graham, Samuel L, Gregro, Allison R, Hazuda, Daria, Hochman, Jerome H, Holloway, Katharine, Jin, Lixia, Kahana, Jason, Lai, Ming-tain, Lineberger, Janet, McGaughey, Georgia, Moore, Keith P, Nantermet, Philippe, Pietrak, Beth, Price, Eric A, Rajapakse, Hemaka, Stauffer, Shaun, Steinbeiser, Melissa A, Seabrook, Guy, Selnick, Harold G, Shi, Xiao-Ping, Stanton, Matthew G, Swestock, John, Tugusheva, Katherine, Tyler, Keala X, Vacca, Joseph P, Wong, Jacky, Wu, Guoxin, Xu, Min, Cook, Jacquelynn J, Simon, Adam J

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Design and Synthesis of Conformationally Constrained Inhibitors of Non-Nucleoside Reverse Transcriptase von Gomez, Robert, Jolly, Samson J, Williams, Theresa, Vacca, Joseph P, Torrent, Maricel, McGaughey, Georgia, Lai, Ming-Tain, Felock, Peter, Munshi, Vandna, DiStefano, Daniel, Flynn, Jessica, Miller, Mike, Yan, Youwei, Reid, John, Sanchez, Rosa, Liang, Yuexia, Paton, Brenda, Wan, Bang-Lin, Anthony, Neville

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Discovery of a potent and selective small molecule hGPR91 antagonist von Bhuniya, Debnath, Umrani, Dhananjay, Dave, Bhavesh, Salunke, Deepak, Kukreja, Gagan, Gundu, Jayasagar, Naykodi, Minakshi, Shaikh, Nadim S., Shitole, Prasad, Kurhade, Santosh, De, Siddhartha, Majumdar, Sreemita, Reddy, Srinivasa B., Tambe, Suhas, Shejul, Yogesh, Chugh, Anita, Palle, Venkata P., Mookhtiar, Kasim A., Cully, Doris, Vacca, Joseph, Chakravarty, Prasun K., Nargund, Ravi P., Wright, Samuel D., Graziano, Michael P., Singh, Sheo B., Roy, Sophie, Cai, Tian-Quan

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New advances in the discovery of thrombin and factor Xa inhibitors von Vacca, Joseph P

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