Targeting cancer metabolism in the era of precision oncology von Stine, Zachary E., Schug, Zachary T., Salvino, Joseph M., Dang, Chi V.

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Elevated pre-mRNA 3′ end processing activity in cancer cells renders vulnerability to inhibition of cleavage and polyadenylation von Cui, Yange, Wang, Luyang, Ding, Qingbao, Shin, Jihae, Cassel, Joel, Liu, Qin, Salvino, Joseph M., Tian, Bin

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The Natural Stilbenoid (–)-Hopeaphenol Inhibits Cellular Entry of SARS-CoV-2 USA-WA1/2020, B.1.1.7, and B.1.351 Variants von Tietjen, Ian, Cassel, Joel, Register, Emery T, Zhou, Xiang Yang, Messick, Troy E, Keeney, Frederick, Lu, Lily D, Beattie, Karren D, Rali, Topul, Tebas, Pablo, Ertl, Hildegund C. J, Salvino, Joseph M, Davis, Rohan A, Montaner, Luis J

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Increased glucose availability sensitizes pancreatic cancer to chemotherapy von Vaziri-Gohar, Ali, Hue, Jonathan J., Abbas, Ata, Graor, Hallie J., Hajihassani, Omid, Zarei, Mehrdad, Titomihelakis, George, Feczko, John, Rathore, Moeez, Chelstowska, Sylwia, Loftus, Alexander W., Wang, Rui, Zarei, Mahsa, Goudarzi, Maryam, Zhang, Renliang, Willard, Belinda, Zhang, Li, Kresak, Adam, Willis, Joseph E., Wang, Gi-Ming, Tatsuoka, Curtis, Salvino, Joseph M., Bederman, Ilya, Brunengraber, Henri, Lyssiotis, Costas A., Brody, Jonathan R., Winter, Jordan M.

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Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells von Shen, Fei, Zhang, Yun, Jernigan, Danielle L, Feng, Xin, Yan, Jie, Garcia, Fernando U, Meucci, Olimpia, Salvino, Joseph M, Fatatis, Alessandro

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Recent Advances in Metal-Catalyzed Approaches for the Synthesis of Quinazoline Derivatives von Nandwana, Nitesh K, Patel, Om P S, Mehra, Manish K, Kumar, Anil, Salvino, Joseph M

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Knowledge Based Prediction of Ligand Binding Modes and Rational Inhibitor Design for Kinase Drug Discovery von Ghose, Arup K, Herbertz, Torsten, Pippin, Douglas A, Salvino, Joseph M, Mallamo, John P

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A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors von Barnoud, Thibaut, Leung, Jessica C, Leu, Julia I-Ju, Basu, Subhasree, Poli, Adi Narayana Reddy, Parris, Joshua L D, Indeglia, Alexandra, Martynyuk, Tetyana, Good, Madeline, Gnanapradeepan, Keerthana, Sanseviero, Emilio, Moeller, Rebecca, Tang, Hsin-Yao, Cassel, Joel, Kossenkov, Andrew V, Liu, Qin, Speicher, David W, Gabrilovich, Dmitry I, Salvino, Joseph M, George, Donna L, Murphy, Maureen E

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Small molecule perturbation of the CAND1-Cullin1-ubiquitin cycle stabilizes p53 and triggers Epstein-Barr virus reactivation von Tikhmyanova, Nadezhda, Tutton, Steve, Martin, Kayla A, Lu, Fang, Kossenkov, Andrew V, Paparoidamis, Nicholas, Kenney, Shannon, Salvino, Joseph M, Lieberman, Paul M

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Identification of Novel Allosteric Modulators of Glutamate Transporter EAAT2 von Kortagere, Sandhya, Mortensen, Ole V, Xia, Jingsheng, Lester, William, Fang, Yuhong, Srikanth, Yellamelli, Salvino, Joseph M, Fontana, Andréia C. K

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Elucidation of the Structure and Synthesis of Neuroprotective Low Molecular Mass Components of the Parawixia bistriata Spider Venom von Forster, Yvonne M, Green, Jennifer Leigh, Khatiwada, Apeksha, Liberato, José Luiz, Narayana Reddy, Poli Adi, Salvino, Joseph M, Bienz, Stefan, Bigler, Laurent, Dos Santos, Wagner Ferreira, Karklin Fontana, Andréia Cristina

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Functional Characterization of the Dopaminergic Psychostimulant Sydnocarb as an Allosteric Modulator of the Human Dopamine Transporter von Aggarwal, Shaili, Cheng, Mary Hongying, Salvino, Joseph M, Bahar, Ivet, Mortensen, Ole Valente

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Targeted MDM2 Degradation Reveals a New Vulnerability for p53-Inactivated Triple-Negative Breast Cancer von Adams, Clare M, Mitra, Ramkrishna, Xiao, Youcai, Michener, Peter, Palazzo, Juan, Chao, Allen, Gour, Jitendra, Cassel, Joel, Salvino, Joseph M, Eischen, Christine M

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The In-Cell Western immunofluorescence assay to monitor PROTAC mediated protein degradation von Lu, Lily D, Salvino, Joseph M

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Selective inhibition of Ph-positive ALL cell growth through kinase-dependent and -independent effects by CDK6-specific PROTACs von De Dominici, Marco, Porazzi, Patrizia, Xiao, Youcai, Chao, Allen, Tang, Hsin-Yao, Kumar, Gaurav, Fortina, Paolo, Spinelli, Orietta, Rambaldi, Alessandro, Peterson, Luke F., Petruk, Svetlana, Barletta, Camilla, Mazo, Alexander, Cingolani, Gino, Salvino, Joseph M., Calabretta, Bruno

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Rapid Optimization of the Metabolic Stability of a Human Immunodeficiency Virus Type‑1 Capsid Inhibitor Using a Multistep Computational Workflow von Meuser, Megan E, Reddy, Poli Adi Narayana, Dick, Alexej, Maurancy, Jean Marc, Salvino, Joseph M, Cocklin, Simon

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Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth von Miller, Katelyn D, Pniewski, Katherine, Perry, Caroline E, Papp, Sara B, Shaffer, Joshua D, Velasco-Silva, Jesse N, Casciano, Jessica C, Aramburu, Tomas M, Srikanth, Yellamelli V V, Cassel, Joel, Skordalakes, Emmanuel, Kossenkov, Andrew V, Salvino, Joseph M, Schug, Zachary T

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IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance von Singh, Kumar Sachin, Sharma, Rishabh, Reddy, Poli Adi Narayana, Vonteddu, Prashanthi, Good, Madeline, Sundarrajan, Anjana, Choi, Hyeree, Muthumani, Kar, Kossenkov, Andrew, Goldman, Aaron R, Tang, Hsin-Yao, Totrov, Maxim, Cassel, Joel, Murphy, Maureen E, Somasundaram, Rajasekharan, Herlyn, Meenhard, Salvino, Joseph M, Dotiwala, Farokh

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Metabolic control of BRISC–SHMT2 assembly regulates immune signalling von Walden, Miriam, Tian, Lei, Ross, Rebecca L., Sykora, Upasana M., Byrne, Dominic P., Hesketh, Emma L., Masandi, Safi K., Cassel, Joel, George, Rachel, Ault, James R., El Oualid, Farid, Pawłowski, Krzysztof, Salvino, Joseph M., Eyers, Patrick A., Ranson, Neil A., Del Galdo, Francesco, Greenberg, Roger A., Zeqiraj, Elton

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Knowledge-based chemoinformatic approaches to drug discovery von Ghose, Arup K., Herbertz, Torsten, Salvino, Joseph M., Mallamo, John P.

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