Evolution of Cereblon-Mediated Protein Degradation as a Therapeutic Modality von Chamberlain, Philip P, D’Agostino, Laura A, Ellis, J. Michael, Hansen, Joshua D, Matyskiela, Mary E, McDonald, Joseph J, Riggs, Jennifer R, Hamann, Lawrence G

Volltext

Discovery of Potent Inhibitors of Soluble Epoxide Hydrolase by Combinatorial Library Design and Structure-Based Virtual Screening von Xing, Li, McDonald, Joseph J, Kolodziej, Steve A, Kurumbail, Ravi G, Williams, Jennifer M, Warren, Chad J, O’Neal, Janet M, Skepner, Jill E, Roberds, Steven L

Volltext

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents von Kurumbail, Ravi G, Stevens, Anna M, Gierse, James K, McDonald, Joseph J, Stegeman, Roderick A, Pak, Jina Y, Gildehaus, Daniel, iyashiro, Julie M, Penning, Thomas D, Seibert, Karen, Isakson, Peter C, Stallings, William C

Volltext

Molecular Dynamics Analysis of Binding of Kinase Inhibitors to WT EGFR and the T790M Mutant von Park, Jiyong, McDonald, Joseph J, Petter, Russell C, Houk, K. N

Volltext

Discovery of CC-99677, a selective targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune disorders von Malona, JOHN, CHUAQUI, CLAUDIO, SELETSKY, BORIS M., BEEBE, LISA, CANTIN, SUSAN, KALKEN, DANIEL VAN, FAHNOE, KELLY, WANG, ZHIGANG, BROWNING, BETH, SZABO, HILARY, KOOPMAN, LOUISE A., ORAVECZ, TAMAS, MCDONALD, JOSEPH J., RAMIREZ-VALLE, FRANCISCO, GAUR, RAJULA, MENSAH, KOFI A., THOMAS, MICHAEL, CONNARN, JAMIE N., HU, HAIQING, ALEXANDER, MATTHEW D., CORIN, ALAN F.

Volltext

Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma von Liu, Haibo, Niu, Deqiang, Tham Sjin, Robert Tjin, Dubrovskiy, Alex, Zhu, Zhendong, McDonald, Joseph J, Fahnoe, Kelly, Wang, Zhigang, Munson, Mark, Scholte, Andrew, Barrague, Matthieu, Fitzgerald, Maria, Liu, Jinyu, Kothe, Michael, Sun, Fangxian, Murtie, Joshua, Ge, Jie, Rocnik, Jennifer, Harvey, Darren, Ospina, Beatriz, Perron, Keli, Zheng, Gang, Shehu, Elvis, D’Agostino, Laura Akullian

Volltext

Orally Active MMP-1 Sparing α-Tetrahydropyranyl and α-Piperidinyl Sulfone Matrix Metalloproteinase (MMP) Inhibitors with Efficacy in Cancer, Arthritis, and Cardiovascular Disease von Becker, Daniel P, Barta, Thomas E, Bedell, Louis J, Boehm, Terri L, Bond, Brian R, Carroll, Jeffery, Carron, Chris P, DeCrescenzo, Gary A, Easton, Alan M, Freskos, John N, Funckes-Shippy, Chris L, Heron, Marcia, Hockerman, Susan, Howard, Carol Pearcy, Kiefer, James R, Li, Madeleine H, Mathis, Karl J, McDonald, Joseph J, Mehta, Pramod P, Munie, Grace E, Sunyer, Teresa, Swearingen, Craig A, Villamil, Clara I, Welsch, Dean, Williams, Jennifer M, Yu, Ying, Yao, Jun

Volltext

Correlative neuroanatomy von McDonald, Joseph J., 1913-1967

Volltext bestellen

Assessment of Docking Poses:  Interactions-Based Accuracy Classification (IBAC) versus Crystal Structure Deviations von Kroemer, Romano T, Vulpetti, Anna, McDonald, Joseph J, Rohrer, Douglas C, Trosset, Jean-Yves, Giordanetto, Fabrizio, Cotesta, Simona, McMartin, Colin, Kihlén, Mats, Stouten, Pieter F. W

Volltext

MMP-13 selective isonipecotamide α-sulfone hydroxamates von Kolodziej, Stephen A., Hockerman, Susan L., DeCrescenzo, Gary A., McDonald, Joseph J., Mischke, Debbie A., Munie, Grace E., Fletcher, Theresa R., Stehle, Nathan, Swearingen, Craig, Becker, Daniel P.

Volltext

Orally bioavailable dual MMP-1/MMP-14 sparing, MMP-13 selective α-sulfone hydroxamates von Kolodziej, Stephen A., Hockerman, Susan L., Boehm, Terri L., Carroll, Jeffery N., DeCrescenzo, Gary A., McDonald, Joseph J., Mischke, Debbie A., Munie, Grace E., Fletcher, Theresa R., Rico, Joseph G., Stehle, Nathan W., Swearingen, Craig, Becker, Daniel P.

Volltext

Synthesis and Structure−Activity Relationships of β- and α-Piperidine Sulfone Hydroxamic Acid Matrix Metalloproteinase Inhibitors with Oral Antitumor Efficacy von Becker, Daniel P, Villamil, Clara I, Barta, Thomas E, Bedell, Louis J, Boehm, Terri L, DeCrescenzo, Gary A, Freskos, John N, Getman, Daniel P, Hockerman, Susan, Heintz, Robert, Howard, Susan Carol, Li, Madeleine H, McDonald, Joseph J, Carron, Chris P, Funckes-Shippy, Chris L, Mehta, Pramod P, Munie, Grace E, Swearingen, Craig A

Volltext

Design of potent inhibitors of human β-secretase. Part 1 von Freskos, John N., Fobian, Yvette M., Benson, Timothy E., Bienkowski, Michael J., Brown, David L., Emmons, Thomas L., Heintz, Robert, Laborde, Alice, McDonald, Joseph J., Mischke, Brent V., Molyneaux, John M., Moon, Joseph B., Mullins, Patrick B., Bryan Prince, D., Paddock, Donna J., Tomasselli, Alfredo G., Winterrowd, Gregory

Volltext

Discovery of novel benzothiazolesulfonamides as potent inhibitors of HIV-1 protease von Nagarajan, Srinivasan R, De Crescenzo, Gary A, Getman, Daniel P, Lu, Hwang-Fun, Sikorski, James A, Walker, Jeffrey L, McDonald, Joseph J, Houseman, Kathryn A, Kocan, Geralyn P, Kishore, Nandini, Mehta, Pramod P, Funkes-Shippy, Christie L, Blystone, Lisa

Volltext

Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor von Feng, Yiqing, Likos, John J, Zhu, Leiming, Woodward, Harold, Munie, Grace, McDonald, Joseph J, Stevens, Anna M, Howard, Carol P, De Crescenzo, Gary A, Welsch, Dean, Shieh, Huey-Sheng, Stallings, William C

Volltext

Design of potent inhibitors of human β-secretase. Part 2 von Freskos, John N., Fobian, Yvette M., Benson, Timothy E., Moon, Joseph B., Bienkowski, Michael J., Brown, David L., Emmons, Thomas L., Heintz, Robert, Laborde, Alice, McDonald, Joseph J., Mischke, Brent V., Molyneaux, John M., Mullins, Patrick B., Bryan Prince, D., Paddock, Donna J., Tomasselli, Alfredo G., Winterrowd, Greg

Volltext

Correlative neuroanatomy and functional neurology. by Joseph G. Chusid [and] Joseph J. McDonald von McDonald, Joseph J., 1913-1967

Volltext bestellen

Homo-timeric structural model of human microsomal prostaglandin E synthase-1 and characterization of its substrate/inhibitor binding interactions von Xing, Li, Kurumbail, Ravi G., Frazier, Ronald B., Davies, Michael S., Fujiwara, Hideji, Weinberg, Robin A., Gierse, James K., Caspers, Nicole, Carter, Jeffrey S., McDonald, Joseph J., Moore, William M., Vazquez, Michael L.

Volltext

A Single Amino Acid Difference between Cyclooxygenase-1 (COX-1) and −2 (COX-2) Reverses the Selectivity of COX-2 Specific Inhibitors von Gierse, J K, McDonald, J J, Hauser, S D, Rangwala, S H, Koboldt, C M, Seibert, K

Volltext

Correlative neuroanatomy and functional neurology, by Joseph G. Chusid [and] Joseph J. McDonald von McDonald, Joseph J., 1913-1967

Volltext bestellen