GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease von Wang, Dongdong, Day, Emily A., Townsend, Logan K., Djordjevic, Djordje, Jørgensen, Sebastian Beck, Steinberg, Gregory R.

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GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand von Yang, Linda, Chang, Chih-Chuan, Sun, Zhe, Madsen, Dennis, Zhu, Haisun, Padkjær, Søren B, Wu, Xiaoai, Huang, Tao, Hultman, Karin, Paulsen, Sarah J, Wang, Jishu, Bugge, Anne, Frantzen, Jane Boesen, Nørgaard, Per, Jeppesen, Jacob Fuglsbjerg, Yang, Zhiru, Secher, Anna, Chen, Haibin, Li, Xun, John, Linu Mary, Shan, Bing, He, Zhenhua, Gao, Xiang, Su, Jing, Hansen, Kristian T, Yang, Wei, Jørgensen, Sebastian Beck

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GFRAL-expressing neurons suppress food intake via aversive pathways von Sabatini, Paul V., Frikke-Schmidt, Henriette, Arthurs, Joe, Gordian, Desiree, Patel, Anita, Rupp, Alan C., Adams, Jessica M., Wang, Jine, Jørgensen, Sebastian Beck, Olson, David P., Palmiter, Richard D., Myers, Martin G., Seeley, Randy J.

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Activation of the hypothalamic–pituitary–adrenal axis by exogenous and endogenous GDF15 von Cimino, Irene, Kim, Hanna, Tung, Y. C. Loraine, Pedersen, Kent, Rimmington, Debra, Tadross, John A., Kohnke, Sara N., Neves-Costa, Ana, Barros, André, Joaquim, Stephanie, Bennett, Don, Melvin, Audrey, Lockhart, Samuel M., Rostron, Anthony J., Scott, Jonathan, Liu, Hui, Burling, Keith, Barker, Peter, Clatworthy, Menna R., Lee, E-Chiang, Simpson, A. John, Yeo, Giles S. H., Moita, Luís F., Bence, Kendra K., Jørgensen, Sebastian Beck, Coll, Anthony P., Breen, Danna M., O’Rahilly, Stephen

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Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity von BECK JORGENSEN, Sebastian, O'NEILL, Hayley M, DER POEL, Chris Van, TROUNCE, Ian A, LYNCH, Gordon S, SCHERTZER, Jonathan D, STEINBERG, Gregory R, SYLOW, Lykke, HONEYMAN, Jane, HEWITT, Kimberly A, PALANIVEL, Rengasamy, FULLERTON, Morgan D, ÖBERG, Lisa, BALENDRAN, Anudharan, GALIC, Sandra

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The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract von Tsai, Vicky Wang-Wei, Manandhar, Rakesh, Jørgensen, Sebastian Beck, Lee-Ng, Ka Ki Michelle, Zhang, Hong Ping, Marquis, Christopher Peter, Jiang, Lele, Husaini, Yasmin, Lin, Shu, Sainsbury, Amanda, Sawchenko, Paul E, Brown, David A, Breit, Samuel N

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Growth differentiation factor 15 alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy von Chan, Jordan S.F., Tabatabaei Dakhili, Seyed Amirhossein, Lorenzana-Carrillo, Maria Areli, Gopal, Keshav, Pulente, Serena M., Greenwell, Amanda A., Yang, Kunyan, Saed, Christina T., Stenlund, Magnus J., Ferrari, Sally R., Mangra-Bala, Indiresh A., Shafaati, Tanin, Bhat, Rakesh K., Eaton, Farah, Overduin, Michael, Jørgensen, Sebastian Beck, Steinberg, Gregory R., Mulvihill, Erin E., Sutendra, Gopinath, Ussher, John R.

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AMPK-independent pathways regulate skeletal muscle fatty acid oxidation von Dzamko, Nicolas, Schertzer, Jonathan D., Ryall, James G., Steel, Rohan, Macaulay, S. Lance, Wee, Sheena, Chen, Zhi‐Ping, Michell, Belinda J., Oakhill, Jonathan S., Watt, Matthew J., Jørgensen, Sebastian Beck, Lynch, Gordon S., Kemp, Bruce E., Steinberg, Gregory R.

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TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator von Tsai, Vicky Wang-Wei, Macia, Laurence, Johnen, Heiko, Kuffner, Tamara, Manadhar, Rakesh, Jørgensen, Sebastian Beck, Lee-Ng, Ka Ki Michelle, Zhang, Hong Ping, Wu, Liyun, Marquis, Christopher Peter, Jiang, Lele, Husaini, Yasmin, Lin, Shu, Herzog, Herbert, Brown, David A, Sainsbury, Amanda, Breit, Samuel N

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GDF15 promotes weight loss by enhancing energy expenditure in muscle von Wang, Dongdong, Townsend, Logan K., DesOrmeaux, Geneviève J., Frangos, Sara M., Batchuluun, Battsetseg, Dumont, Lauralyne, Kuhre, Rune Ehrenreich, Ahmadi, Elham, Hu, Sumei, Rebalka, Irena A., Gautam, Jaya, Jabile, Maria Joy Therese, Pileggi, Chantal A., Rehal, Sonia, Desjardins, Eric M., Tsakiridis, Evangelia E., Lally, James S. V., Juracic, Emma Sara, Tupling, A. Russell, Gerstein, Hertzel C., Paré, Guillaume, Tsakiridis, Theodoros, Harper, Mary-Ellen, Hawke, Thomas J., Speakman, John R., Blondin, Denis P., Holloway, Graham P., Jørgensen, Sebastian Beck, Steinberg, Gregory R.

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Ciliary Neurotrophic Factor Stimulates Muscle Glucose Uptake by a PI3-Kinase–Dependent Pathway That Is Impaired With Obesity von Steinberg, Gregory R, Watt, Matthew J, Ernst, Matthias, Birnbaum, Morris J, Kemp, Bruce E, Jørgensen, Sebastian Beck

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Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocation von Jorgensen, Sebastian Beck, Honeyman, Jane, Oakhill, Jonathan S, Fazakerley, Daniel, Stockli, Jacqueline, Kemp, Bruce E, Steinberg, Gregory R

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Central regulation of the anorexigenic receptor GFRAL von Jørgensen, Sebastian Beck, Tang-Christensen, Mads

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Plasma GDF15 levels are similar between subjects after bariatric surgery and matched controls and are unaffected by meals von Martinussen, Christoffer, Svane, Maria Saur, Bojsen-Møller, Kirstine N., Jensen, Christian Zinck, Kristiansen, Viggo B., Bookout, Angie Lynn, Jørgensen, Sebastian Beck, Holst, Jens Juul, Wewer Albrechtsen, Nicolai J., Madsbad, Sten, Kuhre, Rune Ehrenreich

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AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance von Dzamko, Nicolas, van Denderen, Bryce J.W., Hevener, Andrea L., Jørgensen, Sebastian Beck, Honeyman, Jane, Galic, Sandra, Chen, Zhi-Ping, Watt, Matthew J., Campbell, Duncan J., Steinberg, Gregory R., Kemp, Bruce E.

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Circulating and hepatic levels of growth differentiation factor 15 in patients with metabolic dysfunction‐associated steatotic liver disease von Werge, Mikkel Parsberg, Grandt, Josephine, Thing, Mira, Hetland, Liv Eline, Rashu, Elias Badal, Jensen, Anne‐Sofie Houlberg, Junker, Anders Ellekær, Richter, Michael Martin, Møller, Søren, Bendtsen, Flemming, Harder, Lea Mørch, Mazzoni, Gianluca, Viuff, Birgitte Martine, Hvid, Henning, Prada‐Medina, Cesar Augusto, Jørgensen, Sebastian Beck, Bendtsen, Kristian Moss, Kildegaard, Jonas, Vyberg, Mogens, Serizawa, Reza, Galsgaard, Elisabeth Douglas, Wewer Albrechtsen, Nicolai Jacob, Gluud, Lise Lotte

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GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism von Sjøberg, Kim A, Sigvardsen, Casper M, Alvarado-Diaz, Abdiel, Andersen, Nicoline Resen, Larance, Mark, Seeley, Randy J, Schjerling, Peter, Knudsen, Jakob G, Katzilieris-Petras, Georgios, Clemmensen, Christoffer, Jørgensen, Sebastian Beck, De Bock, Katrien, Richter, Erik A

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THERAPEUTIC DERIVATIVES OF INTERLEUKIN-22 von JORGENSEN, SEBASTIAN BECK, THOGERSEN, HENNING, JORGENSEN, RASMUS, SANDRINI, MICHAEL PAOLO BASTNER, SASS-ORUM, KRISTIAN

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Ciliary Neurotrophic Factor Stimulates Muscle Glucose Uptake by a PI3-Kinase-Depeudeut Pathway That Is Impaired With Obesity von STEINBERG, Gregory R, WATT, Matthew J, ERNST, Matthias, BIRNBAUM, Morris J, KEMP, Bruce E, JØRGENSEN, Sebastian Beck

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Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocation von JØRGENSEN, Sebastian Beck, HONEYMAN, Jane, OAKHILL, Jonathan S, FAZAKERLEY, Daniel, STÖCKLI, Jacqueline, KEMP, Bruce E, STEINBERG, Gregory R

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