Discovery of potent small-molecule inhibitors of lipoprotein(a) formation von Diaz, Nuria, Perez, Carlos, Escribano, Ana Maria, Sanz, Gema, Priego, Julian, Lafuente, Celia, Barberis, Mario, Calle, Luis, Espinosa, Juan Felix, Priest, Birgit T., Zhang, Hong Y., Nosie, Amanda K., Haas, Joseph V., Cannady, Ellen, Borel, Anthony, Schultze, Albert E., Sauder, J. Michael, Hendle, Jörg, Weichert, Ken, Nicholls, Stephen J., Michael, Laura F.

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Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints von Winneroski, Leonard L., Erickson, Jon A., Green, Steven J., Lopez, Jose E., Stout, Stephanie L., Porter, Warren J., Timm, David E., Audia, James E., Barberis, Mario, Beck, James P., Boggs, Leonard N., Borders, Anthony R., Boyer, Robert D., Brier, Richard A., Hembre, Erik J., Hendle, Jörg, Garcia-Losada, Pablo, Minguez, Jose Miguel, Mathes, Brian M., May, Patrick C., Monk, Scott A., Rankovic, Zoran, Shi, Yuan, Watson, Brian M., Yang, Zhixiang, Mergott, Dustin J.

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SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo von Buchanan, Sean G, Hendle, Jorg, Lee, Patrick S, Smith, Christopher R, Bounaud, Pierre-Yves, Jessen, Katti A, Tang, Crystal M, Huser, Nanni H, Felce, Jeremy D, Froning, Karen J, Peterman, Marshall C, Aubol, Brandon E, Gessert, Steve F, Sauder, J Michael, Schwinn, Kenneth D, Russell, Marijane, Rooney, Isabelle A, Adams, Jason, Leon, Barbara C, Do, Tuan H, Blaney, Jeff M, Sprengeler, Paul A, Thompson, Devon A, Smyth, Lydia, Pelletier, Laura A, Atwell, Shane, Holme, Kevin, Wasserman, Stephen R, Emtage, Spencer, Burley, Stephen K, Reich, Siegfried H

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Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant von Atwell, Shane, Brouillette, Christie G., Conners, Kris, Emtage, Spencer, Gheyi, Tarun, Guggino, William B., Hendle, Jorg, Hunt, John F., Lewis, Hal A., Lu, Frances, Protasevich, Irina I., Rodgers, Logan A., Romero, Rich, Wasserman, Stephen R., Weber, Patricia C., Wetmore, Diana, Zhang, Feiyu F., Zhao, Xun

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Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor von McKinzie, David L, Winneroski, Leonard L, Green, Steven J, Hembre, Erik J, Erickson, Jon A, Willis, Brian A, Monk, Scott A, Aluise, Christopher D, Baker, Thomas K, Lopez, Jose E, Hendle, Jörg, Beck, James P, Brier, Richard A, Boggs, Leonard N, Borders, Anthony R, Cocke, Patrick J, Garcia-Losada, Pablo, Lowe, Stephen L, Mathes, Brian M, May, Patrick C, Porter, Warren J, Stout, Stephanie L, Timm, David E, Watson, Brian M, Yang, Zhixiang, Mergott, Dustin J

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Discovery and clinical translation of ceperognastat, an O‐GlcNAcase (OGA) inhibitor, for the treatment of Alzheimer's disease von Kielbasa, William, Goldsmith, Paul, Donnelly, Kevin B., Nuthall, Hugh N., Shcherbinin, Sergey, Fleisher, Adam S., Hendle, Jörg, DuBois, Susan L., Lowe, Stephen L., Zhang, Feiyu Fred, Woerly, Eric M., Dreyfus, Nicolas J.‐F., Evans, David, Gilmore, Jeremy, Mancini, Michele, Constantinescu, Cristian C., Gunn, Roger N., Russell, David S., Collins, Emily C., Brys, Miroslaw, Hutton, Michael L., Mergott, Dustin J.

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Epitope topography of agonist antibodies to the checkpoint inhibitory receptor BTLA von Cheung, Timothy C., Atwell, Shane, Bafetti, Lisa, Cuenca, Paulina Delgado, Froning, Karen, Hendle, Jorg, Hickey, Michael, Ho, Carolyn, Huang, Jiawen, Lieu, Ricky, Lim, Stacie, Lippner, David, Obungu, Victor, Ward-Kavanagh, Lindsay, Weichert, Kenneth, Ware, Carl F., Vendel, Andrew C.

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The 1.59 Å resolution crystal structure of TM0096, a flavin mononucleotide binding protein from Thermotoga maritima von Park, Frances, Gajiwala, Ketan, Noland, Brian, Wu, Lydia, He, Dongmei, Molinari, Janessa, Loomis, Kim, Pagarigan, Barbra, Kearins, Peggy, Christopher, Jon, Peat, Tom, Badger, John, Hendle, Jorg, Lin, Johann, Buchanan, Sean

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Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop von Adams, Paul D., Aertgeerts, Kathleen, Bauer, Cary, Bell, Jeffrey A., Berman, Helen M., Bhat, Talapady N., Blaney, Jeff M., Bolton, Evan, Bricogne, Gerard, Brown, David, Burley, Stephen K., Case, David A., Clark, Kirk L., Darden, Tom, Emsley, Paul, Feher, Victoria A., Feng, Zukang, Groom, Colin R., Harris, Seth F., Hendle, Jorg, Holder, Thomas, Joachimiak, Andrzej, Kleywegt, Gerard J., Krojer, Tobias, Marcotrigiano, Joseph, Mark, Alan E., Markley, John L., Miller, Matthew, Minor, Wladek, Montelione, Gaetano T., Murshudov, Garib, Nakagawa, Atsushi, Nakamura, Haruki, Nicholls, Anthony, Nicklaus, Marc, Nolte, Robert T., Padyana, Anil K., Peishoff, Catherine E., Pieniazek, Susan, Read, Randy J., Shao, Chenghua, Sheriff, Steven, Smart, Oliver, Soisson, Stephen, Spurlino, John, Stouch, Terry, Svobodova, Radka, Tempel, Wolfram, Terwilliger, Thomas C., Tronrud, Dale, Velankar, Sameer, Ward, Suzanna C., Warren, Gregory L., Westbrook, John D., Williams, Pamela, Yang, Huanwang, Young, Jasmine

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Idea2Data: Toward a New Paradigm for Drug Discovery von Nicolaou, Christos A, Humblet, Christine, Hu, Hong, Martin, Eva M, Dorsey, Frank C, Castle, Thomas M, Burton, Keith Ian, Hu, Haitao, Hendle, Jorg, Hickey, Michael J, Duerksen, Joel, Wang, Jibo, Erickson, Jon A

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LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants von Westendorf, Kathryn, Žentelis, Stefanie, Wang, Lingshu, Foster, Denisa, Vaillancourt, Peter, Wiggin, Matthew, Lovett, Erica, van der Lee, Robin, Hendle, Jörg, Pustilnik, Anna, Sauder, J. Michael, Kraft, Lucas, Hwang, Yuri, Siegel, Robert W., Chen, Jinbiao, Heinz, Beverly A., Higgs, Richard E., Kallewaard, Nicole L., Jepson, Kevin, Goya, Rodrigo, Smith, Maia A., Collins, David W., Pellacani, Davide, Xiang, Ping, de Puyraimond, Valentine, Ricicova, Marketa, Devorkin, Lindsay, Pritchard, Caitlin, O’Neill, Aoise, Dalal, Kush, Panwar, Pankaj, Dhupar, Harveer, Garces, Fabian A., Cohen, Courtney A., Dye, John M., Huie, Kathleen E., Badger, Catherine V., Kobasa, Darwyn, Audet, Jonathan, Freitas, Joshua J., Hassanali, Saleema, Hughes, Ina, Munoz, Luis, Palma, Holly C., Ramamurthy, Bharathi, Cross, Robert W., Geisbert, Thomas W., Menachery, Vineet, Lokugamage, Kumari, Borisevich, Viktoriya, Lanz, Iliana, Anderson, Lisa, Sipahimalani, Payal, Corbett, Kizzmekia S., Yang, Eun Sung, Zhang, Yi, Shi, Wei, Zhou, Tongqing, Choe, Misook, Misasi, John, Kwong, Peter D., Sullivan, Nancy J., Graham, Barney S., Fernandez, Tara L., Hansen, Carl L., Falconer, Ester, Mascola, John R., Jones, Bryan E., Barnhart, Bryan C.

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Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors von Antonysamy, Stephen S., Aubol, Brandon, Blaney, Jeff, Browner, Michelle F., Giannetti, Anthony M., Harris, Seth F., Hébert, Normand, Hendle, Jörg, Hopkins, Stephanie, Jefferson, Elizabeth, Kissinger, Charles, Leveque, Vincent, Marciano, David, McGee, Ethel, Nájera, Isabel, Nolan, Brian, Tomimoto, Masaki, Torres, Eduardo, Wright, Tobi

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Crystal structure of YIGZ, a conserved hypothetical protein from Escherichia coli k12 with a novel fold von Park, Frances, Gajiwala, Ketan, Eroshkina, Galina, Furlong, Eva, He, Dongmei, Batiyenko, Yelena, Romero, Rich, Christopher, Jon, Badger, John, Hendle, Jorg, Lin, Johann, Peat, Tom, Buchanan, Sean

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A Novel Quaternary Structure of the Dimeric α-Crystallin Domain with Chaperone-like Activity von Feil, Ingeborg K., Malfois, Marc, Hendle, Jörg, van der Zandt, Hans, Svergun, Dmitri I.

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A Novel Mode of Gleevec Binding Is Revealed by the Structure of Spleen Tyrosine Kinase von Atwell, Shane, Adams, Jason M., Badger, John, Buchanan, Michelle D., Feil, Ingeborg K., Froning, Karen J., Gao, Xia, Hendle, Jörg, Keegan, Kevin, Leon, Barbara C., Müller-Dieckmann, Hans J., Nienaber, Vicki L., Noland, Brian W., Post, Kai, Rajashankar, K.R., Ramos, Aurora, Russell, Marijane, Burley, Stephen K., Buchanan, Sean G.

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1.8 and 1.9 Å resolution structures of the ­Penicillium amagasakiense and Aspergillus niger glucose oxidases as a basis for modelling substrate complexes von Wohlfahrt, Gerd, Witt, Susanne, Hendle, Jörg, Schomburg, Dietmar, Kalisz, Henryk M., Hecht, Hans-Jürgen

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Structural Studies of Salmonella typhimurium ArnB (PmrH) Aminotransferase : A 4-Amino-4-Deoxy-L-Arabinose Lipopolysaccharide-Modifying Enzyme von Noland, Brian W., Newman, Janet M., Hendle, Jörg, Badger, John, Christopher, Jon A., Tresser, Jason, Buchanan, Michelle D., Wright, Tobi A., Rutter, Marc E., Sanderson, Wendy E., Müller-Dieckmann, Hans-Joachim, Gajiwala, Ketan S., Buchanan, Sean G.

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Reliable quality-control methods for protein crystal structures von Badger, John, Hendle, Jörg

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ANTI-CORONAVIRUS ANTIBODIES AND METHODS OF USE von SAUDER, JOHN MICHAEL, WANG, LINGSHU, ZHANG, YI, ZENTELIS, STEFANIE, MUTHURAMAN, KRITHIKA, FALCONER, ESTER, SHI, WEI, FRYE, CHRISTOPHER CARL, KONG, WING-PUI, FOSTER, DENISA, GOPALRATHNAM, GANAPATHY, BOYLES, JEFFREY STREETMAN, JONES, BRYAN EDWARD, DAVIES, JULIAN, ABIONA, OLUBUKOLA, CHAI, QING, MASCOLA, JOHN, GRAHAM, BARNEY, HENDLE, JORG, PUSTILNIK, ANNA, WESTENDORF, KATHRYN, JEPSON, KEVIN, CORBETT, KIZZMEKIA, LEDGERWOOD, JULIE

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ANTI-CORONAVIRUS ANTIBODIES AND METHODS OF USE von SAUDER, JOHN MICHAEL, WANG, LINGSHU, ZHANG, YI, ZENTELIS, STEFANIE, MUTHURAMAN, KRITHIKA, FALCONER, ESTER, SHI, WEI, FRYE, CHRISTOPHER CARL, KONG, WING-PUI, FOSTER, DENISA, GOPALRATHNAM, GANAPATHY, BOYLES, JEFFREY STREETMAN, JONES, BRYAN EDWARD, DAVIES, JULIAN, ABIONA, OLUBUKOLA, CHAI, QING, MASCOLA, JOHN, GRAHAM, BARNEY, HENDLE, JORG, PUSTILNIK, ANNA, WESTENDORF, KATHRYN, JEPSON, KEVIN, CORBETT, KIZZMEKIA, LEDGERWOOD, JULIE

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