ROCK inhibitors 4: Structure-activity relationship studies of 7-azaindole-based rho kinase (ROCK) inhibitors von Bandarage, Upul K., Court, John, Gao, Huai, Nanthakumar, Suganthini, Come, Jon H., Giroux, Simon, Green, Jeremy

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ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors von Bandarage, Upul K., Cao, Jingrong, Come, Jon H., Court, John J., Gao, Huai, Jacobs, Marc D., Marhefka, Craig, Nanthakumar, Suganthi, Green, Jeremy

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Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3‑Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of M... von Come, Jon H, Collier, Philip N, Henderson, James A, Pierce, Albert C, Davies, Robert J, Le Tiran, Arnaud, O’Dowd, Hardwin, Bandarage, Upul K, Cao, Jingrong, Deininger, David, Grey, Ron, Krueger, Elaine B, Lowe, Derek B, Liang, Jianglin, Liao, Yusheng, Messersmith, David, Nanthakumar, Suganthi, Sizensky, Emmanuelle, Wang, Jian, Xu, Jinwang, Chin, Elaine Y, Damagnez, Veronique, Doran, John D, Dworakowski, Wojciech, Griffith, James P, Jacobs, Marc D, Khare-Pandit, Suvarna, Mahajan, Sudipta, Moody, Cameron S, Aronov, Alex M

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Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1 von Come, Jon H, Senter, Timothy J, Clark, Michael P, Court, John J, Gale-Day, Zachary, Gu, Wenxin, Krueger, Elaine, Liang, Jianglin, Morris, Mark, Nanthakumar, Suganthini, O’Dowd, Hardwin, Maltais, Francois, Iyer, Ganesh, Andreassi, John, Boucher, Christina, Considine, Tony, Moody, Cameron S, Taylor, William, Mohanty, Arun K, Huang, Yulin, Zuccola, Harmon, Coll, Joyce, Bonanno, Kenneth C, Gagnon, Kevin J, Gan, Lu, Lu, Fan, Gao, Hong, Chakilam, Ananthisrinivas, Engtrakul, Juntyma, Song, Bin, Crawford, Dan, Doyle, Elisabeth, Kramer, Tal, Vought, Bryan, Phillips, Jonathan, Kemper, Raymond, Sanders, Martin, Swett, Rebecca, Furey, Brinley, Winquist, Ray, Bunnage, Mark E, Jackson, Katrina L, Charifson, Paul S, Magavi, Sanjay S

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Discovery of a Novel Series of Potent and Selective Alkynylthiazole-Derived PI3Kγ Inhibitors von Bandarage, Upul K, Aronov, Alex M, Cao, Jingrong, Come, Jon H, Cottrell, Kevin M, Davies, Robert J, Giroux, Simon, Jacobs, Marc, Mahajan, Sudipta, Messersmith, David, Moody, Cameron S, Swett, Rebecca, Xu, Jinwang

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Cell-free formation of protease-resistant prion protein von Kocisko, D.A, Come, J.H, Priola, S.A, Chesebro, B, Raymond, G.J, Lansbury, P.T, Caughey, B

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Novel thiol-based TACE inhibitors: Rational design, synthesis, and SAR of thiol-containing aryl sulfonamides von Govinda Rao, B., Bandarage, Upul K., Wang, Tiansheng, Come, Jon H., Perola, Emanuele, Wei, Yunyi, Tian, Shi-Kai, Saunders, Jeffrey O.

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4-(Benzimidazol-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: Potent and selective p70S6 kinase inhibitors von Bandarage, Upul, Hare, Brian, Parsons, Jonathan, Pham, Ly, Marhefka, Craig, Bemis, Guy, Tang, Qing, Moody, Cameron Stuver, Rodems, Steve, Shah, Sundeep, Adams, Chris, Bravo, Jose, Charonnet, Emmanuelle, Savic, Vladimir, Come, Jon H., Green, Jeremy

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Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones von Bandarage, Upul K., Wang, Tiansheng, Come, Jon H., Perola, Emanuele, Wei, Yunyi, Rao, B. Govinda

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A Kinetic Model for Amyloid Formation in the Prion Diseases: Importance of Seeding von Come, Jon H., Fraser, Paul E., Lansbury, Peter T.

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Discovery of Novel, Orally Bioavailable Pyrimidine Ether-Based Inhibitors of ELOVL1 von Boyd, Michael J, Collier, Philip N, Clark, Michael P, Deng, Hongbo, Kesavan, Sarathy, Ronkin, Steven M, Waal, Nathan, Wang, Jian, Cao, Jingrong, Li, Pan, Come, Jon, Davies, Ioana, Duffy, John P, Cochran, John E, Court, John J, Chandupatla, Kishan, Jackson, Katrina L, Maltais, Francois, O’Dowd, Hardwin, Boucher, Christina, Considine, Tony, Taylor, William P, Gao, Hong, Chakilam, Ananthisrinivas, Engtrakul, Juntyma, Crawford, Dan, Doyle, Elizabeth, Phillips, Jonathan, Kemper, Raymond, Swett, Rebecca, Empfield, James, Bunnage, Mark E, Charifson, Paul S, Magavi, Sanjay Shivayogi

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Discovery of Highly Isoform Selective Thiazolopiperidine Inhibitors of Phosphoinositide 3‑Kinase γ von Collier, Philip N., Messersmith, David, Le Tiran, Arnaud, Bandarage, Upul K., Boucher, Christina, Come, Jon, Cottrell, Kevin M., Damagnez, Veronique, Doran, John D., Griffith, James P., Khare-Pandit, Suvarna, Krueger, Elaine B., Ledeboer, Mark W., Ledford, Brian, Liao, Yusheng, Mahajan, Sudipta, Moody, Cameron S., Roday, Setu, Wang, Tiansheng, Xu, Jinwang, Aronov, Alex M.

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Abstract LB-B15: A novel PI3K gamma isoform selective small molecule kinase inhibitor demonstrates single agent anti-tumor activity and enhanced combination activity with checkpoin... von Saha, Saurabh, Zhang, Linping, Hoock, Thomas, Aronov, Alex, Mahajan, Sudipta, Boyd, Michael, Come, Jon, Damagnez, Veronique, Dworakowski, Wojciech, Khare-Pandit, Suvarna, LeTiran, Arnaud, Moody, Cameron, O'Dowd, Harwin, Prezioso, Joseph, Roday, Setu, Zhang, Xiaoyan M.

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Predisposition of prion protein homozygotes to Creutzfeldt-Jakob disease can be explained by a nucleation-dependent polymerization mechanism von Come, Jon H, Lansbury, Peter T

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Convenient synthesis of N-(4-(2-aminopyridin-4-yl)thiazol-2-yl)-2-phenylacetamides von Bandarage, Upul K., Come, Jon H., Green, Jeremy

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2-Aminopyrazolo[1,5- a]pyrimidines as potent and selective inhibitors of JAK2 von Ledeboer, Mark W., Pierce, Albert C., Duffy, John P., Gao, Huai, Messersmith, David, Salituro, Francesco G., Nanthakumar, Suganthini, Come, Jon, Zuccola, Harmon J., Swenson, Lora, Shlyakter, Dina, Mahajan, Sudipta, Hoock, Thomas, Fan, Bin, Tsai, Wan-Jung, Kolaczkowski, Elaine, Carrier, Scott, Hogan, James K., Zessis, Richard, Pazhanisamy, S., Bennani, Youssef L.

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A Three-Hybrid Approach to Scanning the Proteome for Targets of Small Molecule Kinase Inhibitors von Becker, Frank, Murthi, Krishna, Smith, Chase, Come, Jon, Costa-Roldán, Nuria, Kaufmann, Christine, Hanke, Urs, Degenhart, Carsten, Baumann, Sabine, Wallner, Wolfgang, Huber, Andrea, Dedier, Severine, Dill, Simone, Kinsman, David, Hediger, Mark, Bockovich, Nicholas, Meier-Ewert, Sebastian, Kluge, Arthur F, Kley, Nikolai

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NOVEL MODULATORS OF EHMT1 AND EHMT2 AND THERAPEUTIC USE THEREOF von Williams, Brett, Throner, Scott, Vacca, Joseph P, Maxwell, John P, Come, Jon H

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N2-((5-HYDROXY)-2-PYRIDYL)-PYRIDINE-2,4-DIAMINE DERIVATIVES AS EHMT1/2 MODULATORS FOR THE TREATMENT OF CANCER von COME, Jon H, THRONER, Scott, MAXWELL, John P, WILLIAMS, Brett, VACCA, Joseph P

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Mechanistic and preparative studies of the intramolecular photocyclization of methylated 2-(4-pentenyl)tropones von Feldman, Ken S, Come, Jon H, Kosmider, Benedict J, Smith, Pamela M, Rotella, David P, Wu, Ming Jung

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