Structure of the pseudokinase–kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition von Lupardus, Patrick J., Ultsch, Mark, Wallweber, Heidi, Kohli, Pawan Bir, Johnson, Adam R., Eigenbrot, Charles

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Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton’s Tyrosine Kinase Inhibitor in Early Clinical Development von Crawford, James J, Johnson, Adam R, Misner, Dinah L, Belmont, Lisa D, Castanedo, Georgette, Choy, Regina, Coraggio, Melis, Dong, Liming, Eigenbrot, Charles, Erickson, Rebecca, Ghilardi, Nico, Hau, Jonathan, Katewa, Arna, Kohli, Pawan Bir, Lee, Wendy, Lubach, Joseph W, McKenzie, Brent S, Ortwine, Daniel F, Schutt, Leah, Tay, Suzanne, Wei, BinQing, Reif, Karin, Liu, Lichuan, Wong, Harvey, Young, Wendy B

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Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7 von Wertz, Ingrid E., Kusam, Saritha, Lam, Cynthia, Okamoto, Toru, Sandoval, Wendy, Anderson, Daniel J., Helgason, Elizabeth, Ernst, James A., Eby, Mike, Liu, Jinfeng, Belmont, Lisa D., Kaminker, Joshua S., O’Rourke, Karen M., Pujara, Kanan, Kohli, Pawan Bir, Johnson, Adam R., Chiu, Mark L., Lill, Jennie R., Jackson, Peter K., Fairbrother, Wayne J., Seshagiri, Somasekar, Ludlam, Mary J. C., Leong, Kevin G., Dueber, Erin C., Maecker, Heather, Huang, David C. S., Dixit, Vishva M.

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NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus von Brightbill, Hans D., Suto, Eric, Blaquiere, Nicole, Ramamoorthi, Nandhini, Sujatha-Bhaskar, Swathi, Gogol, Emily B., Castanedo, Georgette M., Jackson, Benjamin T., Kwon, Youngsu C., Haller, Susan, Lesch, Justin, Bents, Karin, Everett, Christine, Kohli, Pawan Bir, Linge, Sandra, Christian, Laura, Barrett, Kathy, Jaochico, Allan, Berezhkovskiy, Leonid M., Fan, Peter W., Modrusan, Zora, Veliz, Kelli, Townsend, Michael J., DeVoss, Jason, Johnson, Adam R., Godemann, Robert, Lee, Wyne P., Austin, Cary D., McKenzie, Brent S., Hackney, Jason A., Crawford, James J., Staben, Steven T., Alaoui Ismaili, Moulay H., Wu, Lawren C., Ghilardi, Nico

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A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors von Sohn, Sue J, Barrett, Kathy, Van Abbema, Anne, Chang, Christine, Kohli, Pawan Bir, Kanda, Hidenobu, Smith, Janice, Lai, Yingjie, Zhou, Aihe, Zhang, Birong, Yang, Wenqian, Williams, Karen, Macleod, Calum, Hurley, Christopher A, Kulagowski, Janusz J, Lewin-Koh, Nicholas, Dengler, Hart S, Johnson, Adam R, Ghilardi, Nico, Zak, Mark, Liang, Jun, Blair, Wade S, Magnuson, Steven, Wu, Lawren C

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Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists von Fauber, Benjamin P., Gobbi, Alberto, Robarge, Kirk, Zhou, Aihe, Barnard, Adrian, Cao, Jianhua, Deng, Yuzhong, Eidenschenk, Céline, Everett, Christine, Ganguli, Arunima, Hawkins, Julie, Johnson, Adam R., La, Hank, Norman, Maxine, Salmon, Gary, Summerhill, Susan, Ouyang, Wenjun, Tang, Wei, Wong, Harvey

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Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity von Huang, Christine S., Oberbeck, Nina, Hsiao, Yi-Chun, Liu, Peter, Johnson, Adam R., Dixit, Vishva M., Hymowitz, Sarah G.

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Crystal structure of bis(3,5-dichloro-2-hydroxybenzyl)(2-methoxyethyl)amine von Wile, Bradley M, Griffith, Claire L, Johnson, Adam R

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Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc von Fauber, Benjamin P., de Leon Boenig, Gladys, Burton, Brenda, Eidenschenk, Céline, Everett, Christine, Gobbi, Alberto, Hymowitz, Sarah G., Johnson, Adam R., Liimatta, Marya, Lockey, Peter, Norman, Maxine, Ouyang, Wenjun, René, Olivier, Wong, Harvey

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Discovery and Characterization of a Novel Inhibitor of Matrix Metalloprotease-13 That Reduces Cartilage Damage in Vivo without Joint Fibroplasia Side Effects von Johnson, Adam R., Pavlovsky, Alexander G., Ortwine, Daniel F., Prior, Faith, Man, Chiu-Fai, Bornemeier, Dirk A., Banotai, Craig A., Mueller, W. Thomas, McConnell, Patrick, Yan, Chunhong, Baragi, Vijay, Lesch, Charles, Roark, W. Howard, Wilson, Michael, Datta, Kaushik, Guzman, Roberto, Han, Hyo-Kyung, Dyer, Richard D.

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The Crystal Structure of the Catalytic Domain of the NF-κB Inducing Kinase Reveals a Narrow but Flexible Active Site von de Leon-Boenig, Gladys, Bowman, Krista K., Feng, Jianwen A., Crawford, Terry, Everett, Christine, Franke, Yvonne, Oh, Angela, Stanley, Mark, Staben, Steven T., Starovasnik, Melissa A., Wallweber, Heidi J.A., Wu, Jiansheng, Wu, Lawren C., Johnson, Adam R., Hymowitz, Sarah G.

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Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties von René, Olivier, Fauber, Benjamin P., Barnard, Adrian, Chapman, Kerry, Deng, Yuzhong, Eidenschenk, Céline, Everett, Christine, Gobbi, Alberto, Johnson, Adam R., La, Hank, Norman, Maxine, Salmon, Gary, Summerhill, Susan, Wong, Harvey

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A Community Springs to Action to Enable Virtual Laboratory Instruction von Nataro, Chip, Johnson, Adam R

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Noncovalent inhibition of C481S Bruton tyrosine kinase by GDC-0853: a new treatment strategy for ibrutinib-resistant CLL von Reiff, Sean D., Muhowski, Elizabeth M., Guinn, Daphne, Lehman, Amy, Fabian, Catherine A., Cheney, Carolyn, Mantel, Rose, Smith, Lisa, Johnson, Amy J., Young, Wendy B., Johnson, Adam R., Liu, Lichuan, Byrd, John C., Woyach, Jennifer A.

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Catalytic Intramolecular Hydroamination of Substituted Aminoallenes by Chiral Titanium Amino-Alcohol Complexes von Hoover, Jessica M, Petersen, Juliette R, Pikul, Jessica H, Johnson, Adam R

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Ultrasound Induces Similar Temporal Endothelial Expression Patterns of eNOS and KLF2 as Normal Flow von Sahni, Jaideep, McCue, Ian S., Johnson, Adam R., Schake, Morgan A., Sotelo, Luz D., Turner, Joseph A., Pedrigi, Ryan M.

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Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations von Johnson, Adam R, Kohli, Pawan Bir, Katewa, Arna, Gogol, Emily, Belmont, Lisa D, Choy, Regina, Penuel, Elicia, Burton, Luciana, Eigenbrot, Charles, Yu, Christine, Ortwine, Daniel F, Bowman, Krista, Franke, Yvonne, Tam, Christine, Estevez, Alberto, Mortara, Kyle, Wu, Jiansheng, Li, Hong, Lin, May, Bergeron, Philippe, Crawford, James J, Young, Wendy B

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Literature-Based Teaching Strategies for Organometallic Courses von Duncan, Andrew P, Johnson, Adam R, Nataro, Chip

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Computational analysis of kinase inhibitor selectivity using structural knowledge von Lo, Yu-Chen, Liu, Tianyun, Morrissey, Kari M, Kakiuchi-Kiyota, Satoko, Johnson, Adam R, Broccatelli, Fabio, Zhong, Yu, Joshi, Amita, Altman, Russ B

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Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease von Terrett, Jack A., Ly, Justin Q., Katavolos, Paula, Hasselgren, Catrin, Laing, Steven, Zhong, Fiona, Villemure, Elisia, Déry, Martin, Larouche-Gauthier, Robin, Chen, Huifen, Shore, Daniel G., Lee, Wyne P., Suto, Eric, Johnson, Kevin, Brooks, Marjory, Stablein, Alyssa, Beaumier, Francis, Constantineau-Forget, Léa, Grand-Maître, Chantal, Lépissier, Luce, Ciblat, Stéphane, Sturino, Claudio, Chen, Yong, Hu, Baihua, Elstrott, Justin, Gandham, Vineela, Joseph, Victory, Booler, Helen, Cain, Gary, Chou, Carolina, Fullerton, Aaron, Lepherd, Michelle, Stainton, Shannon, Torres, Elizabeth, Urban, Konnie, Yu, Lanlan, Zhong, Yu, Bao, Linda, Chou, Kang-Jye, Lin, Jessica, Zhang, Wei, La, Hank, Liu, Liling, Mulder, Teresa, Chen, Jun, Chernov-Rogan, Tania, Johnson, Adam R., Hackos, David H., Leahey, Rebecca, Shields, Shannon D., Balestrini, Alessia, Riol-Blanco, Lorena, Safina, Brian S., Volgraf, Matthew, Magnuson, Steven, Kakiuchi-Kiyota, Satoko

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