Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970 von Hall, Amy B, Newsome, Dave, Wang, Yuxin, Boucher, Diane M, Eustace, Brenda, Gu, Yong, Hare, Brian, Johnson, Mac A, Milton, Sean, Murphy, Cheryl E, Takemoto, Darin, Tolman, Crystal, Wood, Mark, Charlton, Peter, Charrier, Jean-Damien, Furey, Brinley, Golec, Julian, Reaper, Philip M, Pollard, John R

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Spatio-Temporal Patterns of Demyelination and Remyelination in the Cuprizone Mouse Model von Tagge, Ian, O'Connor, Audrey, Chaudhary, Priya, Pollaro, Jim, Berlow, Yosef, Chalupsky, Megan, Bourdette, Dennis, Woltjer, Randy, Johnson, Mac, Rooney, William

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In vivo MRI is sensitive to remyelination in a nonhuman primate model of multiple sclerosis von Donadieu, Maxime, Lee, Nathanael J, Gaitán, María I, Ha, Seung-Kwon, Luciano, Nicholas J, Roy, Snehashis, Ineichen, Benjamin, Leibovitch, Emily C, Yen, Cecil C, Pham, Dzung L, Silva, Afonso C, Johnson, Mac, Jacobson, Steve, Sati, Pascal, Reich, Daniel S

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Hyperpolarized helium-3 magnetic resonance lung imaging of non-sedated infants and young children: a proof-of-concept study von Altes, Talissa A, Meyer, Craig H, Mata, Jaime F, Froh, Deborah K, Paget-Brown, Alix, Gerald Teague, W, Fain, Sean B, de Lange, Eduard E, Ruppert, Kai, Botfield, Martyn C, Johnson, Mac A, Mugler, John P

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Assessment of Repeatability of Hyperpolarized Gas MR Ventilation Functional Imaging in Cystic Fibrosis von O’Sullivan, Brian, MD, Couch, Marcus, MSc, Roche, John P., PhD, Walvick, Ronn, PhD, Zheng, Shaokuan, PhD, Baker, Dawn, ARNP, Johnson, Mac, PhD, Botfield, Martyn, PhD, Albert, Mitchell S., PhD

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Regulated Expression of Wnts and Frizzleds at Specific Stages of Follicular Development in the Rodent Ovary von Hsieh, Minnie, Johnson, Mac A, Greenberg, Norman M, Richards, JoAnne S

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Island biogeography effects on microbial evolution may contribute to Crohn's disease von Johnson, Mac A., Winquist, Raymond J.

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The Power of Optimization Over Randomization in Designing Experiments Involving Small Samples von Bertsimas, Dimitris, Johnson, Mac, Kallus, Nathan

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Origin of Androgen-Insensitive Poorly Differentiated Tumors in the Transgenic Adenocarcinoma of Mouse Prostate Model von Huss, Wendy J., Gray, Danny R., Tavakoli, Keyvan, Marmillion, Meghan E., Durham, Lori E., Johnson, Mac A., Greenberg, Norman M., Smith, Gary J.

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AKT-1, -2, and -3 are Expressed in Both Normal and Tumor Tissues of the Lung, Breast, Prostate, and Colon von ZINDA, Michael J, JOHNSON, Mac A, GRAFF, Jeremy R, PAUL, Jonathan D, HORN, Candice, KONICEK, Bruce W, LU, Zhao Hai, SANDUSKY, George, THOMAS, James E, NEUBAUER, Blake Lee, LAI, Mei T

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Castration triggers growth of previously static androgen-independent lesions in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model von Johnson, Mac A., Iversen, Philip, Schwier, Phillip, Corn, Angela L., Sandusky, George, Graff, Jeremy, Neubauer, Blake Lee

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The selective estrogen receptor modulator trioxifene (LY133314) inhibits metastasis and extends survival in the PAIII rat prostatic carcinoma model von NEUBAUER, Blake Lee, MCNULTY, Ann M, GRAFF, Jeremy R, CHEDID, Marcio, CHEN, Keyue, GOODE, Robin L, JOHNSON, Mac A, JONES, C. David, KRISHNAN, Venkatesh, LYNCH, Rebecca, OSBORNE, Harold E

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Use of hyperpolarized helium-3 MRI to assess response to ivacaftor treatment in patients with cystic fibrosis von Altes, Talissa A, Johnson, Mac, Fidler, Meredith, Botfield, Martyn, Tustison, Nicholas J, Leiva-Salinas, Carlos, de Lange, Eduard E, Froh, Deborah, Mugler, John P

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In vivo MRI is sensitive to remyelination in a nonhuman primate model of multiple sclerosis von Donadieu, Maxime, Lee, Nathanael J, Gaitán, María I, Ha, Seung-Kwon, Luciano, Nicholas J, Roy, Snehashis, Ineichen, Benjamin, Leibovitch, Emily C, Yen, Cecil C, Pham, Dzung L, Silva, Afonso C, Johnson, Mac, Jacobson, Steve, Sati, Pascal, Reich, Daniel S

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Evidence for a p53-independent pathway for upregulation of SDI1/CIP1/WAF1/P21 RNA in human cells von Johnson, Mac, Dimitrov, Diana, Vojta, Patrick J., Barrett, J. Carl, Noda, Asao, Pereira-Smith, Olivia M., Smith, James R.

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Perspectives on molecular and anatomical imaging in drug discovery von Silva, Matthew D, Johnson, Mac, Cvet, Donna, Robertson, Rob, Kupperman, Erik, Reimer, Corinne, Hibner, Barbara, Chandra, Sudeep

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Abstract ND09: M3913 induces the maladaptive unfolded protein response through a novel mechanism resulting in strong anti-tumor activity von Czauderna, Frank, Schneider, Richard, Ramaswamy, Shivapriya, Brandstetter, Susanne, Drouin, Elise, Bogatyrova, Olga, Mazur, Johanna, Sun, Qing, Jorand-Lebrun, Catherine, Sherbetjian, Eva, Nachtigall, Jonny, Wing, Carolyn, Hildebrand, Christian, Ellinghaus, Peter, Lemoine, Isabelle, Johnson, Mac, Hoover, Russell, Clark, Michael, Lindemann, Ralph

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Isolation and characterization of mouse probasin: An androgen-regulated protein specifically expressed in the differentiated prostate von Johnson, Mac A., Hernandez, Inmaculada, Wei, Yongli, Greenberg, Norman

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Regulated expression of Wnts and Frizzleds at specific stages of follicular development in the rodent ovary von Hsieh, Minnie, Johnson, Mac A, Greenberg, Norman M, Richards, JoAnne S

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Abstract 3717: Defining optimal dose schedules for ATR inhibitors in combination with DNA damaging drugs: Informing clinical studies of VX-970, the first-in-class ATR inhibitor von Pollard, John, Reaper, Phil, Peek, Adele, Hughes, Stuart, Gladwell, Scott, Jones, Julie, Chiu, Peter, Wood, Mark, Tolman, Crystal, Johnson, Mac, Littlewood, Peter, Penney, Marina, McDermott, Katherine, Hare, Brian, Fields, Scott Z., Asmal, Mohammed, O’Carrigan, Brent, Yap, Timothy A.

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