IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance von Mumm, John B., Emmerich, Jan, Zhang, Xueqing, Chan, Ivan, Wu, Lingling, Mauze, Smita, Blaisdell, Steven, Basham, Beth, Dai, Jie, Grein, Jeff, Sheppard, Catherine, Hong, Kyu, Cutler, Collette, Turner, Scott, LaFace, Drake, Kleinschek, Melanie, Judo, Michael, Ayanoglu, Gulesi, Langowski, John, Gu, Danling, Paporello, Brittany, Murphy, Erin, Sriram, Venkataraman, Naravula, Saraswathi, Desai, Bela, Medicherla, Satya, Seghezzi, Wolfgang, McClanahan, Terrill, Cannon-Carlson, Susan, Beebe, Amy M., Oft, Martin

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IL-10 Directly Activates and Expands Tumor-Resident CD8+ T Cells without De Novo Infiltration from Secondary Lymphoid Organs von EMMERICH, Jan, MUMM, John B, CHAN, Ivan H, LAFACE, Drake, TRUONG, Hoa, MCCLANAHAN, Terrill, GORMAN, Daniel M, OFT, Martin

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PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8+ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients von Naing, Aung, Infante, Jeffrey R., Papadopoulos, Kyriakos P., Chan, Ivan H., Shen, Cong, Ratti, Navneet P., Rojo, Bianca, Autio, Karen A., Wong, Deborah J., Patel, Manish R., Ott, Patrick A., Falchook, Gerald S., Pant, Shubham, Hung, Annie, Pekarek, Kara L., Wu, Victoria, Adamow, Matthew, McCauley, Scott, Mumm, John B., Wong, Phillip, Van Vlasselaer, Peter, Leveque, Joseph, Tannir, Nizar M., Oft, Martin

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Pegylated IL-10 induces cancer immunity von Mumm, John B., Oft, Martin

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IL-33 Induces IL-13-Dependent Cutaneous Fibrosis von Rankin, Andrew L, Mumm, John B, Murphy, Erin, Turner, Scott, Yu, Ni, McClanahan, Terrill K, Bourne, Patricia A, Pierce, Robert H, Kastelein, Rob, Pflanz, Stefan

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Safety, Antitumor Activity, and Immune Activation of Pegylated Recombinant Human Interleukin-10 (AM0010) in Patients With Advanced Solid Tumors von Naing, Aung, Papadopoulos, Kyriakos P, Autio, Karen A, Ott, Patrick A, Patel, Manish R, Wong, Deborah J, Falchook, Gerald S, Pant, Shubham, Whiteside, Melinda, Rasco, Drew R, Mumm, John B, Chan, Ivan H, Bendell, Johanna C, Bauer, Todd M, Colen, Rivka R, Hong, David S, Van Vlasselaer, Peter, Tannir, Nizar M, Oft, Martin, Infante, Jeffrey R

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IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression von Wang, Yaya, Mumm, John Brian, Herbst, Ronald, Kolbeck, Roland, Wang, Yue

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PEGylated IL-10 Activates Kupffer Cells to Control Hypercholesterolemia von Chan, Ivan H, Van Hoof, Dennis, Abramova, Marina, Bilardello, Melissa, Mar, Elliot, Jorgensen, Brett, McCauley, Scott, Bal, Harminder, Oft, Martin, Van Vlasselaer, Peter, Mumm, John B

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The Protein Product of the Tumor Suppressor Gene, Melanoma Differentiation-Associated Gene 7, Exhibits Immunostimulatory Activity and Is Designated IL-24 von Caudell, Eva G, Mumm, John B, Poindexter, Nancy, Ekmekcioglu, Suhendan, Mhashilkar, Abner M, Yang, Xiaohong Helena, Retter, Mark W, Hill, Paul, Chada, Sunil, Grimm, Elizabeth A

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755 DEKA-1 a dose-finding Phase 1 trial: observing safety and biomarkers using DK210 (EGFR) for inoperable locally advanced and/or metastatic EGFR+ tumors failing systemic therapy... von Spira, Alexander I, Orr, Douglas, Marabelle, Aurélien, Moser, Elizabeth C, Kientop, Deb, Mumm, John

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Pegylated IL-10 induces cancer immunity: the surprising role of IL-10 as a potent inducer of IFN-γ-mediated CD8(+) T cell cytotoxicity von Mumm, John B, Oft, Martin

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Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor von RAMESH, Rajagopal, MHASHILKAR, Abner M, GRIMM, Elizabeth A, RENAULD, Jean-Christophe, KOTENKO, Sergei, CHADA, Sunil, TANAKA, Fumihiro, SAITO, Yuji, BRANCH, Cynthia D, SIEGER, Kerry, MUMM, John B, STEWART, Alexis L, BOQUIO, Amelia, DUMOUTIER, Laure

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PEG-rIL-10 treatment decreases FoxP3+ Tregs despite upregulation of intratumoral IDO von Chan, Ivan H., Wu, Victoria, Bilardello, Melissa, Jorgenson, Brett, Bal, Harminder, McCauley, Scott, Van Vlasselaer, Peter, Mumm, John B.

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Bystander activity of Ad-mda7: human MDA-7 protein kills melanoma cells via an IL-20 receptor-dependent but STAT3-independent mechanism von Chada, Sunil, Mhashilkar, Abner M, Ramesh, Rajagopal, Mumm, John B, Sutton, R Bryan, Bocangel, Dora, Zheng, Mingzhong, Grimm, Elizabeth A, Ekmekcioglu, Suhendan

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Quantitative Analysis of Hepatitis C Virus-Specific CD8+ T Cells in Peripheral Blood and Liver Using Peptide-MHC Tetramers von He, Xiao-Song, Rehermann, Barbara, López-Labrador, F. Xavier, Boisvert, Judie, Cheung, Ramsey, Mumm, John, Wedemeyer, Heiner, Berenguer, Marina, Wright, Teresa L., Davis, Mark M., Greenberg, Harry B.

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Autochthonous T cells to the rescue: IL-10 directly activates tumor-resident CD8+ T cells von Emmerich, Jan, Mumm, John B., Oft, Martin

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Killing of human melanoma cells induced by activation of class I interferon-regulated signaling pathways via MDA-7/IL-24 von Ekmekcioglu, Suhendan, Mumm, John B., Udtha, Malini, Chada, Sunil, Grimm, Elizabeth A.

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MDA-7/IL-24 is a unique cytokine–tumor suppressor in the IL-10 Family von Chada, Sunil, Sutton, R.Bryan, Ekmekcioglu, Suhendan, Ellerhorst, Julie, Mumm, John B., Leitner, Wolfgang W., Yang, Heng-Yin, Sahin, Aysegul A., Hunt, Kelly K., Fuson, Kerry L., Poı̀ndexter, Nancy, Roth, Jack A., Ramesh, Rajagopal, Grimm, Elizabeth A., Mhashilkar, Abner M.

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Killing from within von Mumm, John B., Emmerich, Jan, Oft, Martin

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mda-7/IL24 kills pancreatic cancer cells by inhibition of the Wnt/PI3K signaling pathways: Identification of IL-20 receptor-mediated bystander activity against pancreatic cancer von Chada, Sunil, Bocangel, Dora, Ramesh, Rajagopal, Grimm, Elizabeth A., Mumm, John B., Mhashilkar, Abner M., Zheng, Mingzhong

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