The Current State of Peptide Drug Discovery: Back to the Future? von Henninot, Antoine, Collins, James C, Nuss, John M

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Author Correction: Genetically encoded discovery of perfluoroaryl macrocycles that bind to albumin and exhibit extended circulation in vivo von Wong, Jeffrey Y. K., Ekanayake, Arunika I., Kharchenko, Serhii, Kirberger, Steven E., Qiu, Ryan, Kelich, Payam, Sarkar, Susmita, Li, Jiaqian, Fernandez, Kleinberg X., Alvizo-Paez, Edgar R., Miao, Jiayuan, Kalhor-Monfared, Shiva, John, J. Dwyer, Kang, Hongsuk, Choi, Hwanho, Nuss, John M., Vederas, John C., Lin, Yu-Shan, Macauley, Matthew S., Vukovic, Lela, Pomerantz, William C. K., Derda, Ratmir

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Genetically encoded discovery of perfluoroaryl macrocycles that bind to albumin and exhibit extended circulation in vivo von Wong, Jeffrey Y. K., Ekanayake, Arunika I., Kharchenko, Serhii, Kirberger, Steven E., Qiu, Ryan, Kelich, Payam, Sarkar, Susmita, Li, Jiaqian, Fernandez, Kleinberg X., Alvizo-Paez, Edgar R., Miao, Jiayuan, Kalhor-Monfared, Shiva, John, J. Dwyer, Kang, Hongsuk, Choi, Hwanho, Nuss, John M., Vederas, John C., Lin, Yu-Shan, Macauley, Matthew S., Vukovic, Lela, Pomerantz, William C. K., Derda, Ratmir

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Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Syntha... von Wagman, Allan S, Boyce, Rustum S, Brown, Sean P, Fang, Eric, Goff, Dane, Jansen, Johanna M, Le, Vincent P, Levine, Barry H, Ng, Simon C, Ni, Zhi-Jie, Nuss, John M, Pfister, Keith B, Ramurthy, Savithri, Renhowe, Paul A, Ring, David B, Shu, Wei, Subramanian, Sharadha, Zhou, Xiaohui A, Shafer, Cynthia M, Harrison, Stephen D, Johnson, Kirk W, Bussiere, Dirksen E

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Selective Glycogen Synthase Kinase 3 Inhibitors Potentiate Insulin Activation of Glucose Transport and Utilization In Vitro and In Vivo von RING, David B, JOHNSON, Kirk W, WAGMAN, Allan S, HAMMOND, Mary-Ellen Wernette, HARRISON, Stephen D, HENRIKSEN, Erik J, NUSS, John M, GOFF, Dane, KINNICK, Tyson R, MA, Sylvia T, REEDER, John W, SAMUELS, Isa, SLABIAK, Trina

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Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973) von Rice, Kenneth D, Aay, Naing, Anand, Neel K, Blazey, Charles M, Bowles, Owen J, Bussenius, Joerg, Costanzo, Simona, Curtis, Jeffry K, Defina, Steven C, Dubenko, Larisa, Engst, Stefan, Joshi, Anagha A, Kennedy, Abigail R, Kim, Angie I, Koltun, Elena S, Lougheed, Julie C, Manalo, Jean-Claire L, Martini, Jean-Francois, Nuss, John M, Peto, Csaba J, Tsang, Tsze H, Yu, Peiwen, Johnston, Stuart

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Discovery of XL413, a potent and selective CDC7 inhibitor von Koltun, Elena S., Tsuhako, Amy Lew, Brown, David S., Aay, Naing, Arcalas, Arlyn, Chan, Vicky, Du, Hongwang, Engst, Stefan, Ferguson, Kim, Franzini, Maurizio, Galan, Adam, Holst, Charles R., Huang, Ping, Kane, Brian, Kim, Moon H., Li, Jia, Markby, David, Mohan, Manisha, Noson, Kevin, Plonowski, Arthur, Richards, Steven J., Robertson, Scott, Shaw, Kenneth, Stott, Gordon, Stout, Thomas J., Young, Jenny, Yu, Peiwen, Zaharia, Cristiana A., Zhang, Wentao, Zhou, Peiwen, Nuss, John M., Xu, Wei, Kearney, Patrick C.

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The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors von Kim, Moon H., Tsuhako, Amy Lew, Co, Erick W., Aftab, Dana T., Bentzien, Frauke, Chen, Jason, Cheng, Wei, Engst, Stefan, Goon, Levina, Klein, Rhett R., Le, Donna T., Mac, Morrison, Parks, Jason J., Qian, Fawn, Rodriquez, Monica, Stout, Thomas J., Till, Jeffrey H., Won, Kwang-Ai, Wu, Xiang, Michael Yakes, F., Yu, Peiwen, Zhang, Wentao, Zhao, Yeping, Lamb, Peter, Nuss, John M., Xu, Wei

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Discovery and optimization of novel pyridines as highly potent and selective glycogen synthase kinase 3 inhibitors von Ramurthy, Savithri, Pfister, Keith B., Boyce, Rustum S., Brown, Sean P., Costales, Abran Q., Desai, Manoj C., Fang, Eric, Levine, Barry H., Ng, Simon C., Nuss, John M., Ring, David B., Shafer, Cynthia M., Shu, Wei, Subramanian, Sharadha, Wagman, Allan S., Wang, Haixia, Bussiere, Dirksen E.

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Discovery of a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR) von Takeuchi, Craig S, Kim, Byung Gyu, Blazey, Charles M, Ma, Sunghoon, Johnson, Henry W. B, Anand, Neel K, Arcalas, Arlyn, Baik, Tae Gon, Buhr, Chris A, Cannoy, Jonah, Epshteyn, Sergey, Joshi, Anagha, Lara, Katherine, Lee, Matthew S, Wang, Longcheng, Leahy, James W, Nuss, John M, Aay, Naing, Aoyama, Ron, Foster, Paul, Lee, Jae, Lehoux, Isabelle, Munagala, Narsimha, Plonowski, Arthur, Rajan, Sharmila, Woolfrey, John, Yamaguchi, Kyoko, Lamb, Peter, Miller, Nicole

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Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase γ Inhibitors von Leahy, James W, Buhr, Chris A, Johnson, Henry W. B, Kim, Byung Gyu, Baik, TaeGon, Cannoy, Jonah, Forsyth, Timothy P, Jeong, Joon Won, Lee, Matthew S, Ma, Sunghoon, Noson, Kevin, Wang, Longcheng, Williams, Matthew, Nuss, John M, Brooks, Eric, Foster, Paul, Goon, Leanne, Heald, Nathan, Holst, Charles, Jaeger, Christopher, Lam, Scott, Lougheed, Julie, Nguyen, Lam, Plonowski, Arthur, Song, Joanne, Stout, Thomas, Wu, Xiang, Yakes, Michael F, Yu, Peiwen, Zhang, Wentao, Lamb, Peter, Raeber, Olivia

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Discovery of XL888: A novel tropane-derived small molecule inhibitor of HSP90 von Bussenius, Joerg, Blazey, Charles M., Aay, Naing, Anand, Neel K., Arcalas, Arlyn, Baik, TaeGon, Bowles, Owen J., Buhr, Chris A., Costanzo, Simona, Curtis, Jeffrey K., DeFina, Steven C., Dubenko, Larisa, Heuer, Timothy S., Huang, Ping, Jaeger, Christopher, Joshi, Anagha, Kennedy, Abigail R., Kim, Angie I., Lara, Katherine, Lee, Jae, Li, Jonathan, Lougheed, Julie C., Ma, Sunghoon, Malek, Shiva, Manalo, Jean-Claire L., Martini, Jean-Francois, McGrath, Garth, Nicoll, Monique, Nuss, John M., Pack, Michael, Peto, Csaba J., Tsang, Tsze H., Wang, Longcheng, Womble, Scott W., Yakes, Michael, Zhang, Wentao, Rice, Kenneth D.

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The design, synthesis, and biological evaluation of PIM kinase inhibitors von Tsuhako, Amy Lew, Brown, David S., Koltun, Elena S., Aay, Naing, Arcalas, Arlyn, Chan, Vicky, Du, Hongwang, Engst, Stefan, Franzini, Maurizio, Galan, Adam, Huang, Ping, Johnston, Stuart, Kane, Brian, Kim, Moon H., Douglas Laird, A., Lin, Rui, Mock, Lillian, Ngan, Iris, Pack, Michael, Stott, Gordon, Stout, Thomas J., Yu, Peiwen, Zaharia, Cristiana, Zhang, Wentao, Zhou, Peiwen, Nuss, John M., Kearney, Patrick C., Xu, Wei

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SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors von Forsyth, Timothy, Kearney, Patrick C., Kim, Byung Gyu, Johnson, Henry W.B., Aay, Naing, Arcalas, Arlyn, Brown, David S., Chan, Vicky, Chen, Jeff, Du, Hongwang, Epshteyn, Sergey, Galan, Adam A., Huynh, Tai P., Ibrahim, Mohamed A., Kane, Brian, Koltun, Elena S., Mann, Grace, Meyr, Lisa E., Lee, Matthew S., Lewis, Gary L., Noguchi, Robin T., Pack, Michael, Ridgway, Brian H., Shi, Xian, Takeuchi, Craig S., Zu, Peiwen, Leahy, James W., Nuss, John M., Aoyama, Ron, Engst, Stefan, Gendreau, Steven B., Kassees, Robert, Li, Jia, Lin, Shwu-Hwa, Martini, Jean-Francois, Stout, Thomas, Tong, Philip, Woolfrey, John, Zhang, Wentao, Yu, Peiwen

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Discovery of a Novel Class of Potent and Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists von Ibrahim, Mohamed A, Johnson, Henry W. B, Jeong, Joon Won, Lewis, Gary L, Shi, Xian, Noguchi, Robin T, Williams, Matthew, Leahy, James W, Nuss, John M, Woolfrey, John, Banica, Monica, Bentzien, Frauke, Chou, Yu-Chien, Gibson, Anna, Heald, Nathan, Lamb, Peter, Mattheakis, Larry, Matthews, David, Shipway, Aaron, Wu, Xiang, Zhang, WenTao, Zhou, Sihong, Shankar, Geetha

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Pyrazolopyrimidines as dual Akt/p70S6K inhibitors von Rice, Kenneth D., Kim, Moon H., Bussenius, Joerg, Anand, Neel K., Blazey, Charles M., Bowles, Owen J., Canne-Bannen, Lynne, Chan, Diva S.-M., Chen, Baili, Co, Erick W., Costanzo, Simona, DeFina, Steven C., Dubenko, Larisa, Engst, Stefan, Franzini, Maurizio, Huang, Ping, Jammalamadaka, Vasu, Khoury, Richard G., Klein, Rhett R., Laird, A.Douglas, Le, Donna T., Mac, Morrison B., Matthews, David J., Markby, David, Miller, Nicole, Nuss, John M., Parks, Jason J., Tsang, Tsze H., Tsuhako, Amy L., Wang, Yong, Xu, Wei

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Design and evaluation of a series of pyrazolopyrimidines as p70S6K inhibitors von Bussenius, Joerg, Anand, Neel K., Blazey, Charles M., Bowles, Owen J., Bannen, Lynne Canne, Chan, Diva S.-M., Chen, Baili, Co, Erick W., Costanzo, Simona, DeFina, Steven C., Dubenko, Larisa, Engst, Stefan, Franzini, Maurizio, Huang, Ping, Jammalamadaka, Vasu, Khoury, Richard G., Kim, Moon H., Klein, Rhett R., Laird, Douglas, Le, Donna T., Mac, Morrison B., Matthews, David J., Markby, David, Miller, Nicole, Nuss, John M., Parks, Jason J., Tsang, Tsze H., Tsuhako, Amy L., Wang, Yong, Xu, Wei, Rice, Kenneth D.

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An improved synthesis of 1,2,4-oxadiazoles on solid support von Rice, Kenneth D., Nuss, John M.

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Transition Metal Catalyzed Cycloadditions:  An Intramolecular [4 + 4] Cycloaddition Strategy for the Efficient Synthesis of Dicyclopenta[a,d]cyclooctene 5−8−5 Ring Systems von Wender, Paul A, Nuss, John M, Smith, David B, Suárez-Sobrino, Angel, Vågberg, Jan, Decosta, Debra, Bordner, Jon

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Simple and Efficient Synthesis of 3,4-Dihydro-2-pyridones via Novel Solid-Supported Aza-Annulation von Wagman, Allan S, Wang, Liang, Nuss, John M

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