Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance von Barbier, Valerie, Erbani, Johanna, Fiveash, Corrine, Davies, Julie M., Tay, Joshua, Tallack, Michael R., Lowe, Jessica, Magnani, John L., Pattabiraman, Diwakar R., Perkins, Andrew C., Lisle, Jessica, Rasko, John E. J., Levesque, Jean-Pierre, Winkler, Ingrid G.

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GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice von Chang, Jungshan, Patton, John T., Sarkar, Arun, Ernst, Beat, Magnani, John L., Frenette, Paul S.

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FLT3 inhibitors upregulate CXCR4 and E-selectin ligands via ERK suppression in AML cells and CXCR4/E-selectin inhibition enhances anti-leukemia efficacy of FLT3-targeted therapy in... von Jia, Yannan, Zhang, Weiguo, Basyal, Mahesh, Chang, Kyung Hee, Ostermann, Lauren, Burks, Jared K., Ly, Charlie, Mu-Mosley, Hong, Zhang, Qi, Han, Xin, Fogler, William E., Magnani, John L., Lesegretain, Arnaud, Zal, Anna A., Zal, Tomasz, Andreeff, Michael

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From carbohydrate leads to glycomimetic drugs von Ernst, Beat, Magnani, John L

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Phase 1 study of the E-selectin inhibitor GMI 1070 in patients with sickle cell anemia von Wun, Ted, Styles, Lori, DeCastro, Laura, Telen, Marilyn J, Kuypers, Frans, Cheung, Anthony, Kramer, William, Flanner, Henry, Rhee, Seungshin, Magnani, John L, Thackray, Helen

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E-selectin-targeting lipid nanoparticles improve therapeutic efficacy and reduce side effects of bortezomib in multiple myeloma von Maksimos, Mina, Muz, Barbara, Magnani, John L., Azab, Abdel Kareem

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Targeting Neutrophil Adhesive Events to Address Vaso-Occlusive Crisis in Sickle Cell Patients von Morikis, Vasilios A, Hernandez, Alfredo A, Magnani, John L, Sperandio, Markus, Simon, Scott I

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Bone vascular niche E-selectin induces mesenchymal–epithelial transition and Wnt activation in cancer cells to promote bone metastasis von Esposito, Mark, Mondal, Nandini, Greco, Todd M., Wei, Yong, Spadazzi, Chiara, Lin, Song-Chang, Zheng, Hanqiu, Cheung, Corey, Magnani, John L., Lin, Sue-Hwa, Cristea, Ileana M., Sackstein, Robert, Kang, Yibin

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Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow von Morikis, Vasilios A., Chase, Shannon, Wun, Ted, Chaikof, Elliot L., Magnani, John L., Simon, Scott I.

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Phase 1/2 study of uproleselan added to chemotherapy in patients with relapsed or refractory acute myeloid leukemia von DeAngelo, Daniel J., Jonas, Brian A., Liesveld, Jane L., Bixby, Dale L., Advani, Anjali S., Marlton, Paula, Magnani, John L., Thackray, Helen M., Feldman, Eric J., O'Dwyer, Michael E., Becker, Pamela S.

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Use of GMI‐1271, an E‐selectin antagonist, in healthy subjects and in 2 patients with calf vein thrombosis von Devata, Sumana, Angelini, Dana E., Blackburn, Susan, Hawley, Angela, Myers, Daniel D., Schaefer, Jordan K., Hemmer, Martina, Magnani, John L., Thackray, Helen M., Wakefield, Thomas W., Sood, Suman L.

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Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use von Telen, Marilyn J., Wun, Ted, McCavit, Timothy L., De Castro, Laura M., Krishnamurti, Lakshmanan, Lanzkron, Sophie, Hsu, Lewis L., Smith, Wally R., Rhee, Seungshin, Magnani, John L., Thackray, Helen

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Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance von Winkler, Ingrid G, Barbier, Valérie, Nowlan, Bianca, Jacobsen, Rebecca N, Forristal, Catherine E, Patton, John T, Magnani, John L, Lévesque, Jean-Pierre

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Determination of Glycolipid Ligands of Carbohydrate-Binding Proteins Directly on Thin Layer Chromatograms von Magnani, John L.

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A randomized clinical trial of the efficacy and safety of rivipansel for sickle cell vaso-occlusive crisis von Dampier, Carlton D., Telen, Marilyn Jo, Wun, Ted, Brown, R. Clark, Desai, Payal, El Rassi, Fuad, Fuh, Beng, Kanter, Julie, Pastore, Yves, Rothman, Jennifer, Taylor, James G., Readett, David, Sivamurthy, Krupa M., Tammara, Brinda, Tseng, Li-Jung, Lozier, Jay Nelson, Thackray, Helen, Magnani, John L., Hassell, Kathryn L.

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Clinical Trials and Applications of Galectin Antagonists von Girard, Armand, Magnani, John L.

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Combining 5-azacitidine with the E-selectin antagonist uproleselan is an effective strategy to augment responses in myelodysplasia and acute myeloid leukaemia von Enjeti, Anoop K, Fogler, William E, Smith, Theodore A G, Lincz, Lisa F, Bond, Danielle R, Magnani, John L

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E-Selectin Inhibition Mitigates Splenic HSC Activation and Myelopoiesis in Hypercholesterolemic Mice With Myocardial Infarction von Dutta, Partha, Hoyer, Friedrich Felix, Sun, Yuan, Iwamoto, Yoshiko, Tricot, Benoit, Weissleder, Ralph, Magnani, John L, Swirski, Filip K, Nahrendorf, Matthias

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Targeting hematologic malignancies by inhibiting E-selectin: A sweet spot for AML therapy? von Uy, Geoffrey L., DeAngelo, Daniel J., Lozier, Jay N., Fisher, Dennis M., Jonas, Brian A., Magnani, John L., Becker, Pamela S., Lazarus, Hillard M., Winkler, Ingrid G.

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P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment von Azab, Abdel Kareem, Quang, Phong, Azab, Feda, Pitsillides, Costas, Thompson, Brian, Chonghaile, Triona, Patton, John T., Maiso, Patricia, Monrose, Val, Sacco, Antonio, Ngo, Hai T., Flores, Ludmila M., Lin, Charles P., Magnani, John L., Kung, Andrew L., Letai, Anthony, Carrasco, Ruben, Roccaro, Aldo M., Ghobrial, Irene M.

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