Challenges in Modern Drug Discovery: A Case Study of Boceprevir, an HCV Protease Inhibitor for the Treatment of Hepatitis C Virus Infection von Njoroge, F. George, Chen, Kevin X, Shih, Neng-Yang, Piwinski, John J

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Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models von Han, Xu, Mei, Yang, Mishra, Rama K, Bi, Honghao, Jain, Atul D, Schiltz, Gary E, Zhao, Baobing, Sukhanova, Madina, Wang, Pan, Grigorescu, Arabela A, Weber, Patricia C, Piwinski, John J, Prado, Miguel A, Paulo, Joao A, Stephens, Len, Anderson, Karen E, Abrams, Charles S, Yang, Jing, Ji, Peng

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Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor von Arasappan, Ashok, Bennett, Frank, Bogen, Stephane L, Venkatraman, Srikanth, Blackman, Melissa, Chen, Kevin X, Hendrata, Siska, Huang, Yuhua, Huelgas, Regina M, Nair, Latha, Padilla, Angela I, Pan, Weidong, Pike, Russell, Pinto, Patrick, Ruan, Sumei, Sannigrahi, Mousumi, Velazquez, Francisco, Vibulbhan, Bancha, Wu, Wanli, Yang, Weiying, Saksena, Anil K, Girijavallabhan, Viyyoor, Shih, Neng-Yang, Kong, Jianshe, Meng, Tao, Jin, Yan, Wong, Jesse, McNamara, Paul, Prongay, Andrew, Madison, Vincent, Piwinski, John J, Cheng, Kuo-Chi, Morrison, Richard, Malcolm, Bruce, Tong, Xiao, Ralston, Robert, Njoroge, F. George

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Asymmetric Synthesis of 4,4-Disubstituted-2-Imidazoli-dinones:  Potent NK1 Antagonists von Reichard, Gregory A, Stengone, Carmine, Paliwal, Sunil, Mergelsberg, Ingrid, Majmundar, Sapna, Wang, Cheng, Tiberi, Robert, McPhail, Andrew T, Piwinski, John J, Shih, Neng-Yang

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A Useful Pd-Catalyzed Negishi Coupling Approach to Benzylic Sulfonamide Derivatives von Zhou, Gang, Ting, Pauline, Aslanian, Robert, Piwinski, John J

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Cyclic urea derivatives as potent NK1 selective antagonists. Part II: Effects of fluoro and benzylic methyl substitutions von Shue, Ho-Jane, Chen, Xiao, Schwerdt, John H, Paliwal, Sunil, Blythin, David J, Lin, Ling, Gu, Danlin, Wang, Cheng, Reichard, Gregory A, Wang, Hongwu, Piwinski, John J, Duffy, Ruth A, Lachowicz, Jean E, Coffin, Vicki L, Nomeir, Amin A, Morgan, Cynthia A, Varty, Geoffrey B, Shih, Neng-Yang

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Structural characterization of in vitro rat liver microsomal metabolites of antihistamine desloratadine using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydro... von Chen, Guodong, Daaro, Ibrahim, Pramanik, Birendra N, Piwinski, John J

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Identification of a dual histamine H1/H3 receptor ligand based on the H1 antagonist chlorpheniramine von ASLANIAN, Robert, MUTAHI, Mwangi Wa, SHIH, Neng-Yang, PIWINSKI, John J, WEST, Robert, WILLIAMS, Shirley M, SHE, Susan, WU, Ren-Long, HEY, John A

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Discovery and SAR of hydantoin TACE inhibitors von Yu, Wensheng, Guo, Zhuyan, Orth, Peter, Madison, Vincent, Chen, Lei, Dai, Chaoyang, Feltz, Robert J., Girijavallabhan, Vinay M., Kim, Seong Heon, Kozlowski, Joseph A., Lavey, Brian J., Li, Dansu, Lundell, Daniel, Niu, Xiaoda, Piwinski, John J., Popovici-Muller, Janeta, Rizvi, Razia, Rosner, Kristin E., Shankar, Bandarpalle B., Shih, Neng-Yang, Arshad Siddiqui, M., Sun, Jing, Tong, Ling, Umland, Shelby, Wong, Michael K.C., Yang, De-yi, Zhou, Guowei

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Discovery of oxazole-based PDE4 inhibitors with picomolar potency von Kuang, Rongze, Shue, Ho-Jane, Xiao, Li, Blythin, David J., Shih, Neng-Yang, Chen, Xiao, Gu, Danlin, Schwerdt, John, Lin, Ling, Ting, Pauline C., Cao, Jianhua, Aslanian, Robert, Piwinski, John J., Prelusky, Daniel, Wu, Ping, Zhang, Ji, Zhang, Xiang, Celly, Chander S., Billah, Motasim, Wang, Peng

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2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors von Dai, Chaoyang, Li, Dansu, Popovici-Muller, Janeta, Zhao, Lianyun, Girijavallabhan, Vinay M., Rosner, Kristin E., Lavey, Brian J., Rizvi, Razia, Shankar, Bandarpalle B., Wong, Michael K.C., Guo, Zhuyan, Orth, Peter, Strickland, Corey O., Sun, Jing, Niu, Xiaoda, Chen, Shiying, Kozlowski, Joseph A., Lundell, Daniel J., Piwinski, John J., Shih, Neng-Yang, Siddiqui, M. Arshad

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5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors von Arasappan, Ashok, Bennett, Frank, Girijavallabhan, Vinay, Huang, Yuhua, Huelgas, Regina, Alvarez, Carmen, Chen, Lei, Gavalas, Stephen, Kim, Seong-Heon, Kosinski, Aneta, Pinto, Patrick, Rizvi, Razia, Rossman, Randall, Shankar, Bandarpalle, Tong, Ling, Velazquez, Francisco, Venkatraman, Srikanth, Verma, Vishal A., Kozlowski, Joseph, Shih, Neng-Yang, Piwinski, John J., MacCoss, Malcolm, Kwong, Cecil D., Clark, Jeremy L., Fowler, Anita T., Geng, Feng, Kezar, Hollis S., Roychowdhury, Abhijit, Reynolds, Robert C., Maddry, Joseph A., Ananthan, Subramaniam, Secrist, John A., Li, Cheng, Chase, Robert, Curry, Stephanie, Huang, Hsueh-Cheng, Tong, Xiao, Njoroge, F. George

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Biaryl substituted hydantoin compounds as TACE inhibitors von Yu, Wensheng, Tong, Ling, Kim, Seong Heon, Wong, Michael K.C., Chen, Lei, Yang, De-Yi, Shankar, Bandarpalle B., Lavey, Brian J., Zhou, Guowei, Kosinski, Aneta, Rizvi, Razia, Li, Dansu, Feltz, Robert J., Piwinski, John J., Rosner, Kristin E., Shih, Neng-Yang, Siddiqui, M. Arshad, Guo, Zhuyan, Orth, Peter, Shah, Himanshu, Sun, Jing, Umland, Shelby, Lundell, Daniel J., Niu, Xiaoda, Kozlowski, Joseph A.

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Novel substituted pyrimidines as HCV replication (replicase) inhibitors von Kwong, Cecil D., Clark, Jeremy L., Fowler, Anita T., Geng, Feng, Kezar, Hollis S., Roychowdhury, Abhijit, Reynolds, Robert C., Maddry, Joseph A., Ananthan, Subramaniam, Secrist, John A., Shih, Neng-Yang, Piwinski, John J., Li, Cheng, Feld, Boris, Huang, Hsueh-Cheng, Tong, Xiao, George Njoroge, F., Arasappan, Ashok

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Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors von Girijavallabhan, Vinay M., Alvarez, Carmen, Bennett, Frank, Chen, Lei, Gavalas, Stephen, Huang, Yuhua, Kim, Seong-Heon, Kosinski, Aneta, Pinto, Patrick, Rizvi, Razia, Rossman, Randall, Shankar, Bandarpalle, Tong, Ling, Velazquez, Francisco, Venkatraman, Srikanth, Verma, Vishal A., Kozlowski, Joseph, Shih, Neng-Yang, Piwinski, John J., MacCoss, Malcolm, Kwong, Cecil D., Bansal, Namita, Clark, Jeremy L., Fowler, Anita T., Kezar, Hollis S., Valiyaveettil, Jacob, Reynolds, Robert C., Maddry, Joseph A., Ananthan, Subramaniam, Secrist, John A., Li, Cheng, Chase, Robert, Curry, Stephanie, Huang, Hsueh-Cheng, Tong, Xiao, Njoroge, F. George, Arasappan, Ashok

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Synthesis and profile of SCH351591, a novel PDE4 inhibitor von Billah, Motasim, Cooper, Nicola, Cuss, Francis, Davenport, Richard J., Dyke, Hazel J., Egan, Robert, Ganguly, Ashit, Gowers, Lewis, Hannah, Duncan R., Haughan, Alan F., Kendall, Hannah J., Lowe, Christopher, Minnicozzi, Michael, Montana, John G., Naylor, Robert, Oxford, Janet, Peake, Joanna C., Piwinski, John J., Runcie, Karen A., Sabin, Verity, Sharpe, Andrew, Shih, Neng-Yang, Warneck, Julie B.H.

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Synthesis and NK1/NK2 binding activities of a series of diacyl-substituted 2-arylpiperazines von BLYTHIN, David J, XIAO CHEN, PIWINSKI, John J, SHIH, Neng-Yang, SHUE, Ho-Jane, ANTHES, John C, MCPHAIL, Andrew T

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Benzimidazole-substituted (3-phenoxypropyl)amines as histamine H3 receptor ligands von Aslanian, Robert, Zhu, Xiaohong, Vaccaro, Henry A., Shih, Neng-Yang, Piwinski, John J., Williams, Shirley M., West, Robert E.

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The discovery of novel tartrate-based TNF-α converting enzyme (TACE) inhibitors von Rosner, Kristin E., Guo, Zhuyan, Orth, Peter, Shipps, Gerald W., Belanger, David B., Chan, Tin Yau, Curran, Patrick J., Dai, Chaoyang, Deng, Yongqi, Girijavallabhan, Vinay M., Hong, Liwu, Lavey, Brian J., Lee, Joe F., Li, Dansu, Liu, Zhidan, Popovici-Muller, Janeta, Ting, Pauline C., Vaccaro, Henry, Wang, Li, Wang, Tong, Yu, Wensheng, Zhou, Guowei, Niu, Xiaoda, Sun, Jing, Kozlowski, Joseph A., Lundell, Daniel J., Madison, Vincent, McKittrick, Brian, Piwinski, John J., Shih, Neng -Yang, Arshad Siddiqui, M., Strickland, Corey O.

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Novel TNF-α converting enzyme (TACE) inhibitors as potential treatment for inflammatory diseases von Girijavallabhan, Vinay M., Chen, Lei, Dai, Chaoyang, Feltz, Robert J., Firmansjah, Luke, Li, Dansu, Kim, Seong Heon, Kozlowski, Joseph A., Lavey, Brian J., Kosinski, Aneta, Piwinski, John J., Popovici-Muller, Janeta, Rizvi, Razia, Rosner, Kristin E., Shankar, Banderpalle B., Shih, Neng-Yang, Siddiqui, M. Arshad, Tong, Ling, Wong, Michael K.C., Yang, De-yi, Yang, Liping, Yu, Wensheng, Zhou, Guowei, Guo, Zhuyan, Orth, Peter, Madison, Vincent, Bian, Hong, Lundell, Daniel, Niu, Xiaoda, Shah, Himanshu, Sun, Jing, Umland, Shelby

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