Prion Strain Mutation and Selection von Collinge, John

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Genetic Factors in Mammalian Prion Diseases von Mead, Simon, Lloyd, Sarah, Collinge, John

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Mammalian prions and their wider relevance in neurodegenerative diseases von Collinge, John

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2.7 Å cryo-EM structure of ex vivo RML prion fibrils von Manka, Szymon W., Zhang, Wenjuan, Wenborn, Adam, Betts, Jemma, Joiner, Susan, Saibil, Helen R., Collinge, John, Wadsworth, Jonathan D. F.

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Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis von Smethurst, Phillip, Risse, Emmanuel, Tyzack, Giulia E, Mitchell, Jamie S, Taha, Doaa M, Chen, Yun-Ru, Newcombe, Jia, Collinge, John, Sidle, Katie, Patani, Rickie

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Prion propagation and toxicity in vivo occur in two distinct mechanistic phases von Sandberg, Malin K., Al-Doujaily, Huda, Sharps, Bernadette, Clarke, Anthony R., Collinge, John

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PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins von Corbett, Grant T., Wang, Zemin, Hong, Wei, Colom-Cadena, Marti, Rose, Jamie, Liao, Meichen, Asfaw, Adhana, Hall, Tia C., Ding, Lai, DeSousa, Alexandra, Frosch, Matthew P., Collinge, John, Harris, David A., Perkinton, Michael S., Spires-Jones, Tara L., Young-Pearse, Tracy L., Billinton, Andrew, Walsh, Dominic M.

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Detection of prion infection in variant Creutzfeldt-Jakob disease: a blood-based assay von Edgeworth, Julie Ann, PhD, Farmer, Michael, BSc, Sicilia, Anita, MSc, Tavares, Paul, MSc, Beck, Jonathan, BSc, Campbell, Tracy, BSc, Lowe, Jessica, BSc, Mead, Simon, PhD, Rudge, Peter, FRCP, Collinge, John, Prof, Jackson, Graham S, Dr

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Lessons of kuru research: background to recent studies with some personal reflections von Collinge, John

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Safety and efficacy of quinacrine in human prion disease (PRION-1 study): a patient-preference trial von Collinge, John, MD, Gorham, Michele, RN, Hudson, Fleur, BA, Kennedy, Angus, MD, Keogh, Geraldine, Pal, Suvankar, MRCP, Rossor, Martin, MD, Rudge, Peter, FRCP, Siddique, Durre, PhD, Spyer, Moira, PhD, Thomas, Dafydd, MD, Walker, Sarah, PhD, Webb, Tom, BSc, Wroe, Steve, MD, Darbyshire, Janet, FRCP

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A naturally occurring variant of the human prion protein completely prevents prion disease von Asante, Emmanuel A., Smidak, Michelle, Grimshaw, Andrew, Houghton, Richard, Tomlinson, Andrew, Jeelani, Asif, Jakubcova, Tatiana, Hamdan, Shyma, Richard-Londt, Angela, Linehan, Jacqueline M., Brandner, Sebastian, Alpers, Michael, Whitfield, Jerome, Mead, Simon, Wadsworth, Jonathan D. F., Collinge, John

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Bank vole prion protein extends the use of RT-QuIC assays to detect prions in a range of inherited prion diseases von Mok, Tze How, Nihat, Akin, Luk, Connie, Sequeira, Danielle, Batchelor, Mark, Mead, Simon, Collinge, John, Jackson, Graham S.

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Large C9orf72 Hexanucleotide Repeat Expansions Are Seen in Multiple Neurodegenerative Syndromes and Are More Frequent Than Expected in the UK Population von Beck, Jon, Poulter, Mark, Hensman, Davina, Rohrer, Jonathan D., Mahoney, Colin J., Adamson, Gary, Campbell, Tracy, Uphill, James, Borg, Aaron, Fratta, Pietro, Orrell, Richard W., Malaspina, Andrea, Rowe, James, Brown, Jeremy, Hodges, John, Sidle, Katie, Polke, James M., Houlden, Henry, Schott, Jonathan M., Fox, Nick C., Rossor, Martin N., Tabrizi, Sarah J., Isaacs, Adrian M., Hardy, John, Warren, Jason D., Collinge, John, Mead, Simon

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Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked von Sandberg, Malin K., Al-Doujaily, Huda, Sharps, Bernadette, De Oliveira, Michael Wiggins, Schmidt, Christian, Richard-Londt, Angela, Lyall, Sarah, Linehan, Jacqueline M., Brandner, Sebastian, Wadsworth, Jonathan D. F., Clarke, Anthony R., Collinge, John

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Prion protein gene mutation detection using long-read Nanopore sequencing von Kroll, François, Dimitriadis, Athanasios, Campbell, Tracy, Darwent, Lee, Collinge, John, Mead, Simon, Vire, Emmanuelle

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A high-content neuron imaging assay demonstrates inhibition of prion disease-associated neurotoxicity by an anti-prion protein antibody von Reilly, Madeleine, Benilova, Iryna, Khalili-Shirazi, Azadeh, Schmidt, Christian, Ahmed, Parvin, Yip, Daniel, Jat, Parmjit S., Collinge, John

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Structural features distinguishing infectious ex vivo mammalian prions from non-infectious fibrillar assemblies generated in vitro von Terry, Cassandra, Harniman, Robert L., Sells, Jessica, Wenborn, Adam, Joiner, Susan, Saibil, Helen R., Miles, Mervyn J., Collinge, John, Wadsworth, Jonathan D. F.

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Two mouse models of Alzheimer’s disease accumulate amyloid at different rates and have distinct Aβ oligomer profiles unaltered by ablation of cellular prion protein von Purro, Silvia A., Farmer, Michael, Noble, Elizabeth, Sarell, Claire J., Powell, Megan, Yip, Daniel, Giggins, Lauren, Zakka, Leila, Thomas, David X., Farrow, Mark, Nicoll, Andrew J., Walsh, Dominic, Collinge, John

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Depleting Neuronal PrP in Prion Infection Prevents Disease and Reverses Spongiosis von Mallucci, Giovanna, Dickinson, Andrew, Linehan, Jacqueline, Klöhn, Peter-Christian, Brandner, Sebastian, Collinge, John

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Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease von White, Melanie D, Farmer, Michael, Mirabile, Ilaria, Brandner, Sebastian, Collinge, John, Mallucci, Giovanna R

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