Pharmacological inhibition of hematopoietic progenitor kinase 1 positively regulates T-cell function von Wang, Yun, Zhang, Kelvin, Georgiev, Peter, Wells, Steven, Xu, Haiyan, Lacey, Brian M, Xu, Zangwei, Laskey, Jason, Mcleod, Robbie, Methot, Joey L, Bittinger, Mark, Pasternak, Alexander, Ranganath, Sheila

Volltext

Nucleophilic Phosphine Organocatalysis von Methot, Joey L., Roush, William R.

Volltext

High-Throughput Covalent Modifier Screening with Acoustic Ejection Mass Spectrometry von Wen, Xiujuan, Liu, Chang, Tovar, Kiersten, Curran, Patrick, Richards, Matthew, Agrawal, Sony, Johnstone, Richard, Loy, Ryan E., Methot, Joey L., Mansueto, My Sam, Koglin, Markus, Wildey, Mary Jo, Burton, Lyle, Covey, Thomas R., Bateman, Kevin P., Kavana, Michael, McLaren, David G.

Volltext

Identification of Potent Reverse Indazole Inhibitors for HPK1 von Yu, Elsie C, Methot, Joey L, Fradera, Xavier, Lesburg, Charles A, Lacey, Brian M, Siliphaivanh, Phieng, Liu, Ping, Smith, Dustin M, Xu, Zangwei, Piesvaux, Jennifer A, Kawamura, Shuhei, Xu, Haiyan, Miller, J. Richard, Bittinger, Mark, Pasternak, Alexander

Volltext

Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow von Fradera, Xavier, Methot, Joey L., Achab, Abdelghani, Christopher, Matthew, Altman, Michael D., Zhou, Hua, McGowan, Meredeth A., Kattar, Sam D., Wilson, Kevin, Garcia, Yudith, Augustin, Martin A., Lesburg, Charles A., Shah, Sanjiv, Goldenblatt, Peter, Katz, Jason D.

Volltext

Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators von Methot, Joey L, Zhou, Hua, McGowan, Meredeth A, Anthony, Neville John, Christopher, Matthew, Garcia, Yudith, Achab, Abdelghani, Lipford, Kathryn, Trotter, Benjamin Wesley, Altman, Michael D, Fradera, Xavier, Lesburg, Charles A, Li, Chaomin, Alves, Stephen, Chappell, Craig P, Jain, Renu, Mangado, Ruban, Pinheiro, Elaine, Williams, Sybill M. G, Goldenblatt, Peter, Hill, Armetta, Shaffer, Lynsey, Chen, Dapeng, Tong, Vincent, McLeod, Robbie L, Lee, Hyun-Hee, Yu, Hongshi, Shah, Sanjiv, Katz, Jason D

Volltext

Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors von Zhou, Hua, McGowan, Meredeth A., Lipford, Kathryn, Christopher, Matthew, Fradera, Xavier, Witter, David, Lesburg, Charles A., Li, Chaomin, Methot, Joey L., Lampe, John, Achab, Abdelghani, Shaffer, Lynsey, Goldenblatt, Peter, Shah, Sanjiv, Bass, Alan, Schroeder, Gottfried, Chen, Dapeng, Zeng, Haoyu, Augustin, Martin A., Katz, Jason D.

Volltext

Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds von Vara, Brandon A, Levi, Samuel M, Achab, Abdelghani, Candito, David A, Fradera, Xavier, Lesburg, Charles A, Kawamura, Shuhei, Lacey, Brian M, Lim, Jongwon, Methot, Joey L, Xu, Zangwei, Xu, Haiyan, Smith, Dustin M, Piesvaux, Jennifer A, Miller, J. Richard, Bittinger, Mark, Ranganath, Sheila H, Bennett, David J, DiMauro, Erin F, Pasternak, Alexander

Volltext

Discovery of a new series of PI3K-δ inhibitors from Virtual Screening von Fradera, Xavier, Deng, Qiaolin, Achab, Abdelganhi, Garcia, Yudith, Kattar, Solomon D., McGowan, Meredeth A., Methot, Joey L., Wilson, Kevin, Zhou, Hua, Shaffer, Lynsey, Goldenblatt, Peter, Tong, Vincent, Augustin, Martin A, Altman, Michael D., Lesburg, Charles A., Shah, Sanjiv, Katz, Jason D.

Volltext

Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability von Methot, Joey L, Zhou, Hua, Kattar, Sam D, McGowan, Meredeth A, Wilson, Kevin, Garcia, Yudith, Deng, Yongi, Altman, Michael, Fradera, Xavier, Lesburg, Charles, Fischmann, Thierry, Li, Chaomin, Alves, Steve, Shah, Sanjiv, Fernandez, Rafael, Goldenblatt, Peter, Hill, Armetta, Shaffer, Lynsey, Chen, Dapeng, Tong, Vince, McLeod, Robbie L, Yu, Hongshi, Bass, Alan, Kemper, Ray, Gatto, Nicholas T, LaFranco-Scheuch, Lisa, Trotter, Benjamin Wesley, Guzi, Timothy, Katz, Jason D

Volltext

Discovery of 1‑(1H‑Pyrazolo[4,3‑c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers von Lim, Jongwon, Kelley, Elizabeth H, Methot, Joey L, Zhou, Hua, Petrocchi, Alessia, Chen, Hongmin, Hill, Susan E, Hinton, Marlene C, Hruza, Alan, Jung, Joon O, Maclean, John K. F, Mansueto, My, Naumov, George N, Philippar, Ulrike, Raut, Shruti, Spacciapoli, Peter, Sun, Dongyu, Siliphaivanh, Phieng

Volltext

Corrigendum to “Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow” [Bioorg. Med. Chem. Lett. 29 (2019) 2575–2580] von Fradera, Xavier, Methot, Joey L., Achab, Abdelghani, Christopher, Matthew, Altman, Michael D., Zhou, Hua, McGowan, Meredeth A., Kattar, Sam D., Wilson, Kevin, Garcia, Yudith, Augustin, Martin A., Lesburg, Charles A., Shah, Sanjiv, Goldenblatt, Peter, Katz, Jason D.

Volltext

Optimization of Versatile Oxindoles as Selective PI3Kδ Inhibitors von Methot, Joey L, Achab, Abdelghani, Christopher, Matthew, Zhou, Hua, McGowan, Meredeth A, Trotter, B. Wesley, Fradera, Xavier, Lesburg, Charles A, Goldenblatt, Peter, Hill, Armetta, Chen, Dapeng, Otte, Karin M, Augustin, Martin, Shah, Sanjiv, Katz, Jason D

Volltext

Molecular and biologic analysis of histone deacetylase inhibitors with diverse specificities von Newbold, Andrea, Matthews, Geoffrey M, Bots, Michael, Cluse, Leonie A, Clarke, Christopher J P, Banks, Kellie-Marie, Cullinane, Carleen, Bolden, Jessica E, Christiansen, Ailsa J, Dickins, Ross A, Miccolo, Claudia, Chiocca, Susanna, Kral, Astrid M, Ozerova, Nicole D, Miller, Thomas A, Methot, Joey L, Richon, Victoria M, Secrist, J Paul, Minucci, Saverio, Johnstone, Ricky W

Volltext

Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2) von Methot, Joey L., Chakravarty, Prasun K., Chenard, Melissa, Close, Joshua, Cruz, Jonathan C., Dahlberg, William K., Fleming, Judith, Hamblett, Christopher L., Hamill, Julie E., Harrington, Paul, Harsch, Andreas, Heidebrecht, Richard, Hughes, Bethany, Jung, Joon, Kenific, Candia M., Kral, Astrid M., Meinke, Peter T., Middleton, Richard E., Ozerova, Nicole, Sloman, David L., Stanton, Matthew G., Szewczak, Alexander A., Tyagarajan, Sriram, Witter, David J., Paul Secrist, J., Miller, Thomas A.

Volltext

Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors von Gulati, Anmol, Yeung, Charles S, Lapointe, Blair, Kattar, Solomon D, Gunaydin, Hakan, Scott, Jack D, Childers, Kaleen K, Methot, Joey L, Simov, Vladimir, Kurukulasuriya, Ravi, Pio, Barbara, Morriello, Greg J, Liu, Ping, Tang, Haiqun, Neelamkavil, Santhosh, Wood, Harold B, Rada, Vanessa L, Ardolino, Michael J, Yan, Xin Cindy, Palte, Rachel, Otte, Karin, Faltus, Robert, Woodhouse, Janice, Hegde, Laxminarayan G, Ciaccio, Paul, Minnihan, Ellen C, DiMauro, Erin F, Fell, Matthew J, Fuller, Peter H, Ellis, J. Michael

Volltext

Synthetic Studies toward FR182877. Remarkable Solvent Effect in the Vinylogous Morita−Baylis−Hillman Cyclization von Methot, Joey L, Roush, William R

Volltext

Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors von Lacey, Brian M., Xu, Zangwei, Chai, Xiaomei, Laskey, Jason, Fradera, Xavier, Mittal, Payal, Mishra, Sasmita, Piesvaux, Jennifer, Saradjian, Peter, Shaffer, Lynsey, Vassileva, Galya, Gerdt, Catherine, Wang, Yun, Ferguson, Heidi, Smith, Dustin M., Ballard, Jeanine, Wells, Steven, Jain, Rishabh, Mueller, Uwe, Addona, George, Kariv, Ilona, Methot, Joey L., Bittinger, Mark, Ranganath, Sheila, Mcleod, Robbie, Pasternak, Alexander, Miller, J. Richard, Xu, Haiyan

Volltext

Total Synthesis and Stereochemical Revision of (+)-Aeruginosin 298-A von Wipf, Peter, Methot, Joey-Lee

Volltext

Potent benzoazepinone γ-secretase modulators with improved bioavailability von Methot, Joey L., Fischer, Christian, Li, Chaomin, Rivkin, Alexey, Ahearn, Sean P., Brown, William Colby, Kattar, Sam, Kelley, Elizabeth, Mampreian, Dawn M., Schell, Adam, Rosenau, Andrew, Zhou, Hua, Ball, Richard, Deshmukh, Sujal V., Jeliazkova-Mecheva, Valentina V., Diaz, Damaris, Moy, Lily Y., Kenific, Candia M., Moxham, Chris, Shah, Sanjiv, Nuthall, Hugh, Szewczak, Alexander A., Hill, Armetta, Hughes, Bethany, Smotrov, Nadya, Munoz, Benito, Miller, Thomas A., Shearman, Mark S.

Volltext