Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors von Lindsley, Craig W., Zhao, Zhijian, Leister, William H., Robinson, Ronald G., Barnett, Stanley F., Defeo-Jones, Deborah, Jones, Raymond E., Hartman, George D., Huff, Joel R., Huber, Hans E., Duggan, Mark E.

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Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors von Zhao, Zhijian, Leister, William H., Robinson, Ronald G., Barnett, Stanley F., Defeo-Jones, Deborah, Jones, Raymond E., Hartman, George D., Huff, Joel R., Huber, Hans E., Duggan, Mark E., Lindsley, Craig W.

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A Naphthyridine Carboxamide Provides Evidence for Discordant Resistance between Mechanistically Identical Inhibitors of HIV-1 Integrase von Hazuda, Daria J., Anthony, Neville J., Gomez, Robert P., Jolly, Samson M., Wai, John S., Zhuang, Linghang, Fisher, Thorsten E., Embrey, Mark, Guare, James P., Egbertson, Melissa S., Vacca, Joseph P., Huff, Joel R., Felock, Peter J., Witmer, Marc V., Stillmock, Kara A., Danovich, Robert, Grobler, Jay, Miller, Michael D., Espeseth, Amy S., Jin, Lixia, I-Wu Chen, Lin, Jiunn H., Kassahun, Kelem, Ellis, Joan D., Wong, Bradley K., Xu, Wei, Pearson, Paul G., Schleif, William A., Cortese, Riccardo, Emini, Emilio, Summa, Vincenzo, Holloway, M. Katharine, Young, Steven D., Coffin, John M.

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Discovery of Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 5 from a Series of N-(1,3-Diphenyl-1H- pyrazol-5-yl)benzamides That Potentiate Receptor... von Lindsley, Craig W, Wisnoski, David D, Leister, William H, O'Brien, Julie A, Lemaire, Wei, Williams, David L, Burno, Maryann, Sur, Cyrille, Kinney, Gene G, Pettibone, Doug J, Tiller, Philip R, Smith, Sheri, Duggan, Mark E, Hartman, George D, Conn, P. Jeffrey, Huff, Joel R

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Identification of MK-944a:  A Second Clinical Candidate from the Hydroxylaminepentanamide Isostere Series of HIV Protease Inhibitors von Dorsey, Bruce D, McDonough, Colleen, McDaniel, Stacey L, Levin, Rhonda B, Newton, Christina L, Hoffman, Jacob M, Darke, Paul L, Zugay-Murphy, Joan A, Emini, Emilio A, Schleif, William A, Olsen, David B, Stahlhut, Mark W, Rutkowski, Carrie A, Kuo, Lawrence C, Lin, Jiunn H, Chen, I-W, Michelson, Stuart R, Holloway, M. Katharine, Huff, Joel R, Vacca, Joseph P

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HIV protease: a novel chemotherapeutic target for AIDS von Huff, Joel R

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Nonpeptide αvβ3 Antagonists. 8. In Vitro and in Vivo Evaluation of a Potent αvβ3 Antagonist for the Prevention and Treatment of Osteoporosis von Hutchinson, John H, Halczenko, Wasyl, Brashear, Karen M, Breslin, Michael J, Coleman, Paul J, Duong, Le T, Fernandez-Metzler, Carmen, Gentile, Michael A, Fisher, John E, Hartman, George D, Huff, Joel R, Kimmel, Donald B, Leu, Chih-Tai, Meissner, Robert S, Merkle, Kara, Nagy, Rose, Pennypacker, Brenda, Perkins, James J, Prueksaritanont, Thomayant, Rodan, Gideon A, Varga, Sandor L, Wesolowski, Greg A, Zartman, Amy E, Rodan, Sevgi B, Duggan, Mark E

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3-Aminopyrrolidinone Farnesyltransferase Inhibitors:  Design of Macrocyclic Compounds with Improved Pharmacokinetics and Excellent Cell Potency von Bell, Ian M, Gallicchio, Steven N, Abrams, Marc, Beese, Lorena S, Beshore, Douglas C, Bhimnathwala, Hema, Bogusky, Michael J, Buser, Carolyn A, Culberson, J. Christopher, Davide, Joseph, Ellis-Hutchings, Michelle, Fernandes, Christine, Gibbs, Jackson B, Graham, Samuel L, Hamilton, Kelly A, Hartman, George D, Heimbrook, David C, Homnick, Carl F, Huber, Hans E, Huff, Joel R, Kassahun, Kelem, Koblan, Kenneth S, Kohl, Nancy E, Lobell, Robert B, Lynch, Joseph J, Robinson, Ronald, Rodrigues, A. David, Taylor, Jeffrey S, Walsh, Eileen S, Williams, Theresa M, Zartman, C. Blair

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Conformational Restriction of Flexible Ligands Guided by the Transferred NOE Experiment:  Potent Macrocyclic Inhibitors of Farnesyltransferase von Dinsmore, Christopher J, Bogusky, Michael J, Culberson, J. Christopher, Bergman, Jeffrey M, Homnick, Carl F, Zartman, C. Blair, Mosser, Scott D, Schaber, Michael D, Robinson, Ronald G, Koblan, Kenneth S, Huber, Hans E, Graham, Samuel L, Hartman, George D, Huff, Joel R, Williams, Theresa M

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Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands von Ghosh, Arun K, Thompson, Wayne J, Holloway, M. Katharine, McKee, Sean P, Duong, Tien T, Lee, Hee Yoon, Munson, Peter M, Smith, Anthony M, Wai, Jenny M, Darke, Paul L, Zugay, Joan A, Emini, Emilio A, Schleif, William A, Huff, Joel R, Anderson, Paul S

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Design and Biological Activity of (S)-4-(5-{[1-(3-Chlorobenzyl)-2- oxopyrrolidin-3-ylamino]methyl}imidazol-1-ylmethyl)benzonitrile, a 3-Aminopyrrolidinone Farnesyltransferase Inhib... von Bell, Ian M, Gallicchio, Steven N, Abrams, Marc, Beshore, Douglas C, Buser, Carolyn A, Culberson, J. Christopher, Davide, Joseph, Ellis-Hutchings, Michelle, Fernandes, Christine, Gibbs, Jackson B, Graham, Samuel L, Hartman, George D, Heimbrook, David C, Homnick, Carl F, Huff, Joel R, Kassahun, Kelem, Koblan, Kenneth S, Kohl, Nancy E, Lobell, Robert B, Lynch, Joseph J, Miller, Patricia A, Omer, Charles A, Rodrigues, A. David, Walsh, Eileen S, Williams, Theresa M

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Nonpeptide αvβ3 antagonists. Part 2: Constrained glycyl amides derived from the RGD tripeptide von MEISSNER, Robert S, PERKINS, James J, RODAN, Gideon A, RODAN, Sevgi B, WHITMAN, David B, WESOLOWSKI, Gregg A, DUGGAN, Mark E, DUONG, Le T, HARTMAN, George D, HOFFMAN, William F, HUFF, Joel R, IHLE, Nathan C, LEU, Chih-Tai, NAGY, Rose M, NAYLOR-OLSEN, Adel

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The total synthesis of D- and L-myo-inositol 1,4,5-trisphosphate von Vacca, Joseph P, DeSolms, S. Jane, Huff, Joel R

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N-Arylpiperazinone Inhibitors of Farnesyltransferase:  Discovery and Biological Activity von Williams, Theresa M, Bergman, Jeffrey M, Brashear, Karen, Breslin, Michael J, Dinsmore, Christopher J, Hutchinson, John H, MacTough, Suzanne C, Stump, Craig A, Wei, Donna D, Zartman, C. Blair, Bogusky, Michael J, Culberson, J. Christopher, Buser-Doepner, Carolyn, Davide, Joseph, Greenberg, Ian B, Hamilton, Kelly A, Koblan, Kenneth S, Kohl, Nancy E, Liu, Dongming, Lobell, Robert B, Mosser, Scott D, O'Neill, Timothy J, Rands, Elaine, Schaber, Michael D, Wilson, Francine, Senderak, Edith, Motzel, Sherri L, Gibbs, Jackson B, Graham, Samuel L, Heimbrook, David C, Hartman, George D, Oliff, Allen I, Huff, Joel R

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Nonpeptidal P2 Ligands for HIV Protease Inhibitors:  Structure-Based Design, Synthesis, and Biological Evaluation von Ghosh, Arun K, Kincaid, John F, Walters, D. Eric, Chen, Yan, Chaudhuri, Narayan C, Thompson, Wayne J, Culberson, Chris, Fitzgerald, Paula M. D, Lee, Hee Yoon, McKee, Sean P, Munson, Peter M, Duong, Tien T, Darke, Paul L, Zugay, Joan A, Schleif, William A, Axel, Melinda G, Lin, Juinn, Huff, Joel R

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Synthesis of Conformationally Constrained 5,6,7,8-Tetrahydroimidazo[1,5-a]pyridine Inhibitors of Farnesyltransferase von Dinsmore, Christopher J, Zartman, C. Blair, Baginsky, Walter F, O'Neill, Timothy J, Koblan, Kenneth S, Chen, I-Wu, McLoughlin, Debra A, Olah, Timothy V, Huff, Joel R

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Structure-Based Design of HIV-1 Protease Inhibitors: Replacement of Two Amides and a 10.pi.-Aromatic System by a Fused Bis-tetrahydrofuran von Ghosh, Arun K, Thompson, Wayne J, Fitzgerald, Paula M. D, Culberson, J. Chris, Axel, Melinda G, McKee, Sean P, Huff, Joel R, Anderson, Paul S

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The total synthesis of myo-inositol phosphates via myo-inositol orthoformate von BILLINGTON, D. C, BAKER, R, KULAGOWSKI, J. J, MAWER, I. M, VACCA, J. P, DESOLMS, S. J, HUFF, J. R

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Cyclic sulfone-3-carboxamides as novel P2-ligands for Ro 31-8959 based HIV-1 protease inhibitors von Ghosh, Arun K., Thompson, Wayne J., Munson, Peter M., Liu, Wenming, Huff, Joel R.

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Cyclic sulfone-3-carboxamides as novel P 2-ligands for Ro 31-8959 based HIV-1 protease inhibitors von Ghosh, Arun K., Thompson, Wayne J., Munson, Peter M., Liu, Wenming, Huff, Joel R.

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